Dr Steven A Julious BSc(Hons) MSc PhD

Professor of Medical Statistics

Medical Statistics Group, ScHARR
The University of Sheffield
Regent Court, 30 Regent Street
SHEFFIELD S1 4DA

Tel: +44 (0) 114 222 0709
Fax: +44 (0) 114 222 0749

Biography

I graduated with a BSc(Hons) in Mathematics, Statistics and Operational Research (MSOR) from the University of Manchester Institute of Science and Technology (UMIST) and an MSc in Biometry from the University of Reading. For my PhD from University College London, which I did part time while working in industry, I investigated the issue of designing clinical trials when you have imprecise estimates to base calculations on.

Statistically I have an interest in all aspects of clinical trials from molecule through to marketplace. My main research focus is clinical trial design and the development of new technologies related to clinical trials.

The methodologies around sample size estimation are a particular interest and as well as a book I have developed a mobile app for the calculations.

I also have an interest in asthma epidemiology and I am the Chief Investigator of the PLEASANT trial: Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term.

Research interests

My research interest include

Clinical trials
Clinical trial design
Early phase trials
Non-inferiority
Asthma epidemiology

Teaching activities

My teaching activities include

Module co-ordinator for HAR6036 including Intercalated BMedSci Medical Students and RTP Training Programme
Teach on MAS6062 Further Clinical Trials for the MSc in Statistics with Medical Applications
Teach on the MBChB degree programme
Teach on HAR6035

Professional activities

External to the university I am a Member of NICE appraisal Committee D and I am on the editorial board of the journals Pharmaceutical Statistics and Statistical Methods in Medical Research.

Within the university I am a member of the University Senate and Chair of the Advisory Board of the Clinical Trials Research Unit (CTRU).

Current projects

Chief Investigator

NHS Health Technology Assessment Programme. Preventing and Lessening Exacerbations of Asthma in School-age children Associated with a New Term (PLEASANT). Julious SA, Horspool M, Boote J, Smithson H, Elphick H, van Staa T, Davis S, Norman P and Cooper CL. £486,500.
NIHR Research Methods Fellowship. Adaptive designs in publicly funded research. Nicholl J and Julious SA. £91,000, 2011.

Co-Investigator

NIHR Doctoral Fellowship. Adaptive designs in publicly funded research: Munya Dimairo. Dimairo M, Julious SA, Nicholl J and Todd SC. £194,000.
Medical Research Council - National Prevention Research Initiative. Time to change! Using the transition from school to university to promote healthy lifestyle habits in young people (U@Uni). Norman P, Brennan A, Ciravegna F, Harris P, Julious SA, Meier PS, Naughton D, Petroczi A, Sheeran P and Webb T. £542,899.
Research for Patient Benefit. Evaluating the cost effectiveness of computer therapy compared with usual stimulation for people with long standing aphasia: a pilot study (CACTUS). Palmer R, Julious SA, Enderby P and Cooper C. £250,000.
NHS Health Technology Assessment Programme. Randomised Assessment of Treatment using Panel Assay of Cardiac markers (RATPAC). Goodacre A, Julious SA, Oluboyede Y, Dixon S, Hall A, Barth J, Hassan T, Collinson P, Newby D, Gray A, Capewell S, Benger J and Coats T. HAT 06/302/19 £716,500.

Key Publications

Key publications since 2008

Books

Julious SA. Sample sizes for clinical trials. Chapman and Hall, 2009
Julious SA. Early phase trials. Wiley, 2010

Papers

Julious SA and Campbell MJ. Tutorial in Biostatistics: Sample Sizes for clinical trials with binary data. Statistics in Medicine (DOI: 10.1002/sim.5381)
Sutton, L., Julious, S.A., Goodacre, S.W. Influence of Adaptive Analysis on Unnecessary Patient Recruitment: Reanalysis of the RATPAC Trial. Annals of Emergency Medicine (DOI: 10.1016/j.annemergmed.2012.03.032)
Julious SA. Safety and efficacy of SSRIs. Statistical Methods in Medical Research (DOI: 10.1177/0962280211432210).
Julious SA and McIntyre N. Sample size considerations with multiple must win comparisons. Pharmaceutical Statistics 2012: 11(2): 177-185
Julious SA and Whitehead A. Investigating the assumption of homogeneity of effect in clinical studies with application to-meta analysis. Pharmaceutical Statistics 2012: 11(1): 49-56
Julious SA. The ABC of non-inferiority margin setting: an investigation of approaches. Pharmaceutical Statistics 2011 10(5):448-53
Senn, S, Rolfe K and Julious SA. Assessing response in clinical trials. Statistical Methods in Medical Research (DOI:10.1177/0962280210379174).
Julious SA, Campbell MJ, Bianchi SM and Murray-Thomas T. Seasonality of medical contacts in school-aged children with asthma: Association with school holidays. Public Health 2011:125(11):769-76
Julious SA and Owen R. Sample size calculations for non-inferiority studies with binary outcomes. Statistical Methods in Medical Research 2011:20(6);595-612
Julious SA, Jain, R and Mason S. Environmental triggers of hospital admissions for school-age children with asthma in two British cities. Emerg Med J doi:10.1136/emj.2011.114546
Matcham J, Julious SA, Pyke S, O’Kelly M, Todd S, Davies J, Seldrup J and Day S. Proposed best practice for statisticians in the reporting of industry sponsored clinical trials in medical journals. Pharmaceutical Statistic (DOI: 10.1002/pst.417)
Senn S and Julious SA. Assessing the repeatability of response in clinical trials. Statistics in Medicine 2009 28:3189-3209
Julious SA and Wang SJ. Issues with indirect comparisons in clinical trials particularly with respect to non-inferiority trials. DIJ 2008: 42(6): 625-33

View a full list of publications here.

Section

I am based in the Designs, Trials & Statistics section.