Genomics and Nucleic Acids

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At the genomic level, state-of-the-art computational methods are being used for a broad range of applications to enhance our understanding of molecular evolution. At a cellular level, we are unravelling the molecular basis of nucleic acid stability, DNA damage repair and various RNA processes. Particular emphasis is put on genetic processes that lead to disorders such as neurological ataxia, amyloidoses and cancers.

Genomic and nucleic acid research in our department at a glance:

  • Genomics - molecular evolution, mutagenesis screens, whole genome sequencing, expression studies
  • DNA - genome stability, damage repair, meiosis, disorders, cancer
  • RNA - expression, assembly, export, trafficking, interference

For further information and research opportunities, please see the staff page of individual researchers below:

Also see the closely related research theme Eukaryotic Cell Biology.


chaudhurir

Dr Roy Chaudhuri

Room: B112
0114 222 2837
r.chaudhuri@sheffield.ac.uk

Functional and comparative genomics of bacteria, particularly E. coli and Salmonella. Development of methods for analysing data derived from transposon mutagenesis screens such as TraDIS. Development of user-friendly web interfaces for bacterial genomics.


el-khamisys

Prof Sherif El-Khamisy

FRSC FRSB
Director of Research and Innovation

Room: C7b
0114 222 2791
S.El-Khamisy@sheffield.ac.uk

Mammalian genome stability in health and disease. Head of the human DNA repair group aiming to understand how defects in repairing DNA damage cause degenerative disorders, cancer and ageing.

SelfPhD


goldmana

Prof Alastair Goldman

Head Of Department

Room: D6b
0114 222 2779
a.goldman@sheffield.ac.uk

Genetic and molecular analysis of DNA double-strand break (DSB) repair in meiosis, using yeast as a model organisation. Analysis of testis cancer antigens expression in cancer cells, and determination of its significance.

SelfPhD


hornbyd

Prof David Hornby

Room: F9a
0114 222 4232
d.hornby@sheffield.ac.uk

Methodology in protein and nucleic acid biochemistry; developing analytical methods for genomics and proteomics, expanding the functional repertoire of natural macromolecular assemblies, remodelling enzymes and toxins.


mitchellp

Dr Phil Mitchell

Room: E21a
0114 222 2821
p.j.mitchell@sheffield.ac.uk

Building on the discovery and characterisation of the exosome ribonuclease complex (Mitchell et al., 1997; Allmang et al., 1999), my lab’s research addresses the molecular mechanisms of RNA quality control in eukaryotic cells.

SelfPhD


sorefank

Dr Karim Sorefan

Room: E1a
0114 222 2720
k.sorefan@sheffield.ac.uk

Molecular mechanisms regulating plant development with a particular focus on linking miRNA and hormonal pathways in plant stem cells. Understanding how meristematic cells are programmed will contribute to improving crop productivity.


sudberyi

Dr Ian Sudbery

Room: B108
0114 222 2738
i.sudbery@sheffield.ac.uk

Understanding how eukaryotes integrate information and regulate gene expression using computational and functional genomics tools, for example miRNAs in transcript destabilisation and translational inhibition.

FundedPhD


wests

Dr Steven West

Room: E22a
0114 222 2848
steve.west@sheffield.ac.uk

RNA processes linked to human disease, such as CTD kinase regulation in Amyotrophic Lateral Sclerosis and Oculopharyngeal Muscular Dystrophy; pre-mRNA processing, maturation, quality control and degradation.


wilsons

Prof Stuart Wilson

Room: E24a
0114 222 2849
stuart.wilson@sheffield.ac.uk

The regulation of gene expression in mammals, focusing on mRNA; mRNA export from the nucleus to the cytoplasm; mechanisms of RNA interference. Large scale sequencing and gene function analysis in vertebrates.