Professor Helen E Bryant

Clinical Medicine, School of Medicine and Population Health

Professor of Cancer Therapeutics

Head of The DNA replication and repair group

h.bryant@sheffield.ac.uk

GU11, G Floor, The Medical School

Full contact details

Professor Helen E Bryant
Clinical Medicine, School of Medicine and Population Health
GU11, G Floor
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries please contact - ClinMed-Operational@sheffield.ac.uk

Current PhD Opportunities

Advanced 3D models for Cancer Research
MRC DiMeN Doctoral Training Partnership: Targeting the DNA damage response to overcome cancer dormancy and chemotherapy-resistance

Qualifications

1991 - 1995 BSc Medical Biochemistry University of Glasgow

1996 - 1999 PhD MRC Virology Unit, Glasgow

2000 - 2003 Post-doctoral Researcher Ludwig Institute of Cancer Research, St Mary´s Hospital, London.

2003 - 2007 Post-doctoral Researcher YCR Institute for Cancer Studies, University of Sheffield.

2007 - 2012 RCUK Academic Fellow YCR Institute for Cancer Studies, University of Sheffield.

2012 - 2013 Lecturer Department of Oncology, University of Sheffield.

2013 - present Senior Lecturer Department of Oncology and Metabolism, University of Sheffield

Research interests

Dr Bryant has worked in the area of genome biology for 20 years. Her lab employs chemists, biologists and clinicians in order to promote a multi-disciplinary approach to translational research.

By understanding the control of the fidelity of DNA replication in normal cells we aim to understand why defects in the proteins involved are associated with cancer. Her aim is to pinpoint differences between dividing tumour cells and dividing normal cells and determine which are important in cancer development. This has enabled the group to develop drugs which can specifically kill the tumour cells rather than just all dividing cells (personalized therapy).

A separate side to Dr Bryant’s work is the development of novel transition metal-containing photodynamic therapy agents that bind to DNA and induce damage only upon irradiation with specific wavelengths of light. This is a collaboration with Prof. Julia Weinstein in the Department of Chemistry (TUOS).

To this end there are 4 board themes that overlap in the lab.

Understanding of the cellular pathways activated when DNA replication is perturbed.
Improving and understanding radiotherapy response
Identification of the changes in expression of these genes and phenotypic consequences in cancer
Exploitation of these changes in hypothesis-driven drug development.
Chemical development of novel therapeutic agents (focus on PDT agents)

Current projects examine these themes in Bladder, Breast, NSCLC, HNSCC and Neuroblastoma.

