Dr Martin Zeidler
Reader
Department of Biomedical Science
The University of Sheffield
Western Bank
Sheffield S10 2TN
United Kingdom
Room: D43/D43a Firth Court
Telephone (office): +44 (0) 114 222 6093
Telephone (lab): +44 (0) 114 222 6094
email : m.zeidler@sheffield.ac.uk
Career history
- 2007-present: Reader, University of Sheffield, UK.
- 2006-2007: Senior Lecturer, University of Sheffield, UK.
- 2001-2006: Emmy Noether Independent Group Leader, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
- 1996-2001: Postdoctoral Fellow, Department of Genetics, Harvard Medical School, Boston, MA, USA
- 1991-1996: Pre-doctoral student at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
- 1987-1991: BSc in Biology with European Studies (German), The University of Sussex, Brighton, UK.
Research interests
My lab is interested in identifying and analysing regulators of the JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies. We use both high throughput RNAi screening technologies and developmental genetic assays in Drosophila to determine the mechanisms of action of pathway regulators and their interactions in vivo.
Read more (link to the Centre for Developmental and Biomedical Genetics)
Activities and distinctions
- CR-UK Senior Cancer Research Fellow
- Emmy Noether Prize holder (2001-2006)
Funding
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Recent Publications
Stec WJ, Zeidler MP.
Drosophila SOCS Proteins.
J Signal Transduct. 2011;2011:894510. Epub 2011 Dec 13.
Wright VM, Vogt KL, Smythe E, Zeidler MP.
Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3.
Cell Signal. 2011 23:920-7. Epub 2011 Jan 22.
Vidal OM, Stec W, Bausek N, Smythe E, Zeidler MP.
Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.
J Cell Sci. 2010 123:3457-66. Epub 2010 Sep 14.
Bina S, Wright VM, Fisher KH, Milo M, Zeidler MP.
Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation.
EMBO Rep. 2010 Mar;11(3):201-7.
Bina S, Wright VM, Fisher KH, Milo M, Zeidler MP.
Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation.
EMBO Rep. 2010 Mar;11(3):201-7.
Elliott GC, Zeidler MP.
MsSOCS expression indicates a potential role for JAK/STAT signalling in the early stages of Manduca sexta spermatogenesis.
Insect Mol Biol. 2008 Sep;17(5):475-83
Rivas ML, Cobreros L, Zeidler MP, Hombría JC.
Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences.
EMBO Rep.2008 Nov;9(11):1114-20. Epub 2008 Sep 19.
Müller P, Boutros M, Zeidler MP.
Identification of JAK/STAT pathway regulators-Insights from RNAi screens.
Semin Cell Dev Biol. Epub 2008 Jun 8.
Bina S, Zeidler M
JAK/STAT Pathway Signalling in Drosophila Melanogaster
In: Stephanou A. JAK-STAT Pathway in Disease Landes Bioscience. 2008 [Book Chapter]
Brown S, Zeidler MP.
Unphosphorylated STATs go nuclear.
Curr Opin Genet Dev. 2008: 455-60. Review.