Professor Michael J Cork BSc MB PhD FRCP

Professor of Dermatology

Picture of Professor Cork

Academic Unit of Dermatology Research
Department of Infection and Immunity
The University of Sheffield Medical School
Beech Hill Road
Sheffield
S10 2RX
UK


Administrator - Mr Les Hunter
Tel: +44 (0)114 271 2933
Email: l.hunter@sheffield.ac.uk
Secretary - Mrs Sue Clary
Tel: +44 (0)114 226 8961
Email: s.clary@sheffield.ac.uk

Biography

I joined the University of Sheffield in 1991 as a lecturer in dermatology whilst continuing as a practising dermatologist for the NHS in Sheffield. I had previously been a Registrar in Dermatology at the Royal Hallamshire Hospital, Sheffield, and before that a Registrar in Respiratory General Medicine at Leeds General Infirmary.

I have been closely involved with research in many areas of dermatology; including Atopic Eczema(dermatitis), Psoriasis, Vitiligo and the Genetics of Skin Disease. My major current research work is aimed at identifying gene–environment interactions in the development of atopic dermatitis leading to skin barrier breakdown and the understanding of how topical agents interact with the skin barrier; using this information to enhance the treatment of atopic dermatitis.

I am currently Head of Academic Dermatology Research in the Department of Infection & Immunity at The University of Sheffield Medical School and am Honorary Consultant Dermatologist to both Sheffield Children´s Hospital NHS Foundation Trust and to Sheffield Teaching Hospitals NHS Foundation Trust; my time is evenly split between the University and the NHS.

Research Interests

My research interests are inflammatory skin disorders including: atopic dermatitis (atopic eczema), psoriasis, alopecia areata and vitiligo. The group which includes both clinical and non-clinical staff has identified genetic variants associated with all of these diseases.

Internationally, the Academic Unit of Dermatology Research is one of the leading groups translating basic dermatological science into new treatments for the clinic. Examples include `Skin Protease Inhibitors´ and `Vitamin A Metabolic Pathway Inhibitors´. In 2001, with help from The Wellcome Trust, the group formed a `spin-out´ company called `Molecular SkinCare´, with the aim of developing these treatments.

Another major focus of the group is the effect of topical pharmaceuticals, cosmetics and oils on the structure and function of the skin barrier. Research in this area comprises investigation of the skin barrier defect associated with skin disorders such as atopic dermatitis, how skin barrier defects develop and how to treat or repair the skin barrier defect. This includes the determination of the effect of topical agents/products on the skin of volunteers visiting our clinical diagnostic `skin laboratory´, where we can measure specific properties of the skin barrier, non-invasively, using an array of specialised equipment. These results are then correlated with variants in the genes that determine the structure and function of the skin barrier.

Research conducted by the AuDR is at the interface between the clinic, academia and industry. Work has been funded by charities, including: The Wellcome Trust, British Skin Foundation and Psoriasis Association; also by the Kuwait Ministry of Health; and by pharmaceutical/cosmetics companies; including Astellas, Johnson & Johnson and Stiefel-GSK.

Teaching Interests

My teaching interests within The University include medical undergraduate lecturing and in-clinic training plus postgraduate researcher training and mentoring. I also lecture to related courses at other universities, such as the MSc in Dermatology at Cardiff and at major international and national conferences in the field of dermatology. In addition I undertake a large number of atopic eczema related educational presentations at local, national and international level to a wide range of audiences including; pharmacists, general practitioners, hospital nurses, community nurses, midwives, paediatricians, practice nurses and patient support charities (e.g. National Eczema Society, Skin Care Campaign and Psoriasis Association).

Education of Children with Skin Diseases
I have developed a special interest in `translating´ the complex pathophysiology of skin disease into cartoons and language that can be understood by a child of six. I presented these to the National Eczema Society and the Skin Care Campaign. I have written papers for these charities describing the content of the lectures, for example Cork et al 2000; 2002 "Skin Wars". I use the cartoons in my clinics to teach children and their parent about skin diseases. The medical students that sit-in during my clinics, suggested I incorporated the "Skin Wars" cartoons into their lectures because they made dermatology exciting. The "Skin Wars" cartoons have been disseminated to many other dermatology departments. I have assigned all commercial profits from use of the "Skin Wars" cartoons to the National Eczema Society. The "Skin Wars" teaching approach was cited as being an innovative approach to education by the judges in the Hospital Doctor Dermatology Team of the Year Awards, which our paediatric dermatology team won in 2001. This teaching method was also highlighted in the National Eczema Society Health Care Professionals Award 2004.

