Professor Alison Gartland

BSc (Hons), PhD

Clinical Medicine, School of Medicine and Population Health

Professor of Bone and Cancer Biology

a.gartland@sheffield.ac.uk
+44 114 215 9046

DU34, The Medical School

Full contact details

Professor Alison Gartland
Clinical Medicine, School of Medicine and Population Health
DU34
The Medical School
Beech Hill Road
Sheffield
S10 2RX

Profile

For enquiries, please contact – ClinMed-Operational@sheffield.ac.uk

I studied Biomedical Technology at Sheffield Hallam University and - following a period in industry - studied for my PhD at The University of Liverpool in Prof Jim Gallagher´s lab on the "Expression and functional significance of the P2X7 receptor in skeletal tissue".

I then moved to Montpellier, France where I was a Post-Doctoral Researcher at IGMM, CNRS in Bob Hipskind´s lab. Following this, I was a Senior Post-Doctoral Researcher in the Department of Cell Biology at the University of Massachusetts Medical School USA, in the late Prof Sandy Marks Jnr´s lab.

I joined the University of Sheffield in 2006 as a Lecturer in Bone Biology.

Research interests: My research interests are in P2 receptor signalling in musculoskeletal disease and cancer. The role of P2 purinoreceptor ligands (ATP and other nucleotides) as extracellular messengers is well established and there is now conclusive evidence, from my previous work and that of others, that extracellular nucleotides have a highly influential role in the bone microenvironment. In addition to their roles in bone, nucleotides and P2 receptor signalling have been shown to play a role in cancer.

Publications

Show: Featured publications All publications

Featured publications

Journal articles

Gartland A, Erler JT & Cox TR (2016) The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. Journal of Bone Oncology. View this article in WRRO
Proctor C & Gartland A (2016) Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing. Frontiers in Endocrinology, 7. View this article in WRRO
Varley I, Greeves JP, Sale C, Friedman E, Moran DS, Yanovich R, Wilson PJ, Gartland A, Hughes DC, Stellingwerff T , Ranson C et al (2016) Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. Purinergic Signalling, 12(1), 103-113.
Cox TR, Gartland A & Erler JT (2016) Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis. Cancer Research, 76(2), 188-192.
Cox TR, Schoof EM, Gartland A, Erler JT & Linding R (2015) Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data in Brief, 5, 621-625. View this article in WRRO
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR , Huggins ID et al (2015) The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature, 522(7554), 106-110. View this article in WRRO
Shah KM, Wilkinson JM & Gartland A (2015) Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
Agrawal A & Gartland A (2015) P2X7 receptors: role in bone cell formation and function. Journal of Molecular Endocrinology, 54(2), R75-R88.
Shah KM, Quinn PD, Gartland A & Wilkinson JM (2015) Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
Wang N, Rumney RMH, Yang L, Robaye B, Boeynaems J-M, Skerry TM & Gartland A (2013) The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.. J Bone Miner Res, 28(6), 1446-1456. View this article in WRRO
Gheryani N, Coffelt SB, Gartland A, Rumney RMH, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN & Miller G (2013) Generation of a novel mouse model for the inducible depletion of macrophages in vivo.. Genesis, 51(1), 41-49.
Syberg S, Petersen S, Beck Jensen JE, Gartland A, Teilmann J, Chessell I, Steinberg TH, Schwarz P & Jorgensen NR (2012) Genetic background strongly influences the bone phenotype of P2X7 receptor knockout mice. Journal of Osteoporosis, 2012. View this article in WRRO
Gartland A, Skarratt KK, Hocking LJ, Parsons C, Stokes L, Jørgensen NR, Fraser WD, Reid DM, Gallagher JA & Wiley JS (2012) Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.. Eur J Hum Genet, 20(5), 559-564. View this article in WRRO
Gartland A (2012) P2X receptors in bone. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 1(2), 221-227.
Rumney RMH, Wang N, Agrawal A & Gartland A (2012) Purinergic signalling in bone.. Front Endocrinol (Lausanne), 3, 116. View this article in WRRO
Jørgensen NR, Husted LB, Skarratt KK, Stokes L, Tofteng CL, Kvist T, Jensen J-EB, Eiken P, Brixen K, Fuller S , Clifton-Bligh R et al (2012) Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics.
Wang N, Robaye B, Agrawal A, Skerry TM, Boeynaems J-M & Gartland A (2012) Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.. Mol Endocrinol, 26(1), 142-152. View this article in WRRO
Dillon JP, Waring-Green VJ, Taylor AM, Wilson PJM, Birch M, Gartland A & Gallagher JA (2012) Primary human osteoblast cultures.. Methods Mol Biol, 816, 3-18.
Gartland A, Orriss IR, Rumney RMH, Bond AP, Arnett T & Gallagher JA (2012) Purinergic signalling in osteoblasts.. Front Biosci (Landmark Ed), 17, 16-29.
Agrawal A, Gallagher JA & Gartland A (2012) Human osteoclast culture and phenotypic characterization.. Methods Mol Biol, 806, 357-375.
Gartland A, Rumney RMH, Dillon JP & Gallagher JA (2012) Isolation and culture of human osteoblasts.. Methods Mol Biol, 806, 337-355.
Rumney RMH, Sunters A, Reilly GC & Gartland A (2012) Application of multiple forms of mechanical loading to human osteoblasts reveals increased ATP release in response to fluid flow in 3D cultures and differential regulation of immediate early genes.. J Biomech, 45(3), 549-554.
Orriss IR, Wang N, Burnstock G, Arnett TR, Gartland A, Robaye B & Boeynaems J-M (2011) The P2Y(6) receptor stimulates bone resorption by osteoclasts.. Endocrinology, 152(10), 3706-3716. View this article in WRRO
Andrews RE, Shah KM, Wilkinson JM & Gartland A (2011) Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.. Bone, 49(4), 717-723. View this article in WRRO
Wesselius A, Bours MJL, Agrawal A, Gartland A, Dagnelie PC, Schwarz P & Jorgensen NR (2011) Role of purinergic receptor polymorphisms in human bone. FRONT BIOSCI-LANDMRK, 16, 2572-2585.
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A & Erler JT (2011) LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.. Cancer Res, 71(5), 1561-1572.
Gartland A (2011) Fast Facts: Osteoporosis, 6th edition. PERSPECT PUBLIC HEAL, 131(1), 48-48.
Agrawal A, Buckley KA, Bowers K, Gaw A, Furber M, Gallagher JA & Gartland A (2010) The Effect of Different P2X(7) Receptor Antagonists on the Formation and Function of Human Osteoclast in vitro. PURINERG SIGNAL, 6(1), 139-140.
Agrawal A, Buckley KA, Bowers K, Furber M, Gallagher JA & Gartland A (2010) The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro. Purinergic Signalling, 6(3), 307-315.
Gartland A, Mason-Savas A, Yang M, MacKay CA, Birnbaum MJ & Odgren PR (2009) Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections. American Journal of Pathology, 175(6), 2668-2675.
Chan BY, Gartland A, Wilson PJM, Buckley KA, Dillon JP, Fraser WD & Gallagher JA (2007) PPAR agonists odulate human osteoclast formation and activity in vitro. BONE, 40(1), 149-159.
Gartland A, Mechler J, Mason-Savas A, MacKay CA, Mailhot G, Marks SC & Odgren PR (2005) In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: An improved isolation and cryopreservation method. Bone, 37(4), 530-544.
Gartland A, Buckley KA, Bowler WB & Gallagher JA (2003) Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.. Calcif Tissue Int, 73(4), 361-369.
Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB & Gallagher JA (2003) Multinucleated osteoclast formation in vivo and in vitro by P2X(7) receptor-deficient mice. CRIT REV EUKAR GENE, 13(2-4), 243-253.
Gartland A, Buckley KA, Hipskind RA, Bowler WB & Gallagher JA (2003) P2 receptors in bone - Modulation of osteoclast formation and activity via P2X(7) activation. CRIT REV EUKAR GENE, 13(2-4), 237-242.
Buckley KA, Hipskind RA, Gartland A, Bowler WB & Gallagher JA (2002) Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand.. Bone, 31(5), 582-590.
Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G & Gallagher JA (2001) Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.. Bone, 28(5), 507-512.
Gartland A, Hipskind RA, Gallagher JA & Bowler WB (2001) Expression of a P2X7 receptor by a subpopulation of human osteoblasts.. J Bone Miner Res, 16(5), 846-856.

