Dr Jarema Malicki
Reader in Developmental Genetics
MRC Centre for Developmental and Biomedical Genetics
Department of Biomedical Science
The University of Sheffield
Firth Court, Western Bank
Sheffield S10 2TN
United Kingdom
Room: D18 Firth Court
Office: +44 (0) 114 222 4638
email: j.malicki@sheffield.ac.uk
Career history
- 2013-present: Reader, University of Sheffield
- 2012-present: Senior Research Fellow, University of Sheffield
- 1996-2010: Assistant Professor, Harvard Medical School, USA
- 1993-1996: Postdoctoral Fellow, Harvard Medical School, USA
- 1989-1993: Yale University, USA, Ph.D.
- 1987-1988: Bates College, USA
- 1983-1987: Warsaw University, Poland
Research interests
Eukaryotic cilia are fascinating highly polarized cell surface features that frequently detect and/or process extracellular signals, including small molecules, light, and polypeptides. We aim to understand how signal transduction mechanisms are assembled in cilia and how they function is processes as diverse as embryonic patterning, vision, and metabolism. The laboratory has also some interest in other aspects of cell polarity, such as membrane subcompartmentalization and organelle positioning in cell’s cytoplasm.
Recent activities
- Reviewer for journals: Development, Developmental Cell, EMBO Journal, Human Molecular Genetics, Human Genetics, Journal of Clinical Investigation, Journal of Neuroscience, Neuron, PloS Genetics, & others.
- Reviewer for funding bodies: Canada Foundation for Innovation (Canada), Fundação para a Ciência e a Tecnologia (Portugal), Medical Research Council (UK), Narodowe Centrum Nauki (Poland), National Institutes of Health (USA), National Science Foundation (USA)
Selected recent publications
- Malicki J (2012)
Who drives the ciliary highway?
Bioarchitecture, 2(4). - Zhao C, Omori Y, Brodowska K, Kovach P & Malicki J (2012)
Kinesin-2 family in vertebrate ciliogenesis.
Proc Natl Acad Sci U S A, 109(7), 2388-2393. - Zhao C & Malicki J (2011)
Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos.
EMBO J, 30(13), 2532-2544. - Kim S, Lehtinen MK, Sessa A, Zappaterra MW, Cho SH, Gonzalez D, Boggan B, Austin CA, Wijnholds J, Gambello MJ, Malicki J, LaMantia AS, Broccoli V & Walsh CA (2010)
The apical complex couples cell fate and cell survival to cerebral cortical development.
Neuron, 66(1), 69-84.