Professor Stephen Matcher
PhD, BSc
Department of Electronic and Electrical Engineering
Professor of Biophotonics
- Profile
-
I graduated from Imperial College London with a BSc in Physics and subsequently a PhD in optical astronomy, where I used high-speed, low-light-level imaging to overcome atmospheric turbulence and achieve diffraction-limited ground-based imaging.
I translated my expertise in low-light-level imaging into medicine at University College London, where I developed near-infrared spectroscopy techniques to study tissue oxygen delivery, especially in newborn infants at risk from birth asphyxia.
I joined the staff of the Physics department at the University of Exeter, where I established research programmes in visible light spectroscopy of skin and optical coherence tomography (OCT).
In 2006 I joined the University of Sheffield where I am currently Professor of Biophotonics.
My chief research interest lies in the development and application of novel biophotonic imaging tools to aid the characterisation of native and engineered biological tissues.
I work extensively with optical coherence tomography (OCT), including novel variants such as polarization-sensitive OCT for the non-invasive assessment of collagen organization and OCT angiography for the measurement of tissue vascularization.
I also develop novel microscopy tools based on second harmonic generation (SHG) and novel clinical sensors based on fluorescence.
I am currently collaborating with clinical colleagues to improve the detection of bacterial and fungal eye infections, to provide tools for the early prediction of pre-term birth to develop non-invasive tools, to characterise skin barrier function and assess inflammatory skin disorders such as atopic dermatitis and to determine the biomechanical factors affecting the interaction between skin and man-made objects.
- Qualifications
-
- PhD in optical astronomy, Imperial College, London
- BSc in Physics, Imperial College, London
- Research interests
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- Biophotonics
- Medical Imaging
- OCT
- Publications
-
Books
- Optical Techniques in Regenerative Medicine.
Journal articles
- Fast-sweeping continuous wave quantum cascade laser operating in an external cavity with polygon mirror. Optics Express, 30(12), 21843-21853. View this article in WRRO
- Imaging striae distensae : a comparison between PS-OCT and digital dermoscopy. Biomedical Optics Express, 12(6), 3296-3311. View this article in WRRO
- Noise-like pulses with an h-shape from a 2 μm semiconductor saturable-absorber mirror mode-locked fiber oscillator. Laser Physics Letters, 17(11), 115101-115101.
- Morphological parametric mapping of 21 skin sites throughout the body using optical coherence tomography. Journal of the Mechanical Behavior of Biomedical Materials. View this article in WRRO
- Polarization-sensitive optical coherence tomography with a conical beam scan for the investigation of birefringence and collagen alignment in the human cervix. Biomedical Optics Express, 10(8), 4190-4206. View this article in WRRO
- Attenuation of stripe artifacts in optical coherence tomography images through wavelet-FFT filtering. Biomedical Optics Express, 10(8), 4179-4189. View this article in WRRO
- Superparamagnetic graphene quantum dot as a dual‐modality contrast agent for confocal fluorescence microscopy and magnetomotive optical coherence tomography. Journal of Biophotonics, 12(2). View this article in WRRO
- Sub-clinical assessment of atopic dermatitis severity using angiographic optical coherence tomography. Biomedical Optics Express, 9(4), 2001-2001. View this article in WRRO
- Measuring contact area in a sliding human finger-pad contact. Skin Research and Technology, 24(1), 31-44. View this article in WRRO
- A new mode of contrast in biological second harmonic generation microscopy. Scientific Reports, 7. View this article in WRRO
- Vascular patterning of subcutaneous mouse fibrosarcomas expressing individual VEGF isoforms can be differentiated using angiographic optical coherence tomography. Biomedical Optics Express, 8(10), 4551-4551. View this article in WRRO
- New Non-invasive Techniques to Quantify Skin Surface Strain and Sub-surface Layer Deformation of Finger-pad during Sliding. Biotribology. View this article in WRRO
- In vivo measurement of skin surface strain and sub-surface layer deformation induced by natural tissue stretching. Journal of the Mechanical Behavior of Biomedical Materials, 62, 556-569. View this article in WRRO
- Evaluation of selective laser sintering processes by optical coherence tomography. Materials and Design, 88, 837-846. View this article in WRRO
- Sensitivity Advantage of QCL Tunable-Laser Mid-Infrared Spectroscopy Over FTIR Spectroscopy. Applied Spectroscopy Reviews, 50(10), 822-839. View this article in WRRO
- The contributions of skin structural properties to the friction of human finger-pads. Proceedings of the Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology, 229(3), 294-311. View this article in WRRO
- What can biophotonics tell us about the 3D microstructure of articular cartilage?. Quant Imaging Med Surg, 5(1), 143-158.
- Imaging of 3D Tissue-Engineered Models of Oral Cancer Using 890 and 1300 nm Optical Coherence Tomography. Sovremennye tehnologii v medicine, 7(1), 60-68. View this article in WRRO
- Depth-Resolved Dynamics of Aceto-Whitening in Rabbit Cornea Studied by 1300 nm Optical Coherence Tomography. Sovremennye tehnologii v medicine, 7(1), 52-59.