Professional Activities

  • Member of the National Institute of Clinical Excellence (NICE) clinical guideline development group for the treatment of Atopic Eczema in children.
  • Advisor, Lecturer and developer of educational materials for the National Eczema Society, Skin Care Campaign, Psoriasis Association and Allergy UK.
  • Wellcome Trust Translational Grants Reviewer & Expert Panel member.
  • Grant Reviewer, British Skin Foundation, Psoriasis Association and Wellcome Trust.
  • Fellow of the Royal College of Physicians, London and Edinburgh.
  • Member of British Association of Dermatologists.
  • Member of European Academy of Dermatology and Venereology.
  • Member of British Society for Investigative Dermatology.
  • Member of European Society for Dermatological Research.
  • Member of British Society for Paediatric Dermatology.
  • Member of Dowling Dermatology Society.
  • Professional Member of the National Eczema Society.
  • Member of The Council (board) of the Psoriasis Association.
  • South Yorkshire Biotech Enterprise Network (SYBEN): York Pharma – Biotech company of the year, 2006.
  • Yorkshire Forward Bioscience Yorkshire Annual Awards: Molecular Skin Care: Recognised for Outstanding Achievements in Bioscience. Awarded to the company who has made the greatest advances in Yorkshire in 2005.
  • Leader of the team awarded ‘Health Care Professional Team of the Year’ by the National Eczema Society in 2004.
  • Leader of the team awarded ‘Hospital Doctor Dermatology Team of the Year’ 2001.

Publications

For Key Publications see below.  For a full list of publications click here.

