The University of Sheffield
Department of Biomedical Science

Professor SJ Winder: Full Publications

Winder SJ, Lipscomb L, Angela Parkin C, Juusola M.
The proteasomal inhibitor MG132 prevents muscular dystrophy in zebrafish.
PLoS Curr. 2011 Nov 17;3

Parberry-Clark C, Bury JP, Cross SS, Winder SJ.
Loss of dystroglycan function in oesophageal cancer.
Histopathology. 2011 Aug;59(2):180-7.

Le Rumeur E, Winder SJ, Hubert JF.
Dystrophin: more than just the sum of its parts.
Biochim Biophys Acta. 2010 Sep;1804(9):1713-22. Epub 2010 May 21. Review.

Moore CJ, Winder SJ.
Dystroglycan versatility in cell adhesion: a tale of multiple motifs.
Cell Commun Signal. 2010 Feb 17;8:3.

Thompson O, Moore CJ, Hussain SA, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJ.
Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.
J Cell Sci. 2010 Jan 1;123(Pt 1):118-27.
PDF version PDF version [Journal of Cell Science provides access to first 50 downloads free. Subscription to the journal thereafter.]

Robertson AS, Allwood EG, Smith AP, Gardiner FC, Costa R, Winder , Ayscough KR.
The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.
Mol Biol Cell. 2009; 20(6):1618-28.

Thompson O, Kleino I, Crimaldi L, Gimona M, Saksela K, Winder SJ.
Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts.
PLoS ONE. 2008, 3, e3638.

Cross SS, Lippitt J, Mitchell A, Hollingsbury F, Balasubramanian SP, Reed MW, Eaton C, Catto JW, Hamdy F, Winder SJ.
Expression of beta-dystroglycan is reduced or absent in many human carcinomas.
Histopathology. 2008 53:561-6.

Gheorghe DM, Aghamohammadzadeh S, Smaczynska-de Rooij II, Allwood EG, Winder SJ, Ayscough KR.
Interactions between the yeast SM22 homologue Scp1 and actin demonstrate the importance of actin bundling in endocytosis.
J Biol Chem. 2008 283:15037-46.

Higginson JR, Thompson O, Winder SJ
Targeting of dystroglycan to the cleavage furrow and midbody in cytokinesis.
Int J Biochem Cell Biol. 2008; 40:892-900.

Bryant RJ, Winder SJ, Cross SS, Hamdy FC, Cunliffe VT.
The polycomb group protein EZH2 regulates actin polymerization in human prostate cancer cells.
Prostate. 2008; 68(3):255-63.

N Lin, A Chen, JR. Mackley, S J Winder & H Yokota (2007)
AntModeler Analysis of Mechanical Stress Driven Transcription in Three Cell Types. in 'Data Mining, Systems Analysis and Optimization in Biomedicine
O. Seref, O. E. Kundakcioglu, P. Pardalos, eds. AIP, NY, USA ISBN: 978-0-7354-0467-0
AIP Conf. Proc. 953, 122-131.

Thompson, O., Higginson, J. R., Batchelor, C. L., Spence, H. J., Chen, Y-J., and Winder, S. J. (2007)
Dystroglycan: a multifunctional adaptor protein. In 'Gafsa- A Focus on Biochemistry and Genetics: from Concepts to Therapeutic Advances'.
A. Fattoum, editor. Repro-France Industries. pp364-372.

Avizienyte E., Keppler M., Sandilands E., Brunton V. G., Winder, S. J., Ng, T. and. Frame M. C.
An active Src kinase-¾-actin association is linked to actin dynamics at the periphery of colon cancer cells.
Exp. Cell Res. 2007; 313, 3175-3188.

Anderson C, Winder SJ, Borycki AG.
Dystroglycan protein distribution coincides with basement membranes and muscle differentiation during mouse embryogenesis.
Dev Dyn. 2007 236:2627-35.

Rezniczek, G. A., Konieczny, P., Nikolic, B., Reipert, S., Schneller, D., Abrahamsberg, C., Winder, S. J. & Wiche, G.
Plectin 1f scaffolding at the sarcolemma of dystrophic (mdx) muscle fibers through multiple interactions with β-dystroglycan.
J. Cell Biol. 2007; 176: 965-977

Batchelor C.L. Winder S. J.
Recruitment of Dbl by ezrin and dystroglycan drives membrane proximal Cdc42 activation and filopodia formation.
Cell Cycle 2007; 6: 353-363

K. Hnia, D. Zouiten, S. Cantel, D. Chazalette, G. Hugon, J.-A. Fehrentz, A. Masmoudi, A. Diment, & Winder S. J.
ZZ domain of dystrophin and utrophin: topology and mapping of a β−dystroglycan interaction site.
Biochem. J. 2007; 401: 667-677

Mackley, J. R., Ando, J., Herzyk, P. & Winder, S. J.
Phenotypic responses to mechanical stress in fibroblasts from tendon, cornea and skin.
Biochem. J. 2006; 396(2):307-16.