All publications

Journal articles

Coleman JC, Tattersall L, Yianni V, Knight L, Yu H, Hallett S, Johnson P, Caetano A, Cosstick C, Ridley A , Gartland A et al (2024) The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis. iScience, 109288-109288.
Roberts BC, Cheong VS, Oliviero S, Arredondo Carrera HM, Wang N, Gartland A & Dall'Ara E (2024) Combining PTH(1‐34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice. Journal of Orthopaedic Research. View this article in WRRO
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR , Huggins ID et al (2023) Retraction Note: The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature, 617(7959), 208-208.
Green D, Singh A, Tippett VL, Tattersall L, Shah KM, Siachisumo C, Ward NJ, Thomas P, Carter S, Jeys L , Sumathi V et al (2023) YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522. Journal of Bone Oncology, 39, 100474-100474.
Gartland A, Pasello M, Lézot F & Lamoureux F (2023) Editorial: New therapies in the treatment of sarcomas. Frontiers in Endocrinology, 14.
Pickering GAE, Felix-Ilemhenbhio F, Clark MJ, Kocsy K, Simpson J, Bellantuono I, Gartland A, Wilkinson JM, Hatzikotoulas K & Kiss-Toth E (2022) The kinesin gene KIF26B modulates the severity of post-traumatic heterotopic ossification. International Journal of Molecular Sciences, 23(16). View this article in WRRO
Agrawal A, Ellegaard M, Haanes KA, Wang N, Gartland A, Ding M, Praetorius H & Jørgensen NR (2022) Absence of P2Y2 receptor does not prevent bone destruction in a murine model of muscle paralysis-induced bone loss. Frontiers in Endocrinology, 13. View this article in WRRO
He J, Zhou Y, Carrera HA, Wang N & Gartland A (2022) Defining the role of P2X4 receptor in the prostate cancer bone metastasis. Bone Reports, 16, 101209-101209.
Tattersall L, Gagui DC, Tippett VL, Latif NBA, Shah KM & Gartland A (2022) A systematic review of the expression, signalling and function of P2 receptors in primary bone cancer. Frontiers in Bioscience-Landmark, 27(4).
Jin Y, Liu Q, Chen P, Zhao S, Jiang W, Wang F, Li P, Zhang Y, Lu W, Zhong TP , Ma X et al (2022) A novel prostaglandin E receptor 4 (EP4) small molecule antagonist induces articular cartilage regeneration. Cell Discovery, 8(1).
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al (2021) The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties. Journal of Bone Oncology, 31. View this article in WRRO
Shah KM, Dunning MJ, Gartland A & Wilkinson JM (2021) Distinct concentration-dependent molecular pathways regulate bone cell responses to cobalt and chromium exposure from joint replacement prostheses. International Journal of Molecular Sciences, 22(10). View this article in WRRO
Roberts B, Cheong VS, Oliviero S, Carrera HA, Wang N, Gartland A & Dall'Ara E (2021) Oral Communications & Poster Abstracts. JBMR PLUS, 5.
He J, Zhou Y, Arredondo Carrera HM, Sprules A, Neagu R, Zarkesh SA, Eaton C, Luo J, Gartland A & Wang N (2020) Inhibiting the P2X4 receptor suppresses prostate cancer growth in vitro and in vivo, suggesting a potential clinical target. Cells, 9(11). View this article in WRRO
Agrawal A, Kruse LS, Vangsted AJ, Gartland A & Jørgensen NR (2020) Human P2X7 receptor causes cycle arrest in RPMI-8226 myeloma cells to alter the interaction with osteoblasts and osteoclasts. Cells, 9(11).
Roberts BC, Arredondo Carrera HM, Zanjani-pour S, Boudiffa M, Wang N, Gartland A & Dall’Ara E (2020) PTH(1–34) treatment and/or mechanical loading have different osteogenic effects on the trabecular and cortical bone in the ovariectomized C57BL/6 mouse. Scientific Reports, 10(1). View this article in WRRO
Hatzikotoulas K, Pickering GAE, Clark MJ, Felix-Ilemhenbhio F, Kocsy K, Simpson J, MacInnes SJ, Koprulu M, Southam L, Bellantuono I , Baidžajevas K et al (2019) Genome-wide association and functional analyses identify CASC20 and KIF26B as target loci in heterotopic ossification.
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A & Erler JT (2019) Correction: LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution. Cancer Research, 79(19), 5123-5123.
Wang N, Agrawal A, Jørgensen NR & Gartland A (2018) P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis. Scientific Reports, 8(1). View this article in WRRO
Steinberg J, Shah KM, Gartland A, Zeggini E & Wilkinson JM (2017) Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study. Journal of Orthopaedic Research, 35(10), 2323-2328. View this article in WRRO
Ellegaard M, Agca C, Petersen S, Agrawal A, Kruse LS, Wang N, Gartland A, Jensen J-EB, Jørgensen NR & Agca Y (2017) Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor. Purinergic Signalling.
Agca C, Syberg S, Jørgensen N, Gartland A & Agca Y (2016) Restoration of body composition and bone integrity following cryopreserved ovarian tissue auto-grafting in a rat model. Cryobiology, 73(3), 416-416.
Dastgheib SA, Gartland A, Tabei SMB, Omrani GR & Teare MD (2016) A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population. Frontiers in Endocrinology, 7. View this article in WRRO
Shah KM, Orton P, Mani N, Wilkinson JM & Gartland A (2016) Osteocyte physiology and response to fluid shear stress are impaired following exposure to cobalt and chromium: Implications for bone health following joint replacement.. Journal of Orthopaedic Research. View this article in WRRO
Gartland A, Erler JT & Cox TR (2016) The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis. Journal of Bone Oncology. View this article in WRRO
