Dr. Simon A. Whawell (BSc(Hons), PGDip Ed, FHEA, PhD)
Senior Lecturer in the Academic Unit of Oral & Maxillofacial Pathology
Academic Unit of Oral & Maxillofacial Pathology
The School of Clinical Dentistry
The University of Sheffield
19 Claremont Crescent
Sheffield
S10 2TA
Tel: 0114 271 7953
Fax: 0114 271 7894
email : s.whawell@sheffield.ac.uk
Administrative Role
Theme Leader DEN 103 (Human Body, 1st BDS)
Course Co-ordinator, MMedSci in Diagnostic Oral Pathology
Chair, Oral & Maxillofacial Pathology Unit Courses Review Committee
National Administrative Role
Editorial Board member, Journal Oral Pathology & Medicine (2009-)
Secretary, Oral Medicine and Pathology Group, British Society for Oral & Dental Research
Deputy Chair awards committee, British Society for Oral & Dental Research
Young investigator awards committee member (2010-2013), International Association for Dental Research
Research Interests
Integrins, proteases and the extracellular matrix in the modification of epithelial cell behaviour, oral squamous cell carcinoma invasion in particular.
Epithelial-bacterial interactions, including mechanisms of bacterial invasion and strategies for killing intracellular bacteria
Recently Published Papers
Hunt S, Jones AV, Hinsley EE, Whawell S and Lambert DW (2010) MicroRNA-124 Suppresses Oral Squamous Cell Carcinoma Invasion by Targeting ITGB1. FEBS Letters. In press
Jenkinson S, Whawell SA, Swales BM, Corps E, Kilshaw P, Farthing PM. The αE(CD103)β7 integrin interacts with oral and skin keratinocytes in an E-cadherin-independent manner. Immunology in press
Suwannakul S, Stafford G, Whawell SA, Douglas I. Identification of bistable populations of Porphyromonas gingivalis that differ in epithelial cell invasion. Microbiology 2010: 156: 3052-3064
Khurram SA, Whawell SA, Bingle L, Murdoch C, Farthing PM. Functional expression of the chemokine receptor XCR1 on oral epithelial cells. J. Pathol. 2010; 221: 153-163
Wall IB, Bhadal N, Broad S, Whawell SA, Mudera V, Lewis MP. Force generation and protease gene expression in organotypic cultures of fibroblasts and keratinocytes. J Tiss. Eng. & Regen. Med.2009; 3: 647-650
Bhadal N, Wall IB, Porter SR, Broad S, Lindhal GE, Whawell S, Lewis MP. The effect of mechanical strain on protease production by keratinocytes. British Journal of Dermatology. 2008; 18;158:396-398.
Al-Hazmi N, Thomas GJ, Speight PM, Whawell SA. The 120 kDa cell-binding fragment of fibronectin up-regulates migration of alphavbeta6-expressing cells by increasing matrix metalloproteinase-2 and -9 secretion. European Journal of Oral Science. 2007; 115:454-8.
Current MPhil/PhD Students
Robert Ridley, Nada Al-Hindi
Radko Chmurovic (MCinDent Periodontology)
Personal Web Links:
www.shef.ac.uk/dentalschool/ppg/oral_path.html
www.shef.ac.uk/dentalschool/research/groups/oral-disease/index.html