- Conical scan polarization-sensitive optical coherence tomography. BIOMEDICAL OPTICS EXPRESS, 5(3), 752-762. View this article in WRRO
- Monitoring fibrous scaffold guidance of three-dimensional collagen organisation using minimally-invasive second harmonic generation.. PLoS One, 9(2), e89761. View this article in WRRO
- Depth-resolved dynamics of aceto-whitening in rabbit cornea studied by 1300nm optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8952.
- Anti-biofouling conducting polymer nanoparticles as a label-free optical contrast agent for high resolution subsurface biomedical imaging.. Biomaterials, 34(35), 8925-8940.
- Determination of the collagen fiber 'Brushing direction' in articular cartilage by conical-scan polarization-sensitive optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8934.
- Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8565.
- Photothermal detection of the contrast properties of polypyrrole nanoparticles using optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8596.
- Improved optical axis determination accuracy for fiber-based polarization-sensitive optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8571.
- Investigation of polarization-sensitive optical coherence tomography towards the study of microstructure of articular cartilage. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8571.
- Quantum dot selective area intermixing for broadband light sources.. Opt Express, 20(24), 26950-26957.
- Absolute fast axis determination using non-polarization-maintaining fiber-based polarization-sensitive optical coherence tomography.. Opt Lett, 37(11), 1931-1933.
- Polarization-sensitive optical coherence tomography using continuous polarization modulation with arbitrary phase modulation amplitude.. J Biomed Opt, 17(3), 030504.
- Experimental validation of an extended Jones matrix calculus model to study the 3D structural orientation of the collagen fibers in articular cartilage using polarization-sensitive optical coherence tomography.. Biomed Opt Express, 3(3), 378-387.
- Feasibility of using optical coherence tomography to study the influence of skin structure on finger friction. Tribology International.
- Investigation of the wavelength dependence of SHG from various tissues. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8226.
- Polypyrrole nanoparticles: a potential optical coherence tomography contrast agent for cancer imaging.. Adv Mater, 23(48), 5792-5795.
- Evaluating the use of optical coherence tomography for the detection of epithelial cancers in vitro.. J Biomed Opt, 16(11), 116015. View this article in WRRO
- Comparative study of the angle-resolved backscattering properties of collagen fibers in bovine tendon and cartilage.. J Biomed Opt, 16(8), 080501.
- Method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography. J BIOMED OPT, 16(7).
- Swept-Source Laser Based on Quantum-Dot Semiconductor Optical Amplifier-Applications in Optical Coherence Tomography. IEEE PHOTONIC TECH L, 23(11), 739-741.
- Optical measurement of the structure of articular cartilage. SPIE Newsroom.
- Optic axis determination by fibre-based polarization-sensitive swept-source optical coherence tomography.. Phys Med Biol, 56(4), 1105-1122.
- A theoretical framework for the analysis of optical anisotropy in birefringent biological tissues with polarization-sensitive optical coherence tomography. Optics InfoBase Conference Papers.
- Evaluation of a swept-laser optical coherence tomography light source based on a novel quantum-dot based semiconductor optical amplifier. Optics InfoBase Conference Papers.
- Common path Fourier domain optical coherence tomography based on multiple reflections within the sample arm. Optics Communications, 284(12), 3168-3172. View this article in WRRO
- Optic axis determination by fiber-based polarization-sensitive swept-source optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7889.
- Common path FDOCT based on multiple reflections within the sample arm. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7889.
- Common path michelson interferometer based on multiple reflections within the sample arm: Sensor applications and imaging artefacts. Measurement Science and Technology, 22(2).
- Performance comparison between 8- and 14-bit-depth imaging in polarization-sensitive swept-source optical coherence tomography.. Biomed Opt Express, 2(4), 794-804.
- Practical aspects of OCT imaging in tissue engineering.. Methods Mol Biol, 695, 261-280.
- Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin.. J Tissue Eng Regen Med, 4(8), 652-658.
- Doppler optical coherence tomography in cardiovascular applications. Laser Physics, 20(6), 1491-1499.
- Speckle texture analysis of optical coherence tomography images. Proceedings of SPIE - The International Society for Optical Engineering, 7387.
- Quantum dot superluminescent diodes for optical coherence tomography: Skin imaging. IEEE Journal on Selected Topics in Quantum Electronics, 16(4), 748-754.
- Quantum dot superluminescent diodes for optical coherence tomography: Device engineering. IEEE Journal on Selected Topics in Quantum Electronics, 16(4), 1015-1022. View this article in WRRO
- Using swept source optical coherence tomography to monitor wound healing in tissue engineered skin. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7566.
- Application of intravital microscopy in studies of tumor microcirculation.. J Biomed Opt, 15(1), 011113.
