Professor Phillip Wright

Prof. Phillip Wright

Head of Chemical and Biological Engineering
Director of ChELSI Institute

Email: p.c.wright@sheffield.ac.uk

Tel: +44 (0)114-222 7577

Department of Chemical and Biological Engineering
The University of Sheffield
Sir Robert Hadfield Building
Mappin Street
Sheffield
S1 3JD

Links: University Profile

Research

Biography

My group focuses on the "-omics" side of algal research. In order to engineer algae to become better biofuel producers, we need to understand their cellular processes at a proteomic level. We use proteomic techniques to study algae under growth conditions which induce lipid production.

I started my Chemical Engineering career as a cadet at BHP Steel in Wollongong NSW Australia, and completed my BE in Chemical Engineering by a combination of both full and part time study, graduating from the University of NSW in 1991.

I returned to BHP Steel as a Process Engineer for the years 1991-1993. During this period I also completed a part-time Research Master of Engineering (ME) in Mechanical Engineering with A/Prof WeeKing Soh, at the University of Wollongong, on mass transfer in novel contacting systems for biological applications.

I then returned to The University of NSW to undertake a PhD on three-phase fluidized bed bioreactors with Professor Judy Raper. Upon completing my PhD in 1997 I took up the post of Lecturer, and later Reader, in Chemical Engineering at Heriot-Watt University.

In 2001 I received an EPSRC Advanced Research Fellowship. In 2002 I took up my Chair in Systems Biology and Engineering at the University of Sheffield. I am a Fellow of the Institution of Chemical Engineers. I took up the role of the Department's Director of Research in August 2004, Director of the ChELSI Institute in 2009 and became Head of Department in June 2008.

Students

 

Second supervisor

Emily Hounslow (main supervisor Jim Gilmour)

 

  

Publications

Burja, A.M., Banaigs, B., Abou-Mansour, E., Grant Burgess, J., Wright, P.C., 2001. Marine cyanobacteria—a prolific source of natural products. Tetrahedron 57, 9347–9377.

Burja, A.M., Dhamwichukorn, S., Wright, P.C., 2003. Cyanobacterial postgenomic research and systems biology. Trends Biotechnol. 21, 504–511.

McEvoy, E., Wright, P.C., Bustard, M.T., 2004. The effect of high concentration isopropanol on the growth of a solvent-tolerant strain of Chlorella vulgaris. Enzyme Microb. Technol. 35, 140–146.

Bhadury, P., Wright, P.C., 2004. Exploitation of marine algae: biogenic compounds for potential antifouling applications. Planta 219, 561–578.

Gan, C.S., Reardon, K.F., Wright, P.C., 2005. Comparison of protein and peptide prefractionation methods for the shotgun proteomic analysis ofSynechocystis sp. PCC 6803. PROTEOMICS 5, 2468–2478.

Chong, P.K., Gan, C.S., Pham, T.K., Wright, P.C., 2006. Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) Reproducibility: Implication of Multiple Injections. J. Proteome Res. 5, 1232–1240.

Gan, C.S., Chong, P.K., Pham, T.K., Wright, P.C., 2007. Technical, Experimental, and Biological Variations in Isobaric Tags for Relative and Absolute Quantitation (iTRAQ). J. Proteome Res. 6, 821–827.

Pandhal, J., Wright, P.C., Biggs, C.A., 2007. A Quantitative Proteomic Analysis of Light Adaptation in a Globally Significant Marine Cyanobacterium Prochlorococcus marinus MED4. J. Proteome Res. 6, 996–1005.

Barrios-Llerena, M.E., Burja, A.M., Wright, P.C., 2007. Genetic analysis of polyketide synthase and peptide synthetase genes in cyanobacteria as a mining tool for secondary metabolites. J. Ind. Microbiol. Biotechnol. 34, 443–456.

