Research Interests

RA Genetics
The group has been involved in many of the recent large studies that have mapped novel genetic contributions to RA risk (A G Wilson)

Genotype-phenotype studies
Functional studies of RA susceptibility genes including gene expression studies of gene clusters and detailed characterisation of candidate genes identified in genetic studies (A G Wilson)

Antigenic targets in RA and their use as biomarkers
We have used a phage display system to identify novel antigenic targets in RA. This has led to the identification of antibodies to ferritin as a marker of radiological damage (A G Wilson)

Pharmacogenetics
Along with colleagues in the Universities of Manchester, Leeds and Newcastle we have recruited 2,000 anti-TNF treated RA patients into a study of genetic markers of response (see 'See Also' box).This is the largest such study worldwide and we have reported biomarkers of differential response to individual TNF agents (A G Wilson)

Epigenetic regulation of cytokine gene expression
The importance of epigenetic modification of DNA and histone proteins on control of pro-inflammatory cytokine expression is being examined in inflammatory arthritis (Prof G W Duff).

Cartilage Turnover

The major focus of Dave Buttle's research (D J Buttle) revolves around proteolytic enzymes, their regulation and roles in diseases such as arthritis and cancer. Of particular interest are the so-called 'aggrecanases', and the factors such as binding to the extracellular matrix and inhibitors that control their activities. Dave's interests stretch to parasitology and the control of nematode infections by treating with proteolytic enzymes that literally digest the worms.