Journal articles

  • Danby SG, Chittock J, Brown K, Albenali LH & Cork MJ (2014) The effect of tacrolimus compared with betamethasone valerate on the skin barrier in volunteers with quiescent atopic dermatitis.. Br J Dermatol, 170(4), 914-921.
  • Mason A, Mason J, Cork M, Hancock H & Dooley G (2013) Topical treatments for chronic plaque psoriasis: An abridged Cochrane Systematic Review. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 69(5), 799-807.
  • Lu Z, Boadi J, Danby S, Cork M & Matcher SJ (2013) Optical coherence tomography demonstrates differential epidermal thinning of human forearm volar skin after 2 weeks application of a topical corticosteroid vs a non-steroidal anti-inflammatory alternative. Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 8565.
  • Mason AR, Mason JM, Cork MJ, Hancock H & Dooley G (2013) Topical treatments for chronic plaque psoriasis of the scalp: a systematic review. BRITISH JOURNAL OF DERMATOLOGY, 169(3), 519-527.
  • Mason JM, Carr J, Buckley C, Hewitt S, Berry P, Taylor J & Cork MJ (2013) Improved emollient use reduces atopic eczema symptoms and is cost neutral in infants: before-and-after evaluation of a multifaceted educational support programme.. BMC Dermatol, 13, 7.
  • Cork MJ, Mason AR, Mason J, Dooley G & Hancock H (2013) Topical Treatments for Chronic Plaque Psoriasis. Journal of the American Academy of Dermatology(In Press).
  • Mason AR, Mason J, Cork MJ, Dooley G & Hancock H (2013) Topical treatments for chronic plaque psoriasis. Cochrane Database Syst Rev..
  • Lavender T, Bedwell C, Roberts SA, Carter L-A, Hart A, Turner MA & Cork MJ (2013) Randomized, Controlled Trial Evaluating a Baby Wash Product on Skin Barrier Function in Healthy, Term Neonates. JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing.
  • Danby SG, Alenezi T, Sultan A, Lavender T, Chittock J, Brown K & Cork MJ (2013) Effect of olive and sunflower seed oil on the adult skin barrier: Implications for neonatal skin care. Pediatric Dermatology, 30(1), 42-50.
  • Danby SG & Cork MJ (2013) The effects of pimecrolimus on the innate immune response in atopic dermatitis.. Br J Dermatol, 168(2), 235-236.
  • Danby SG, AlEnezi T, Sultan A, Lavender T, Chittock J, Brown K & Cork MJ (2013) Effect of olive and sunflower seed oil on the adult skin barrier: implications for neonatal skin care.. Pediatr Dermatol, 30(1), 42-50.
  • Furber C, Bedwell C, Campbell M, Cork M, Jones C, Rowland L & Lavender T (2012) The Challenges and Realties of Diaper Area Cleansing for Parents. JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing, 41(6).
  • Tsoi LC, Spain SL, Barker JNWN, Trembath RC, Knight J, Ellinghaus E, Schreiber S, Stuart PE, Tejasvi T, Gudjonsson JE, Voorhees JJ, Hiremagalore R, Nair RP, Capon F, Allen MH, Nestle FO, Onoufriadis A, Weale ME, Mathew CG, Ding J, Li Y, Kang HM, Abecasis GR, McManus R, Barnes L, Coleman C, Conroy J, Ennis S, McPartlin J, Ryan AW, Novelli G, Samuelsson L, Naluai AT, Schalkwijk J, Bergboer JGM, van de Kerkhof PC, Zeeuwen PLJM, Ståhle M, Mallbris L, Wolk K, Burden AD, Leman J, Smith CH, Cork MJ, Tazi-Ahnini R, Estivill X, Riveira-Munoz E, Bowcock AM, Helms C, Gardner J, Krueger GG, Duffin KC, Goldgar D, Feng BJ, Weger W, Hofer A, Salmhofer W, Wolf P, Worthington J, Barton A, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Ricano-Ponce I, Trynka G, Langford C, Edkins S, Andrews R, Blackburn H, Deloukas P, Peltonen L, Hunt SE, Gwilliam R, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CCA, Rautanen A, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Su Z, Mrowietz U, Weidinger S, Weichenthal M, Christophers E, Henseler T, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Wichmann HE, Chandran V, Gladman DD, Pellett FJ, Rosen CF, Rahman P, Griffiths CEM, Warren RB, Young HS, Reis A, Badorf P, Hüffmeier U, Kere J, Paschall J, Malloy MJ, Pullinger CR, Kane JP, Perlmutter A, Miner A, Ike RW, Ruether A, Franke A, Schrodi SJ, Begovich AB, Prahalad S, Guthery SL, Fischer J, Lathrop GM, Liao W, Kwok P, Menter A, Wise C, Kainu K, Saarialho-Kere U, Suomela S, Kurrat W, Küster W, Lascorz J, Mössner R, Schürmeier-Horst F, Traupe H, Ständer M, Heijer MD, Campbell LE, McLean WHI, Cusack C, Markham T, Fitzgerald O, Gallagher P, Kirby B, Rogers SF, Zawirska A, Irvine AD, Giardina E, Lepre T, Perricone C, Martín-Ezquerra G, Pujol RM, Inerot A, Henschel A, Aurand M, Bebo B, Gieger C, Illig T, Moebus S, Jöckel K-H, Erbel R, Donnelly P, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Duncanson A, Jankowski J, Markus HS, McCarthy MI, Palmer CNA, Plomin R, Sawcer SJ, Samani N, Viswanathan AC, Wood NW & Elder JT (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics.
