Professor Damien Lacroix

Professor Damien LacroixProfessor of Mechanobiology

Department of Mechanical Engineering
F32, Pam Liversidge
Mappin Street
Sheffield
S1 3JD

Telephone: +44(0)114 2220156

Email: d.lacroix@sheffield.ac.uk


Profile

Damien Lacroix is Professor of Mechanobiology in the Department of Mechanical Engineering. He has a first degree in Mechanical Engineering from the National Institute of Applied Science (INSA Lyon, France) and a PhD in Biomechanics from Trinity College Dublin.

After a post-doc in 2001 in Toulouse (France) for Smith and Nephew at the Purpan Hospital, he was awarded a Marie-Curie TMR EU fellowship in 2002 and a Ramon y Cajal senior fellowship in 2004 at the Technical University of Catalonia (Spain). In 2008 he was appointed Group Leader of Biomechanics and Mechanobiology at the Institute of Bioengineering of Catalonia (Spain). Damien joined the Department in 2012 when he took a Chair in Biomedical Engineering within the INSIGNEO research institute.

Other professional activities and achievements

  • Past-President of the European Society of Biomechanics
  • Council Member of the European Alliance for Medical and Biological Engineering and Science (EAMBES)
  • Editorial Board member of Biomaterials, Journal of Biomechanics and Clinical Biomechanics
  • 2010 Jean Leray Award from the European Society of Biomaterials
  • 2006 City Award of Barcelona in Technology Research for the development of a new injectable porous material based on calcium phosphate
  • Recipient of European Research Council Starting Grant in 2011

Research Areas

Professor Lacroix's research covers bone mechanobiology (bone tissue engineering, bone distraction, fracture healing) and spine biomechanics (mechanobiology of disc degeneration, disc angiogenesis, disc implant analysis).

The focus of his research group is the study of the effect of mechanical stimuli on biological response. The group's objective is to make scientific advancements in simulations of in vitro and in vivo biomechanics and mechanobiology and in experimental in vitro mechanobiology. The current focus of the group is mainly on the development of simulations in spine biomechanics, tissue engineering and cell mechanics. These numerical simulations based on the finite element method are complemented with in vitro tests using bioreactors and microfluid chambers.

Research Projects

  • Multiscale modelling of the musculoskeletal system
  • Development of a predictive computational platform for disc degenration
  • Simulation of a biological / biomaterials interactions in tissue engineering
  • Simulation of bone fracture healing
  • Modelling of cell mechanics
  • Study of cell adhesion
  • Microfluidic study of fluid shear stresses
  • Implant prothesis design

Teaching

Prof. Lacroix supervises final year undergraduate and MSc projects.

Current Research Grants

  • European Research Council Starting Grant, MECHANOBIO - 'Finite element simulations of mechanobiology in tissue engineering', 10/2011-09/2016. €1.49m
  • European Commission, FP7 ICT 269909, MySpine - 'Functional prognosis simulation of patient-specific spinal treatment for clinical use', 03/2011-02/2014. €0.68m.
  • ESPRC Frontier Engineering Award (EP/K03877X/1), M J Hounslow, D Lacroix, M Viceconti, S  A Billings, V Kadirkamanathan, A pavic, E McCloskey, T Skerry, 'Modelling Complex and Partially Identified Engineering Problems - Application to the Individualised Multi-scale Simulation of the Musculoskeletal System', 01.09.2013 to 31.08.2018 £4.86m

Journal articles

Conference proceedings papers

  • Marin AC, Grossi T, Bianchi E, Dubini G & Lacroix D (2015) mu-Particle Image Velocimetry and Computational Fluid Dynamics Study of Perfusion Cell Seeding Within a 3d Porous Scaffold. TISSUE ENGINEERING PART A, Vol. 21 (pp S117-S118)
  • Shariatzadeh M, Perrault C & Lacroix D (2015) Effect of Mechanical Stimulation on Osteogenic Differentiation of Self-Assembled Collagen-Cell Seeded Hydrogels. TISSUE ENGINEERING PART A, Vol. 21 (pp S271-S271)
  • Burnett A & Lacroix D (2015) MultiSim: Report of Stakeholder Workshop Outcomes. MultiSim: Report of Stakeholder Workshop Outcomes, Vol. 1(1) (pp 1-7). Insigneo Institute for in silico medicine, 7 September 2014 - 7 September 2014. View this article in White Rose Research Online
  • Checa S, Sandino C, Byrne DP, Kelly DJ, Lacroix D & Prendergast PJ (2011) Computational techniques for selection of biomaterial scaffolds for tissue engineering. Computational Methods in Applied Sciences, Vol. 20 (pp 55-69)
  • Planell JA, Navarro M, Altankov G, Aparicio C, Engel E, Gil J, Ginebra MP & Lacroix D (2010) Materials Surface Effects on Biological Interactions. ADVANCES IN REGENERATIVE MEDICINE: ROLE OF NANOTECHNOLOGY AND ENGINEERING PRINCIPLES (pp 233-252)
  • Koch MA, Engel E, Planell JA & Lacroix D (2007) Static and dynamic cell seeding of bone composite scaffolds in a perfusion bioreactor. TISSUE ENGINEERING, Vol. 13(7) (pp 1757-1757)
  • Lacroix D, Villagomez M & Planell JA (2007) Finite element study of regular scaffolds for bone tissue engineering. TISSUE ENGINEERING, Vol. 13(7) (pp 1698-1698)