- Evaluation of a cheap ultrasonic stage for light source coherence function measurement, optical coherence tomography and dynamic focusing. MEAS SCI TECHNOL, 20(10). View this article in WRRO
- A review of some recent developments in polarization-sensitive optical imaging techniques for the study of articular cartilage. J APPL PHYS, 105(10). View this article in WRRO
- Is mean blood saturation a useful marker of tissue oxygenation?. Am J Physiol Heart Circ Physiol, 296(5), H1289-H1295.
- Evaluation of a cheap ultrasonic stage for light source coherence function measurement, optical coherence tomography, optical coherence microscopy and dynamic focusing. Optics InfoBase Conference Papers.
- Exploring the use of optical coherence tomography in the non-invasive imaging of tissue engineered skin. European Cells and Materials, 18(SUPPL. 2), 105.
- Application of doppler optical coherence tomography in rheological studies: Blood flow and vessels mechanical properties evaluation. Journal of Innovative Optical Health Sciences, 2(4), 431-440.
- Evaluation of a cheap ultrasonic stage for light source coherence function measurement, optical coherence tomography, optical coherence microscopy and dynamic focusing. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7372.
- Polarization sensitive optical coherence tomography in equine bone. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 7166.
- Novel optical imaging technique to determine the 3-D orientation of collagen fibers in cartilage: variable-incidence angle polarization-sensitive optical coherence tomography.. Osteoarthritis Cartilage, 17(1), 33-42. View this article in WRRO
- Collagen fiber arrangement in normal and diseased cartilage studied by polarization sensitive nonlinear microscopy.. J Biomed Opt, 13(4), 044020.
- Doppler optical coherence tomography in cardiovascular physiology. Proceedings of SPIE - The International Society for Optical Engineering, 7139.
- Second-harmonic and two-photon imaging and polarimetry of articular cartilage. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6442.
- Three-dimensional optic axis determination using variable-incidence-angle polarization-optical coherence tomography.. Opt Lett, 31(15), 2305-2307.
- Imaging articular cartilage using non-linear microscopy. Journal of Biomechanics, 39, S452-S453.
- The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography. J PHYS D APPL PHYS, 38(15), 2612-2619.
- The effect of multiple scattering on velocity profiles measured using Doppler OCT. J PHYS D APPL PHYS, 38(15), 2597-2605.
- Effects of multiple scattering on flow velocity profiles measured using DOCT. Optics InfoBase Conference Papers.
- Studies of equine articular cartilage using PS-OCT. Optics InfoBase Conference Papers.
- The effect of multiple scattering upon velocity profiles measured using doppler OCT. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5861, 1-12.
- The 3-D collagen structure of equine articular cartilage, characterized using variable-angle-of-incidence polarization-sensitive optical coherence tomography. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 5861, 1-8.
- Measuring red blood cell flow dynamics in a glass capillary using Doppler optical coherence tomography and Doppler amplitude optical coherence tomography.. J Biomed Opt, 9(5), 982-994.
- Monte Carlo modeling of polarized light propagation in biological tissues. LASER PHYS, 14(6), 886-891.
- The collagen structure of bovine intervertebral disc studied using polarization-sensitive optical coherence tomography.. Phys Med Biol, 49(7), 1295-1306.
- Measurement of bone mineral density via light scattering.. Phys Med Biol, 49(3), 469-483.
- Computer simulation of the skin reflectance spectra.. Comput Methods Programs Biomed, 70(2), 179-186.
- Laser diagnostics of dynamic phenomena in biological objects: Model measurements, numerical simulations, and medical applications. Institute of Physics Conference Series, 177, 249.
- Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions.. Physiol Meas, 23(4), 741-753.
- Analysis of the Spatial Distribution of Detector Sensitivity in a Multilayer Randomly Inhomogeneous Medium with Strong Light Scattering and Absorption by the Monte Carlo Method. Optics and Spectroscopy (English translation of Optika i Spektroskopiya), 91(4), 654-659.
- Sampling volume produced by shallow optical probes in skin reflectance measurements. Proceedings of SPIE - The International Society for Optical Engineering, 4427, 61-69.
- Modelling the sampling volume for skin blood oxygenation measurements.. Med Biol Eng Comput, 39(1), 44-50.
- The application of the Monte Carlo technique for estimation of the detector depth sensitivity for the skin oxygenation measurements. Monte Carlo Methods and Applications, 6(1), 15-25.
- Nonuniqueness in optical tomography: relevance of the P1 approximation.. Opt Lett, 24(23), 1729-1731.
- The determination of skin oxygenation by near-infrared spectroscopy: Estimation of signal localisation using Monte Carlo modelling. J VASC RES, 36(4), 338-338.
- Noninvasive assessment of changes in cytochrome-c oxidase oxidation in human subjects during visual stimulation.. J Cereb Blood Flow Metab, 19(6), 592-603.
