Disease Models and Mechanisms Cover Image
Another cover for the Chico lab. A whole-mount immunostained brain of a 9-day-old zebrafish showing different cellular markers, acquired using a Zeiss Lightsheet fluorescent microscope. Glutamate receptors on neurons and glial cells are in green, phalloidin stain for actin fibers is in red, DAPI stain for nuclear localization is in cyan and the enzyme, glutamine synthetase, is in blue. Expression of these, particularly glutamine synthetase, is reduced under hyperglycemia, a prominent pathology of diabetes.
Read the full paper ‘Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behavior in zebrafish’, here: DMM (2019) 039867.