The Bateson Centre is a vibrant partnership between basic and clinician scientists at the University of Sheffield, and is the world’s first Centre for Lifecourse Biology; studying mechanisms of change throughout life, including growth, remodelling, degeneration and repair with obvious importance in maintaining health and treating disease. The Centre is directed by Professor Stephen Renshaw and builds on the outstanding achievements of the MRC Centre for Developmental and Biomedical Genetics.
Lifecourse Biology is the biology of change throughout life: the biology of growth, remodelling, degeneration and repair. The basic mechanistic understanding of these processes has obvious importance in maintaining health and treating disease. Lifecourse Biology is of direct importance to understanding how we age and how external stresses exacerbate disease and contribute to decline with age. Our aim is therefore to use innovative interdisciplinary biology approaches to help understand fundamental biological processes and then use our strong clinical links to translate this new understanding to improvements in human health.
Lifecourse Biology is a multidisciplinary area of strength, built on whole organism physiology and in vivo imaging requiring expertise in cell biology, stem cell biology, developmental biology, imaging and mathematical modelling together with translational biomedicine. Lifecourse Biology is of direct importance to understanding both healthy ageing and diseases of ageing and how environmental and cellular stresses influence growth, remodelling, degeneration and repair. In particular, environmental and cellular stresses contribute to decline in regenerative capacity with age. These stresses include external factors such as infection and environmental (including metabolic) stressors, and internal responses such as inflammation and altered endocrine function.