- Identification and quantification of intrinsic optical contrast for near-infrared mammography.. Photochem Photobiol, 67(1), 4-14.
- Identification and Quantification of Intrinsic Optical Contrast for Near-infrared Mammography. Photochemistry and Photobiology, 67(1), 4-4.
- Closed-form expressions for obtaining the absorption and scattering coefficients of a turbid medium with time-resolved spectroscopy.. Appl Opt, 36(31), 8298-8302.
- Measurement of cytochrome oxidase redox state by near infrared spectroscopy.. Adv Exp Med Biol, 413, 63-73.
- Measurement of cerebral venous saturation in adults using near infrared spectroscopy.. Adv Exp Med Biol, 411, 453-460.
- In vivo measurements of the wavelength dependence of tissue-scattering coefficients between 760 and 900 nm measured with time-resolved spectroscopy.. Appl Opt, 36(1), 386-396.
- The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy.. Pediatr Res, 39(1), 32-38.
- NONINVASIVE MEASUREMENT OF ABSOLUTE DEOXY-HEMOGLOBIN CONCENTRATION IN THE NEONATAL BRAIN. PEDIATR RES, 38(3), 429-429.
- Performance comparison of several published tissue near-infrared spectroscopy algorithms.. Anal Biochem, 227(1), 54-68.
- Near-infrared spectroscopy of the brain: relevance to cytochrome oxidase bioenergetics.. Biochem Soc Trans, 22(4), 974-980.
- Absolute quantification of deoxyhaemoglobin concentration in tissue near infrared spectroscopy.. Phys Med Biol, 39(8), 1295-1312.
- Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy.. Phys Med Biol, 39(1), 177-196.
- SPECKLE INTERFEROMETRY OF HIPPARCOS LINK STARS .3.. MON NOT R ASTRON SOC, 248(3), 411-413.
- SPECKLE INTERFEROMETRIC OBSERVATIONS OF SUPERNOVA 1987A AND OF A BRIGHT ASSOCIATED SOURCE. NATURE, 329(6140), 608-611.
- The potential application of PS-OCT in the safety assessment of non-steroidal topical creams for Atopic Dermatitis treatment. Biomedical Optics Express.
- Visible-light optical coherence tomography platform for the characterization of the skin barrier. Biomedical Optics Express.
Chapters
- Second-Harmonic Generation, Optical Techniques in Regenerative Medicine (pp. 61-91).
- Optical Coherence Tomography, Optical Techniques in Regenerative Medicine (pp. 267-306). Taylor & Francis
- Optical Transillumination and Projection Tomography for Multidimensional Mesoscopic Imaging, Optical Techniques in Regenerative Medicine (pp. 239-266). Taylor & Francis
- Application of Polarization-Sensitive OCT and Doppler OCT in Tissue Engineering, Optical Techniques in Regenerative Medicine (pp. 307-328). Taylor & Francis
- Bioluminescence Imaging, Optical Techniques in Regenerative Medicine (pp. 403-418). Taylor & Francis
- Macroscopic Imaging in Regenerative Medicine, Optical Techniques in Regenerative Medicine (pp. 383-402). Taylor & Francis
- Optical Microscopy in Regenerative Medicine, Optical Techniques in Regenerative Medicine (pp. 27-28). Taylor & Francis
- In Situ Microscopy, Optical Techniques in Regenerative Medicine (pp. 115-142). Taylor & Francis
- Optical Macroscopic Imaging in Regenerative Medicine, Optical Techniques in Regenerative Medicine (pp. 381-382). Taylor & Francis
- Raman Spectroscopy, Optical Techniques in Regenerative Medicine (pp. 205-236). Taylor & Francis
- Optical Spectroscopy in Regenerative Medicine, Optical Techniques in Regenerative Medicine (pp. 143-144). Taylor & Francis
- Index (pp. 419-430). Taylor & Francis
- The Role of Optical Techniques in Regenerative Medicine, Optical Techniques in Regenerative Medicine (pp. 3-26). Taylor & Francis
- Second-Harmonic Generation, Optical Techniques in Regenerative Medicine (pp. 61-92). Taylor & Francis
- Photoacoustic Tomography, Optical Techniques in Regenerative Medicine (pp. 329-354). Taylor & Francis
- Two-Photon Polymerization for Tissue-Engineered Scaffold Fabrication, Optical Techniques in Regenerative Medicine (pp. 93-114). Taylor & Francis
- Introduction and Background, Optical Techniques in Regenerative Medicine (pp. 1-2). Taylor & Francis
- Fluorescence Spectroscopy, Optical Techniques in Regenerative Medicine (pp. 171-204). Taylor & Francis
- Optical Tomography in Regenerative Medicine, Optical Techniques in Regenerative Medicine (pp. 237-238). Taylor & Francis
- Ultrasound-Modulated Optical Tomography, Optical Techniques in Regenerative Medicine (pp. 355-380). Taylor & Francis
- Light Scattering as Polarization Spectroscopy, Optical Techniques in Regenerative Medicine (pp. 145-170). Taylor & Francis
- Color Insert, Optical Techniques in Regenerative Medicine (pp. 431-438). Taylor & Francis
- Fluorescence Microscopy In Morgan S, Rose FR & Matcher SJ (Ed.), Optical Techniques in Regenerative Medicine (pp. 29-59). Boca Raton: Taylor & Francis.
