Recent publications from members of the Bateson Centre

Tomecka MJ, Ethiraj LP, Sanchez LM, Roehl HH, Carney TJ (2019). Clinical pathologies of bone fracture modelled in zebrafish. Dis Model Mech. Doi: 10.1242/dmm.037630 [Epub ahead of print].

Souihol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC (2019). Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology

Isles HM, Herman KD, Robertson AL, Loynes CA, Prince LR, Elks PM, Renshaw SA (2019). The CXCL12/CXCR4 signaling axis retains neutrophils at inflammatory sites in zebrafish. Front. Immunol. doi: 10.3389/fimmu.2019.017 84.

Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E, Angyal A, Hegedus Z, Kovacs L, Hill AVS, Jefferies CA, Wilson HL, Yongliang Z, Kiss-Toth E (2019). TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages. Proc Natl Acad Sci U S A doi: 10.1073/pnas. 190109 0116. [Epub ahead of print].

Abugable AA, Morris JLM, Palminha NM, Zaksauskaite R, Ray S, El-Khamisy SF (2019). DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms. DNA Repair (Amst). 102669.

Oakes JA, Li N, Wistow BRC, Griffin A, Barnard L, Storbeck KH, Cunliffe VT, Krone NP (2019). Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish. Endocrinology. doi: 10.1210/2n.2019-00068 [Epub ahead of print].

Gremese E, Alivernini S, Tolusso B, Zeidler MP, Ferraccioli G (2019). JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy. J Leukoc Biol. doi: 10.1002/JLB.5RU0519-145R [Epub ahead of print].

Amin H, Lin AC (2019). Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. Current opinion in Insect Science 36:9-17.

Fisher KH, Strutt D, Fletcher AG (2019). Experimental and Theoretical Evidence for Bidirectional Signaling via Core Planar Polarity Protein Complexes in Drosophila. iScience 17:49-66.

Osman DI, El-Sheikh SM, Sheta SM, Ali OI, Salem AM, Shousha WG, El-Khamisy SF, Shawky SM (2019). Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. Biosens Bioelectron 141:111451.

Bielopolski N, Amin H, Apostolopoulou AA, Rozenfeld E, Lerner H, Huetteroth W, Lin AC, Parnas M (2019). Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila. Elife e48264.

Kugler EC, van Lessen M, Daetwyler S, Chhabria K, Savage AM, Silva V, Plant K, MacDonald RB, Huisken J, Wilkinson RN, Schulte-Merker S, Armitage P, Chico TJA (2019). Cerebrovascular endothelial cells from transient Notch-dependent cystic structures in zebrafish. EMBO Reps. e47047.

Diamantopoulou E, Baxendale S, de la Vega de Leon A, Asad A, Holdsworth CJ, Abbas L, Gillet VJ, Wiggin GR, Whitfield TT (2019). Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. Elife e44889.

Nowotschin S, Hadjantonakis A-K, Campbell K (2019). The endoderm: a divergent cell lineage with many commanalities. Development 146:dev150920.

Campbell K, Rossi F, Adams J, Pitsidianaki I, Barriga FM, Garcia-Gerique L, Batlle E, Casanova J, Casali A (2019). Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. Nature Comms. 10: 2311.

Roddie HG, Armitage EL, Coates JA, Johnston SA, Evans IR (2019). Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution. PLoS Biol. 17(5):e2006741.

Xanthis I, Souihol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L, Akhtar N, Feng S, ridger V, Waltho J, Pinteaux E, Humphries MJ, Byran MT, Evans PC (2019). β1 integrin is a sensor of blood flow direction. J Cell Sci. doi: 10.1242/jcs.229542.

Fu T, Pearson C, Towers M, Placzek M (2019). Development of the Basal Hypothalamus through Anisotropic Growth. J Neuroendocrinol. e12727.

Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honore E, Patel A (2019). TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nat Commun 10(1):2024.

Hartwell RD, England SJ, Monk NAM, van Hateren NJ, Baxendale S, Marzo M, Lewis KE, Whitfield TT (2019). Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genet. 15(4):e1008051.

Elworthy S, Savage AM, Wilkinson RN, Malicki JJ, Chico TJA (2019). The role of endothelial cilia in post-embryonic vascular development. Dev Dyn. doi: 10.1002/dvdy.40 [Epub ahead of print].

Watson L, Keatinge M, Gegg M, Bai Q, Sandulescu C, Vardi A, Futeman AH, Schapira AHV, Burton EA, Bandmann O (2019). Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher’s disease. Neurobiol Dis. doi: 10.1016/j .nbd.2019.04.008 [Epub ahead of print].

Buchan KD, Prajsnar TK, Ogryzko NV, de Jong NWM, van Gent M, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA (2019). A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase. PLoS One 14(4):e0215592.

King JS, Kay RR (2019). The origins and evolution of micropinocytosis. Philos Trans R Soc Lond B: Biol Sci 374(1765):20180158.

Swanson JA, King JS (2019). The breadth of micropinocytosis research. Philos Trans R Soc Lond B: Biol Sci 374(1765):20180146.

Charlton-Perkins M, Almeida AD, MacDonald RB, Harris WA (2019). Genetic control of cellular morphogenesis in Müller glia. Glia doi: 10.1002/glia.23615. [Epub ahead of print]

Abbas L, Rivolta MN (2019). The use of animal models to study cell transplantation in neuropathic hearing loss. Hear Res. 377:72-87.