Ow, S.Y., Cardona, T., Taton, A., Magnuson, A., Lindblad, P., Stensjö, K., Wright, P.C., 2008. Quantitative Shotgun Proteomics of Enriched Heterocysts from Nostoc sp. PCC 7120 Using 8-Plex Isobaric Peptide Tags. J. Proteome Res. 7, 1615–1628.

Pandhal, J., Snijders, A.P.L., Wright, P.C., Biggs, C.A., 2008. A cross-species quantitative proteomic study of salt adaptation in a halotolerant environmental isolate using15N metabolic labelling. PROTEOMICS 8, 2266–2284.

Fuszard, M.A., Wright, P.C., Biggs, C.A., 2010. Cellular acclimation strategies of a minimal picocyanobacterium to phosphate stress. Fems Microbiol. Lett. 306, 127–134.

Robert, F.O., Pandhal, J., Wright, P.C., 2010. Exploiting cyanobacterial P450 pathways. Curr. Opin. Microbiol. 13, 301–306.

Pham, T.K., Roy, S., Noirel, J., Douglas, I., Wright, P.C., Stafford, G.P., 2010. A quantitative proteomic analysis of biofilm adaptation by the periodontal pathogen Tannerella forsythia. PROTEOMICS 10, 3130–3141.

Ekman, M., Ow, S.Y., Holmqvist, M., Zhang, X., van Wagenen, J., Wright, P.C., Stensjö, K., 2011. Metabolic Adaptations in a H2 Producing Heterocyst-Forming Cyanobacterium: Potentials and Implications for Biological Engineering. J. Proteome Res. 10, 1772–1784.

Pinto, F., van Elburg, K.A., Pacheco, C.C., Lopo, M., Noirel, J., Montagud, A., Urchueguia, J.F., Wright, P.C., Tamagnini, P., 2011. Construction of a chassis for hydrogen production: physiological and molecular characterization of a Synechocystis sp. PCC 6803 mutant lacking a functional bidirectional hydrogenase. Microbiology 158, 448–464.

Pereira, S.B., Ow, S.Y., Barrios-Llerena, M.E., Wright, P.C., Moradas-Ferreira, P., Tamagnini, P., 2011. iTRAQ-based quantitative proteomic analysis of Gloeothece sp. PCC 6909: Comparison with its sheathless mutant and adaptations to nitrate deficiency and sulfur limitation. J. Proteomics 75, 270–283.

Fuszard, M.A., Wright, P.C., Biggs, C.A., 2012. Comparative quantitative proteomics of prochlorococcus ecotypes to a decrease in environmental phosphate concentrations. Aquat. Biosyst. 8, 7.

Wase, N., Ow, S., Salim, M., Nissum, M, Whalley, M, Wright, P.C., 2012. A Free Flow Electrophoresis Separation Strategy for Segregation of High Abundant Phycobilisomes from Cyanobacterium Nostoc punctiforme PCC 73102. Proteromics Bioinforma. 5, 67–72.

Wright, P.C., Noirel, J., Ow, S.-Y., Fazeli, A., 2012. A review of current proteomics technologies with a survey on their widespread use in reproductive biology investigations. Theriogenology 77, 738–765.e52.

Scaife, M.A., Ma, C.A., Ninlayarn, T., Wright, P.C., Armenta, R.E., 2012. Comparative Analysis of β-Carotene Hydroxylase Genes for Astaxanthin Biosynthesis. J. Nat. Prod. 75, 1117–1124.

Longworth, J., Noirel, J., Pandhal, J., Wright, P.C.., Vaidyanathan, S., 2012. HILIC- and SCX-Based Quantitative Proteomics of Chlamydomonas reinhardtii during Nitrogen Starvation Induced Lipid and Carbohydrate Accumulation. J. Proteome Res. 11, 5959–5971.

Fuszard, M.A., Ow, S., Gan, C., Noirel, J., Ternan, N.G., McMullan, G., Biggs, C.A., Reardon, K.F., Wright, P.C., 2013. The quantitative proteomic response of Synechocystis sp. PCC6803 to phosphate acclimation. Aquat. Biosyst. 9, 5.