- OCT blood flow imaging, Optical Coherence Tomography in Cardiovascular Research (pp. 319-328). CRC Press
- OCT blood flow imaging, Optical Coherence Tomography in Cardiovascular Research (pp. 319-328).
- Signal Quantification and Localization in Tissue Near-Infrared Spectroscopy, Handbook of Optical Biomedical Diagnostics, Second Edition, Volume 1: Light-Tissue Interaction SPIE PRESS
- QD Ultrafast and Continuous Wavelength Laser Diodes for Applications in Biology and Medicine, The Physics and Engineering of Compact Quantum Dot-based Lasers for Biophotonics (pp. 171-230). Wiley-VCH Verlag GmbH & Co. KGaA
- Optical Oximetry, Handbook of Biophotonics Wiley-VCH Verlag GmbH & Co. KGaA
Conference proceedings papers
- Optical design and simulation of a cervical scanning probe for polarization-sensitive optical coherence tomography using Ansys Zemax OpticStudio. Optical Coherence Imaging Techniques and Imaging in Scattering Media V, 25 June 2023 - 30 June 2023.
- Visible-light optical coherence tomography platform for the development of novel atopic dermatitis treatment. Photonics in Dermatology and Plastic Surgery 2023, 28 January 2023 - 3 March 2023.
- Fast swept continuous wave quantum cascade laser operating in external cavity with polygon mirror. Semiconductor Lasers and Laser Dynamics X, 3 May 2022 - 23 May 2022.
- Assessing the severity of striae distensae using polarization-sensitive optical coherence tomography. BRITISH JOURNAL OF DERMATOLOGY, Vol. 187(1) (pp E22-E23)
- A RANDOMIZED CONTROLLED PHASE 2 TRIAL COMPARING THE EFFECTS OF CRISABOROLE 2% OINTMENT TO BETAMETHASONE VALERATE 0.1% CREAM ON SKIN STRUCTURE IN PARTICIPANTS WITH ATOPIC DERMATITIS. ACTA DERMATO-VENEREOLOGICA, Vol. 102 (pp 56-57)
- Methods for reducing relative intensity noise in swept-source mid-infrared OCT. Biomedical Spectroscopy, Microscopy, and Imaging, 6 April 2020 - 10 April 2020.
- Modelling the wavelength-dependent response of SHG excitation efficiency. Biomedical Spectroscopy, Microscopy, and Imaging, 6 April 2020 - 10 April 2020.
- Translating Optical Coherence Tomography Technologies from Clinical Studies to Botany: Real Time Imaging of Long-Distance Signaling in Plants. Biophotonics Congress: Biomedical Optics 2020 (Translational, Microscopy, OCT, OTS, BRAIN), 2020. View this article in WRRO
- Swept-source OCT using pulsed mid-infrared light. Label-free Biomedical Imaging and Sensing (LBIS) 2019, 2 February 2019 - 7 February 2019.
- Polarisation-Sensitive Optical Coherence Tomography as a Potential Tool for Assessing the Orientation of Collagen Fibres in the Human Cervix.. REPRODUCTIVE SCIENCES, Vol. 26 (pp 128A-128A)
- In vitro characterization of collagen organization in the human cervix using polarization-sensitive optical coherence tomography (PS-OCT). Diseases in the Breast and Reproductive System V, 2 February 2019 - 7 February 2019.
- Polarization-sensitive swept-source optical coherence tomography for investigating depth, birefringence, depolarization and orientation of collagen structure of human cervix tissue. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 2 February 2019 - 7 February 2019.
- Ghosting artifact reduction of polarization sensitive optical coherence tomography images through wavelet-FFT filtering. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIII, 2 February 2019 - 7 February 2019.
- Towards swept-source mid-infrared OCT. Biophotonics: Photonic Solutions for Better Health Care VI, 22 April 2018 - 26 April 2018.
- Characterizing the microcirculation of atopic dermatitis using angiographic optical coherence tomography. Proceedings of SPIE, Vol. 10037 View this article in WRRO
- Novel magnetic graphene quantum dot as dual modality fluorescence/MMOCT contrast agent for tracking epithelial cells. Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications IX
- Investigation into surface interaction between the contact lens, the upper eyelid and cornea using optical coherence tomography. Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVII View this article in WRRO
- System for tracking transplanted limbal epithelial stem cells in the treatment of corneal stem cell deficiency
(Conference Presentation). Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues IX, 13 February 2016 - 18 February 2016.