  • Tsoi LC, Spain SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Tejasvi T, Gudjonsson JE, Kang HM, Allen MH, McManus R, Novelli G, Samuelsson L, Schalkwijk J, Ståhle M, Burden AD, Smith CH, Cork MJ, Estivill X, Bowcock AM, Krueger GG, Weger W, Worthington J, Tazi-Ahnini R, Nestle FO, Hayday A, Hoffmann P, Winkelmann J, Wijmenga C, Langford C, Edkins S, Andrews R, Blackburn H, Strange A, Band G, Pearson RD, Vukcevic D, Spencer CCA, Deloukas P, Mrowietz U, Schreiber S, Weidinger S, Koks S, Kingo K, Esko T, Metspalu A, Lim HW, Voorhees JJ, Weichenthal M, Wichmann HE, Chandran V, Rosen CF, Rahman P, Gladman DD, Griffiths CEM, Reis A, Kere J, Nnair RP, Franke A, Barker JN, Abecasis GR, Eelder JT, Ttrembath R, Duffin KC, Helms C, Goldgar D, Li Y, Paschall J, Malloy MJ, Pullinger CR, Kane JP, Gardner J, Perlmutter A, Miner A, Feng BJ, Hiremagalore R, Ike RW, Christophers E, Henseler T, Ruether A, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok P, Menter A, Lathrop GM, Wise C, Begovich AB, Onoufriadis A, Weale ME, Hofer A, Salmhofer W, Wolf P, Kainu K, Saarialho-Kere U, Suomela S, Badorf P, Hüffmeier U, Kurrat W, Küster W, Lascorz J, Mössner R, Schürmeier-Horst F, Ständer M, Traupe H, Bergboer JGM, Heijer MD, Van De Kerkhof PC, Zeeuwen PLJM, Barnes L, Campbell LE, Cusack C, Coleman C, Conroy J, Ennis S, Fitzgerald O, Gallagher P, Irvine AD, Kirby B, Markham T, McLean WHI, McPartlin J, Rogers SF, Ryan AW, Zawirska A, Giardina E, Lepre T, Perricone C, Martín-Ezquerra G, Pujol RM, Riveira-Munoz E, Inerot A, Naluai ÅT, Mallbris L, Wolk K, Leman J, Barton A, Warren RB, Young HS, Ricano-Ponce I, Trynka G, Pellett FJ, Henschel A, Aurand M, Bebo B, Gieger C, Illig T, Moebus S, Jöckel K-H, Erbel R, Donnelly P, Peltonen L, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Craddock N, Duncanson A, Jankowski J, Markus HS, Mathew CG, McCarthy MI, Palmer CNA, Plomin R, Rautanen A, Sawcer SJ, Samani N, Viswanathan AC, Wood NW, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Su Z, Hunt SE, Gwilliam R, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Perez ML, Potter SC, Ravindrarajah R, Ricketts M, Waller M, Weston P, Widaa S, Whittaker P, Neir RP, Barker JNWN, Abecasis GR, Elder JT & Trembath RC (2012) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics, 44(12), 1341-1348.
  • Lavender T, Furber C, Campbell M, Victor S, Roberts I, Bedwell C & Cork MJ (2012) Effect on skin hydration of using baby wipes to clean the napkin area of newborn babies: Assessor-blinded randomised controlled equivalence trial. BMC Pediatrics, 12.
  • Bieber T, Cork M & Reitamo S (2012) Atopic dermatitis: A candidate for disease-modifying strategy. Allergy: European Journal of Allergy and Clinical Immunology, 67(8), 969-975.
  • Bieber T, Cork M & Reitamo S (2012) Atopic dermatitis: A candidate for disease-modifying strategy. Allergy: European Journal of Allergy and Clinical Immunology.
  • Cork MJ (2011) Patient education about topical treatments. BRITISH JOURNAL OF DERMATOLOGY, 165(6), 1159-1160.
  • Moustafa M, Holden CR, Athavale P, Cork MJ, Messenger AG & Gawkrodger DJ (2011) Patch testing is a useful investigation in children with eczema. CONTACT DERMATITIS, 65(4), 208-212.
  • Cork MJ & Danby S (2011) Aqueous cream damages the skin barrier.. Br J Dermatol, 164(6), 1179-1180.
  • Lavender T, Bedwell C, O'Brien E, Cork MJ, Turner M & Hart A (2011) Infant skin-cleansing product versus water: A pilot randomized, assessor-blinded controlled trial. BMC PEDIATR, 11.
  • Danby SG, Al-Enezi T, Sultan A, Chittock J, Kennedy K & Cork MJ (2011) The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis.. Br J Dermatol, 165(2), 329-334.
  • Moustafa M, Holden CR, Athavale P, Cork MJ, Messenger AG & Gawkrodger DJ (2011) Patch testing is a useful investigation in children with eczema.. Contact Dermatitis, 65(4), 208-212.
  • Vasilopoulos Y, Sagoo GS, Cork MJ, Walters K & Tazi-Ahnini R (2011) HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction.. J Hum Genet, 56(6), 423-427.
  • Bangert C, Strober BE, Cork M, Ortonne JP, Luger T, Bieber T, Ferguson A, Ecker RC, Kopp T, Weise-Riccardi S, Guettner A & Stingl G (2011) Clinical and Cytological Effects of Pimecrolimus Cream 1% after Resolution of Active Atopic Dermatitis Lesions by Topical Corticosteroids: A Randomized Controlled Trial. DERMATOLOGY, 222(1), 36-48.
  • Vasilopoulos Y, Sharaf N, di Giovine F, Simon M, Cork MJ, Duff GW & Tazi-Ahnini R (2011) The 3′-UTR AACCins5874 in the stratum corneum chymotryptic enzyme gene (SCCE/KLK7), associated with atopic dermatitis; causes an increased mRNA expression without altering its stability. Journal of Dermatological Science, 61(2), 131-133.
  • Danby SG, Al-Enezi T, Sultan A, Chittock J, Kennedy K & Cork MJ (2011) The effect of aqueous cream BP on the skin barrier in volunteers with a previous history of atopic dermatitis. British Journal of Dermatology, 165(2), 329-334.
