Stem Cells and Cancer
Stem cells may ultimately be useful in achieving the repair of diseased tissues, but recently it has been established that stem cells represent the source of some, and perhaps all, cancers.
The sub-division of Stem Cells and Cancer includes research into cell polarity, the biology of human stem cells and cell signalling, specifically that mediated by the JAK/STAT, Wnt, Hedgehog and Notch signalling pathways.
In vitro and in vivo animal models are used to study cancer, cranio-facial abnormalities and retinoblastoma.
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Principal Investigator
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Research Area
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| Professor Peter Andrews | Human embryonic stem cells, germ cell tumours |
| Dr Beppe Battaglia | Bionanotechnology and physical biology |
| Dr Anne-Gaelle Borycki | Somite patterning and Sonic Hedgehog signalling |
| Dr Vincent Cunliffe | Development of the zebrafish central nervous system |
| Dr Freek van Eeden | Disease models and Shh receptor function in zebrafish |
| Dr Kai Erdmann | Membrane Trafficking and signalling in polarised cells |
| Dr Andrew Furley | Role of L1-related cell adhesion molecules in neural development in mammals |
| Professor Harry Moore | Molecular reproduction and development |
| Professor Marysia Placzek | Neural patterning and neural differentiation |
| Dr Penny Rashbass | Apical-basal polarity in vertebrate development and disease |
| Dr Marcelo Rivolta | Human auditory stem cells, cell-based therapies for deafness |
| Dr Henry Roehl | Zebrafish musculoskeletal development |
| Professor Carl Smythe | Molecular and cell biology of the eukaryotic cell cycle |
| Professor Elizabeth Smythe | Regulation of membrane trafficking |
| Professor David Strutt | Drosophila cell polarity |
| Professor Steve Winder | Dystroglycan mediated cell adhesion in muscular dystrophy and cancer |
| Dr Martin Zeidler | JAK/STAT signalling |