Eukaryotic Cell Biology

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Culturable mammalian cells are an invaluable model to study human genetics in combination with more traditional eukaryotic organisms, such as the model yeast Saccharomyces cerevisiae. Our department has a strong focus on the regulation of DNA damage repair systems and the disorders resulting from defects in DNA repair, including neurological ataxia and cancer.

Eukaryotic cell research in our department at a glance:

  • Genetics - regulation of meiosis, gene regulation, macromolecular complexes
  • Disorders - genome stability, DNA damage repair, degenerative disorders, cancer biology
  • Immunology - leucocytes, antibody response, tetraspanins

For further information and research opportunities, please see the staff page of individual researchers below:

Also see the closely related research theme Genomics and Nucleic Acids.


el-khamisys

Prof Sherif El-Khamisy

FRSC FRSB
Director of Research and Innovation

Room: C7b
0114 222 2791
S.El-Khamisy@sheffield.ac.uk

Mammalian genome stability in health and disease. Head of the human DNA repair group aiming to understand how defects in repairing DNA damage cause degenerative disorders, cancer and ageing.

SelfPhD


goldmana

Prof Alastair Goldman

Head Of Department

Room: D6b
0114 222 2779
a.goldman@sheffield.ac.uk

Genetic and molecular analysis of DNA double-strand break (DSB) repair in meiosis, using yeast as a model organisation. Analysis of testis cancer antigens expression in cancer cells, and determination of its significance.

SelfPhD


hettemae

Dr Ewald Hettema

Room: E28
0114 222 2732
e.hettema@sheffield.ac.uk

Use of the model yeast Saccharomyces cerevisiae and the fruitfly Drosophila melanogaster to study eukaryotic peroxisomes. Particular focus on the role of peroxisome membrane proteins in the biogenesis, maturation, segregation and breakdown of peroxisomes.


hornbyd

Prof David Hornby

Room: F9a
0114 222 4232
d.hornby@sheffield.ac.uk

Methodology in protein and nucleic acid biochemistry; developing analytical methods for genomics and proteomics, expanding the functional repertoire of natural macromolecular assemblies, remodelling enzymes and toxins.


hub

Dr Bin Hu

University Research Fellow

Room: E18a
0114 222 2715
b.hu@sheffield.ac.uk

Eukaryotic cell cycle regulation, with particular focus on protein-DNA interactions in chromosomes and how cells incorporate environmental signals into cell proliferation and how cells make a decision on growth or death upon environmental stress.


mitchellp

Dr Phil Mitchell

Room: E21a
0114 222 2821
p.j.mitchell@sheffield.ac.uk

Building on the discovery and characterisation of the exosome ribonuclease complex (Mitchell et al., 1997; Allmang et al., 1999), my lab’s research addresses the molecular mechanisms of RNA quality control in eukaryotic cells.

SelfPhD


partridgel

Dr Lynda Partridge

Room: E7a
0114 222 4185
l.partridge@sheffield.ac.uk

Human leucocyte antigens, specifically the structure and function of tetraspanins, a conserved family of mammalian transmembrane proteins. Role of tetraspanins in bacterial infection. Monoclonal antibody technology for research and medicine.

SelfPhD


sudberyp

Prof Peter Sudbery

Roper Chair in Genetics

Room: E18b
0114 222 6186
p.sudbery@sheffield.ac.uk

The molecular and cellular biology of hyphal and pseudohyphal morphogenesis in the human fungal pathogen Candida albicans, the cause of thrush and candidiasis: a lethal infection common in immuno-compromised patients.


wilsons

Prof Stuart Wilson

Room: E24a
0114 222 2849
stuart.wilson@sheffield.ac.uk

The regulation of gene expression in mammals, focusing on mRNA; mRNA export from the nucleus to the cytoplasm; mechanisms of RNA interference. Large scale sequencing and gene function analysis in vertebrates.