Proctor C & Gartland A (2016) Simulated Interventions to Ameliorate Age-Related Bone Loss Indicate the Importance of Timing. Frontiers in Endocrinology, 7. View this article in WRRO
Varley I, Greeves JP, Sale C, Friedman E, Moran DS, Yanovich R, Wilson PJ, Gartland A, Hughes DC, Stellingwerff T , Ranson C et al (2016) Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury. Purinergic Signalling, 12(1), 103-113.
Cox TR, Gartland A & Erler JT (2016) Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis. Cancer Research, 76(2), 188-192.
Cox TR, Schoof EM, Gartland A, Erler JT & Linding R (2015) Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism. Data in Brief, 5, 621-625. View this article in WRRO
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR , Huggins ID et al (2015) The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase. Nature, 522(7554), 106-110. View this article in WRRO
Shah KM, Wilkinson JM & Gartland A (2015) Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro. Journal of Orthopaedic Research, 33(11), 1663-1670. View this article in WRRO
Agrawal A & Gartland A (2015) P2X7 receptors: role in bone cell formation and function. Journal of Molecular Endocrinology, 54(2), R75-R88.
Shah KM, Quinn PD, Gartland A & Wilkinson JM (2015) Understanding the tissue effects of tribo-corrosion: Uptake, distribution, and speciation of cobalt and chromium in human bone cells. Journal of Orthopaedic Research, 33(1), 114-121.
Giuliani AL, Colognesi D, Ricco T, Roncato C, Capece M, Amoroso F, Wang QG, De Marchi E, Gartland A, Di Virgilio F & Adinolfi E (2014) Trophic Activity of Human P2X7 Receptor Isoforms A and B in Osteosarcoma. PLoS ONE, 9(9). View this article in WRRO
Gartland A & Hocking LJ (2014) Editorial overview: Musculoskeletal: Are we on the road to personalised medicine in musculoskeletal diseases?. Curr Opin Pharmacol, 16, vii-ix.
Wang N & Gartland A (2014) Targeting P2 receptors--current progress in treating musculoskeletal diseases.. Curr Opin Pharmacol, 16, 122-126. View this article in WRRO
Wang N, Robaye B, Gossiel F, Boeynaems J-M & Gartland A (2014) The P2Y13 receptor regulates phosphate metabolism and FGF-23 secretion with effects on skeletal development.. FASEB J, 28(5), 2249-2259. View this article in WRRO
Biver G, Wang N, Gartland A, Orriss I, Arnett TR, Boeynaems JM & Robaye B (2013) Role of the P2Y13 receptor in the differentiation of bone marrow stromal cells into osteoblasts and adipocytes. Stem Cells, 31(12), 2747-2758. View this article in WRRO
Wang N & Gartland A (2013) Role of the P2X7 receptor in the osteogenic differentiation of mesenchymal cells and in osteoclast fusion: Presented by: Maria P. Abbracchio. Purinergic Signalling, 9(3), 281-284. View this article in WRRO
Wang N, Rumney RMH, Yang L, Robaye B, Boeynaems J-M, Skerry TM & Gartland A (2013) The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading.. J Bone Miner Res, 28(6), 1446-1456. View this article in WRRO
Gheryani N, Coffelt SB, Gartland A, Rumney RMH, Kiss-Toth E, Lewis CE, Tozer GM, Greaves DR, Dear TN & Miller G (2013) Generation of a novel mouse model for the inducible depletion of macrophages in vivo.. Genesis, 51(1), 41-49.
Syberg S, Petersen S, Beck Jensen JE, Gartland A, Teilmann J, Chessell I, Steinberg TH, Schwarz P & Jorgensen NR (2012) Genetic background strongly influences the bone phenotype of P2X7 receptor knockout mice. Journal of Osteoporosis, 2012. View this article in WRRO
Cox TR, Gartland A & Erler JT (2012) The pre-metastatic niche: is metastasis random?. BoneKEy Reports, 1(5).
Gartland A, Skarratt KK, Hocking LJ, Parsons C, Stokes L, Jørgensen NR, Fraser WD, Reid DM, Gallagher JA & Wiley JS (2012) Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.. Eur J Hum Genet, 20(5), 559-564. View this article in WRRO
Gartland A (2012) P2X receptors in bone. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling, 1(2), 221-227.
Rumney RMH, Wang N, Agrawal A & Gartland A (2012) Purinergic signalling in bone.. Front Endocrinol (Lausanne), 3, 116. View this article in WRRO
Jørgensen NR, Husted LB, Skarratt KK, Stokes L, Tofteng CL, Kvist T, Jensen J-EB, Eiken P, Brixen K, Fuller S , Clifton-Bligh R et al (2012) Single-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fractures. European Journal of Human Genetics.
Wang N, Robaye B, Agrawal A, Skerry TM, Boeynaems J-M & Gartland A (2012) Reduced bone turnover in mice lacking the P2Y13 receptor of ADP.. Mol Endocrinol, 26(1), 142-152. View this article in WRRO
Dillon JP, Waring-Green VJ, Taylor AM, Wilson PJM, Birch M, Gartland A & Gallagher JA (2012) Primary human osteoblast cultures.. Methods Mol Biol, 816, 3-18.
Gartland A, Orriss IR, Rumney RMH, Bond AP, Arnett T & Gallagher JA (2012) Purinergic signalling in osteoblasts.. Front Biosci (Landmark Ed), 17, 16-29.
Agrawal A, Gallagher JA & Gartland A (2012) Human osteoclast culture and phenotypic characterization.. Methods Mol Biol, 806, 357-375.
Gartland A, Rumney RMH, Dillon JP & Gallagher JA (2012) Isolation and culture of human osteoblasts.. Methods Mol Biol, 806, 337-355.
Rumney RMH, Sunters A, Reilly GC & Gartland A (2012) Application of multiple forms of mechanical loading to human osteoblasts reveals increased ATP release in response to fluid flow in 3D cultures and differential regulation of immediate early genes.. J Biomech, 45(3), 549-554.