  • Cooke A, Cork MJ, Danby S & Lavender T (2011) Use of oil for baby skincare: A survey of UK maternity and neonatal units. British Journal of Midwifery, 19(6), 354-362.
  • Vasilopoulos Y, Sharaf N, di Giovine F, Simon M, Cork MJ, Duff GW & Tazi-Ahnini R (2011) The 3'-UTR AACCins5874 in the stratum corneum chymotryptic enzyme gene (SCCE/KLK7), associated with atopic dermatitis; causes an increased mRNA expression without altering its stability.. J Dermatol Sci, 61(2), 131-133.
  • Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 , Strange A, Capon F, Spencer CC, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JG, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, Estivill X, Fitzgerald O, Freeman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, Mallbris L, Markus HS, Mathew CG, McLean WH, McManus R, Mössner R, Moutsianas L, Naluai AT, Nestle FO, Novelli G, Onoufriadis A, Palmer CN, Perricone C, Pirinen M, Plomin R, Potter SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, Samuelsson L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, Wood N, Worthington J, Young HS, Zeeuwen PL, Hayday A, Burden AD, Griffiths CE, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donnelly P & Trembath RC (2010) A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.. Nat Genet, 42(11), 985-990.
  • Strange A, Capon F, Spencer CCA, Knight J, Weale ME, Allen MH, Barton A, Band G, Bellenguez C, Bergboer JGM, BlackweL JM, Bramon E, Bumpstead SJ, Casas JP, Cork MJ, Corvin A, Deloukas P, Dilthey A, Duncanson A, Edkins S, EstiviL X, Fitzgerald O, FrEman C, Giardina E, Gray E, Hofer A, Hüffmeier U, Hunt SE, Irvine AD, Jankowski J, Kirby B, Langford C, Lascorz J, Leman J, Leslie S, MaLbris L, Markus HS, Mathew CG, McLean WHI, McManus R, MöSner R, Moutsianas L, Naluai AT, Nestle FO, NoveLi G, Onoufriadis A, Palmer CNA, Perricone C, Pirinen M, Plomin R, PoTer SC, Pujol RM, Rautanen A, Riveira-Munoz E, Ryan AW, Salmhofer W, SamuelSon L, Sawcer SJ, Schalkwijk J, Smith CH, Ståhle M, Su Z, Tazi-Ahnini R, Traupe H, Viswanathan AC, Warren RB, Weger W, Wolk K, WOd N, Worthington J, Young HS, Zeeuwen PLJM, Hayday A, Burden AD, Griffiths CEM, Kere J, Reis A, McVean G, Evans DM, Brown MA, Barker JN, Peltonen L, Donely P & Trembath RC (2010) A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1. Nature Genetics, 42(11), 985-990.
  • Blume-Peytavi U, Cork MJ, Faergemann J, Szczapa J, Vanaclocha F & Gelmetti C (2009) Bathing and cleansing in newborns from day 1 to first year of life: recommendations from a European round table meeting. J EUR ACAD DERMATOL, 23(7), 751-759.
  • Lavender T, Bedwell C, Tsekiri-O'Brien E, Hart A, Turner M & Cork M (2009) A qualitative study exploring women's and health professionals' views of newborn bathing practices. Evidence Based Midwifery, 7(4), 112-121.
  • Cork MJ & Danby S (2009) Skin barrier breakdown: a renaissance in emollient therapy.. British journal of nursing (Mark Allen Publishing), 18(14).
  • Mason AR, Mason J, Cork M, Dooley G & Edwards G (2009) Topical treatments for chronic plaque psoriasis. COCHRANE DB SYST REV(2).
  • Tazi-Ahnini R, McDonagh AJ, Wengraf DA, Lovewell TR, Vasilopoulos Y, Messenger AG, Cork MJ & Gawkrodger DJ (2008) The autoimmune regulator gene (AIRE) is strongly associated with vitiligo.. Br J Dermatol, 159(3), 591-596.
  • Vasilopoulos Y, Walters K, Cork MJ, Duff GW, Sagoo GS & Tazi-Ahnini R (2008) Association analysis of the skin barrier gene cystatin A at the PSORS5 locus in psoriatic patients: evidence for interaction between PSORS1 and PSORS5.. Eur J Hum Genet, 16(8), 1002-1009. View this article in White Rose Research Online
  • Simon M, Tazi-Ahnini R, Jonca N, Caubet C, Cork MJ & Serre G (2008) Alterations in the desquamation-related proteolytic cleavage of corneodesmosin and other corneodesmosomal proteins in psoriatic lesional epidermis.. Br J Dermatol, 159(1), 77-85.
  • Wengraf DA, McDonagh AJ, Lovewell TR, Vasilopoulos Y, Macdonald-Hull SP, Cork MJ, Messenger AG & Tazi-Ahnini R (2008) Genetic analysis of autoimmune regulator haplotypes in alopecia areata.. Tissue Antigens, 71(3), 206-212.
  • Vasilopoulos Y, Cork MJ, Teare D, Marinou I, Ward SJ, Duff GW & Tazi-Ahnini R (2007) A nonsynonymous substitution of cystatin A, a cysteine protease inhibitor of house dust mite protease, leads to decreased mRNA stability and shows a significant association with atopic dermatitis.. Allergy, 62(5), 514-519.
  • Kemp EH, McDonagh AJ, Wengraf DA, Messenger AG, Gawkrodger DJ, Cork MJ & Tazi-Ahnini R (2006) The non-synonymous C1858T substitution in the PTPN22 gene is associated with susceptibility to the severe forms of alopecia areata.. Human Immunology, 67(7), 535-539.
