Welcome to the REPOSE study website
REPOSE: The Relative Effectiveness of Pumps over MDI and Structured Education for Type-1 diabetes
The REPOSE study is a multicentre randomised controlled trial comparing optimised multiple insulin injections (MDI) therapy (using rapid and twice daily long-acting insulin analogues) with CSII (pump therapy) in adult type-1 diabetic patients provided with high quality structured education (Dose Adjustment for Normal Eating-DAFNE).
Insulin is generally administered by multiple injections (MDI) with the dose adjusted according to eating and exercise. Insulin can now also be administered using a pump (CSII), which is a device, roughly the size of a mobile phone and containing sufficient insulin to supply both the needs of basal metabolism throughout the day, and the boluses which have to cover meals. The use of CSII is expensive compared to injections, but there are important potential benefits which include improved glycaemic control, reduced risk of hypoglycaemia (low blood sugar) and a more flexible lifestyle and better quality of life. There have been no trials in adults that have compared CSII treatment with MDI where the same structured training in intensive insulin therapy has been given, so the precise benefit of the pump technology is still unclear.
The REPOSE trial aims to establish the added benefit of insulin pump therapy MDI on glycaemic control and hypoglycaemia in individuals with Type 1 diabetes receiving similar high quality structured training in insulin therapy (DAFNE).
The study is currently recruiting patients.
Project Staff |
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|---|---|---|---|
| Name | Site | Telephone number | |
| Simon Heller Chief Investigator |
School of Medicine, University of Sheffield |
+44 (0)114 271 3204 | s.heller@sheffield.ac.uk |
| Cindy Cooper Director of CTRU |
ScHARR | +44 (0)114 22 20743 | c.l.cooper@sheffield.ac.uk |
| Diana Papaioannou Trial Manager |
ScHARR | +44 (0)114 22 20766 | d.papaioannou@sheffield.ac.uk |
|
Gemma Hackney |
ScHARR | +44 (0)114 22 24343 | g.hackney@sheffield.ac.uk |
|
Lucy Wraith |
ScHARR | +44 (0)114 22 20866 | l.wraith@sheffield.ac.uk |
| David White Research Assistant |
ScHARR | +44 (0)114 22 20807 | d.a.white@sheffield.ac.uk |
| Tim Chater Data Manager |
ScHARR | +44 (0)114 22 20876 | t.chater@sheffield.ac.uk |
|
Kirsty Pemberton |
ScHARR | +44 (0) 114 22 20861 | k.j.pemberton@sheffield.ac.uk |
| Mike Campbell Statistician |
ScHARR | +44 (0)114 22 20839 | m.j.campbell@sheffield.ac.uk |
| Munyaradzi Dimairo Statistician |
ScHARR | +44 (0) 114 222 5204 | m.dimairo@sheffield.ac.uk |
| Simon Dixon Professor of Health Economics |
ScHARR | +44 (0)114 22 20724 | s.dixon@sheffield.ac.uk |
| Hasan Basarir Health Economist |
ScHARR | +44 (0)114 22 26397 | h.basarir@sheffield.ac.uk |
| Alan Brennan Professor of Health Economics and Decisions Modelling |
ScHARR | +44 (0)114 22 20684 | a.brennan@sheffield.ac.uk |
| Jen Kruger Health Economist |
ScHARR | +44 (0)114 22 25207 | j.kruger@sheffield.ac.uk |
| Dr Kath Barnard Psychosocial Quantitative Research Fellow |
University of Southampton | + 44 (0) 2380 595548 | K.Barnard@soton.ac.uk |
| Dr Julia Lawton Qualitative Psychosocial Research Fellow |
University of Edinburgh | +44 (0) 1316 506197 | j.lawton@ed.ac.uk |
| Professor Norman Waugh Deputy Chief Investigator |
University of Warwick | norman.waugh@warwick.ac.uk | |
| Gill Thompson National DAFNE director |
Central DAFNE | +44 (0) 1912 934023 | gillian.thompson@northumbria-healthcare.nhs.uk |
Participating Centres |
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|---|---|---|
| Centre name |
Principal Investigator | Educators- DSNs and dieticians |
| Sheffield Teaching Hospitals NHS Foundation Trust | Simon Heller Co-investigator: Jackie Elliott |
Carolin Taylor Carla Gianfrancesco Valerie Gordon Val Nayor Karen Towse |
| Addenbrookes Hospital, Cambridge | Mark Evans Co-investigator: Leila Faghahati |
Candice Ward Sara Hartnell Sarah Donald Katy Davenport Kulbir Kaur Pabla Jane Baillie Karen Callaby Helen Davies |
| Harrogate District Hospital | Peter Hammond Co-investigator: Sutapa Ray |
Janet Carling Joyce Lodge Laura Dinning |
| King’s College Hospital, London | Stephanie Amiel Co-investigator: Pratik Choudhary |
Anita Beckwith Helen Rogers Chris Cheyette Vicky Deprez Alison Cox Philippa Marks |
| Dumfries and Galloway Royal Infirmary | Fiona Green | Pam Young Sheena McDonald Katy Valentine |
| Glasgow Royal Infirmary | Robert Lindsay Co-investigator: Brian Kennon |
Janice Shepherd Ann Boal Bernadette Quinn Emma Gibb |
| Royal Infirmary of Edinburgh | Alan Jaap Co-investigator: Alan Patrick |
Alyson Hutchison |
Sheffield School of Health and Related Research
University of Sheffield
30 Regent Court
Sheffield
S1 4DA
Tel: +44 (0)114 2225454
Fax: +44(0)114 2724095