For USA use only

Consider FDA-approved medical therapies in postmenopausal women and men aged 50 years and older, based on the following:

• A hip or vertebral (clinical or morphometric) fracture
• T-score ≤ -2.5 at the femoral neck or spine after appropriate evaluation to exclude secondary causes
• Low bone mass (T-score between -1.0 and -2.5 at the femoral neck or spine) and a 10-year probability of a hip fracture ≥ 3% or a 10-year probability of a major osteoporosis-related fracture ≥ 20% based on the US-adapted WHO algorithm
• Clinicians judgment and/or patient preferences may indicate treatment for people with 10-year fracture probabilities above or below these levels