Orriss IR, Wang N, Burnstock G, Arnett TR, Gartland A, Robaye B & Boeynaems J-M (2011) The P2Y(6) receptor stimulates bone resorption by osteoclasts.. Endocrinology, 152(10), 3706-3716. View this article in WRRO
Andrews RE, Shah KM, Wilkinson JM & Gartland A (2011) Effects of cobalt and chromium ions at clinically equivalent concentrations after metal-on-metal hip replacement on human osteoblasts and osteoclasts: implications for skeletal health.. Bone, 49(4), 717-723. View this article in WRRO
Orriss I, Syberg S, Wang N, Robaye B, Gartland A, Jorgensen NR, Arnett T & Boeynaems JM (2011) Bone phenotypes of P2 receptor knockout mice. Frontiers in Bioscience(S3), 1038-1046.
Wesselius A, Bours MJL, Agrawal A, Gartland A, Dagnelie PC, Schwarz P & Jorgensen NR (2011) Role of purinergic receptor polymorphisms in human bone. FRONT BIOSCI-LANDMRK, 16, 2572-2585.
Barker HE, Chang J, Cox TR, Lang G, Bird D, Nicolau M, Evans HR, Gartland A & Erler JT (2011) LOXL2-mediated matrix remodeling in metastasis and mammary gland involution.. Cancer Res, 71(5), 1561-1572.
Gartland A (2011) Fast Facts: Osteoporosis, 6th edition. PERSPECT PUBLIC HEAL, 131(1), 48-48.
(2010) 1st UK Purine Symposium. Purinergic Signalling, 6(1), 125-144.
Agrawal A, Buckley KA, Bowers K, Gaw A, Furber M, Gallagher JA & Gartland A (2010) The Effect of Different P2X(7) Receptor Antagonists on the Formation and Function of Human Osteoclast in vitro. PURINERG SIGNAL, 6(1), 139-140.
Agrawal A, Buckley KA, Bowers K, Furber M, Gallagher JA & Gartland A (2010) The effects of P2X7 receptor antagonists on the formation and function of human osteoclasts in vitro. Purinergic Signalling, 6(3), 307-315.
Gartland A (2010) The role of the P2X←7 receptor in bone cell function..
Gartland A, Mason-Savas A, Yang M, MacKay CA, Birnbaum MJ & Odgren PR (2009) Septoclast deficiency accompanies postnatal growth plate chondrodysplasia in the toothless (tl) osteopetrotic, colony-stimulating factor-1 (CSF-1)-deficient rat and is partially responsive to CSF-1 injections. American Journal of Pathology, 175(6), 2668-2675.
Chan BY, Gartland A, Wilson PJM, Buckley KA, Dillon JP, Fraser WD & Gallagher JA (2007) PPAR agonists odulate human osteoclast formation and activity in vitro. BONE, 40(1), 149-159.
Gartland A, Mechler J, Mason-Savas A, MacKay CA, Mailhot G, Marks SC & Odgren PR (2005) In vitro chondrocyte differentiation using costochondral chondrocytes as a source of primary rat chondrocyte cultures: An improved isolation and cryopreservation method. Bone, 37(4), 530-544.
Devraj K, Bonassar LJ, MacKay CA, Mason-Savas A, Gartland A & Odgren PR (2004) A New Histomorphometric Method to Assess Growth Plate Chondrodysplasia and Its Application to theToothless(tl, Csf1nullOsteopetrotic Rat. Connective Tissue Research, 45(1), 1-10.
Wise GE & Yao S (2003) Expression of Vascular Endothelial Growth Factor in the Dental Follicle. Critical Reviews in Eukaryotic Gene Expression, 13(2-4), 8-8.
Gartland A, Buckley KA, Bowler WB & Gallagher JA (2003) Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.. Calcif Tissue Int, 73(4), 361-369.
Odgren PR, Philbrick WM & Gartland A (2003) Perspective osteoclastogenesis and growth plate chondrocyte differentiation: Emergence of convergence. CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 13(2-4), 181-193.
Wise GE & Yao S (2003) Expression of vascular endothelial growth factor in the dental follicle.. Crit Rev Eukaryot Gene Expr, 13(2-4), 173-180.
Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessell I, Bowler WB & Gallagher JA (2003) Multinucleated osteoclast formation in vivo and in vitro by P2X(7) receptor-deficient mice. CRIT REV EUKAR GENE, 13(2-4), 243-253.
Gartland A, Buckley KA, Hipskind RA, Bowler WB & Gallagher JA (2003) P2 receptors in bone - Modulation of osteoclast formation and activity via P2X(7) activation. CRIT REV EUKAR GENE, 13(2-4), 237-242.
Buckley KA, Hipskind RA, Gartland A, Bowler WB & Gallagher JA (2002) Adenosine triphosphate stimulates human osteoclast activity via upregulation of osteoblast-expressed receptor activator of nuclear factor-kappa B ligand.. Bone, 31(5), 582-590.
Bowler WB, Buckley KA, Gartland A, Hipskind RA, Bilbe G & Gallagher JA (2001) Extracellular nucleotide signaling: a mechanism for integrating local and systemic responses in the activation of bone remodeling.. Bone, 28(5), 507-512.
Gartland A, Hipskind RA, Gallagher JA & Bowler WB (2001) Expression of a P2X7 receptor by a subpopulation of human osteoblasts.. J Bone Miner Res, 16(5), 846-856.
Tattersall L, Agrawal A, Adinolfi E & Gartland A () EU COST Action CA21130 PRESTO ‘P2X receptors as therapeutic targets’ inaugural meeting report. Purinergic Signalling.
Song H, Arredondo Carrera HM, Sprules A, Ji Y, Zhang T, He J, Lawrence E, Gartland A, Luo J & Wang N () C‐terminal variants of the P2X7 receptor are associated with prostate cancer progression and bone metastasis – evidence from clinical and pre‐clinical data. Cancer Communications.
Tippett VL, Tattersall L, Ab Latif NB, Shah KM, Lawson MA & Gartland A () The strategy and clinical relevance of in vitro models of MAP resistance in osteosarcoma: a systematic review. Oncogene.
Yue Z, Niu X, Yuan Z, Qin Q, Jiang W, He L, Gao J, Ding Y, Liu Y, Xu Z , Li Z et al () RSPO2/RANKL-LGR4 signaling regulates osteoclastic pre-metastatic niche formation and bone metastasis. Journal of Clinical Investigation.
Gartland A () Purinergic ADP receptors: from block buster blood drugs to bone-disease busters. IBMS BoneKEy, 10.

