Representative Publications

Gravells P, Hoh L, Solovieva S, Patil A, Dudziec E, Rennie IG, Sisley K, Bryant HE.
Reduced FANCD2 influences spontaneous SCE and RAD51 foci formation in uveal melanoma and Fanconi anaemia.
Oncogene 2013 Jan ;14. doi: 10.1038/onc.2012.627. [Epub ahead of print]

Wong IN, Sayers JR, Sanders CM.
Characterization of an unusual bipolar helicase encoded by bacteriophage T5.
Nucleic Acids Res 2013 41: 4587-600. doi: 10.1093/nar/gkt105

Staples CJ, Myers KN, Beveridge RD, Patil AA, Lee AJ, Swanton C, Howell M, Boulton SJ & Collis SJ.
The centriolar satellite protein Cep131 is important for genome stability.
J Cell Sci. 125(20), 4770-4779, 2012

Camp NJ*, Parry P*, Knight S, Abo R, Elliott G, Rigas S, Balasubramanian SP, Reed MWR, McBurney H, Latif A, Newman WG, Cannon-Albright LA, Evans DG, Cox A.
Fine-mapping CASP8 risk variants in Breast Cancer.
Cancer Epidemiology, Biomarkers and Prevention 2012 21, 176-81

Whelan F, Stead JA, Shkumatov AV, Svergun DI, Sanders CM, Antson AA.
A flexible brace maintains the assembly of a hexameric replicative helicase during DNA unwinding.
Nucleic Acids Res 2012 40: 2271-83. doi: 10.1093/nar/gkr906

Fathers C, Drayton RM, Solovieva S, Bryant HE.
Inhibition of poly(ADP-ribose) glycohydrolase (PARG) specifically kills BRCA2-deficient tumor cells.
Cell Cycle. 2012 Mar 1;11(5). 990-997

Gagou ME, Ganesh A, Thompson R, Phear G, Sanders C, Meuth M.
Suppression of apoptosis by PIF1 helicase in human tumor cells.
Cancer Res 2011 71: 4998-5008. doi: 10.1158/0008-5472.CAN-10-4404

Gravells P, Hoh L, Canovas D, Rennie IG, Sisley K, Bryant H.
Resistance of uveal melanoma to the interstrand cross-linking agent mitomycin C is associated with reduced expression of CYP450R.
Br J Cancer. 2011 Mar 29;104(7):1098-105

Hoh L, Gravells P, Canovas D, Ul-Hassan A, Rennie IG, Bryant H, Sisley K.
Atypically low spontaneous sister chromatid exchange formation in uveal melanoma.
Genes Chromosomes Cancer. 2011 Jan;50(1):34-42.

Dudziec E et al.
Hypermethylation of CpG Islands and Shores adjacent to mirtron and microRNA genes in bladder cancer.
Clin Cancer Res 2011 Jan 28

Lin WY, Camp NJ, Cannon-Albright LA, Allen-Brady K, Balasubramanian S, Reed MW, Hopper JL, Apicella C, Giles GG, Southey MC, Milne RL, Arias-Pérez JI, Menéndez-Rodríguez P, Benítez J, Grundmann M, Dubrowinskaja N, Park-Simon TW, Dörk T, Garcia-Closas M, Figueroa J, Sherman M, Lissowska J, Easton DF, Dunning AM, Rajaraman P, Sigurdson AJ, Doody MM, Linet MS, Pharoah PD, Schmidt MK, Cox A.
A role for XRCC2 gene polymorphisms in breast cancer risk and survival.
J Med Genet. 2011 Jul;48(7):477-84. Epub 2011 May 31.

Broeks, A et al.
Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: Findings from the Breast Cancer Association Consortium.
Hum Mol Genet. 2011 Aug 15;20(16):3289-303. doi: 10.1093/hmg/ddr228

Kote-Kote-Jarai, Z. et al. (2011)
Seven novel prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.
Nat Genet. 2011 Jul 10;43(8):785-91. doi: 10.1038/ng.882

Gagou, M.E., Zuazua-Villar, P. and Meuth, M.
Enhanced H2AX phosphorylation, DNA replication fork arrest and cell death in the absence of Chk1.
Mol. Biol. Cell 2010 21, 739-752.

Meuth, M.
Chk1 suppressed cell death (review).
Cell Division 2010 5:21doi:10.1186/1747-1028-5-21

Chu MLH, Lang Z, Chavas LMG, Neres J, Federova OS, Tabernero L, Cherry M, Williams DH, Douglas KT and Eyers PA.
Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes
Biochemistry 2010 49: 1689-1701

Chu MLH and Eyers PA.
UCSD/Nature Signaling Gateway, Molecule Pages: Mps1 2010

Sloane DA Trikic MZ, Lang Z, Chu MLH, Lamers MBAC, Mason CS, Mueller I, Savory WJ, Williams DH and Eyers PA.
Drug-Resistant Aurora A Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors MLN8054 and MLN8237
ACS Chem. Biol 2010 5: 563-576.

Sanders C.
Human Pif1 helicase is a G-quadruplex DNA binding protein with G-quadruplex DNA unwinding activity.
Biochem. J. 2010 430, 119-128.

Azzato, EM et al
Association Between a Germline OCA2 Polymorphism at chromosome 15q13.1 and estrogen receptor–Negative Breast cancer Survival
J Natl Cancer Inst. 2010 May 5;102(9):650-62. doi: 10.1093/jnci/djq057

Murad AS, Davey Smith G, Lewis SJ, Cox A, Donovan JL, Neal DE, Hamdy FC, Martin RM.
A polymorphism in the glucokinase gene that raises plasma fasting glucose, rs1799884, is associated with diabetes mellitus and prostate cancer: findings from a population-based, case-control study (the ProtecT study).
Int J Mol Epidemiol Genet. 2010 Apr 1;1(3):175-83

Blows, F. et al.
Subtyping of breast cancer by immunohistochemistry to investigate a relationship between subtype and short and long term survival: a collaborative analysis of data for 10,159 cases from 12 studies.
PLoS Med. 2010 May 25;7(5):e1000279. doi: 10.1371

Adamo A*, Collis SJ*, Adelman CA, Silva N, Ward JD, Martinez-Perez E, Boulton SJ & La Volpe A. (2010)
*co-first authorship
Preventing Non-Homologous End Joining Suppresses DNA repair defects of Fanconi Anemia.
Molecular Cell 39(1), 25-35 2010.

Owen HC, et al. (2010)
Low frequency of epigenetic events in urothelial tumors from young patients.
J Urol. 2010 Aug;184(2):459-63

Catto JWF, et al. (2010)
Microarray analysis using artificial intelligence identifies a novel progression signature for superficial bladder cancer.
Eur Urol 2010 Mar;57(3):398-406

Blundred R, Myers K, Helleday T, Goldman AS, Bryant HE. (2010)
Human RECQL5 overcomes thymidine-induced replication stress.
DNA Repair (Amst). 2010 Sep 4;9(9):964-75.

Gottipati P, Vischioni B, Schultz N, Solomons J, Bryant HE, Djureinovic T, Issaeva N, Sleeth K, Sharma RA, Helleday T. (2010)
Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.
Cancer Res. 2010 Jul 1;70(13):5389-98.

Loseva O, Jemth AS, Bryant HE, Schüler H, Lehtiö L, Karlberg T, Helleday T. (2010)
PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA.
J Biol Chem. 2010 Mar 12;285(11):8054-60.