  • Carlisle J, Shickle D, Cork M & McDonagh A (2006) Concerns over confidentiality may deter adolescents from consulting their doctors. A qualitative exploration.. J Med Ethics, 32(3), 133-137.
  • Chen HM, Wilkins LM, Aziz N, Cannings C, Wyllie DH, Bingle C, Rogus J, Beck JD, Offenbacher S, Cork MJ, Rafie-Kolpin M, Hsieh CM, Kornman KS & Duff GW (2006) Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. HUM MOL GENET, 15(4), 519-529.
  • Mee JB, Cork MJ, di Giovine FS, Duff GW & Groves RW (2006) Interleukin-1: a key inflammatory mediator in psoriasis?. Cytokine, 33(2), 72-78.
  • Cork MJ, Robinson D, Vasilopoulos Y, Ferguson A, Moustafa M, Mac Gowan A, Ward SJ & Tazi-Ahnini R (2005) Predisposition to sensitive skin and atopic eczema.. Community Pract, 78(12), 440-442.
  • Stevens KJ, Brazier JE, McKenna SP, Doward LC & Cork MJ (2005) The development of a preference-based measure of health in children with atopic dermatitis.. Br J Dermatol, 153(2), 372-377.
  • Lench N, Iles MM, Mackay I, Patel R, Sagoo GS, Ward SJ, Dechairo B, Olavesen M, Carey A, Duff GW, Cork MJ & Tazi-Ahnini R (2005) Single-point haplotype scores telomeric to human leukocyte antigen-C give a high susceptibility major histocompatibility complex haplotype for psoriasis in a Caucasian population.. J Invest Dermatol, 124(3), 545-552.
  • Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ & Tazi-Ahnini R (2004) Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis.. J Invest Dermatol, 123(1), 62-66.
  • Tazi-Ahnini R, Cork MJ, Wengraf D, Wilson AG, Gawkrodger DJ, Birch MP, Messenger AG & McDonagh AJ (2003) Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata.. Hum Genet, 112(4), 400-403.
  • Goustas P, Cork MJ & Higson D (2003) Eumovate™ (clobetasone butyrate 0.05%) cream: A review of clinical efficacy and safety. Journal of Dermatological Treatment, 14(2), 71-85.
  • Tazi-Ahnini R, Cork MJ, Gawkrodger DJ, Birch MP, Wengraf D, McDonagh AJ & Messenger AG (2002) Role of the autoimmune regulator (AIRE) gene in alopecia areata: strong association of a potentially functional AIRE polymorphism with alopecia universalis.. Tissue Antigens, 60(6), 489-495.
  • Tazi-Ahnini R, Cork MJ, Gawkrodger D, Wengraf D, Messenger AG & McDonagh AJG (2002) Role of the autoimmune regulator (AIRE) gene in alopecia areata: Strong association of a potentially functional AIRE polymorphism with alopecia universalis. J INVEST DERMATOL, 119(3), 719-719.
  • Tazi-Ahnini R, Cox A, McDonagh AJ, Nicklin MJ, di Giovine FS, Timms JM, Messenger AG, Dimitropoulou P, Duff GW & Cork MJ (2002) Genetic analysis of the interleukin-1 receptor antagonist and its homologue IL-1L1 in alopecia areata: strong severity association and possible gene interaction.. Eur J Immunogenet, 29(1), 25-30.
  • Tazi-Ahnini R, McDonagh AJ, Cox A, Messenger AG, Britton JE, Ward SJ, Båvik CO, Duff GW & Cork MJ (2001) Association analysis of IL1A and IL1B variants in alopecia areata.. Heredity (Edinb), 87(Pt 2), 215-219.
  • Tazi-Ahnini R, di Giovine FS, McDonagh AJ, Messenger AG, Amadou C, Cox A, Duff GW & Cork MJ (2000) Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region.. Hum Genet, 106(6), 639-645.
  • Harper JI, Ahmed I, Barclay G, Lacour M, Hoeger P, Cork MJ, Finlay AY, Wilson NJE, Graham-Brown RAC, Sowden JM, Beard AL, Sumner MJ & Berth-Jones J (2000) Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy. BRIT J DERMATOL, 142(1), 52-58.
  • Tazi-Ahnini R, di Giovine FS, Cox A, Keohane SG & Cork MJ (1999) Corneodesmosin (MHC S) gene in guttate psoriasis.. Lancet, 354(9178), 597.
  • Tazi Ahnini R, Camp NJ, Cork MJ, Mee JB, Keohane SG, Duff GW & di Giovine FS (1999) Novel genetic association between the corneodesmosin (MHC S) gene and susceptibility to psoriasis.. Hum Mol Genet, 8(6), 1135-1140.
  • Carter MJ, di Giovine FS, Sorrell JA, Wilson AG, Keohane S, Cork MJ, Sanders DS, Duff GW & Lobo AJ (1999) The tumor necrosis factor alpha gene promoter polymorphisms and Crohns disease: Study of genetic suscepibility and disease behavior. GASTROENTEROLOGY, 116(4), A678-A678.
  • Cockayne SE, Cork MJ & Gawkrodger DJ (1999) Treatment of psoriasis: day care vs. inpatient therapy. BRIT J DERMATOL, 140(2), 375-376.
  • Kemp EH, Ajjan RA, Waterman EA, Gawkrodger DJ, Cork MJ, Watson PF & Weetman AP (1999) Analysis of a microsatellite polymorphism of the cytotoxic T-lymphocyte antigen-4 gene in patients with vitiligo.. Br J Dermatol, 140(1), 73-78.
  • Humphrey KM, Cork MJ & Haycox A (1998) A retrospective cost-effectiveness analysis of the treatment of onychomycosis in general practice. BRIT J DERMATOL, 139(4), 660-664.
  • Mee JB & Cork MJ (1998) Vitamin D receptor polymorphism and calcipotriol response in patients with psoriasis. J INVEST DERMATOL, 110(3), 301-302.