Chapters

Tattersall L, Davison Z & Gartland A (2020) Osteosarcoma, Encyclopedia of Bone Biology (pp. 362-378). Elsevier
Buckley KA, Gartland A & Gallagher JA (2006) The role of purinergic signaling in the interactions between skeletal cells, Nucleotides and Regulation of Bone Cell Function (pp. 61-74).
Gartland A, Buckley KA, Dillon JP, Curran JM, Hunt JA & Gallagher JA (2005) Isolation and culture of human osteoblasts. (pp. 29-54).

Conference proceedings papers

Sprules AR, Latif NB, Brown JE, Gartland A & Wang N (2021) Abstract 2904: Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone. Cancer Research, Vol. 81(13_Supplement) (pp 2904-2904)
Gartland A (2021) Primordial signalling in prehistoric cancer. JOURNAL OF ANATOMY, Vol. 238(1) (pp 191-191)
Sprules AR, Latif NB, Brown JE, Gartland A & Wang N (2021) Mechanical loading induced osteogenic response does not interfere with the colonization of breast cancer in bone.. CANCER RESEARCH, Vol. 81(13)
Roberts B, Carrera HA, Pour SZ, Boudiffa M, Gartland A, Wang N & Dall'Ara E (2019) Longitudinal Effects of Combined Bone Anabolic Interventions on Ovariectomised Mice. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 34 (pp 258-259)
Tattersall L, De Marchi E, Williamson A, Di VF, Lawson MA, Adinolfi E & Gartland A (2018) P2X7R in primary bone cancer. PURINERGIC SIGNALLING, Vol. 14 (pp S13-S14)
Syberg S, Agrawal A, Petersen S, Jensen J-EB, Schwarz P, Gartland A, Boes M & Jorgensen N (2014) The P2X7 Antagonist AFC-5261 rescues Ovariectomy-induced Bone Loss in Mice.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 29 (pp S402-S403)
Dillon J, Wilson P, Gartland A, Hipskind R & Gallagher J (2013) A Novel Factor Derived From Resorbing Bone In Vitro Potently Stimulates C-Fos Expression In Breast Cancer Cells. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
Wang QG, Adinolfi E & Gartland A (2013) P2X7 Receptor Polymorphisms Modulate Osteoblast Cell Functions. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 28
Wang QG, Mohanty S, Bellantuono I & Gartland A (2012) TIBIAL PLATEAU BONE SURFACE ROUGHNESS - A POTENTIAL NEW EARLY MARKER TO DETECT ARTHRITIS?. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S574-S574)
Shah K, Quinn P, Wilkinson M & Gartland A (2012) SPECIATION AND DISTRIBUTION OF COBALT AND CHROMIUM IN OSTEOBLASTS AND OSTEOCLASTS USING MICROFOCUS X-RAY FLUORESCENCE AND X-RAY ABSORPTION NEAR-EDGE STRUCTURE. OSTEOPOROSIS INTERNATIONAL, Vol. 23 (pp S592-S592)
Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S85-S86)
Syberg S, Agca C, Wang N, Petersen S, Gartland A, Schwarz P, Jorgensen NR & Agca Y (2012) P2Y2 receptor overexpression results in decreased bone formation. BONE, Vol. 50 (pp S67-S67)
Greeves J, Fraser W, Friedman E, Wilson P, Dillon J, Gartland A & Gallagher J (2012) Association of polymorphisms in the P2X7 receptor gene with stress fracture risk in military recruits. BONE, Vol. 50 (pp S108-S108)
Agrawal A & Gartland A (2011) Expression of NFATc1 is inducible by P2X7 receptor activation in human osteoclasts. BONE, Vol. 48 (pp S126-S126)
Wang N, Robaye B, Agrawal A, Reilly G, Boeynaems JM & Gartland A (2011) Deletion of the P2Y13 receptor leads to reduced bone turnover and protection from ovariectomy-induced bone loss. BONE, Vol. 48 (pp S227-S227)
Evans HR, Ab Latif N, Cox TR, Bird D, Lang G, Erler JT & Gartland A (2011) Tumour-secreted lox mediates osteolytic bone metastases prior to metastatic tumour cell colonisation. BONE, Vol. 48(1) (pp S21-S21)
Syberg S, Schwarz P, Petersen S, Jensen JEB, Steinberg TH, Gartland A, Chessell I & Jorgensen NR (2010) Bone status of P2X7 knockout mice in two different strains. PURINERG SIGNAL, Vol. 6 (pp 158-158)
Shah K, Patel V, Wang N & Gartland A (2010) The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. PURINERG SIGNAL, Vol. 6(1) (pp 140-140)
Wang N, Rumney RMH, Agrawal A, Robaye B, Boeynaems JM & Gartland A (2010) Bone Phenotype of P2Y13 Receptor Knock-Out Mice. PURINERG SIGNAL, Vol. 6(1) (pp 144-144)