- 1300 nm and 890 nm OCT images of oral cancer tissue engineered models and biopsy samples offer complimentary performance (Conference Presentation). Photonic Therapeutics and Diagnostics XII, 13 February 2016 - 18 February 2016.
- Towards in-situ process monitoring in selective laser sintering using optical coherence tomography. Laser 3D Manufacturing III View this article in WRRO
- High-resolution label-free vascular imaging using a commercial, clinically approved dermatological OCT scanner. Photonic Therapeutics and Diagnostics XII, Vol. 9689
- High Speed Optical Coherence Elastography for Human Skin Deformation Studies. Photonics West 2016
- Skin Surface and Sub-Surface Strain and Deformation Imaging using OCT and DIC. Photonics West 2016
- High-speed high-sensitivity infrared spectroscopy using mid-infrared swept lasers
(Conference Presentation). High-Speed Biomedical Imaging and Spectroscopy: Toward Big Data Instrumentation and Management, 13 February 2016 - 18 February 2016.
- Optical coherence elastography for human finger-pad skin deformation studies. Optical Elastography and Tissue Biomechanics III
- Skin surface and sub-surface strain and deformation imaging using optical coherence tomography and digital image correlation. Optical Elastography and Tissue Biomechanics III
- Rigorous comparison of the spectral SNR of FTIR and EC-QCL spectroscopy
(Conference Presentation). Biomedical Vibrational Spectroscopy 2016: Advances in Research and Industry, 13 February 2016 - 18 February 2016.
- Profilometry of the air-tissue interface by all-semiconductor akinetic programmable swept-source with centimeters coherence length. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XX
- Lasers and SLEDs for optical coherence tomography. 2015 17th International Conference on Transparent Optical Networks (ICTON), 5 July 2015 - 9 July 2015.
- The mid-infrared swept laser: life beyond OCT?. Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIX
- System for tracking transplanted limbal epithelial stem cells in the treatment of corneal stem cell deficiency. Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIII
- A Rapid Swept-Source Mid-Infrared Laser. 2014 International Semiconductor Laser Conference, 7 September 2014 - 10 September 2014.
- A Rapid Swept-Source Mid-Infrared Laser. 2014 24TH IEEE INTERNATIONAL SEMICONDUCTOR LASER CONFERENCE (ISLC 2014) (pp 155-156)
- Front Matter (pp i-xvi)
- Optical coherence tomography based angle-resolved backscattering studies on bovine tendon and cartilage. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVI, Vol. 8213
- Self-Assembled Quantum Dot Based Swept Laser Source for Optical Coherence Tomography Applications. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVI, Vol. 8213
- Polarization-sensitive optical coherence tomography measurements with different phase modulation amplitude when using continuous polarization modulation. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XVI, Vol. 8213
- Polypyrrole nanoparticles: A new class of contrast agent for cancer imaging. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 242
- Digital phase stabilization for improving sensitivity and degree of polarization accuracy in polarization sensitive optical coherence tomography. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XV, Vol. 7889
- Performance comparison between 8 and 14 bit-depth imaging in polarization-sensitive swept-source optical coherence tomography. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICINE XV, Vol. 7889
- Evaluation of a swept-laser optical coherence tomography light source based on a novel quantum-dot based semiconductor optical amplifier. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE TECHNIQUES V, Vol. 8091
- A method to calibrate phase fluctuation in polarization-sensitive swept-source optical coherence tomography. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE TECHNIQUES V, Vol. 8091
- theoretical framework for the analysis of optical anisotropy in birefringent biological tissues with polarization-sensitive optical coherence tomography. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE TECHNIQUES V, Vol. 8091
- Using tissue-engineered oral cancer models to evaluate non-invasive diagnostic technologies. ORAL DIS, Vol. 16(6) (pp 518-518)
- EVIDENCE OF A CENTRAL RESPIRATORY OSCILLATOR OBSERVED IN THE CUTANEOUS MICROCIRCULATION. HYPERTENSION, Vol. 54(5) (pp 1171-1171)
- GaAs Based Quantum Dot Superluminescent Diodes for Optical Coherence Tomography of Skin Tissue. 2009 4TH INTERNATIONAL CONFERENCE ON COMPUTERS AND DEVICES FOR COMMUNICATION (CODEC 2009) (pp 426-431)
- Optical coherence tomography with high power quantum-dot superluminescent diodes. 2009 IEEE LEOS ANNUAL MEETING CONFERENCE PROCEEDINGS, VOLS 1AND 2 (pp 207-208)
