Neurodegeneration
Degenerative diseases of the human motor system studied at Sheffield include motor neurone disease (MND) and hereditary spastic paraplegia. Work includes studies to delay the onset of symptoms and prolong the lives of our current patients. To conquer these diseases, however, we need a more complete understanding of their underlying mechanisms, which we hope to gain through long-term laboratory-based research.See Professor Pamela Shaw's staff profile page for more details of these research programmes.
| Many of the components of a disease can only be accessed through the study of tissue samples following autopsy. From these studies we are attempting to trace the changes associated with decreased cognitive function in the ageing brain, examining the role of vascular pathology, neurofibrillary tangles (NFT) and b-amyloid plaques, in dementia. See Professor Paul Ince's staff profile page for more details of these research programmes. |
Other strands of research in this area include:
- Gene Therapy for Neurodegenterative disease - Professor Mimoun Azzouz
- Regulation of axonal transport in neurones - Dr Andy Grierson
- Neuroinflammation - Dr Pete Monk
- Molecular mechanisms of Neurodegeneration - Dr Jon Wood
- Genetics of Basal Ganglia disorders - Dr Oliver Bandmann
- Neuro-genetics and gene expression progiling in Neurodegeneration diseases - Dr Janine Kirby
- Molecular mechanisms of neurodegeneration and improving treatment of patients with neurodegenerative disorders Dr Christopher McDermott
- Models and Mechanisms of Neurogeneration – Dr Tennore Ramesh