The University of Sheffield
The School of Clinical Dentistry

Professor Ian M. Brook BDS FDSRCS MDS PhDIan Brook

Professor of Oral Surgery and Oral Medicine

Academic Unit of Oral & Maxillofacial Medicine & Surgery
The Clinical School of Dentistry,
Claremont Crescent,
Sheffield
S10 2TA

Telephone +44 [0] 114 2717851 or 7849

Email : i.brook@sheffield.ac.uk

Biography

Professor Brook graduated with a dental degree from the University of Liverpool in 1978. Hospital posts in Liverpool, London (The Middlesex and St. Bartholomew´s), Truro and Aberdeen followed. Appointed to the University of Sheffield in 1983 he gained his MDS in 1986 for `In vitro studies into the development of intra-oral inserts for the controlled delivery of drugs´, and PhD in 1994 for studies into the biocompatibility of Glass-ionomer cements.

With Professors Ric van Noort and Paul Hatton Professor Brook leads an internationally recognised biomaterials/tissue engineering group undertaking fundamental and applied studies into the biological response induced by implanted materials and the nature of the biomaterial/tissue interface. The group has particular expertise in the field of ionomeric materials, ceramics, and surface modification of biomaterials and tissue engineering of mucosa, cartilage and bone. Major funding for this work has been received from the EU since 1992.

In the clinical field Professor Brook´s interests lie in the field of dental Implantology and in maintaining standards.

Professor Brook has published over 100 papers and 200 scientific abstracts.

National Administrative Role

Maintaining clinical standards – CGD conduct committees, NHS litigation authority and work for Dental indemnity societies.

Research Interests

Tissue Engineering, Biomaterials, Dental Implants

Current Research Projects:

Recently Published Papers

S. Bandyopadhyay-Ghosh, P. E. P. Faria, A. Johnson, D. N. B. Felipucci, L. A. Salata, I. M. Reaney, I. M. Brook and P. V. Hatton, “Osteoconductivity of modified fluorcanasite glass-ceramics for bone tissue augmentation and repair’, Journal of Biomedical Research Vol 98A issue 3, 760-768 (2010) Published Online: Mar 24 2010 1:57PM DOI: 10.1002/jbm.a.32750 A (ERA rank)

Wen- Lin Chai, Keyvan Moharamzadeh, Ian M. Brook, Lena Emanuelsson, Anders Palmquisit, Richard VanNoort . Development of a novel model for the investigation of implant-soft tissue interface Journal of Periodontology Aug;81(8):1187-95 (2010) A (ERA rank)

Shashwat Bhakta, Deepak K. Pattanayak , Hiroaki Takadama ,Tadashi Kokubo , Cheryl A. Miller, Mehdi Mirsaneh, Ian M. Reaney, Ian Brook, Richard van Noort and Paul V. Hatton. “Prediction of osteoconductive activity of modified potassiumfluorrichterite glass-ceramics by immersion in simulatedbody fluid”. J Mater.Sci. Materials in Medicine (2010) 21: 2979–2988 B (ERA rank)

Wen Lin Chai,; K Moharamzadeh, I Brook, R VanNoort, "A Review Of The Histomorphometric Analysis Techniques For The Assessment Of Implant-Soft Tissue Interface" Biotechnic & Histochemistry.August 2011, Vol. 86, No. 4 : Pages 242-254.http://www.ncbi.nlm.nih.gov/pubmed/20392135

Shashwat Bhakta, Mehdi Mirsaneh, Cheryl A. Miller, Ian M. Reaney, Ian M Brook, Richard van Noort and Paul V. Hatton. “In vitro biocompatibility of modified potassium fluorrichterite and potassium fluorrichterite glass-ceramics”. J Mater.Sci. Materials in Medicine Volume 22, Number 9 (2011), 2065-2070. DOI: 10.1007/s10856-011-4382-8doi 10.1007/s10856-011-4382-8 online 25.6.2011 B (ERA rank)

I. M. Brook, C. O. Freemam, S. Grubb, D. J. Curran, C. J. Reidy, N. M. Cummins, S. Hampshire, & M. R. Towler. "Biological evaluation of nano hydroxyapatite-zirconia (HA-ZrO2) composites and strontium-hydroxyapatite (Sr-HA) for load bearing applications." The Journal of Biomaterials Applications 16th Sept 2011 http://jba.sagepub.com/content/early/2011/05/20/0885328211403020. B (ERA rank) DOI: 10.1177/0885328211403020

W L. Chai, I M. Brook, Lena Emanuelsson, Anders Palmquist, Richard van Noort, Keyvan Moharamzadeh. “Ultrastructural analysis of implant–soft tissue interface on a three dimensional tissue-engineered oral mucosal model” Journal of Biomedical Material Research, Part A Volume 100A, Issue 2, pages 269–277, February 2012 DOI: 10.1002/jbm.a.33245 A (ERA rank)

Ibrahim Hussain, Keyvan Moharamzadeh, Ian Brook, Patrício José de Oliveira Neto and L. Salata "Evaluation of Osteoconductive and Osteogenic Potential of a Dentin-Based Bone Substitute Using a Calvarial Defect Model," International Journal of Dentistry, vol. 2012, Article ID 396316, 7 pages, 2012. doi:10.1155/2012/396316.

K. Moharamzadeh1, H. Colley, C. Murdoch, V. Hearnden, W.L.Chai, I.M. Brook, M.H. Thornhill and S. MacNeil "Tissue Engineered Oral Mucosa," ". Journal of Dental Research. 0022034511435702, first published on January 19, 2012 as doi:10.1177/0022034511435702 A* (ERA rank)

K. Moharamzadeh1, L.E. Smith1,2, K. Franklin1,A.J. Ryan3, C. Freeman1, M.H. Thornhill1, I.M. Brook1&S. MacNeil ‘Transplantation of oral mucosa explants using different biological and synthetic membranes in an attempt to achieve one-stage reconstruction of soft-tissue defects.’ Oral Surgery 5 (2012) 118–126. ISSN 1752-2471. doi:10.1111/j.1752-248X.2012.01165.x.

S Bhakta, P E Faira, L A Salata,L A Salata, PJ de Olivera Neto, C A. Miller, R van Noort, I M. Reaney, IM Brook P V. Hatton. “Determination of relative in vivo osteoconductivity of modified potassium fluorrichterite glass-ceramics compared with 45S5 bioglass”. J Mater.Sci. Materials in Medicine (2012) Publication date: 03 July 2012 DOI: 10.1007/s10856-012-4707-2 B (ERA rank)

Wen L. Chai, Ian M. Brook, Anders Palmquist, Richard van Noort and Keyvan Moharamzadeh “The biological seal of the implant-soft tissue interface evaluated in a tissue-engineered oral mucosal model” J. R. Soc. Interface published online 22 August 2012 doi: 10.1098/rsif.2012.0507.

Research Students

4 in the field of biomaterials/tissue engineering

Personal Web Links

Research

Dental Implants