Welcome to the SABRE study website
SABRE: Hypertonic Saline in Acute Bronchiolitis: A Randomised Controlled Trial and Economic Evaluation
The SABRE study is a randomised controlled trial and economic evaluation of hypertonic saline in acute bronchiolitis in babies taking place in nine NHS hospitals around the United Kingdom.
Acute bronchiolitis is a common, distressing illness affecting young children. A virus infects the lungs, and the airways become blocked, leading to breathing difficulties, particularly in those under 6 months of age. Current treatment (after 40 years of research) involves suppportive care and oxygen. The SABRE trial aims to determine if giving babies nebulised hypertonic saline (salt water sprayed as a mist so they can breath it in) will reduce symptoms and distress for babies, parents and carers as well as reducing the length of time in hospital.
The study started recruiting patients in October 2011.
| Name | Site | Telephone number | |
|---|---|---|---|
| Mark Everard Chief Investigator |
Sheffield Children's Hospital | +44 (0)114 2717400 | m.l.everard@sheffield.ac.uk |
| Danny Hind Assistant Director, CTRU |
ScHARR | +44 (0)114 2220707 | d.hind@sheffield.ac.uk |
| Liz Cross Trial Manager |
ScHARR | +44 (0)114 2220762 | e.a.cross@sheffield.ac.uk |
| Joseph Clark Trial Researcher |
ScHARR | +44 (0)114 2226126 | joseph.clark@sheffield.ac.uk |
| Kylie Cross Trial Support Officer |
ScHARR | +44 (0)114 2226385 | kylie.cross@sheffield.ac.uk |
| John Martindale Data Manager |
ScHARR | +44 (0)114 2220685 | j.martindale@sheffield.ac.uk |
| Simon Dixon Health Economist |
ScHARR | +44 (0)114 2220724 | s.dixon@sheffield.ac.uk |
| Jenny Freeman Statistician |
ScHARR | +44 (0)114 2220695 | j.v.freeman@sheffield.ac.uk |
| Centre Name | Principal Investigator | Research Nurse(s) |
|---|---|---|
| Alder Hey Children's Hospital, Liverpool | Dr Paul McNamara | Becky Evans Hannah Leyland Gail Wallace |
| Bradford Royal Infirmary | Dr Eduardo Moya | Kelly Young Louise Akeroyd |
| University Hospital of Wales, Cardiff | Dr Colin Powell | Pauline Jones Ann Russell Caroline Amphlett |
| Doncaster Royal Infirmary | Dr Matthew Kurian | Janet Queen |
| Calderdale Royal Hospital | Dr Jonathan Garside | Rachel Swingler |
| Leeds General Infirmary | Dr Phillip Chetcuti | Rebecca Mottram Marjorie Allen |
| Rotherham General Hospital | Dr Peter MacFarlane | Sarah Johns |
| Sheffield Children's Hospital | Dr Heather Elphick | Alyson Barber |
|
City General Hospital, Stoke |
Dr John Alexander | Marie Phipps Kate Leech |
Sheffield School of Health and Related Research
University of Sheffield
30 Regent Court
Sheffield
S1 4DA
Tel: +44 (0)114 2225454
Fax: +44(0)114 2724095