Publications

Journal articles

Saldana-Guerrero IM, Montano-Gutierrez LF, Hafemeister C, Stavish D, Shaw LE, Fetahu IS, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S , Shoeb MR et al (2023) Abstract 3542: A stem cell model dissects detrimental effects of neuroblastoma-linked chromosomal aberrations on cell differentiation during neural crest development. Cancer Research, 83(7_Supplement), 3542-3542.
King D, Southgate HED, Roetschke S, Gravells P, Fields L, Watson JB, Chen L, Chapman D, Harrison D, Yeomanson D , Curtin NJ et al (2021) Increased replication stress determines ATR inhibitor sensitivity in neuroblastoma cells. Cancers, 13(24).
Aguilar Cosme JR, Gagui DC, Bryant HE & Claeyssens F (2021) Morphological response in cancer spheroids for screening photodynamic therapy parameters. Frontiers in Molecular Biosciences, 8(11). View this article in WRRO
Aguilar Cosme JR, Gagui DC, Green NH, Bryant HE & Claeyssens F (2021) In Vitro Low-Fluence Photodynamic Therapy Parameter Screening Using 3D Tumor Spheroids Shows that Fractionated Light Treatments Enhance Phototoxicity.. ACS Biomater Sci Eng.
Piberger AL, Bowry A, Kelly RDW, Walker AK, González-Acosta D, Bailey LJ, Doherty AJ, Méndez J, Morris JR, Bryant HE & Petermann E (2020) PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts. Nature Communications, 11(1). View this article in WRRO
Halliwell JA, Gravells P & Bryant HE (2020) DNA fiber assay for the analysis of DNA replication progression in human pluripotent stem cells. Current Protocols in Stem Cell Biology, 54(1). View this article in WRRO
George SL, Lorenzi F, King D, Hartlieb S, Campbell J, Pemberton H, Toprak UH, Barker K, Tall J, da Costa BM , van den Boogaard ML et al (2020) Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma. EBioMedicine, 59.
Harrision D, Gravells P, Thompson R & Bryant HE (2020) Poly(ADP-Ribose) glycohydrolase (PARG) vs. poly(ADP-Ribose) polymerase (PARP) – function in genome maintenance and relevance of inhibitors for anti-cancer therapy. Frontiers in Molecular Biosciences, 7.
King D, Li XD, Almeida GS, Kwok C, Gravells P, Harrison D, Burke S, Hallsworth A, Jamin Y, George S , Robinson SP et al (2020) MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma. Oncotarget, 11(23), 2141-2159. View this article in WRRO
Kim HR, Santhakumar K, Markham E, Baldera D, Greenald D, Bryant HE, El-Khamisy SF & van Eeden FJ (2020) Investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish. Oncotarget, 11(13), 1109-1130. View this article in WRRO
Doherty RE, Bryant HE, Valluru MK, Rennie IG & Sisley K (2019) Increased non-homologous end joining makes DNA-PK a promising target for therapeutic intervention in uveal melanoma. Cancers, 11(9). View this article in WRRO
Aguilar Cosme JR, Bryant HE & Claeyssens F (2019) Carbon dot-protoporphyrin IX conjugates for improved drug delivery and bioimaging. PLoS ONE, 14(7). View this article in WRRO
Willan J, Cleasby AJ, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant HE & Ciani B (2019) ESCRT-III is necessary for the integrity of the nuclear envelope in micronuclei but is aberrant at ruptured micronuclear envelopes generating damage. Oncogenesis, 8(5). View this article in WRRO
Crowston B, Shipp J, Chekulaev DM, McKenzie L, Jones C, Weinstein J, Meijer AJHM, Bryant HE, Natrajan L, Woodward AW & Ward MD (2019) Heteronuclear d-d and d-f Ru(II)/M complexes [M = Gd(III), Yb(III), Nd(III), Zn(II) or Mn(II)] of ligands combining phenanthroline and aminocarboxylate binding sites: combined relaxivity, cell imaging and photophysical studies. Dalton Transactions. View this article in WRRO
