Dr Alberto Marzo

Lecturer

Course Director: MEC6000 Courses

Bioengineering 3rd Year Tutor

Department of Mechanical Engineering
Sir Frederick Mappin Building
Mappin Street
Sheffield
S1 3JD
UK

Telephone: +44 (0)114 222 0155

Profile

Dr Marzo is a lecturer of Computational Biomechanics at the Department of Mechanical Engineering, University of Sheffield.

Dr Marzo has a 5-year degree in Mechanical Engineering from the University of Cagliari, Italy, and a PhD from the University of Sheffield. In the early stages of his PhD he was awarded the David Crighton Fellowship, and spent one year of his doctoral studies at the Department of Applied Mathematics and Theoretical Physics, the University of Cambridge. Here he investigated the theory behind flow-induced oscillations in elastic vessels, under the supervision of Professor Timothy J. Pedley.

In 2011-12 he worked as a Principal Research Scientist for the NHS to support technology development and dissemination for people with long-term disabilities.

Dr Marzo's research area stands at the interface between the physical and life sciences. It is firmly rooted in engineering and mathematics in the context of computational mechanics, including state-of-the-art fluid-structure interaction, but has a strong emphasis on clinical interpretation and translation of engineering technologies into clinical tools.

Teaching

MEC316/6316 Renewable Energy - Wind Energy
MEC6008 Graphical Programming with LabView (Course Director)
MEC6009 Finite Element Analysis with Ansys (Course Director)
MEC6013 Drawing with SolidWorks (Course Director)
MEC6014 An Introduction to Matlab (Course Director)

Research Interests

Numerical modelling of wall motion in cardiovascular applications
Image-based computational vascular haemodynamics
Minimally invasive image-based interventional planning and guidance
Influence of haemodynamics on cardiovascular disease
Influence of lifestyle on haemodynamics and cardiovascular disease
Fluid structure interaction and flow-induced oscillations in elastic vessels

Current Research Grants

2012-13 EPSRC Engineering for Life, Intracranial aneurysms: are we treating a disease, or trying to interfere with one of nature's defence mechanisms? (with Cardiovascular Science and Sheffield Teaching Hospitals NHS Trust, Principal Investigator)
2013-17 VPH-DARE@IT (EU FP7 - ICT) - Large-scale Intergated Project (IP) on patient-specific predictive models for early diagnosis of dementias and their evolution (co-investigator, PI Prof Alejandro Frangi)

Selected Publications

Accuracy vs. computational time: Translating aortic simulations to the clinic,
Brown, A. G., Shi, Y., Marzo, A., Staicu, C., Valverde, I., Beerbaum, P., Lawford, P. V. & Hose, D. R. (2011),
Journal of Biomechanics, 45(3), pp. 516-523.

Patient-specific modeling of cerebral blood flow: Geometrical variations in a 1D model,
Mulder, G., Marzo, A., Bogaerds, A. C. B., Coley, S. C., Rongen, P., Hose, D. R. & Van de Vosse, F. N. (2011),
Cardiovascular Engineering and Technology, 2(4), pp. 334-348.

@neurIST complex information processing toolchain for the integrated management of cerebral aneursyms,
Villa-Uriol, M. C., Berti, G., Hose, D. R., Marzo, A., Chiarini, A., Penrose, J., Pozo, J., Schmidt, J. G., Singh, P. Lycett, R., Larrabide, I. & Frangi, A. F. (2011),
Interface Focus, 1(3), pp. 308-319.

Computer modelling of haemodynamics and morphology in patient-specific intracranial aneurysms,
Marzo, A., Sweney, D. & Murphy, M. (2011),
Computer Aided Medical Engineering, 1, pp. 24-26.

Prediction of pressure gradient in aortic coarctation by computational fluid-dynamic simulations,
Valverde, I., Staicu, C., Marzo, A., Grotenhuis, H., Rhode, K., Tzifa, A., Razavi, R., Lawford, P., Hose, R. & Beerbaum, P.
Cardiology in the Young, 45th Annual Meeting of the Association for European Pediatric Cardiology (AEPC), Vol 21, Supplement 1, pp. S1-S167.

