Jordan Bye

Email: j.w.bye@sheffield.ac.uk

Biography

I obtained a 2:1 BSc in Biochemistry from The University of East Anglia in 2011. I started my PhD in the Department of Chemical and Biological Engineering at The University of Sheffield in 2012. I am looking at the effects of small inorganic molecules on the structural stability of proteins.

Supervisor: Dr Robert Falconer

Biological and Environmental Systems

Publications

Jordan W. Bye, Nathan P. Cowieson, Aaron J. Cowieson, Peter H. Selle and Robert J. Falconer (2012). Dual Effects of Sodium Phytate on the Structural Stability and Solubility of Proteins. The Journal of Agriculture and Food Chemistry. 61, 290−295

Research

In 1888 Franz Hofmeister showed with a series of experiments that different salts had different effects on the solubility of protein ensembles found in hen egg white. This effect was found to be consistent for a number of protein ensembles and a ranking order was developed showing the effect of different anions and cations on protein solubility and stability called "The Hofmeister Series". The mechanistic action of how these salts affect the solubility and stability of proteins is currently subject to reappraisal. We are currently using Differential Scanning Calorimetry, solubility experiments and synchrotron radiation to study the interaction of small inorganic molecules with proteins.