The University of Sheffield
Department of Cardiovascular Science

Dr. Julian Gunn MA MB BChir MD MRCP

Senior Lecturer & Honorary Consultant Cardiologist

Dr Julian Gunn

Address
Department of Cardiovascular Science
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Tel University Secretary: +44 (0)114 271 2052
Tel NHS Secretary - Royal Hallamshire Hospital: +44 (0) 114 271 2437
Tel NHS Secretary - Northern General Hospital: +44 (0) 114 271 4952/3
Tel South Yorkshire Cardiology Rotation: +44 (0)114 305 2175
Fax: +44 (0)114 271 1863
Email: j.gunn@sheffield.ac.uk

Biography:

I was trained in Medicine at Cambridge, and took junior hospital posts around England before being appointed Clinical Lecturer in Cardiology at the University of Sheffield in 1994 and BCS Young Investigator of the Year 1995. I was trained in Cardiology in Sheffield, and in coronary angioplasty by Professor David Cumberland. I was appointed Senior Lecturer in 2000. I am a member of the Coronary Artery Disease group within the Department of Cardiovascular Science.

Research Activities:

My higher degree was in the field of local coronary artery injury, and my interests since then have exclusively centred on coronary artery disease (CAD), its endovascular treatment with percutaneous coronary intervention (PCI; angioplasty), the injury and healing resulting from that, computer modelling of CAD, and how we can improve upon the results of PCI. This research spans basic research, in vivo experimentation and translation into clinical studies.

Teaching Interests:

I lecture to undergraduate medical students and enjoy bedside teaching. I also teach Cardiology trainees on a regional level in my role as South Yorkshire Training Programme Director. I am a trainer in PCI in Sheffield and lecture on advanced PCI techniques nationally and internationally.

Professional Activities:

I am Honorary Consultant Cardiologist at the Sheffield Teaching Hospitals NHS Foundation Trust, and am an Investigator at the NIHR Biomedical Research Unit at the Northern General Hospital. I am the Training Programme Director in Cardiology for South Yorkshire / South Humberside and the Clinical Lead for Primary Angioplasty for North Trent. I am a member of the British Cardiovascular Society, and of the British Cardiovascular Intervention Society.

Current Pojects:

Key Publications:

  1. Iqbal J, Sumaya W, Tatman V, Parviz Y, Morton AC, Campbell S, Storey RF, Gunn J. Incidence and predictors of stent thrombosis: a cohort study of 5,834 consecutive patients in a single UK centre. EuroIntervention (in press).

  2. Iqbal J, Gunn J, Serruys PW. Coronary stents: historical development, current status and future directions. Br Med Bulletin (in press).

  3. Van der Heiden K, Gijsen F, Narracott A, Hsaio S, Gunn J, Evans P. The effects of stenting on shear stress: relevance to endothelial injury and repair. Cardiovasc Res 2013 (in press).

  4. Morris P, Ryan D, Lycett R, Hose DR, Morton A, Gunn J. Virtual fractional flow reserve from a single rotational coronary angiogram: anatomy and physiology in one test. J Am Coll Cardiol Cardiovasc Intv 2013;6:149–57.

  5. Malkin C, Ghobrial M, Krishnan A, Gunn J. Residual SYNTAX score after PCI for triple vessel coronary artery disease: quantifying the adverse effect of incomplete revascularisation. EuroIntervention 2013 (in press).

  6. Malkin CJ, Ghobrial MSA, Raina T, Siotia A, Morton AC, Gunn J. Impact of incomplete revascularisation in patients undergoing PCI for unprotected LMS stenosis. Cathet Cardiovasc Interv 2012 Oct 16. doi: 10.1002/ccd.24695. [Epub ahead of print]

  7. Ghosh DA, Garg P, West JN, Muthusamy R, Gunn J. ST elevation in ECG lead aVR signals acute severe left main coronary artery disease. J Roy Soc Med 2012 (in press).

  8. Sillano D, Resmini C, Meliga E, Boccuzzi G, Zuffi A, Barbato E, Gunn J, Price MJ, Gaita F, Sheiban I. A retrospective multicentre observational study on the interventional management of coronary disease in the very elderly: The NINETY (NonagenariaNs trEated by means of sTents studY). Cathet Cardiovasc Interv 2012 Apr 19. doi: 10.1002/ccd.24406.

  9. Siotia A, Malkin C, Morton A, Gunn J. Simultaneous kissing paclitaxel-eluting stents to treat unprotected left main stem bifurcation disease: long-term outcomes in 150 patients. EuroIntervention 2012;8:691-700.

  10. Karunakaran A, Sumaya W, Gunn J, Morton A, Storey R. Contemporary management of ST-elevation myocardial infarction. Hospital Practice 2012;40:224-31.

  11. Gunn J, Siotia A, Malkin C, Iqbal J, Raina T, Morton A. Novel use of a pericardium-covered stent graft to treat bulky coronary artery thrombus. Catheter Cardiovasc Interv 2012;80:59-64.

  12. Kelly D, Morton A, Arnold N, Mecinovic J, Schofield C, Lupton H, Al-Lamee K, Crossman D, Gunn J*, Gershlick A*. Activation of hypoxia-inducible factor by di-methyl oxalyl glycine (DMOG) increases neovascularisation but not functional vascular supply within ischemic myocardium in a porcine coronary artery occlusion model. J Clin Exp Cardiol 2011;2:8. doi: 10.4172/2155-9880.1000148.

  13. Morlacchi S, Keller B, Arcangeli P, Balzan M, Migliavacca F, Dubini G, Gunn J, Arnold N, Evans D, Lawford P. Hemodynamics and instent restenosis: micro-CT images, histology and computer simulations. Ann Biomed Eng 2011;39:2615-26.

  14. Tahir H, Hoekstra A, Lorenz E, Lawford P, Hose D, Gunn J, Evans D. Multi-scale simulations of the dynamics of in-stent restenosis: impact of stent deployment and design. Interface Focus 2011;1:365-73.

  15. Caiazzo A, Evans D, Falcone J-L, Hegewald J, Lorenz E, Stahl B, Wang D, Bernsdorf J, Chopard B, Gunn J, Hose R, Krafczyk M, Lawford P, Smallwood R, Walker D, Hoekstra A. A complex automata approach for in-stent restenosis: two-dimensional multiscale modeling and simulations. J Computational Science 2011;2:9-17.

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