Rumney RMH, Wang N & Gartland A (2010) The role of P2X(7) receptors in ATP release from osteoblasts. PURINERG SIGNAL, Vol. 6(1) (pp 129-129)
Andrews R, Wilkinson J & Gartland A (2010) The effect of cobalt and chromium ions at clinically relevant concentrations on human osteoblast and osteoclast physiology in vitro: implications for skeletal health. BONE, Vol. 46 (pp S71-S71)
Orriss IR, Burnstock G, Gartland A & Arnett TR (2009) Regulation of osteoblast function and mineralisation by extracellular nucleotides: The role of P2Y and P2X receptors. BONE, Vol. 44 (pp S154-S154)
Gartland A, Skarratt KK, Hocking LJ, Stokes L, Clifton-Bligh R, Parsons C, Fraser WD, Reid DM, Wiley JS & Gallagher JA (2008) Loss of Function Polymorphisms in The P2X(7) Receptor Gene Are Associated with Accelerated Lumbar Spine Bone Loss in Postmenopausal Women.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S296-S296)
Gartland A, Buckley KA, Bowers K, Gaw A, Furber M & Gallagher JA (2008) A Novel Selective P2X(7) Receptor Antagonist Inhibits Human Osteoclast Formation in vitro.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 23 (pp S403-S403)
Orriss IR, Evans HR, Gartland A & Arnett TR (2008) Microct analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. CALCIFIED TISSUE INT, Vol. 83(1) (pp 2-3)
Rumney RMH, Sittichokechaiwut A, Reilly G & Gartland A (2008) ATP release from osteoblasts is increased in response to mechanical loading by different amounts when grown in standard monolayer and novel 3D scaffolds. CALCIFIED TISSUE INT, Vol. 83(1) (pp 16-16)
Patel V, Rumney R, Wang N, Hipskind RH, Gallagher JA & Gartland A (2008) The effect of ATP, alone and in combination with EGF, on breast cancer cell survival. PURINERG SIGNAL, Vol. 4 (pp S205-S206)
Gartland A, Skarratt K, Hocking L, Clifton-Bligh R, Parsons C, Fraser W, Reid D, Wiley J & Gallagher J (2008) A polymorphism in the P2X7 receptor gene is associated with loss of lumbar spine bone mineral density in postmenopausal women. PURINERG SIGNAL, Vol. 4 (pp S172-S173)
Orriss I, Evans H, Arnett T & Gartland A (2008) MicroCT analysis of P2Y1 and P2Y2 receptor knockout mice demonstrates significant changes in bone phenotype. PURINERG SIGNAL, Vol. 4 (pp S176-S176)
Gallagher JA, Dillon JP, Kimani BM, Hayton MJ & Gartland A (2008) Regulation and mechanisms of ATP release from osteoblasts. PURINERG SIGNAL, Vol. 4 (pp S161-S161)
Rumney R, Wang N, Sittichokechaiwut A, Reilly G & Gartland A (2008) Different types of mechanical loading induce differentitial ATP release from osteoblasts grown on 3-dimensional scaffolds. PURINERG SIGNAL, Vol. 4 (pp S164-S165)
Rumney RMH, Sittichokechaiwut A, Reilly GC & Gartland A (2008) Cyclical compressive loading induces changes in cellular behaviour and ATP release from osteoblasts grown on 3-dimensional scaffolds. CALCIFIED TISSUE INT, Vol. 82 (pp S115-S116)
Gartland A, Skarrat KK, Hocking LJ, Clifton-Bligh R, Parsons C, Fraser WD, Reid DM, Gallagher JA & Wiley JS (2008) Novel association between a polymorphism in the P2X7 receptor gene and loss of lumbar spine bone mineral density in postmenopausal women. CALCIFIED TISSUE INT, Vol. 82 (pp S43-S43)
Gallaigher JA, Dillon JP, Wilson PM, Burrell HE, Hayton MJ, Fraser WD & Gartland A (2007) ATP is released from human osteoblasts by multiple mechanisms.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 22 (pp S146-S146)
Mwaura BK, Hayton MJ, Dillon JP, Burrell HE, Gallagher JA & Gartland A (2006) Release of ATP from human osteoblastic cell lines and primary osteoblasts occurs via exocytosis. BONE, Vol. 38(3) (pp S11-S11)
Gartland A, Hipskind RA, Fraser WD & Gallagher JA (2006) The synergistic effect of extracellular nucleotides and EGF on c-fos expression in two breast cancer cell lines. BONE, Vol. 38(3) (pp S35-S35)
Buckley KA, Dillon JP, Chan BYY, Gartland A, Fraser WD & Gallagher JA (2006) Low dose PTH, insufficient to induce cyclic AMP or C-fos, stimulates an anabolic gene response in human osteoblasts in vitro. BONE, Vol. 38(3) (pp S10-S11)