Batchelor C.L. & Winder S. J.
Sparks, signals and shock absorbers: how dystrophin loss causes muscular dystrophy.
Trends Cell Biol. 2006;16(4):198-205.

Smythe, G Winder, S. J. & Rando T. A. (2006)
The functional biology of dystrophin: Associated signaling pathways and potential targets for therapeutic intervention. In 'Duchenne Muscular Dystrophy: Advances in Experimental Therapeutics'
(J.S. Chamberlain & T. A. Rando eds) Marcel Dekker, New York, USA Chapter 3, pp53-75

Winder, S. J. (2006)
Cell Adhesion and Signalling in the Muscular Dystrophies. in 'Molecular mechanisms of muscular dystrophies'.
(S. J. Winder, ed) Landes Bioscience, Georgetown. Chapter 16, pp193-205. ISBN 1-58706-264-X

Winder SJ (2006)
Molecular mechanisms of muscular dystrophies.
Landes Bioscience, Georgetown 235 pages. ISBN: 1-58706-264-X

Winder S.J.. & Ayscough, K. R.
Actin binding proteins.
J. Cell Sci. 2005; 118, 651-654

Higginson & Winder S. J.
Dystroglycan, a multifunctional adaptor protein.
Biochem. Soc. Trans. 2005; 33, 1254-1255.

Broderick, & Winder, S. J.
Spectrin, a-Actinin and Dystrophin.
Adv. Protein Chem. 2005; 70, 203-246.

Gimona, M & Winder, S. J. (2004)
The calponin homology (CH) domain. In 'Modular protein domains'.
(G Cesareni, M Gimona, M Sudol, M Yaffe eds) Wiley-VCH Germany
Chapter 16, pp321-336. ISBN 3-527-30813-X

Winder, S. J.
Filopodia formation and Disabled degradation downstream of Reelin.
Biochem J. 2004; 384, e1-2

Ayscough, K. R. & Winder S. J.
Two billion years of actin.
EMBO Reports 2004; 5, 947-952

Spence, H.J. & Winder, S.J.
Ezrin-dependent regulation of the actin cytoskeleton by b-dystroglycan
Hum. Mol. Genet. 2004; 13, 1657-1668

Spence, H.J. & S. J. Winder
Dystroglycan, a scaffold for the ERK-MAP kinase cascade.
EMBO Reports 2004; 5, 484-489

Campbell W. Gourlay, Steven J. Winder, and Kathryn R. Ayscough
A role for the actin cytoskeleton in cell death and aging in yeast.
J. Cell Biol. 2004; 164: 803-809

Chen, Y-J., Spence, H. J., Cameron, J. M. Jess, T., Ilsley, J. L. & Winder S. J.
Direct interaction of b-dystroglycan with F-actin.
Biochem. J. 2003; 375, 329-337

Winder, S.J., Jess, T. & Ayscough, K.R.
SCP1 encodes an actin bundling protein in yeast.
Biochem. J. 2003; 375, 287-295

S. J. Winder,
Structural insights into actin-binding, branching and bundling proteins.
Curr. Opin. Cell Biol. 2003; 15, 14-2

Broderick, M. J. & Winder, S.J.
Towards a complete atomic structure of spectrin family proteins.
J. Struct. Biol. 2002; 137, 184-193

Spence, H. J., Chen, Y.-J. & Winder, S.J.
Muscular dystrophy, cell adhesion and the cytoskeleton.
Bioessays 2002; 24, 542-552

Aasland, R., Abrams, C., Ampe, C., Ball, L. J., Bedford, M. T., Cesareni, C., Gimona, M., Hurley, J. H., Jarchau, T., Lehto, V-P., Lemmon, M. A., Linding, R., Mayer, B. J., Nagai, M., Sudol, M., Walter, U. & Winder S. J.
Normalization of nomenclature for functional peptide motifs as ligands of modular protein domains.
Febs Lett. 2002; 513, 141-144

Gimona, M, Djinovic-Carugo, K., Kranewitter, W. J., & Winder, S. J.
Functional plasticity of CH domains.
Febs Lett. 2002; 513, 98-106

Bramham, J., Hodgkinson, J., Smith, B. O., Uhrín, D., Barlow P. N. and Winder, S. J.
Solution structure of the calponin CH domain and fitting to the 3D helical reconstruction of F-actin:calponin.
Structure 2002; 10, 249-258

