Dr. Endre Kiss-Toth

Reader in Cell Signalling
Academic Leader of High Throughput Robotics Core Facility

Address
Department of Cardiovascular Science
University of Sheffield
Medical School
Beech Hill Road
Sheffield
S10 2RX

Tel (Personal): +44 (0)114 271 2228
Tel (Secretary) Steven Rowley: +44 (0)114 271 2052
Fax: +44 (0)114 271 1863
Email: e.kiss-toth@sheffield.ac.uk

Website: http://e-kisstoth.staff.shef.ac.uk/index.html
HTS Facility: http://www.shef.ac.uk/medicine/research/corefacilities/robotics

Biography:

I joined the University of Sheffield in 1988 as a postdoctoral researcher and was working on the development and implementation of a novel genetic screening approach. This is based on detecting the bioactivity of proteins, which are transiently overexpressed in mammalian cells. We used this approach to identify novel components of signalling pathways key in innate immunity. I have kept interest and association with this screening platform ever since and have recently been leading research identifying novel inflammatory regulators of macrophages.

In 2000, I was awarded a Career Development Fellowship by the Arthritis Research Campaign (now AR-UK) to characterise the mode of action of a novel family of proteins, tribbles.

In 2002, I joined the Cardiovascular Research Group as a Lecturer and developed my interest in tribbles further, by investigating their biological importance in vascular cells.

I am currently a Reader in the Department of Cardiovascular Science with the same overall focus around regulation of innate immune signalling.

Research Interests:

My research interests are centred on characterising regulatory mechanisms responsible for inter-individual differences in susceptibility to innate immune challenges.

Teaching Interests:

I lecture on technologies and approaches designed to identify novel genes with a particular function. My other main area of teaching involves bioinformatics for molecular biology and functional genomics applications.

Current Projects:

• Discovery or novel signalling proteins.
• Basic inflammatory cell signalling.
• Characterisation the in vivo biological importance of some of the novel signalling molecules we identified in our discovery platform.
• Development of novel anti-inflammatory drug-like molecules.

Key Publications:

1. Gordon, A., E. M. Greenfield, R. Eastell, E. Kiss-Toth, and J. M. Wilkinson. 2010. Individual susceptibility to periprosthetic osteolysis is associated with altered patterns of innate immune gene expression in response to pro-inflammatory stimuli. J Orthop Res (in press)
2. Gilby, D. C., H. Y. Sung, P. R. Winship, A. C. Goodeve, J. T. Reilly, and E. Kiss-Toth. 2010. Tribbles-1 and -2 are tumour suppressors, down-regulated in human acute myeloid leukaemia. Immunol Lett 130: 115-124.
3. Eder, K., H. Guan, H. Y. Sung, J. Ward, A. Angyal, M. Janas, G. Sarmay, E. Duda, M. Turner, S. K. Dower, S. E. Francis, D. C. Crossman, and E. Kiss-Toth. 2008. Tribbles-2 is a novel regulator of inflammatory activation of monocytes. Int Immunol 20: 1543-1550.
4. Gordon, A., E. Kiss-Toth, I. Stockley, R. Eastell, and J. M. Wilkinson. 2008. Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Arthritis Rheum 58: 3157-3165.
5. Hegedus, Z., A. Czibula, and E. Kiss-Toth. 2007. Tribbles: A family of kinase-like proteins with potent signalling regulatory function. Cell Signal 19: 238-250.
6. Sung, H. Y., H. Guan, A. Czibula, A. R. King, K. Eder, E. Heath, S. K. Suvarna, S. K. Dower, A. G. Wilson, S. E. Francis, D. C. Crossman, and E. Kiss-Toth. 2007. Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways. J Biol Chem 282: 18379-18387.
7. Kiss-Toth, E., D. H. Wyllie, K. Holland, L. Marsden, V. Jozsa, K. M. Oxley, T. Polgar, E. E. Qwarnstrom, and S. K. Dower. 2006. Functional mapping and identification of novel regulators for the Toll/Interleukin-1 signalling network by transcription expression cloning. Cell Signal 18: 202-214.
8. Hegedus, Z., A. Czibula, and E. Kiss-Toth. 2006. Tribbles: novel regulators of cell function; evolutionary aspects. Cell Mol Life Sci 63: 1632-1641.
9. Kiss-Toth, E., S. M. Bagstaff, H. Y. Sung, V. Jozsa, C. Dempsey, J. C. Caunt, K. M. Oxley, D. H. Wyllie, T. Polgar, M. Harte, A. O'Neill L, E. E. Qwarnstrom, and S. K. Dower. 2004. Human tribbles, a protein family controlling mitogen-activated protein kinase cascades. J Biol Chem 279: 42703-42708.
10. MacKenzie, A., H. L. Wilson, E. Kiss-Toth, S. K. Dower, R. A. North, and A. Surprenant. 2001. Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15: 825-835.
11. Kiss-Toth, E., F. M. Guesdon, D. H. Wyllie, E. E. Qwarnstrom, and S. K. Dower. 2000. A novel mammalian expression screen exploiting green fluorescent protein-based transcription detection in single cells. J Immunol Methods 239: 125-135.
12. Bowie, A., E. Kiss-Toth, J. A. Symons, G. L. Smith, S. K. Dower, and L. A. O'Neill. 2000. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll- like receptor signaling. Proc Natl Acad Sci USA 97: 10162-10167.
13. Wyllie, D. H., E. Kiss-Toth, A. Visintin, S. C. Smith, S. Boussouf, D. M. Segal, G. W. Duff, and S. K. Dower. 2000. Evidence for an accessory protein function for toll-like receptor 1 in anti-bacterial responses. J Immunol 165: 7125-7132.

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