Research
Pulmonary inflammation and mechanisms of apoptosis
Pulmonary inflammation and mechanisms of apoptosis - led by Prof Moira Whyte
Understanding the molecular mechanisms of inflammatory cell apoptosis in chronic inflammatory lung diseases. We study candidate molecules with the potential to actively regulate neutrophil apoptosis at sites of inflammation because targeting these mechanisms has the potential for novel therapies to treat inflammation and/or augment host responses in infectious disease.
Members of Group.
Regulation of neutrophilic inflammation by the HIF/hydroxylase pathway
Regulation of neutrophilic inflammation by the HIF/hydroxylase pathway - led by Dr Sarah Walmsley
Understanding how the HIF/hydroxylase oxygen sensing pathway regulates phagocyte host defence and function which is central to the pathogenesis of major inflammatory diseases and represents a key area for scientific development.
Members of Group.
In vivo and in vitro models of infectious diseases
In vivo and in vitro models of infectious diseases - led by Prof David Dockrell
Understanding the molecular regulation of apoptosis in the macrophage and how this regulates innate immune responses to pulmonary infection and HIV. Research models include in vivo models of infection and translational studies in patient groups using experimental medicine approaches.
Members of Group.
In vivo models of infection and immunity
In vivo models of infection and immunity - led by Dr Stephen Renshaw
Understanding inflammation resolution and host-pathogen interaction, using the unique advantages of in vivo zebrafish models.
Members of Group.
Pattern recognition receptors and regulation of airway inflammation
Pattern recognition receptors and regulation of airway inflammation - led by Prof Ian Sabroe
Understanding the inflammatory mechanisms involved in airways disease, focusing on asthma and COPD. Principal interests include:
♦ A study of neutrophil biology and the pathways regulating neutrophil recruitment and survival in the human in vivo and in vitro.
♦ The mechanisms by which human respiratory viruses, particularly rhinovirus, induce airways inflammation (led by Dr Lisa Parker).
♦ Understanding how the airways respond through the actions of cell networks, and how these can be dissected and manipulated for therapeutic benefit.
Novel pulmonary epithelial proteins
Novel pulmonary epithelial proteins - led by Dr Colin Bingle
Cellular differentiation and regulation of gene expression within the developing and adult pulmonary epithelium. This work involves the isolation, regulation and function of novel pulmonary epithelial cell specific genes and analysis of their expression in normal and diseased lungs.
Members of Group.
Mast cell research
Mast cell research - led by Dr Peter Peachell
Pharmacological regulation of human lung mast cells. Signal transduction in human lung mast cells.
Members of Group.
Role of nucleoside diphosphate kinases in neutrophilic inflammation
Role of nucleoside diphosphate kinases in neutrophilic inflammation - led by Dr Richmond Muimo
Regulation of CFTR function by associated proteins. Histidine phosphorylation in mammalian cells.
Members of Group.