- Is mean blood saturation (SmbO2) a useful marker of tissue oxygenation?. HYPERTENSION, Vol. 52(4) (pp 752-752)
- Novel optical imaging technique to determine the 3D structure of collagen fibers in articular cartilage: variable-incidence-angle polarization-sensitive optical coherence tomography. INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Vol. 89(3) (pp A20-A21)
- Measurement of sinusoidal flow oscillations in a glass capillary tube using phase-resolved DOCT - art. no. 68472O. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE XII, Vol. 6847 (pp O8472-O8472)
- Determination of 3D optic axis orientation in cartilage by Polarization-Sensitive Optical Coherence Tomography - art. no. 68580I. OPTICS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE II, Vol. 6858 (pp I8580-I8580)
- Visible-light OCT spectrometer for microvascular oximetry - art. no. 68471D. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE XII, Vol. 6847 (pp D8471-D8471)
- Local variations in bone mineral density: A comparison of OCT vs X-ray micro-CT - art. no. 684725. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE XII, Vol. 6847 (pp 84725-84725)
- Combined optical and near infrared reflectance measurements of vasomotion in both skin and underlying muscle. - art. no. 643421. Optical Tomography and Spectroscopy of Tissue VII, Vol. 6434 (pp 43421-43421)
- Determination of 3D optic axis orientation in cartilage by polarization-sensitive optical coherence tomography - art. no. 64292P. Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, Vol. 6429 (pp P4292-P4292)
- Innovative application of optical techniques to comprehensive study the etiology of osteoarthritis - art. no. 616308. Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, Vol. 6163 (pp 16308-16308)
- Imaging articular cartilage using second harmonic generation microscopy - art. no. 60891O. Multiphoton Microscopy in the Biomedical Sciences VI, Vol. 6089 (pp O891-O891)
- Rhythmic oscillations in blood volume observed simultaneously in skin and underlying muscle of the forearm.. JOURNAL OF VASCULAR RESEARCH, Vol. 43 (pp 93-93)
- The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography and non-linear microscopy - art. no. 604715. Fourth International Conference on Photonics and Imaging in Biology and Medicine, Pts 1 and 2, Vol. 6047 (pp 4715-4715)
- Variable-angle-of-incidence polarization-sensitive optical coherence tomography: its use to study the 3-D collagen structure of equine articular cartilage. - art. no. 60792C. Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine X, Vol. 6079 (pp C792-C792)
- Absolute SO2 measurements in layered media.. Biomedical Optical Spectroscopy and Diagnostics, 1996.
- Optical Mapping of the Human Breast using Second Derivative Near Infrared Spectroscopy. Biomedical Optical Spectroscopy and Diagnostics, 1996.
- The effect of multiple scattering upon velocity profiles measured using Doppler OCT. Optical Coherence Tomography and Coherence Techniques II
- The 3-D collagen structure of equine articular cartilage, characterized using variable-angle-of-incidence polarization-sensitive optical coherence tomography. Optical Coherence Tomography and Coherence Techniques II
- Studies of Equine Articular Cartilage Using Polarization-Sensitive Optical Coherence Tomography. Optical Coherence Tomography and Coherence Techniques II, 2005.
- PSOCT studies of intervertebral disk.. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VIII, Vol. 5316 (pp 383-390)
- Estimation of bone mineral density from OCT images. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VIII, Vol. 5316 (pp 128-135)
- Polarization-sensitive OCT of bovine intervertebral disk.. OPTICAL COHERENCE TOMOGRAPHY AND COHERENCE TECHNIQUES, Vol. 5140 (pp 204-211)
- Optical studies of changes in bone mineral density. OPTICAL DIAGNOSTICS AND SENSING IN BIOMEDICINE III, Vol. 4965 (pp 77-83)
- Polarization-sensitive OCT applied to equine tendon and bovine intervertebral disk.. COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VII, Vol. 4956 (pp 360-365)
- Measuring blood flow dynamics using DOCT and Doppler amplitude optical coherence tomography (DAOCT). COHERENCE DOMAIN OPTICAL METHODS AND OPTICAL COHERENCE TOMOGRAPHY IN BIOMEDICINE VII, Vol. 4956 (pp 366-373)
- Polarization-sensitive OCT of bovine intervertebral disk.. Optics InfoBase Conference Papers (pp 204-211)
- Monte Carlo modeling of polarized light propagation in a biological tissue. COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS VI, Vol. 4619 (pp 281-288)
- Development of a phase-resolved Doppler optical coherence tomography system for use in cutaneous microcirculation research. COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS VI, Vol. 4619 (pp 269-275)
- Effect of mechanical pressure on the skin surface produced by fibre-optic probe in a blood microcirculation study. Biomedical Topical Meeting, 2002.