Kadhim A, McKenzie LK, Bryant HE & Twyman LJ (2019) Synthesis and Aggregation of a Porphyrin-Cored Hyperbranched Polyglycidol and Its Application as a Macromolecular Photosensitizer for Photodynamic Therapy. Molecular Pharmaceutics, 16(3), 1132-1139. View this article in WRRO
Omar SAE, Scattergood PA, McKenzie LK, Jones C, Patmore NJ, Meijer AJHM, Weinstein JA, Rice CR, Bryant HE & Elliott PIP (2018) Photophysical and Cellular Imaging Studies of Brightly Luminescent Osmium(II) Pyridyltriazole Complexes. Inorganic Chemistry. View this article in WRRO
McKenzie LK, Bryant HE & Weinstein JA (2018) Transition metal complexes as photosensitisers in one- and two-photon photodynamic therapy. Coordination Chemistry Reviews. View this article in WRRO
Daniels RE, McKenzie LK, Shewring JR, Weinstein JA, Kozhevnikov VN & Bryant HE (2018) Pyridazine-bridged cationic diiridium complexes as potential dual-mode bioimaging probes. RSC Advances, 8(18), 9670-9676. View this article in WRRO
Gravells P, Neale J, Grant E, Nathubhai A, Smith KM, James DI & Bryant HE (2018) Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib. DNA Repair, 61, 25-36. View this article in WRRO
Gravells PL, Grant E, Smith KM, James DI & Bryant HE (2017) Specific killing of DNA damage-response deficient cells with inhibitors of poly(ADP-ribose) glycohydrolase. DNA Repair, 52, 81-91. View this article in WRRO
Mateo J, Boysen G, Barbieri CE, Bryant HE, Castro E, Nelson PS, Olmos D, Pritchard CC, Rubin MA & de Bono JS (2017) DNA Repair in Prostate Cancer: Biology and Clinical Implications.. European Urology, 71(3), 417-425. View this article in WRRO
McKenzie L, Sazanovich I, Baggaley E, Bonneau M, Guerchais V, Williams G, Weinstein J & Bryant HE (2017) Metal Complexes For Two-photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-photon Photosensitization of Cancer Cells Under Near-IR Light.. Chemistry - A European Journal, 23(2), 234-238. View this article in WRRO
McKenzie LK, Sazanovich IV, Baggaley E, Bonneau M, Guerchais V, Williams JAG, Weinstein JA & Bryant HE (2017) Frontispiece: Metal Complexes for Two-Photon Photodynamic Therapy: A Cyclometallated Iridium Complex Induces Two-Photon Photosensitization of Cancer Cells under Near-IR Light. Chemistry - A European Journal, 23(2), 234-234.
Ali R, Rakha EA, Madhusudan S & Bryant HE (2016) DNA damage repair in breast cancer and its therapeutic implications. Pathology.
Omar SA, Scattergood PA, McKenzie LK, Bryant HE, Weinstein JA & Elliott PI (2016) Towards Water Soluble Mitochondria-Targeting Theranostic Osmium(II) Triazole-Based Complexes.. Molecules, 21(10). View this article in WRRO
Patterson K, Arya L, Bottomley S, Morgan S, Cox A, Catto J & Bryant HE (2016) Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy.. Oncotarget. View this article in WRRO
Bryant HE (2016) The Clinical Impact of BRCA2 Loss in Prostate Cancer. European Urology, 69(6), 996-997.
Jana A, Crowston BJ, Shewring JR, McKenzie LK, Bryant HE, Botchway SW, Ward AD, Amoroso AJ, Baggaley E & Ward MD (2016) Heteronuclear Ir(III)–Ln(III) Luminescent Complexes: Small-Molecule Probes for Dual Modal Imaging and Oxygen Sensing. Inorganic Chemistry, 55(11), 5623-5633. View this article in WRRO
Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA & Bryant HE (2016) Photodynamic killing of cancer cells by a Platinum(II) complex with cyclometallating ligand. Scientific Reports, 6. View this article in WRRO
Arora A, Abdel-Fatah TMA, Agarwal D, Doherty R, Croteau DL, Moseley PM, Hameed K, Green A, Aleskandarany MA, Rakha EA , Patterson K et al (2016) Clinicopathological and prognostic significance of RECQL5 helicase expression in breast cancers. Carcinogenesis, 37(1), 63-71. View this article in WRRO
