Dr Stephen J Matcher

Dr S J Matcher

BSc PhD
Reader in Biomedical Engineering

Address:
The Kroto Research Institute
North Campus
University of Sheffield
Broad Lane
Sheffield
S3 7HQ

Telephone: +44 (0) 114 222 5994
Fax: +44 (0) 114 222 5945

Email: s.j.matcher@sheffield.ac.uk

Steve Matcher joined the department as lecturer in biomedical engineering in October 2006. Previously he was with the biomedical physics group at the University of Exeter and before that he worked as a research fellow at the Department of Medical Physics and Bioengineering, University College London.

Research interests

Steve Matcher's main interest is in the development and application of novel biophotonic tools to aid the characterisation of biological tissues. Photonics offers many unique advantages over other imaging techniques for studying biological systems, including structural and functional contrast, cellular level resolution, speed, non-destructiveness and cost. The group´s work focuses on techniques offering high resolution such as optical coherence tomography (OCT) and non-linear laser scanning microscopy. Facilities include Doppler and polarisation OCT systems plus supercontinuum and titanium-sapphire light sources to allow cellular resolution OCT imaging. The group works closely with the Tissue Engineering group within the Kroto Institute (Prof S MacNeil) and with the III-V device fabrication group within Dept of Electrical and Electronic Engineering (Prof R Hogg). Ongoing collaborative links also exist with the Dental School (Dr A Crawford, Dr K Hunter) and with the Dept of Mechanical Engineering (Prof Roger Lewis and Dr Matt Carré). He has provided consultancy services to GlaxoSmithKline and is presently working with Kirkstall Ltd (a bioreactor developer). In 2011 he undertook a Royal Academy of Engineering industrial secondment with Michelson Diagnostics Ltd, a leading developer of clinical OCT imaging equipment.

Key projects

  • Structural characterisation of natural and synthetic connective tissue using polarization OCT.
  • Visualisation of extracellular matrix production using non-linear optical microscopy.
  • Monitoring of tissue formation in bioreactors using ultra-high resolution optical coherence tomography.
  • Development of contrast agents for optical imaging.
  • Development of novel light sources for OCT imaging.

Professional activities and recognition

  • Member of EPSRC peer-review college.
  • Member of SPIE, OSA, BMS & BSMB.

Key publications

  • Ugryumova N, Jacobs J, Bonesi M, Matcher SJ, Novel optical imaging technique to determine the 3-D orientation of collagen fibers in cartilage: variable-incidence angle polarization-sensitive optical coherence tomography. OSTEOARTHRITIS AND CARTILAGE 17(1): 33-42 (2009).
  • Smith LE, Bonesi M, Smallwood R, Matcher SJ, MacNeil S, Using swept-source optical coherence tomography to monitor the formation of neo-epidermis in tissue-engineered skin JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE Volume: 4 Issue: 8 Pages: 652-658 (2010).
  • Matcher, S J, ‘Practical aspects of OCT imaging in tissue engineering’, Methods Mol. Biol., 695: 261-80 (2011).
  • Polypyrrole Nanoparticles: A Potential Optical Coherence Tomography Contrast Agent For Cancer Imaging”, K. M. Au, Z Lu, S.J. Matcher & S.P. Armes, Adv Materials 23(48): 5792–5795 (2011).
  • Liu X, Lu Z, Lewis R, Carré MJ, Matcher SJ, Feasibility of using optical coherence tomography to study the influence of skin structure on finger friction. Tribology International 63: 34–44 (2013).

Research group

Dr Zenghai Lu (PDRA)
Dr Xuesong Hu (PDRA)
Dr Raman Maiti (PDRA: joint with Mech Eng)

Mr Joseph Boadi (PhD)
Ms Chrisandrea Charalambous (PhD)

Research centres

Insigneo

The Leonardo Centre

Centre for Biomaterials and Tissue Engineering

EPSRC National Centre for III-V Technologies

External consortia

FASTDOT