Ilsley, J. I., Sudol, M. & Winder S. J.
The WW domain: linking cell signalling to the membrane cytoskeleton.
Cell. Signal. 2002; 14, 183-189

Ilsley, J. I., Sudol, M. & Winder S. J.
The interaction of dystrophin with b-dystroglycan is regulated by tyrosine phosphorylation.
Cell. Signal. 2002; 13, 625-632

Brunton, V.G., Fincham, V.J., McLean, G.W., Winder, S.J., Paraskeva, C., Marshall,
The protrusive phase and full development of integrin-dependent focal adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells.
Neoplasia 2001; 3, 215-226

Bramham, J., Smith, B. O., Uhrín, D., Barlow P. N. and Winder, S. J.
1H, 15N and 13C resonance assignments of the N-terminal region of calponin.
J. Biomol. NMR 2001; 19: 189-190

Winder S. J.
The complexities of dystroglycan.
TIBS 2001; 26, 118-124

Fincham, V. J., James M., Frame, M. C. and Winder S.J. (2000)
Active ERK (MAP kinase) is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src.
EMBO J. 19, 2911-2923

James M., Nuttall, A., Ilsley, J., Ottersbach, K., Tinsley, J. M., Sudol, M. and Winder S.J. (2000)
Adhesion-dependent tyrosine phosphorylation of b-dystroglycan regulates its interaction with utrophin.
J. Cell Sci. 113, 1717-1726

*Keep, N. H., *Winder S. J., Moores, C. A., Walke, S. Norwood, F. L. M., and Kendrick-Jones, J. (1999)
Crystal structure of the actin-binding region of utrophin reveals a head-to-tail dimer.
Structure 7, 1539-1546. *Equal contributors.

Morris, G. E., N-t-Man, N-t-Ngoc Huyen, Pereboev, A., Kendrick-Jones J. & Winder, S.J. (1999)
Disruption of utrophin-actin interaction by monoclonal antibodies and prediction of an actin binding surface of utrophin.
Biochem. J. 337, 119-123

Keep, N. H., Norwood, F. L. M., Moores, C. A., Winder, S.J. & Kendrick-Jones, J. (1999)
The 2.0 A structure of the second calponin homology domain from the actin binding region of the dystrophin homologue utrophin.
J. Mol. Biol. 285, 1257-1264

Winder, S. J., Allen, B. G., Clement-Chomienne, O. & Walsh M. P. (1998)
Regulation of smooth muscle actin-myosin interaction and force by calponin.
Acta. Phys. Scand. 164, 415-426

Gimona, M. & Winder, S. J. (1998)
Single calponin homology domains are not actin binding domains.
Curr. Biol. 8, R674-R675

Stradal, T., Kranewitter, W., Winder, S. J. & Gimona, M. (1998)
CH domains revisited.
FEBS Lett. 431, 134-137

Winder, S. J. (1997)
The membrane-cytoskeleton interface: the role of dystrophin and utrophin.
J. Muscle Res. Cell Motil. 18, 617-629

Pohl, J., Winder, S. J., Allen, B. G., Walsh, M. P., Sellers, J. & Gerthoffer, W. T. (1997)
Phosphorylation of calponin in airway smooth muscle.
Am. J. Physiol. 16, L115-L123

Winder, S. J., Knight, A. E. & Kendrick-Jones, J. Protein Structure. (1997)
In 'Dystrophin: Gene, Protein and Cell Biology' (SC Brown & JA Lucy eds.)
Cambridge University Press pp27-54

Pfuhl, M., Winder, S. J., Castiglione, M. A., Labeit, S. & Pastore, A. (1996)
Correlation between conformational and binding properties of nebulin repeats.
J. Mol. Biol. 257, 367-384

Winder, S. J. & Walsh, M. P. (1996)
Calponin.
Curr. Topics Cell. Reg. 34, 33-61

Winder, S. J. (1996)
Structure-function relationships in dystrophin and utrophin.
Biochem. Soc. Trans. 24, 497-501

Ponting, C., Blake, D. J., Davies, K. E., Kendrick-Jones, J. & Winder, S. J. (1996)
ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins.
TIBS 21, 11-13

Winder, S. J. & Kendrick-Jones, J. (1995)
Protein production in 3 different expression vectors from a single PCR product.
Anal. Biochem. 231, 271-273

Winder, S. J., Gibson, T. J. & Kendrick-Jones, K. (1995)
Dystrophin and utrophin: the missing links!.
FEBS Lett. 369, 27-33

Blake, D. J., Tinsley, J. M., Davies, K. E., Knight, A. E., Winder, S. J. & Kendrick-Jones, J. (1995)
Coiled-coil regions in the carboxy terminal domains of dystrophin and related proteins: potentials for protein-protein interactions.
TIBS 20, 133-135.