Doherty RE, Sazanovich IV, McKenzie LK, Stasheuski AS, Coyle R, Baggaley E, Bottomley S, Weinstein JA & Bryant HE (2015) Photodynamic killing of cancer cells by a platinum-based compound, a derivative of Pt(II) dipyridobenzene. Photodiagnosis and Photodynamic Therapy, 12(3), 338-339.
Pang KH, Miah S, Drayton RM, Rehman I, Clarke R, Stoehr R, Hartmann A, Lavin M, Bryant HE, Martens-Uzunova ES , Jenster G et al (2015) 426 Identification and diagnostic performance of a small RNA within the PCA3 and BMCC1 gene locus that potentially targets mRNA. European Urology Supplements, 14(2), e426-e426b.
King D, Yeomanson D & Bryant HE (2015) PI3King the Lock. Journal of Pediatric Hematology/Oncology, 37(4), 245-251.
Drayton RM, Rehman I, Clarke R, Zhao Z, Pang K, Miah S, Stoehr R, Hartmann A, Blizard S, Lavin M , Bryant HE et al (2015) Identification and Diagnostic Performance of a Small RNA within the PCA3 and BMCC1 Gene Locus That Potentially Targets mRNA. Cancer Epidemiology Biomarkers & Prevention, 24(1), 268-275. View this article in WRRO
Lafta IJ, Bryant HE & Goldman ASH (2014) ‘Sex’ in the cancer cell. Oncotarget, 5(18), 7984-7985. View this article in WRRO
Drayton RM, Peter S, Myers K, Miah S, Dudziec E, Bryant HE & Catto JWF (2014) MicroRNA-99a and 100 mediated upregulation of FOXA1 in bladder cancer. Oncotarget, 5(15), 6375-6386. View this article in WRRO
Drayton RM, Dudziec E, Peter S, Bertz S, Hartmann A, Bryant HE & Catto JW (2014) Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.. Clin Cancer Res, 20(7), 1990-2000. View this article in WRRO
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE , Bundred NJ et al (2013) Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research(5), R92. View this article in WRRO
Gravells P, Hoh L, Solovieva S, Patil A, Dudziec E, Rennie IG, Sisley K & Bryant HE (2013) Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.. Oncogene, 32(46), 5338-5346. View this article in WRRO
Loseva O, Jemth A-S, Bryant HE, Schüler H, Lehtiö L, Karlberg T & Helleday T (2012) PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.: FIGURE 2.. Journal of Biological Chemistry, 287(41), 34494-34494.
Fathers C, Drayton RM, Solovieva S & Bryant HE (2012) Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells.. Cell Cycle, 11(5), 990-997.
Drayton RM, Dudziec E, Catto JWF & Bryant HE (2012) Abstract A10: MicroRNA 27a is downreguated in cisplatin resistant bladder cancer cells, and contributes to resistance through the targeting of xCT, a cystine transporter involved with glutathione production. Cancer Research, 72(2 Supplement), A10-A10.
Bryant HE (2012) DNA double-strand break damage and repair assessed by pulsed-field gel electrophoresis.. Methods Mol Biol, 920, 315-321.
Gravells P, Hoh L, Canovas D, Rennie IG, Sisley K & Bryant HE (2011) Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R.. Br J Cancer, 104(7), 1098-1105. View this article in WRRO
Hoh L, Gravells P, Canovas D, Ul-Hassan A, Rennie IG, Bryant H & Sisley K (2011) Atypically low spontaneous sister chromatid exchange formation in uveal melanoma.. Genes Chromosomes Cancer, 50(1), 34-42.
Blundred R, Myers K, Helleday T, Goldman ASH & Bryant HE (2010) Human RECQL5 overcomes thymidine-induced replication stress.. DNA Repair (Amst), 9(9), 964-975.
Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA & Helleday T (2010) Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.. Cancer Res, 70(13), 5389-5398.
Loseva O, Jemth AS, Bryant HE, Schuler H, Lehtio L, Karlberg T & Helleday T (2010) PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA. J BIOL CHEM, 285(11), 8054-8060.
McLachlan J, Fernandez S, Helleday T & Bryant HE (2009) Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.. DNA Repair (Amst), 8(12), 1424-1433.
