Professor Sheila MacNeil

BSc, PhD
Professor of Tissue Engineering
Director, Interdisciplinary Programmes, Faculty of Engineering 

Telephone: +44 (0) 114 222 5995
Fax: +44 (0) 114 222 5943
Email: s.macneil@sheffield.ac.uk

Address: The Kroto Research Institute
North Campus, University of Sheffield, Broad Lane, Sheffield, S3 7HQ

Prof S Macneil

Sheila MacNeil is Professor of Tissue Engineering in the Department of Materials Science and Engineering, joining the department in 2000. She has an undergraduate degree in physiology from the University of Aberdeen and a doctorate on the endocrinology of manic depression from the Medical School of the University of Sheffield.

She is academic lead of the Biomaterials and Tissue Engineering Group within the Department. Members of this group: Professor John Haycock, Readers Dr Ihtesham Rehman, Dr Steve Matcher and Senior Lecturers Dr CK Chong, Dr Frederik Claeyssens, Dr Gwen Reilly.

She has previously been Deputy Director of the Kroto Research Institute (from 2005 to 2009) and Director of the University Centre for Biomaterials and Tissue Engineering from 2002 to 2009, promoting interdisciplinary research between engineering, physical sciences and life sciences. She was also a founding Director of the University of Sheffield spin-out company, CellTran Limited from 2000 to 2007. She was the Sheffield lead for an EPSRC Doctoral Training Centre in Tissue Engineering and Regenerative Medicine (a DTC held between three Universities, Leeds, Sheffield and York) from 2008 to 2011.

Research interests

Her research focuses on developing tissue engineering which will benefit patients, alongside fundamental work to develop new understanding and tools in the area of tissue engineering. Her primary research interests are in tissue engineering of soft tissues – skin, oral mucosa, urethra and cornea, with a strong focus on translating research for clinical benefit. Her group have a long history of working with clinical NHS colleagues using tissue engineered skin to benefit burns patients (from 1992) and more recently patients with chronic ulcers (2004) and patients requiring reconstructive surgery of the urethra (from 2007). She has developed the product Myskin™ which was clinically evaluated and developed commercially and has been available in the UK for patients with extensive skin loss due to burns injuries and to chronic non-healing ulcers from 2004 to the current time, currently available through the company Regenerys Ltd. Additionally she has developed 3D tissue engineered models used to study a wide range of normal and abnormal conditions spanning wound healing, skin contracture, pigmentation, melanoma invasion, angiogenesis, bacterial infection and skin sensitisation.

Key projects

Her current projects include developing tissue engineering approaches for reconstruction for burns contractures, for stimulating healing in chronic ulcers and she leads a group of scientists and clinicians developing a tissue engineering approach for repair of the weakened tissues of the female pelvic floor . She also has two Wellcome funded projects with India on corneal tissue engineering and early detection of infection in the cornea (with Professor Steve Rimmer in Chemistry and Professor Ian Douglas in Dentistry.)

Professional activities and recognition

  • Awarded the President's Prize from UK Society for Biomaterials in recognition of long standing service to biomaterials science both in the UK and internationally (2014)
  • Member of EPSRC Peer Review College (2010 onwards)
  • Member of UK Tissue and Cell Engineering Society (TCES) (2009 onwards)
  • Member of Swiss National Science Foundation NRP 63 - Stem Cells and Regenerative Medicine (2008 onwards)
  • NC3R Grant Reviewing Panel (2008 - 2011)
  • MRC Small Grant Reviewing Panel (2006-2007)
  • Member of EPSRC Grant Reviewing College (2003-2006)
  • Member of BBSRC Engineering and Biological Systems Panel (2000-2003)
  • Member of MRC Regenerative Medicine Research Committee

Teaching

MAT300/MAT407 (20 credits) – Tissue Engineering
FCE101 (20 credits) - An Introduction to Bioengineering.
FCE201 (10 credits) - Advanced Bioengineering Topics

Supervision of 2 to 3 honours project students per year for 30 credit BEng (MAT356) and 60 credit (MAT404) research projects.

Supervision of 2 MSc students per year for Biomaterials and Regenerative Medicine.

Key publications

  • Deshpande P, Ramachandran C, Sefat F, Mariappan I, Johnson C, McKean R, Hannah M, Sangwan VS, Claeyssens F, Ryan AJ, MacNeil S. Simplifying corneal surface regeneration using a biodegradable synthetic membrane and limbal tissue explants. Biomaterials. 34(21): 5088-5106 (2013)
  • Ortega I, Ryan AJ, Deshpande P, MacNeil S, Claeyssens F. Combined microfabrication and electrospinning to produce 3-D architectures for corneal repair. Acta Biomaterialia. 9(3):5511-5520 (2013)
  • Roman S, Mangera A, Osman NI, Bullock AJ, Chapple CR, Macneil S. Developing a tissue engineered repair material for treatment of stress urinary incontinence and pelvic organ prolapse-which cell source? Neurourol Urodyn.33(5):531-7 (2013)
  • Sangwan VSS, Jain R, Basu S, Bagadi AB, Sureka S, Mariappan I, MacNeil S. Transforming ocular surface stem cell research into successful clinical practice. Indian Journal of Ophthalmology. 62(1):29-40 (2014).
  • Hassan E, Deshpande P, Claeyssens F, Rimmer S, MacNeil S. Amine functional hydrogels as selective substrates for corneal epithelialisation. Acta Biomaterialia 10:3029–3037 (2014)

Publications 2010 onwards.pdf

Research group

Centre for Biomaterials and Tissue Engineering

Postdoctoral Research Assistants

Dr Anthony Bullock
Dr Shweta Mittar
Dr Abigail Pinnock
Dr Marc Daigneault
Dr Sabiniano Roman Regueros

Clinical Research Fellows

Mr Nadir Osman
Ms Naside Mangir
Mr Chris Hillary

PhD Students

Miss Annika Clifton (co-supervised with Chemistry)
Miss Amanda Harvey (co-supervised with Chemistry)
Miss Enas Hassan (co-supervised with Chemistry)
Miss Ceyla Yorucu (co-supervised with Dr I Rehman)
Mr Christopher Tse (co-supervised with Dr P Smith & Prof J Haycock)
Mr Daniel Cozens (co-supervised with the Medical School)
Miss Giulia Gigliobianco (co-supervised with Dr CK Chong)
Miss Jenny Ventress (co-supervised with the Medical School)
Mr Joseph Boadi (co-supervised with Dr S Matcher)
Miss Lindsey Dew (co-supervised with Drs CK Chong and F Claeyssens)
Mr Sam Beckett (co-supervised with Dr S Matcher)
Mr Samand Pashneh-Tala (co-supervised with Dr CK Chong)
Miss Sasima Puwanun (co-supervised with Dr G Reilly)