  • Cork MJ, Keohane SG, Gawkrodger DJ, Hancock BW, Sheridan E & Bleehen SS (1997) Cytokine dermatosis: Reactivation of eczema during interleukin-2 infusion. BRIT J DERMATOL, 136(4), 644-645.
  • Tarlow JK, Cork MJ, Clay FE, SchmittEgenolf M, Crane AM, Stierle C, Boehncke WH, Eiermann TH, Blakemore AIF, Bleehen SS, Sterry W & Duff GW (1997) Association between interleukin-1 receptor antagonist (IL-1ra) gene polymorphism and early and late-onset psoriasis. BRIT J DERMATOL, 136(1), 147-148.
  • Cork MJ (1997) The importance of skin barrier function. J DERMATOL TREAT, 8, S7-S13.
  • Clay FE, Cork MJ, Wilson AG, Crane AM, Lewis F, Harrington CI & Duff GW (1996) Promoter region polymorphism in the human TNF-alpha gene is not associated with lichen sclerosus.. Exp Dermatol, 5(4), 227-229.
  • BerthJones J, Finlay AY, Zaki I, Tan B, Goodyear H, LewisJones S, Cork MJ, Bleehen SS, Salek MS, Allen BR, Friedmann P, Harper J, Camp RDR, Smith S & GrahamBrown RAC (1996) Cyclosporine in severe childhood atopic dermatitis: A multicenter study. J AM ACAD DERMATOL, 34(6), 1016-1021.
  • Clay FE, Tarlow JK, Cork MJ, Cox A, Nicklin MJ & Duff GW (1996) Novel interleukin-1 receptor antagonist exon polymorphisms and their use in allele-specific mRNA assessment.. Hum Genet, 97(6), 723-726.
  • CORK MJ, DIGIOVINE FS, CRANE SA, MEE JB & DUFF GW (1995) NOVEL GENETIC ASSOCIATION OF AN IL-1-BETA GENE VARIATION AT-+3953, SUSCEPTIBILITY TO PSORIASIS AND IL-1-BETA PROTEIN-PRODUCTION. J INVEST DERMATOL, 105(3), 453-453.
  • Cork MJ, Tarlow JK, Clay FE, Crane A, Blakemore AI, McDonagh AJ, Messenger AG & Duff GW (1995) An allele of the interleukin-1 receptor antagonist as a genetic severity factor in alopecia areata.. J Invest Dermatol, 104(5 Suppl), 15S-16S.
  • Wilson AG, Clay FE, Crane AM, Cork MJ & Duff GW (1995) Comparative genetic association of human leukocyte antigen class II and tumor necrosis factor-alpha with dermatitis herpetiformis.. J Invest Dermatol, 104(5), 856-858.
  • KEOHANE SG & CORK MJ (1995) TREATMENT OF GROVERS-DISEASE WITH CALCIPOTRIOL (DOVONEX(R)). BRIT J DERMATOL, 132(5), 832-833.
  • Clay FE, Cork MJ, Tarlow JK, Blakemore AI, Harrington CI, Lewis F & Duff GW (1994) Interleukin 1 receptor antagonist gene polymorphism association with lichen sclerosus.. Hum Genet, 94(4), 407-410.
  • CLAY FE, CORK MJ, TARLOW JK, BLAKEMORE AIF, LEWIS F, HARRINGTON CI & DUFF GW (1994) ASSOCIATION OF THE INTERLEUKIN ONE RECEPTOR ANTAGONIST GENE POLYMORPHISM WITH LICHEN-SCLEROSUS. J INVEST DERMATOL, 103(3), 408-408.
  • Blakemore AI, Tarlow JK, Cork MJ, Gordon C, Emery P & Duff GW (1994) Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus.. Arthritis Rheum, 37(9), 1380-1385.
  • Tarlow JK, Clay FE, Cork MJ, Blakemore AI, McDonagh AJ, Messenger AG & Duff GW (1994) Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene.. J Invest Dermatol, 103(3), 387-390.
  • Lewis FM, Cork MJ, McDonagh AJ & Gawkrodger DJ (1994) An audit of the value of patch testing: the patient's perspective.. Contact Dermatitis, 30(4), 214-216.
  • Cork MJ, Tarlow JK, Blakemore AI, Mee JB, Crane AM, Stierle C, Bleehen SS & Duff GW (1993) Psoriasis and interleukin-1. A translation.. J R Coll Physicians Lond, 27(4), 366.
  • CORK MJ, TARLOW JK, BLAKEMORE AIF, MCDONAGH AJG, MESSENGER AG, BLEEHEN SS & DUFF GW (1993) GENETICS OF INTERLEUKIN ONE RECEPTOR ANTAGONIST IN INFLAMMATORY SKIN DISEASES. J INVEST DERMATOL, 100(4), 522-522.
  • CORK MJ, TARLOW JK, BLAKEMORE AIF, MCDONAGH AJG, MESSENGER AG, BLEEHEN SS & DUFF GW (1993) GENETICS OF INTERLEUKIN ONE RECEPTOR ANTAGONIST IN INFLAMMATORY SKIN DISEASES. CLIN RES, 41(2), A179-A179.
  • CORK MJ, MEE JB, TARLOW JK, BLAKEMORE AIF, DIGIOVINE F, BLEEHEN SS & DUFF GW (1993) INTERLEUKIN ONE RECEPTOR ANTAGONIST POLYMORPHISM - ALLELIC ASSOCIATION WITH INFLAMMATORY DERMATOSES. J INVEST DERMATOL, 100(4), 448-448.
  • Barradell R, Addo A, McDonagh AJ, Cork MJ & Wales JK (1993) Phytophotodermatitis mimicking child abuse.. Eur J Pediatr, 152(4), 291-292.
  • Lewis FM, Cork MJ, McDonagh AJ & Gawkrodger DJ (1993) Allergic contact dermatitis from resin-reinforced plaster.. Contact Dermatitis, 28(1), 40-41.
  • McDonagh AJ, Wright AL, Cork MJ & Gawkrodger DJ (1992) Nickel sensitivity: the influence of ear piercing and atopy.. Br J Dermatol, 126(1), 16-18.
  • MCDONAGH AJG, CORK MJ & HARRINGTON CI (1991) PYODERMA-GANGRENOSUM. BRIT MED J, 303(6807), 925-925.
  • Gawkrodger DJ, Cork MJ & Bleehen SS (1991) Occupational vitiligo and contact sensitivity to para-tertiary butyl catechol.. Contact Dermatitis, 25(3), 200-201.
  • McDonagh AJG, Cork MJ & Harrington CI (1991) Pyoderma gangrenosum [ 8]. British Medical Journal, 303(6807), 925-925.