Catto JWF, Miah S, Owen HC, Bryant H, Myers K, Dudziec E, Larré S, Milo M, Rehman I, Rosario DJ , Di Martino E et al (2009) Distinct microRNA alterations characterize high- and low-grade bladder cancer.. Cancer Res, 69(21), 8472-8481.
Al-Minawi AZ, Lee Y-F, Håkansson D, Johansson F, Lundin C, Saleh-Gohari N, Schultz N, Jenssen D, Bryant HE, Meuth M , Hinz JM et al (2009) The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.. Nucleic Acids Res, 37(19), 6400-6413. View this article in WRRO
Bryant HE, Petermann E, Schultz N, Jemth A-S, Loseva O, Issaeva N, Johansson F, Fernandez S, McGlynn P & Helleday T (2009) PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.. EMBO J, 28(17), 2601-2615.
Ying S, Myers K, Bottomley S, Helleday T & Bryant HE (2009) BRCA2-dependent homologous recombination is required for repair of Arsenite-induced replication lesions in mammalian cells.. Nucleic Acids Res, 37(15), 5105-5113. View this article in WRRO
Bryant H (2007) A function for PARP at stalled replication forks. MUTAGENESIS, 22(6), 431-431.
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ & Helleday T (2007) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature, 447(7142), 346-346.
Bryant HE, Ying S & Helleday T (2006) Homologous recombination is involved in repair of chromium-induced DNA damage in mammalian cells.. Mutat Res, 599(1-2), 116-123.
Bryant HE & Helleday T (2006) Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair.. Nucleic Acids Res, 34(6), 1685-1691. View this article in WRRO
Helleday T, Bryant HE & Schultz N (2005) Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy.. Cell Cycle, 4(9), 1176-1178.
Saleh-Gohari N, Bryant HE, Schultz N, Parker KM, Cassel TN & Helleday T (2005) Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks.. Mol Cell Biol, 25(16), 7158-7169.
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ & Helleday T (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.. Nature, 434(7035), 913-917.
Amon W, Binné UK, Bryant H, Jenkins PJ, Karstegl CE & Farrell PJ (2004) Lytic cycle gene regulation of Epstein-Barr virus.. J Virol, 78(24), 13460-13469.
Bryant HE & Helleday T (2004) Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents.. Biochem Soc Trans, 32(Pt 6), 959-961.
Bryant H & Farrell PJ (2002) Signal Transduction and Transcription Factor Modification during Reactivation of Epstein-Barr Virus from Latency.. J Virol, 76(20), 10290-10298.
Bryant HE, Wadd SE, Lamond AI, Silverstein SJ & Clements JB (2001) Herpes simplex virus IE63 (ICP27) protein interacts with spliceosome-associated protein 145 and inhibits splicing prior to the first catalytic step.. J Virol, 75(9), 4376-4385.
Bryant HE, Matthews DA, Wadd S, Scott JE, Kean J, Graham S, Russell WC & Clements JB (2000) Interaction between herpes simplex virus type 1 IE63 protein and cellular protein p32.. J Virol, 74(23), 11322-11328.
Wadd S, Bryant H, Filhol O, Scott JE, Hsieh TY, Everett RD & Clements JB (1999) The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2.. J Biol Chem, 274(41), 28991-28998.
Fabbrizi MR, Nickson CM, Hughes JR, Robinson EA, Vaidya K, Rubbi CP, Kacperek A, Bryant HE, Helleday T & Parsons JL () Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence. Cell Death & Disease, 15(2).
Martínez-Alonso M, Jones CG, Shipp JD, Chekulaev D, Bryant HE & Weinstein JA () Phototoxicity of cyclometallated Ir(III) complexes bearing a thio-bis-benzimidazole ligand, and its monodentate analogue, as potential PDT photosensitisers in cancer cell killing. JBIC Journal of Biological Inorganic Chemistry.
Taher Z, Legge C, Winder N, Lysyganicz P, Rawlings A, Bryant H, Muthana M & Staniland S () Magnetosomes and Magnetosome Mimics: Preparation, Cancer Cell Uptake and Functionalization for Future Cancer Therapies. Pharmaceutics, 13(3), 367-367.

