Dr Nigel Hoggard MD MRCP FRCR

Clinical Senior Lecturer in Radiology

Academic Radiology
Department of Cardiovascular Science
C Floor
Royal Hallamshire Hospital
Glossop Road
Sheffield
S10 2JF

Tel: + 44 (0) 114 271 2825
Fax: +44 (0) 114 271 1714
Email: n.hoggard@sheffield.ac.uk

Biography:

I joined the University of Sheffield as Clinical Senior Lecturer in 2006 with interests in adult diagnostic neuroradiology and novel MR imaging agents.  Prior to that I had been an NHS Consultant Neuroradiologist at the Manchester Neurosciences Centre, Hope Hospital Salford from 2003.  Between 2002 and 2003 I completed my MD whilst working as a Consultant cross sectional Radiologist.  Between 1999 and 2002 I was a Radiology Research Fellow at The Royal Hallamshire Hospital, Sheffield.  My MD thesis was on the MR imaging of non-traumatic intracranial haemorrhage and its causes.  I was a Radiology trainee in Manchester from 1994 to 1999, obtaining my FRCR in 1997 and CCST 1999.  I undertook a series of SHO posts in Oxford, London and Liverpool from 1992 to 1994, obtaining my MRCP in 2004.  I was a House Officer in Norwich and Cambridge between 1991-1992.  I went to Medical School at the University of Cambridge, 1985 to 1990, MB BChir 1991.

Research Interests:

My research interests remain primarily centred on the diagnostic applications of MR imaging in radiology with a particular emphasis on neuroscience and head and neck imaging.

Teaching Interests:

I am the lead for the academic clinical radiology training scheme. We have had 5 ACFs to date and one academic clinical lecturer. I currently teach on the BMedSci ethics course and the Neuroscience Masters course. I undertake regular teaching in neuroradiology on the Fundamentals of Radiology course here in Sheffield, and on the National ENT imaging course. I undertake regular FRCR part II teaching and I sit on the Royal College of Radiologists FRCR Part I Physics exam committee.

Professional Activities:

• Deputy Editor British Journal of Radiology 2010-present.
• Expert Advisory Panel member, Commission for Human Medicines/MHRA 2009-present.
• Cancer Peer reviewer 2012-present.
• Member of the Royal College of Radiologists FRCR part I examination committee 2011-present.
• British Society of Neuroradiologists representative NIHR fellowship selection panel member 2011.
• NICE guideline specialist interventions committee, 2009-present.
• Secretary British Society of Neuroradiologists research sub-committee 2010-present.
• British Society of Neuroradiologists du Boulay Travelling professorship 2011-2012.
• Sheffield Teaching Hospitals NHS Foundation Trust, Research lead for the Directorate of Radiology at 2008-present.
• I am academic programme director for Radiology and a member of the Clinical Academic Working Group 2010-present.
• Member of the Sheffield Regional Ethics committee 2006-2012.

Current Projects:

1. Diagnostic neuroradiology:
   (a) Cerebellar imaging - Stuart Currie is currently undertaking a PhD looking at ataxia imaging, gluten sensitivity (in collaboration with Marios Hadjivassiliou, we are part of the SIGReD group, a multi-disciplinary research group focussed on gluten related diseases) and effects of alcohol. This is using MR spectroscopy, resting state fMRI and VBM; in the future we wish to extend this research to population cerebellar functional imaging.
   (b) Neuro-oncology - Clinical application of MR spectroscopy and perfusion imaging in brain tumour evaluation. MR perfusion imaging: we have developed in house software for histogram analysis of perfusion data and evaluated imaging interrogation strategies.
   (c) Incidental findings and communication of coincidental information with patients.
   (d) Epilepsy - I collaborate with Paul Armitage assessing the use of recent image analysis techniques for the analysis of patient with focal onset epilepsy but normal conventional MR imaging.
   (e) Central Nervous system cell density MR contrast agent - Successful in vitro tests 2012; applying for ethics for in human studies, supervising ACF Richard List later in 2012.
2. Bone imaging:
   (a) Joint loosening - I am working on imaging prosthetic joint replacement loosening in collaboration with Mark Wilkinson and Martyn Paley. I have devised a CT method for this and we are investigating MR techniques.
   (b) Bone turnover - I am collaborating with Dr Simon Jones (University of Sheffield, department of Chemistry) and Promethean Particles (Nottingham, UK). We have an EPSRC PhD student due to start very soon. We are developing my designs for novel imaging agents which are now at the stage of biological testing. This has been supported to date by KTA, EPSRC KTA and NIHR funding.

