Dr Cecile Perrault

Lecturer

Department of Mechanical Engineering
Sir Frederick Mappin Building
Mappin Street
Sheffield
S1 3JD
UK

Telephone: +44(0)114 2220154

email : c.perrault@sheffield.ac.uk

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Profile

Cecile Perrault received her ME and PhD in Biomedical Engineering from the University of Florida in 2005 and 2007. She then completed a postdoctoral fellowship at McGill University in Montréal, Canada in the nanobioengineering laboratory, where she developed microfluidic tools for biological purposes. In 2009, she joined the Institute of BioEngineering of Catalonia in Barcelona, Spain to study biomechanics and mechanobiology. In 2012, she joined the Department of Mechanical Engineering at the University of Sheffield as lecturer.

Cecile's research focuses on cellular mechanics and microfluidics. Her interest lies in the use of mechanical properties of cells and tissues for diagnostic purposes, with the development of microfluidic tools for cellular analysis. She is also interested in the use of mechanical stimulation for tissue engineering, more particularly bone generation in scaffolds.

Research Interests

• Cellular Mechanics
• Mechanobiology
• Mechanotransduction
• Microfluidics for Biology
• Cancer Mechanics

Selected Publications

• Integrated Microfluidic Probe Station,
  Perrault, C. M., Qasaimeh, M. A., Brastaviceanu, T., Anderson, K., Kabakibo, Y. & Juncker, D. (2010),
  Review of Scientific Instruments, 81(11), 115107
  (Also featured in Virtual Journal of Biological Physics Research, 20(11)),
  Available online


• The extracellular matrix microtopography drives critical changes in cellular motility and Rho A activity in colon cancer cells,
  Rapier, R., Huq, J., Vishnubhotla, R., Bulic, M., Perrault, C. M., Metlushko, V., Cho, M., Tay, R. T. & Glover, S. C. (2010),
  Cancer Cell International, 10(24),
  Available online


• Chamber and microfluidic probe for microperfusion of organotypic brain slices,
  Queval, A., Ghattamaneni, N. R., Perrault, C. M., Gill, R., Mirzaei, M., McKinney, R. A. & Juncker, D. (2010),
  Lab on a Chip, 10(3), pp. 326-34,
  Available online


• The microfluidic probe: Operation and use for localized surface processing,
  Perrault, C. M., Qasaimeh, M. A. & Juncker, D. (2009),
  Journal of Visualised Experiments, 28, e1418.


• Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes,
  Segal, M. S., Shah, R., Afzal, A., Perrault, C. M., Chang, K., Schuler, A., Beem, E., Shaw, L. C., Li Calzi, S., Harrison, J. K., Tran-Son-Tay, R. & Grant, M. B. (2006),
  Diabetes, 55(1), pp. 102-9.


• Transient upregulation of GRP and its receptor critically regulate colon cancer cell motility during remodeling,
  Glover, S., Nathaniel, R., Shakir, L., Perrault, C., Anderson, R. K., Tran-Son-Tay, R. & Benya, R. V. (2005),
  American Journal of Physiology: Gastrointestinal and Liver Physiology, 288(6), G1274-82,
  Available online


• Strength measurement of the Sertoli-spermatid junctional complex,
  Wolski, K. M., Perrault, C., Tran-Son-Tay, R. & Cameron, D. F. (2005),
  Journal of Andrology, 26(3), pp. 354-9,
  Available online


• Altered rheology of lymphocytes in the diabetic mouse,
  Perrault, C. M., Bray, E. J., Didier, N., Ozaki, C. K. & Tran-Son-Tay, R. (2004),
  Diabetologia, 47(10), pp. 1722-6,
  Available online