Research Themes
Translational research within the department focuses upon developing new treatments for the clinical problems of coronary artery disease and its acute atherothrombotic complications, pulmonary arterial hypertension and inherited bleeding disorders. We employ cell biology, computational modelling, genetics, transcriptomics, advanced imaging and physiology techniques in experimental models and man to answer our research questions.
Cardiovascular BiomechanicsIncludes a cross-disciplinary team of biologists, cardiologists, mathematicians, physicists and radiologists. The theme studies the influence of mechanical forces on cardiovascular health and disease, with the intention of developing novel engineering-led interventions to treat cardiovascular diseases. |
Inflammatory MechanismsIncludes programmes focusing on aspects of vascular inflammation ranging from the identification of molecular mechanisms controlling vascular cell responses to the identification and testing of novel anti-inflammatory approaches to atherothrombotic and pulmonary vascular disease through experimental medicine studies in patients. |
Thrombosis & HaemostasisResearch ranges from preclinical studies of platelet biology and pharmacology, genetics of von Willebrand disease and haemophillia to studies of antithrombotic therapies in healthy volunteers and patients with cardiovascular disease. |