Chapters

Shewring JR, Hodgson L, Bryant HL, Bullough PA, Weinstein JA & Verkade P (2021) Refining a correlative light electron microscopy workflow using luminescent metal complexes, Methods in Cell Biology (pp. 69-87). Elsevier
Bryant HE & Shall S (2015) Synthetic Lethality with Homologous Recombination Repair Defects, Cancer Drug Discovery and Development (pp. 315-344). Springer International Publishing

Conference proceedings papers

Jackson CE, Green N, English W, Bryant HE & Claeyssens F (2023) Production of porous polycaprolactone polyHIPEs as substrates for in vitro 3D breast cancer cell culture. TISSUE ENGINEERING PART A, Vol. 29(13-14)
Mitchell T, Jones T, Danson S, Glover M, Bury J, Horsman J, Christian L, Hill E, Harrison E, Hatton M & Bryant H (2021) Investigation of Aurora Kinase A as a Potential Biomarker of Radiation in Non-Small Cell Lung Cancer (NSCLC). JOURNAL OF THORACIC ONCOLOGY, Vol. 16(10) (pp S1163-S1164)
Mitchell T, Astley J, Robinson S, Bryant H, Danson S, Tahir B & Hatton M (2021) Artificial Neural Network-Based Tumour Recurrence Prediction in Non-Small Cell Lung Cancer Patients Following Radical Radiotherapy. JOURNAL OF THORACIC ONCOLOGY, Vol. 16(10) (pp S958-S958)
Bradbury A, King D, Bryant H, Zenke F, Drew Y & Curtin N (2018) Investigating the effect of replication stress and other phenotypic factors as determinants of sensitivity to single agent ATR inhibitor, VE-821 in ovarian cancer cell lines. EUROPEAN JOURNAL OF CANCER, Vol. 103 (pp E32-E32)
Ritchie J, Wyld L & Bryant HE (2013) UPR Activation via glucose deprivation and depletion of GRP78 protein (using siRNA) do not alter radiosensitivity in the human breast cancer cell line MCF7. EUROPEAN JOURNAL OF CANCER, Vol. 49 (pp S425-S425)

Preprints

Saldana-Guerrero IM, Montano-Gutierrez LF, Hafemeister C, Stavish D, Shaw LE, Fetahu IS, Wenninger-Weinzierl A, Sturtzel C, Souilhol C, Tarelli S , Shoeb MR et al (2022) Neuroblastoma-associated chromosomal aberrations drive cell identity loss in human neural crest via disruption of developmental regulators, Cold Spring Harbor Laboratory.
Piberger AL, Bowry A, Kelly RDW, Walker AK, Gonzalez D, Bailey LJ, Doherty AJ, Méndez J, Morris JR, Bryant HE & Petermann E () PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts, Cold Spring Harbor Laboratory.
Kim HR, Santhakumar K, Markham E, Baldera D, Bryant HE, El-Khamisy SF & van Eeden FJ () The investigation of the role of VHL-HIF signaling in DNA repair and apoptosis in zebrafish, Cold Spring Harbor Laboratory.
Willan J, Cleasby A, Flores-Rodriguez N, Stefani F, Rinaldo C, Pisciottani A, Grant E, Woodman P, Bryant H & Ciani B () ESCRT-III accumulates in micronuclei with ruptured nuclear envelopes, Cold Spring Harbor Laboratory.

Research group

Polly Gravells - Postdoctoral Research (Biologist)
David King - Clinical Lecturer
Saskia Roetschke - Clinical Research Fellow
Marta Martinez - Postdoctoral Researcher (Chemist)
Emma Grant - Postgraduate Student
Callum Jones - Postgraduate Student
Chris Legge - Postgraduate Student
Thomas Jones - Postgraduate Student
Fatma Bucklain - Postgraduate Student
Hannah Gagg - Technician

Teaching interests

2012 - Postgraduate certificate in Learning and Teaching

Fellow of the Higher Education Academy

MSc - Translational Oncology

MSc - Molecular Medicine

Undergraduate - Genome Stability & Genetic Change module