(2006) Regulation of ATP release from human osteoblasts: A calcium dependant, exocytotic vesicular mechanism. CALCIFIED TISSUE INTERNATIONAL, Vol. 78 (pp S49-S49)
Chan BY, Buckley KA, Wilson PJ, Wherly N, Cheng Y, Dillon JP, Gartland A, Fraser WD & Gallagher JA (2005) Differential effect of PPAR agonists on human recombinant RANKL generated osteoclast culture in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1303-1303)
Gartland A, Buckley KA, Dillon JP, Curran JM, Chan BYY, Fraser WD & Gallagher JA (2005) A biphasic pattern of osteoblast gene expression by differing concentrations of PTH 1-34. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1308-1308)
Gartland A, Wilson PJ, Dillon JP, Chan BY, Buckley KA, Fraser WD & Gallagher JA (2005) ATP release and P2 receptor expression by human chondrocytes.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 20(7) (pp 1301-1301)
Chan BYY, Buckley KA, Wilson PJ, Wherly N, Cheng JY, Dillon JP, Gartland A, Fraser WD & Gallagher JA (2005) Effect of PPAR agonists, on human osteoclast formation and activity in vitro. BONE, Vol. 36 (pp S300-S301)
Mailhot G, Gartland A, Mason-Savas A, Mackay CA & Odgren PR (2005) Cellular and molecular characterization of primary rat chondrocytes differentiated in culture. BONE, Vol. 36 (pp S173-S173)
Gartland A, Fraser WD, Gallagher JA & Hipskind RA (2005) The effects of extracellular nucleotides on EGF-induced c-fos gene expression. BONE, Vol. 36 (pp S256-S256)
Chan BY, Buckley KA, Gartland A, Fraser WD & Gallagher JA (2005) Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S32-S32)
Chan BY, Buckley KA, Gartland A, Fraser WD & Gallagher JA (2005) Differential effect of PPAR agonists on generation of human osteoclasts in vitro. CLINICA CHIMICA ACTA, Vol. 355 (pp S255-S255)
Gartland A, Mason-Savas A, MacKay C, Lee ER, Mort J, Odgren PR & Marks SC (2004) Abnormal septoclasts at the chondroosseous junction in the TL rat are normalised following CSF-1 treatment. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 19(6) (pp 1049-1049)
Odgren PR, Gartland A, Gartland A, Devraj K, Bonassar LJ, MacKay C & Mason-Savas A (2004) Osteopetrotic chondrodysplasia in the toothless (CSF-1null) rat: A paradigm for the role of osteoclastogenic factors as integrators of endochondral ossification. BONE, Vol. 34 (pp S38-S38)
Gartland A, Mason-Savas A, MacKay C, Lee ER, Mort J, Odgren PR & Marks SC (2003) CSF-1 treatment corrects septoclast abnormalities at the chondroosseous junction in the Toothless rat.. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18 (pp S111-S111)
Gartland A, Mason-Savas A, MacKay CA, Marks SC & Odgren PR (2003) Chondrocytes from the osteopetrotic mutation toothless (TL)/Csf-1 null rat differentiate in vitro. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 18(7) (pp 1370-1370)
Gartland A, Mason-Savas A, MacKay CA, Marks SC & Odgren PR (2002) Chondrocytes, growth plates, and RANKL-induced signalling: Observations and implications of osteopetrotic mutations. JOURNAL OF BONE AND MINERAL RESEARCH, Vol. 17(7) (pp 1339-1339)
Gartland A, Buckley KA, Hipskind RA, Perry MJ, Tobias JH, Buell G, Chessel I, Bowler WB & Gallagher JA (2002) P2X(7) receptor-deficient mice maintain the ability to form multinucleated) osteoclasts in vivo and in vitro. J BONE MINER RES, Vol. 17(7) (pp 1338-1338)
Gartland A, Gallagher JA & Bowler WB (2001) Blockade of P2X(7) receptors inhibits osteoclast fusion in vitro. BONE, Vol. 28(5) (pp S166-S167)
Bowler WB, Gartland A, Buckley KA, Golding SL & Gallagher JA (2000) ATP released into the extracellular environment by osteoblasts regulates differentiation and apoptosis of bone cells.. J BONE MINER RES, Vol. 15 (pp S476-S476)
Gartland A, Gallagher JA & Bowler WB (2000) Expression of the pore forming P2X(7) receptor by human rank ligand-generated osteoclasts and human osteoclastic cells in situ.. J BONE MINER RES, Vol. 15(6) (pp 1227-1227)
Shah KM () The Effect of ATP on cancer cell proliferation in vitro -involvement of multiple P2X Receptors. Purinergic Signalling, Vol. 6(1) (pp 140). Sheffield

