Professor Bazbek Davletov

Professor Bazbek DavletovChair in Biomedical Science
Department of Biomedical Science
Room D225, Denny building
The University of Sheffield
Western Bank, Sheffield S10 2TN
United Kingdom

Telephone: +44 (0) 114 222 5111
email: b.davletov@sheffield.ac.uk


Human SIMA neuroblastoma cells

Career history

  • 2012-present: Chair in Biomedical Science, Department of Biomedical Science, University of Sheffield, UK.
  • 1998-2012: Programme Leader, Medical Research Council, The MRC Laboratory of Molecular Biology, Cambridge, UK.
  • 1995-1997: Wellcome Trust Research Fellow, Imperial College, London.
  • 1988-1991: Research Associate, Institute of Bioorganic Chemistry, Moscow.

Educational qualifications:

  • 1992-1994: PhD, University of Texas Southwestern Medical Center, Dallas, USA. Supervisor: Prof Thomas Sudhof, Nobel Prize in Physiology and Medicine 2013. 11 joint publications.
  • 1980-1985: BA, MSc in Biochemistry, Moscow State University, Russia.

Research interests

We are working on biomolecular assembly, neuronal blockers, medicines for chronic pain, anti-cancer biological drugs. Read more about my research.

In addition, the Davletov group is part of the Centre for Membrane Interactions and Dynamics (CMIAD). Read more about our research group's role at CMIAD.

Mouse sensory neurons in culture

P75_Ganglioside

GT1bgreenSNAP25red_DRG

Images courtesy of Davletov lab 2015

Major scientific accomplishments:

  • Discovery of non-paralysing neuronal blockers for treatment of pain and brain disorders (2011-13).
  • Development of ‘protein stapling’ technology for molecular assembly, cell targeting, enzyme immobilization (2009-2010).
  • Elucidation of molecular mechanisms underlying synaptic neurotransmission (1998-2008).
  • Identification of receptors for spider neurotoxins – neurexin and latrophilin (1988-91, 1995-97).
  • Identification of protein domains involved in synaptic neurotransmission (1992-94).

In the news:

‘Scientists find way to refine Botox for new uses’ - Reuters

Inventions and patents

Patent family entitled “Complexing System” with Priority in United Kingdom and the United States from the 12th of August 2009, also covering Europe, China, India, Singapore, Canada, Australia.

Group Members:

  • Charlotte Leese, Postdoctoral Fellow
  • Ciara Doran, Postdoctoral Fellow
  • Aleksander Rust, PhD Student
  • Rosalyn Hart, PhD Student
  • Rebecca Bresnahan, PhD Student
  • Jaqueline Price, Lab Manager
  • Luis Solabre Valois, MSc Student
  • Rohini Venkatesh, MSc Student
  • Ben Allen, MSc Student

Recent publications

For more publications see: https://www.researchgate.net/profile/Bazbek_Davletov2