Three-dimensional morphological analysis of intracranial aneurysms: a fully automated method for their isolation and quantification,
Larrabide, I., Villa-Uriol, M. C., Cardenes, R., Pozo, J., Macho, J., San Roman, L., Blasco, J., Vivas, E., Marzo, A., Hose R. & Frangi, A. (2011),
Journal of Medical Physics, 38(5), pp. 2439-49.

Computational haemodynamics in intracranial aneurysms: The effects of modelled versus patient-specific boundary conditions,
Marzo. A., Singh, P., Larrabide, I., Radaelli, A., Coley, S., Gwilliam, M., Wilkinson, I. D., Lawford, P., Reymond, P., Patel, U., Frangi, A. & Hose, D.R. (2011),
Annals of Biomedical Engineering, 39(2), pp. 884-96.

Effects of heparin on the haemodynamic characteristics of intracranial aneurysms,
Singh, P.K., Marzo, A., Tahir, H., Weeratunge, T. F., Kumar, K., Boutarbouch, M., Hose, R., Patel, U. J. & Coley, S. C. (2010),
Journal of Neuroradiology, 37(5), pp. 300-1.

The effects of aortic coarctation on cerebral hemodynamics and its importance in the etiopathogenesis of intracranial aneurysms,
Singh, P. K., Marzo, A., Staicu, C., Gwilliam, M., Wilkinson, I., Lawford, P. V., Rufenacht, D. A., Bijlenga, P., Frangi, A. F., Hose, R., Patel, U. J. & Coley, S. C. (2010),
Journal of Vascular and Interventional Neurology, 3(1), pp. 17-30.

Effects of smoking and hypertension on wall shear stress and oscillatory shear index at the site of intracranial aneurysm formation,
Singh P. K., Marzo, A., Howard, B., Rufenacht, D. A., Bijlenga, P., Frangi, A. F., Lawford, P. V., Coley, S. C., Hose, D. R. & Patel, U. J. (2010),
Journal of Clinical Neurology and Neurosurgery, 112(4), pp. 306-13, Trowbridge Prize 2009.

MR derived volumetric flow rate waveforms at locations within the common carotid, internal carotid and basilar arteries,
Gwilliam, M. N., Hoggard, N., Capener, D., Singh, P. K., Marzo, A., Verma, P. K. & Wilkinson, I. D. (2009),
Journal of Cerebral Blood Flow and Metabolism, 29(12), pp. 1975-82.

The role of computational fluid dynamics in the management of unruptured intracranial aneurysms: A clinician's view,
Singh, P. K., Marzo, A., Coley, S. C., Berti, G., Bijlenga, P., Lawford, P. V., Villa-Uriol, M. C., Rufenacht, D. A., McCormack, K. M., Frangi, A., Patel, A. J. & Hose, R. (2009),
Computational Intelligence and Neuroscience, 2009: 760364.

Influence of inlet boundary conditions on the local haemodynamics of intracranial aneurysms,
Marzo, A., Singh, P. K., Reymond, P., Stergiopulos, N. & Hose, R. (2009),
Computer Methods in Biomechanics and Biomedical Engineering, 12(4), pp. 431-44.

Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model - A report on the Virtual Intracranial Stenting Challenge 2007,
Radaelli, A. G., Augsburger, L., Cebral, J. R., Ohta, M., Rüfenacht, D. A., Balossino, R., Benndorf, G., Hose, D. R., Marzo, A., Metcalfe, R., Mortier, P., Mut, F., Reymond, P., Socci, L., Verhegghe, B. & Frangi, A. F. (2008),
Journal of Biomechanics, 41(10), pp. 2069-81.

Three-dimensional collapse and steady flow in thick-walled flexible tubes,
Marzo, A., Luo, X. Y. & Bertram, C. D. (2005),
Journal of Fluids and Structures, 20, pp. 817-835.