Preprints

Coleman JC, Tattersall L, Yianni V, Knight L, Yu H, Hallett S, Johnson P, Caetano A, Cosstick C, Ridley A , Gartland A et al (2023) The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis, Cold Spring Harbor Laboratory.
Roberts BC, Cheong VS, Oliviero S, Carrera HMA, Wang N, Gartland A & Dall’Ara E (2022) Combining PTH(1-34) and mechanical loading has increased benefit to tibia bone mechanics in ovariectomised mice, Research Square Platform LLC.
Shah KM, Tattersall L, Hussain A, Macfarlane SC, Williamson A, Acosta-Martin AE, Erler JT, Ottewell PD & Gartland A () P2RX7 inhibition reduces breast cancer induced osteolytic lesions - implications for bone metastasis, Cold Spring Harbor Laboratory.
Tattersall L, Shah KM, Lath DL, Singh A, Down JM, De Marchi E, Williamson A, Di Virgilio F, Heymann D, Adinolfi E , Fraser WD et al () The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties.

Research group

Current Collaborators

Professor Mark Wilkinson
Dr Dawn Teare
Dr Gaynor Miller
Dr Shelly Lawson

Postgraduate Students

Mr Luke Tattersall

Teaching interests: I am Chair of the Medical School Graduate Research Committee, I lecture on the undergraduate Medical Course as well as being the academic lead for the research Attachment SSC, I also run the Doctoral Development Programme module "Effective Presentation and Seminar Participation" MED605.

Professional activities and memberships: I am the Founder and President of the UK Purine Club, and member of the Bone Research Society, European Calcified Tissue Society, the International Bone and Mineral Society and the American Society for Bone and Mineral Research.