Nguyen thi Man, Helliwell, T. R., Simmons, C., Winder, S. J., Kendrick-Jones, J., Davies, K. E. & Morris, G. (1995)
Full-length and short forms of utrophin, the dystrophin-related protein.
FEBS Lett. 358, 262-266

Winder, S. J. & Kendrick-Jones, J. (1995)
Calcium/calmodulin-dependent regulation of the NH2-terminal F-actin binding domain of utrophin.
FEBS Lett. 357, 125-128

Winder, S. J., Hemmings, L., Maciver, S. K., Bolton S. J., Tinsley, J., Davies, K. E., Critchley, D. R. & Kendrick-Jones, J. (1995)
Utrophin actin binding domain: Analysis of actin binding and cellular targeting.
J. Cell Sci. 108, 63-71

Carmichael, J. D., Winder, S. J., Walsh, M. P. & Kargacin, G. J. (1994)
Calponin and smooth muscle regulation.
Can. J. Physiol. Pharmacol. 72, 1415-1419

Pfuhl, M., Winder, S. J. & Pastore, A. (1994)
Nebulin, a helical actin binding protein.
EMBO J. 13, 1782-1789

Winder, S. J. and Walsh, M. P. (1993)
Calponin: Thin filament-linked regulation of smooth muscle contraction.
Cell Signal. 5, 677-686

Winder S. J., Allen B. G., Fraser, E. D., Kang, H.-M., Kargacin, G. J. and Walsh, M. P. (1993)
Calponin phosphorylation in vitro and in intact muscle.
Biochem. J. 296, 827-836

Winder S. J., Walsh M. P., Vasulka, C. & Johnson, J. D. (1993)
The calponin-calmodulin interaction: Properties and effects on smooth and skeletal muscle actin binding and actomyosin ATPases.
Biochemistry 32, 13327-13333

Pato, M. D., Sutherland, C., Winder, S. J. and Walsh, M. P. (1993)
Smooth muscle caldesmon phosphatase is SMP-1, a type 2A protein phosphatase.
Biochem. J. 293, 35-41

Winder, S. J., Wheatley, S. D. and Forsyth, I. A. (1993)
Receptor binding of IGF-1 to mammary microsomes from non-pregnant, pregnant and lactating sheep.
J. Endocrinol. 136, 297-304

Winder, S. J., Turvey, A. and Forsyth, I. A. (1992)
Characteristics of ruminant mammary epithelial cells grown in primary culture in serum-free medium.
J. Dairy. Res. 59, 491-498

Winder, S. J., Sutherland, C. and Walsh, M. P. (1992)
Comparison of the effects of calponin on smooth and skeletal muscle actomyosin systems in the presence and absence of caldesmon.
Biochem. J. 288, 733-739

Winder, S. J., Pato, M. D. and Walsh M. P. (1992)
Purification and characterisation of calponin phosphatase from smooth muscle: Effect of dephosphorylation on calponin function.
Biochem. J. 286, 197-204

Winder, S. J., Kargacin, G. J., Bonet-Kerrache, A. A., Pato, M. D. and Walsh, M. P. (1992)
Calponin: Localisation and regulation of smooth muscle actomyosin MgATPase.
Jap. J. Pharmacol. 58, 29P-34P

Winder, S. J., Sutherland, C. and Walsh, M. P. (1991)
Biochemical and functional characterisation of smooth muscle calponin.
Adv. Exp. Med. Biol. 304,37-52

Winder, S. J. and Walsh, M. P. (1990)
Structural and functional characterisation of calponin fragments.
Biochem. Int. 22, 335-341

Winder, S. J. and Walsh, M. P. (1990)
Smooth muscle calponin: Inhibition of the actomyosin MgATPase and regulation by phosphorylation.
J. Biol. Chem. 265, 10148-10155

Winder, S. J. and Walsh, M. P. (1990)
Inhibition of the actomyosin MgATPase by chicken gizzard calponin.
Prog. Clin. Biol. Res.
327, 141-148

Winder, S. J. and Walsh M. P. (1989)
Smooth muscle calponin.
Biochem. Soc. Trans. 17, 786-787

Winder, S. J., Turvey, A. and Forsyth, I. A. (1989)
Stimulation of DNA synthesis in cultures of ovine mammary epithelial cells by insulin and insulin-like growth factors.
J. Endocrinol. 123, 319-326