Dr Alice Brockington MBChB BSc MRCP PhD

Clinical Lecturer in Neurology

Academic Neurology Unit
Department of Neuroscience
Sheffield Institute of Translational Neuroscience
University of Sheffield
385a Glossop Road
Sheffield
S10 2HQ


Tel: (+44) 0114 2222267
Pager: (+44) 0114 271 1900 Bleep 258
Fax: 0114 271 3158
Email: a.brockington@sheffield.ac.uk

Secretary: Rebecca Brown
Tel: 0114 2222261
Email:rebecca.brown@sheffield.ac.uk

Clinical Lecturer

2009 PhD, University of Sheffield
2008- Walport clinical lectureship, University of Sheffield
2005-2008 Wellcome trust research training fellowship, Academic neurology unit, University of Sheffield
2003-2005 Clinical research fellow, Academic neurology unit, University of Sheffield
2002-2003 Neurology SHO, Royal Hallamshire Hospital, Sheffield
1998-2002 General medical training (Aberdeen Royal Infirmary, Borders General Hospital (Melrose), Whangerei Base Hospital (New Zealand), Wesern General Hospital (Edinburgh), Christchurch Public Hospital (New Zealand)
2001 Membership of the Royal College of Physicians (Edinburgh)
1991-1997 MBChB with Honours (Edinburgh)
1994 BSc in neuroscience

Research

My main interest is in the pathogenesis of motor neurone disease (MND), and in particular, the role that dysregulation of vascular endothelial growth factor plays in motor neurone survival and degeneration. I am interested in the use of transcriptional profiling to explore the pathogenic mechanisms of disease. Current studies include using microarray analysis to determine factors underlying selective vulnerability of motor neurones, and profiling of non-neuronal cells in MND.

Recent publications

A. Brockington, P.J.Shaw; Vascular endothelial growth factor (VEGF) and the Nervous System; Neuropathology and Applied Neurobiology (2004); 30(5) 427-46; PMID: 15488020

Alice Brockington and Pamela J Shaw; Familial motor neuron diseases other than ALS. In Robert Brown, ed. `Amyotrophic Lateral Sclerosis´ edition 2. Lancaster: Informa healthcare (2006): 141-186

A. Brockington, S. Wharton, M. Fernando, C. Gelsthorpe, L. Baxter, P. Ince, C. Lewis, P.J.Shaw; Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis; J Neuropathol Exp Neurol (2006) 65 26-36; PMID: 16410746

Alice Brockington, Paul Ince and Pamela J Shaw; The clinical and pathological spectrum of ALS. In: Michael J Strong, ed. Dementia and Motor Neurone Disease. Abingdon: Informa healthcare, (2006): 31-58

A. Brockington, B. Wokke, H. Nixon, J. Hartley, P.J. Shaw; Screening of the transcriptional regulatory regions of vascular endothelial growth factor receptor 2 (VEGFR2) in amyotrophic lateral sclerosis.; BMC Med Genet (2007) 8 23; PMID: 17456229

Dalia Kasperaviciute; Mike E. Weale; Kevin V. Shianna; Gareth T. Banks; Claire L. Simpson; Valerie K. Hansen; Martin R. Turner; Christopher E. Shaw; Ammar Al-Chalabi; Hardev S. Pall; Emily F. Goodall; Karen E. Morrison; Richard W. Orrell; Marcus Beck; Sibylle Jablonka; Michael Sendtner; Alice Brockington; Paul G. Ince; Judith Hartley; Hannah Nixon; Pamela J. Shaw; Giampietro Schiavo; Nicholas W. Wood; David B. Goldstein; Elizabeth M.C. Fisher; Large-scale pathways-based association study in amyotrophic lateral sclerosis; Brain (2007) 130 2292-301; PMID: 17439985.

Diether Lambrechts, Koen Poesen, Rubén Fernández-Santiago, Ammar Al-Chalabi, Roberto Del Bo, Paul WJ Van Vught, Saeed Khan, Stefan Marklund, Alice Brockington, Ingrid Van Marion, Johanna Anneser, Christopher Shaw, Albert Ludolph, Nigel Leigh, giacomo comi, Thomas Gasser, Pamela J Shaw, Karen Morrison, Peter Andersen, Leonard H Van den Berg, Vincent Thijs, Teepu Siddique, Wim Robberecht and Peter Carmeliet; Meta-analysis of VEGF variations in ALS: increased susceptibility in male carriers of the -2578AA genotype. Journal of Medical Genetics (2009) 46(12):840-6; PMID: 18413368

Alice Brockington and Pamela J. Shaw; Vascular endothelial growth factor and the nervous system. In: Domenico Ribatti and Beatrice Nico, ed. Recent advances in angiogenesis in the central nervous system. Research Signpost 2009

Turner MR, Brockington A, Scaber J, Hollinger H, Marsden R, Shaw PJ, Talbot K; Pattern of spread and prognosis in lower limb-onset ALS. Amyotroph Lateral Scler (2009) [Epub ahead of print]; PMID: 20001488

Brockington A, Heath PR, Holden H, Kasher P, Bender FL, Claes F, Lambrechts D, Sendtner M, Carmeliet P, Shaw PJ; Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF delta/delta mouse model of amyotrophic lateral sclerosis; BMC Genomics. 2010 11(1):203; PMID: 20346106

Cox LE, Ferraiuolo L, Goodall EF, Heath PR, Higginbottom A, Mortiboys H, Hollinger HC, Hartley JA, Brockington A, Burness CE, Morrison KE, Wharton SB, Grierson AJ, Ince PG, Kirby J, Shaw PJ; Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS); PLoS One (2010) 5(3) e9872; PMID: 20352044