- Effect of mechanical pressure on the skin surface produced by fibre-optic probe in a blood microcirculation study. Optics InfoBase Conference Papers (pp 549-551)
- Confocal probing of skin during it clearing. CLEO(R)/PACIFIC RIM 2001, VOL I, TECHNICAL DIGEST (pp 234-235)
- A Monte Carlo simulation using polarized light in biological tissue. SARATOV FALL MEETING 2001: OPTICAL TECHNOLOGIES IN BIOPHYSICS AND MEDICINE III, Vol. 4707 (pp 248-252)
- Modeling of skin reflectance spectra. SARATOV FALL MEETING 2000: OPTICAL TECHNOLOGIES IN BIOPHYSICS AND MEDICINE II, Vol. 4241 (pp 78-87)
- Estimation of the optical sampling volume for skin reflectance measurements. PHOTON MIGRATION, DIFFUSE SPECTROSCOPY AND OPTICAL COHERENCE TOMOGRAPHY: IMAGING AND FUNCTIONAL ASSESSMENT, Vol. 1(31) (pp 233-241)
- The determination of absorption coefficient of skin melanin in visible and NIR spectral region. LASERS IN SURGERY: ADVANCED CHARACTERIZATION, THERAPEUTICS, AND SYSTEMS X, Vol. 1(1) (pp 143-150)
- Analyses of the sampling volume for fiber optics and confocal detecting probe in back scattered spectral investigations of the skin. COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS IV, Vol. 1(9) (pp 18-24)
- Density of the spatial weight distribution in the multi-layered highly scattering randomly inhomogeneous media. MMET 2000: INTERNATIONAL CONFERENCE ON MATHEMATICAL METHODS IN ELECTROMAGNETIC THEORY, VOLS 1 AND 2, CONFERENCE PROCEEDINGS (pp 317-319)
- Analysis of reflectance spectra for skin oxygenation measurements. CONTROLLING TISSUE OPTICAL PROPERTIES: APPLICATIONS IN CLINICAL STUDY, Vol. 1(33) (pp 46-53)
- Computational model of human skin for reflected spectra simulation. SARTOV FALL MEETING '99: OPTICAL TECHNOLOGIES IN BIOPHYSICS AND MEDICINE, Vol. 4001 (pp 327-335)
- The influence of the complex multi layered highly scattering medium on the light reflectance. SARTOV FALL MEETING '99: OPTICAL TECHNOLOGIES IN BIOPHYSICS AND MEDICINE, Vol. 4001 (pp 336-344)
- The application of Monte Carlo technique for determination of skin oxygenation by near-infrared spectroscopy. Biomedical Optics, 1999.
- The development of Monte Carlo technique for determination of skin oxygenation by near-infrared spectroscopy.. COHERENCE DOMAIN OPTICAL METHODS IN BIOMEDICAL SCIENCE AND CLINICAL APPLICATIONS III, PROCEEDINGS OF, Vol. 3598 (pp 279-287)
- Aspects of determination of skin oxygenation by near-infrared spectroscopy (overview). SARATOV FALL MEETING '98: LIGHT SCATTERING TECHNOLOGIES FOR MECHANICS, BIOMEDICINE, AND MATERIAL SCIENCE, Vol. 3726 (pp 528-534)
- The application of Monte Carlo technique for determination of skin oxygenation by near-infrared spectroscopy. Optics InfoBase Conference Papers (pp 311)
- Quantitation methods for determining the intrinsic composition of breast tissue in vivo using near-infrared transillumination.. PHOTON PROPAGATION IN TISSUES III, PROCEEDINGS OF, Vol. 3194 (pp 522-530)
- Absolute SO
2 measurements in layered media. Optics InfoBase Conference Papers (pp 83-91)
- Optical Mapping of the Human Breast using Second Derivative Near Infrared Spectroscopy. Optics InfoBase Conference Papers (pp 67-71)
- Absolute quantification methods in tissue near infrared spectroscopy.. OPTICAL TOMOGRAPHY, PHOTON MIGRATION, AND SPECTROSCOPY OF TISSUE AND MODEL MEDIA: THEORY, HUMAN STUDIES, AND INSTRUMENTATION, PROCEEDINGS OF, PTS 1 AND 2, Vol. 2359 (pp 486-495)
- QUANTIFICATION OF TISSUE CHROMOPHORE CONCENTRATION VIA WATER PEAK MEASUREMENTS IN NEAR-INFRARED SPECTROSCOPY. PROCEEDINGS OF PHOTON MIGRATION AND IMAGING IN RANDOM MEDIA AND TISSUES, Vol. 1888 (pp 239-247)
- SPECKLE INTERFEROMETRY OF CANDIDATE STARS FOR 2 SPACE TELESCOPE PROGRAMS. AMPLITUDE AND INTENSITY SPATIAL INTERFEROMETRY, Vol. 1237 (pp 231-241)
- Ex vivo and in vivo OCT image contrast. Proceedings of SPIE - The International Society for Optical Engineering, Vol. 7139. 2008, 8 September 2008 - 10 September 2008.
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Student Degree Status Primary/Secondary Byers R A PhD Graduated Primary Li, W PhD Graduated Primary Lin, W C PhD Graduated Primary Yuan, R PhD Current Primary Duan, T PhD Current Primary Williams, S PhD Current Secondary Hooper, S PhD Current Primary Sasi, G PhD Current Secondary