The University of Sheffield
Department of Biomedical Science

Professor Bazbek Davletov

Professor Bazbek DavletovChair in Biomedical Science
Department of Biomedical Science
Room D225, Denny building
The University of Sheffield
Western Bank, Sheffield S10 2TN
United Kingdom

Telephone: +44 (0) 114 222 5111

mCherry-stained neuronsCareer history

Educational qualifications:

Research interests

We are working on biomolecular assembly, neuronal blockers, medicines for chronic pain, anti-cancer biological drugs. Read more about my research.

Major scientific accomplishments:

In the news:

‘Scientists find way to refine Botox for new uses’ - Reuters

Inventions and patents

Patent family entitled “Complexing System” with Priority in United Kingdom and the United States from the 12th of August 2009, also covering Europe, China, India, Singapore, Canada, Australia.

Group Members:

Recent publications

Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B. (2013)
Synthetic Self-Assembling Clostridial Chimera for Modulation of Sensory Functions.
Bioconjug Chem. 24: 1750–59 (featured on the journal cover).

Arsenault J, Ferrari E, Niranjan D, Cuijpers SA, Gu C, Vallis Y, O'Brien J, Davletov B. (2013)
Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells.
J Neurochem. 126:223-33.

Mohrmann R, de Wit H, Connell E, Pinheiro PS, Leese C, Bruns D, Davletov B, Verhage M, Sørensen JB. (2013)
Synaptotagmin Interaction with SNAP-25 Governs Vesicle Docking, Priming, and Fusion Triggering.
J Neurosci. 33:14417-30.

Ferrari E, Soloviev M, Niranjan D, Arsenault J, Gu C, Vallis Y, O'Brien J, Davletov B. (2012)
Assembly of protein building blocks using a short synthetic peptide
Bioconjug Chem. 23:479-84

Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET. (2012)
VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission
Nat Neurosci. 15:738-45

Ferrari E, Maywood E, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings M, Niranjan D, Schiavo G, Davletov B. (2011)
Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity
Toxins 3, 345-55

Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y,  Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B. (2010)
SNARE tagging allows step-wise assembly of a multimodular medicinal toxin
Proc Nat Acad Sci USA 107, 18197-201 (featured in Reuters news and worldwide media).

Darios F, Ruipérez V, López I, Villanueva J, Gutierrez LM, Davletov B. (2010)
Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis.
EMBO Rep 11, 528-33

Davletov B, Montecucco C. (2010)
Lipid function at synapses.
Curr Opin Neurobiol 20, 543-9 Review

Darios, F., Wasser, C., Shakirzyanova, A., Giniatullin, A., Goodman, K., Munoz-Bravo, J. L., Raingo, J., Jorgacevski, J., Kreft, M., Zorec, R., Rosa, J. M., Gandia, L., Gutierrez, L. M., Binz, T., Giniatullin, R., Kavalali, E. T. and Davletov, B. (2009)
Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.
Neuron 62, 683-94 (featured in the same issue of Neuron and in Frontiers in Neuroscience 2010)