Chapters

  • Cork MJ & Danby SG (2012) Current and Future Trends: Skin Diseases and Treatment In Benson HAE & Watkinson AC (Ed.), Topical and Transdermal Drug Delivery Wiley.

Conferences

  • Chalmers JR, Simpson EL, Chen YY, Cork MJ, Brown SJ, Thomas KS, Williams HC & Grp BEEPS (2014) Feasibility study of Barrier Enhancement For Eczema Prevention (BEEP). BRITISH JOURNAL OF DERMATOLOGY, Vol. 170(6) (pp E8-E9)
  • Albenali L, Danby S, Moustafa M, Chittock J, Kennedy K, Shackley F & Cork MJ (2012) Vitamin D supplementation improves atopic dermatitis and atopic dermatitis complicated by eczema herpeticum. BRITISH JOURNAL OF DERMATOLOGY, Vol. 167 (pp 127-127)
  • Moustafa M, Holden C, Athavale P, Cork M, Messenger A & Gawkrodger DJ (2009) Patch testing is a useful investigation in children with eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 161 (pp 125-125)
  • Danby S, Moustafa M, MacGowan AL, Ward SJ & Cork MJ (2009) Skin protease inhibitors: A new treatment for atopic dermatitis. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 60(3) (pp AB67-AB67)
  • Cork MJ, Varghese J, Hadcraft J, Lane M, Ferguson A, Moustafa M, Guy RH & Ward S (2007) Differences in the effect of topical corticosteroids and calcineurin inhibitors on the skin barrier - Implications for therapy. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 127 (pp S45-S45)
  • Kemp EH, McDonagh AJG, Wengraf DA, Messenger AG, Gawkodger DJ, Cork MJ & Tazi-Ahnini R (2007) Severe alopecia areata is associated with a functional polymorphism in the PTPN22 gene. IMMUNOLOGY, Vol. 120 (pp 70-70)
  • Cork M, Robinson D, Vasilopoulos Y & Ferguson A (2007) The effects of topical corticosteroids and pimecrolimus skin barrier function, gene expression, and topical drug penetration in atopic eczema and unaffected controls. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 56(2) (pp AB69-AB69)
  • Simon M, Tazi-Ahnini R, Jonca N, Cork MJ & Serre G (2006) Reduced and abnormal proteolysis of corneodesmosomal proteins in psoriatic skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 126 (pp 116-116)
  • Lovewell TRJ, Cork MJ, Wengraf DA, Messenger AG, McDonagh AJG & Tazi-Ahnini R (2006) A study on the effect of genetic variants of the autoimmune regulator (AIRE) promoter, on AIRE activity and downstream Aire-regulated genes. BRITISH JOURNAL OF DERMATOLOGY, Vol. 155(1) (pp 250-250)
  • Vasilopoulos Y, Cork MJ, Sagoo GS, Ward SJ, Duff GW & Tazi-Ahnini R (2006) A synonymous single nucleotide polymorphism in human cystatin A, a candidate gene in the PSORS5 locus, confers susceptibility to psoriasis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 155(1) (pp 235-235)
  • Cork MJ, Robinson DA, Vasilopoulos Y, Ferguson A, Moustafa M, Tazi-Ahnini R & Ward SJ (2005) Treatment of atopic dermatitis from a skin barrier perspective. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 125(3) (pp 611-611)
  • Cork M (2005) Skin barrier damage: Cause or consequence of atopic dermatitis?. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol. 52(3) (pp P9-P9)
  • Simon M, Tazi-Ahnini R, Cork MJ & Serre G (2003) Abnormal proteolysis of corneodesmosin in psoriatic skin. JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 121(6) (pp 1568-1568)
  • Tazi-Ahnini R, Vasilopoulos Y, Henderson JK, Murphy R, Williams H, Ward SJ, Duff GW & Cork MJ (2003) Role of variants within genes regulating the skin barrier in the pathogenesis of atopic eczema. BRITISH JOURNAL OF DERMATOLOGY, Vol. 149 (pp 4-4)
  • McDonagh AJG, Messenger AG, Birch MP, Cork MJ & Tazi-Ahnini R (2003) Alopecia areata: age at onset, atopy & disease associations. BRITISH JOURNAL OF DERMATOLOGY, Vol. 148(4) (pp 866-867)
  • Wengraf DA, McDonagh AJG, Cork MJ, Gawkrodger D, Messenger AG & Tazi-Ahnini R (2003) Genetic analysis of the autoimmune regulator (aire) gene: potential role of aire in susceptibility to alopecia universalis. BRITISH JOURNAL OF DERMATOLOGY, Vol. 148(4) (pp 849-850)