Selected Recent Publications:

1. Freidman SN, Bamborough PJ, Kotsarini C, Khandanpour N, Hoggard N. Semi-automated and automated glioma grading using dynamic susceptibility-weighted contrast-enhanced perfusion MRI relative cerebral blood volume (CBV) measurements. Br J Radiol in press.


2. Khandanpour N, Connolly D, Raghavan A, Hoggard N. Craniospinal Malformation in Osteogenesis Imperfecta: A Pictorial Review. In press Radiographics.


3. Currie S, Hadjivassiliou M, Craven IJ, Wilkinson ID, Griffiths PD, Hoggard N. Magnetic resonance imaging biomarkers of patients with ataxia: Current status and future direction. Cerebellum 2012 Jul 25.


4. Currie S, Hadjivassiliou M, Wilkinson ID, Griffiths PD, Hoggard N. Magnetic Resonance Spectroscopy of the Normal Cerebellum: What Degree of Variability Can Be Expected? Cerebellum 2012 Sep 18. [Epub ahead of print]


5. Currie S, Hadjivassiliou M, Clark MJ, Sanders DS, Wilkinson ID, Griffiths PD, Hoggard N. Should we be ‘nervous’ about coeliac disease? Brain abnormalities in patients with celiac disease referred for neurological opinion. J Neurol Neurosurg Psychiatry. 2012 Aug 20


6. Khandanpour N, Hoggard N, Connolly D. The Role of Magnetic Resonance Imaging and Computed Tomography of the Brain in First Episode of Psychosis. Clin Radiol. 2012 Sep 4. [Epub ahead of print]


7. Craven I, Griffiths PD, Bhattacharyya D, Grunewald RA, Hodgson T, Connolly DJ, Coley SC, Batty R, Romanowski CAJ, Hoggard N. Magnetic Resonance Imaging of localisation related epilepsy, a review of 2000 consecutive patients imaged at 3.0T. Br J Radiol. 2012 May 9. [Epub ahead of print]


8. Hadjivassiliou M, Wallis LI, Hoggard N, Grünewald RA, Griffiths PD, Wilkinson ID. MR spectroscopy and atrophy in Gluten, Friedreich's and SCA6 ataxias. Acta Neurol Scand. 2011 Nov 10


9. Wignall EL, Griffiths PD, Papadakis NG, Wilkinson ID, Wallis LI, Bandmann O, Cowell PEE, Hoggard N. Corpus callosum morphology and microstructure assessed using MR and DTI in adults with NF1. AJNR Am J Neuroradiol. 2010 May;31(5):856-61. Epub 2010 Mar 18.


10. Leeds JS, Hopper AD, Sidhu R, Simmonette A, Azadbakht N, Hoggard N, Morley S, Sanders DS. Some Patients with Irritable Bowel Syndrome may have Exocrine Pancreatic Insufficiency. Clin Gastroenterol Hepatol. 2010 May;8(5):433-8. Epub 2009 Oct 14.


11. Gwilliam MN, Hoggard N, Capener D, Singh P, Marzo A, Verma P, Wilkinson ID. MR derived Volumetric Flow Rate Waveforms at locations within the Common Carotid, Internal Carotid and Basilar Arteries. J Cereb Blood Flow Metab. 2009 Dec;29(12):1975-82. Epub 2009 Sep 16.


12. Bigley J Griffiths PD, Prydderch A, Romanowski CA, Miles L, Lidiard H, Hoggard N. Use of NLP for MR imaging of claustrophobic patients. Br J Radiol. 2010 Feb;83(986):113-7. Epub 2009 Jun 8.


13. Griffiths PD, Hoggard N. Distribution and conspicuity of intracranial abnormalities on MR imaging in adults with tuberous sclerosis complex: A comparison of sequences including ultrafast T2-weighted images. Epilepsia. 2009 Dec;50(12):2605-10. [Epub ahead of print]


14. Hoggard N, Darwent G, Capener D, Wilkinson ID, Griffiths PD. The high incidence and bioethics of findings on MR brain imaging of normal volunteers for neuroscience research. J Med Ethics. 2009 Mar;35(3):194-9

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