Serbanovic-Canic J, Souihol C, Evans PC (2019). Shear stress makes its mark on the endothelial genome. Cardiovas Res. doi: 10.1093/cvr/cvz088. [Epub ahead of print]

Evans RJ, Pline K, Loynes CA, Needs S, Aldrovandi M, Tiefenbach J, Bielska E, Rubino RE, Nicol CJ, May RC, Krause HM, O’Donnell VB, Renshaw SA, Johnston SA (2019). 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathogens .1371/journal.ppat.1007597

Bannard C, Leriche M, Bandmann O, Brown CH, Ferracane E, Sanchez-Ferro A, Obeso J, Redgrave P, Stafford T (2019). Reduced habit-driven errors in Parkinson’s Disease. Sci Rep 9(1):3423.

Mahmoud M, Souihol C, Serbanovic-Canic J, Evans P (2019). GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis. Cardiovasc Drugs Ther. doi: 10.1007/s10557-019-06863-3 [Epub ahread of print].

Sharma D, Otto G, Warren E, Beesley P, King JS, William RSB (2019). Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function. Autophagy. doi: 10.1080/15548627. [Epub ahead of print].

Hodgkinson JW, Belosevic M, Elks PM, Barreda DR (2019). Teleost contributions to the understanding of mycobacterial diseases. Dev & Comparative Immunology doi: 10.1016/j.dci. 2019.02.011. [Epub ahead of print].

King JS (2019). Cellular microbiology interview – Dr Jason King. Cll Microbiol. e13007.

Bernut A, Dupont C, Ogryzko NV, Neyret A, Hermann J-L, Floto RA, Renshaw SA, Kremer L (2019). CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defences. Cell Reports. 26(7):1828-1840.

Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL, Chico TJA, Wilkinson RN (2019). tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Comms. 10: 732.

Buckley CM, Heath VL, Gueho A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove SK, Michell RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS (2019). PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection. PLoS Pathog. 15(2):e1007551.

Fleifel D, Rahmoon, MA, AlOkda A, Nasr M, Elserafy M, El-Khamisy SF (2019). Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s. J Genet Eng Biotechnol. 16(2):427-432.

Davidson AJ, Millard TH, Evans IR, Wood W (2019). Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis. J Cell Sci. doi: 10.1242/jcs.224618. [Epub ahead of print].

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C (2019). Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation. Cell Death & Disease 10: 108.

Martins RR, Ellis PS, MacDonald RB, Richardson RJ and Henriques CM (2019). Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age. Front. Cell Dev. Biol. 7:12. doi: 10.3389/fcell.2019.00012.

Fehri H, Gooya A, Lu Y, Meijering E, Johnston SA, Frangi AF (2019). Bayesian Polytrees with Learned Deep Features for Multi-Class Cell Segmentation. IEEE Trans Image Process doi: 10.1109/TIP.2019.28955455.

Duvenage L, Walker LA, Bojarczuk A, Johnston SA, MacCallum DM, Munro CA, Gourlay CW (2019). Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition. MBio. 10(1).

Neal A, Nornes S, Payne S, Wallace MD, Fritzsche M, Louphrasitthiphol P, Wilkinson RN, Chouliaras KM, Liu K, Plant K, Sholapurkar R, Ratnayaka I, Herzog W, Bond G, Chico T, Bou-Gharios G, De Val S (2019). Venous identity requires BMP signalling through ALK3. Nat Commun 10(1):453.

McCracken AW, Adams G, Hartshorne L, Simons MJP (2019). The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins. bioRxiv. /533711.

Simms RJ, Doshi T, Metherall P, Ryan D, Wright P, Gruel N, van Gastel MDA, Gansevoort RT, Tindale W, Ong ACM (2019). A rapid high-performance semi-automatd tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease. Eur Radiol. Doi: 10.1007/s00330-018-5918-9 [Epub ahead of print].

Kugler E, Plant K, Chico TJ, Armitage PA (2019). Enhancement and Segmentation Workflow for the Developing Zebrafish Vasculature. J. Imaging 5(1), 14.

de Groot SC, Sliedregt K, van Benthem PPG, Rivolta MN, Huisman MA (2019). Building an Artificial Stem Cell Niche: Prerequisites for Future 3D-Formation of Inner Ear Structures – Towards 3D Inner Ear Biotechnology. Anat Rec (Hoboken). Doi: 10.1002/ar.24067 [Epub ahead of print].

Cayuela ML, Claes KBM, Ferreira MG, Henriques CM, van Eeden F, Varga M, Vierstraete J, Mione MC (2019). The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases. Front Cell Dev Biol 6:178.

Buchan KD, Foster SJ, Renshaw SA (2019). Staphylococcus aureus: setting its sights on the human innate immune system. Microbiology doi: 10.1099/mic.0.000759 [Epub ahead of print].

Vogt KL, Summers C, Condliffe AM (2019). The clinical consequences of neutrophil priming. Curr Opin Hematol. 26(1):22-27.

Tuñón J, Badimón L, Bochaton-Piallat ML, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE, Ketelhuth DF, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C, Bäck M (2019). Identifying the anti-inflammatory response to lipid lowering therapy. A Position Paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovasc Res. 115(1):10-19.

Lopez-Jimenez AT, Munoz EC, Leuba F, Gerstenmaier L, Hagedorn M, King JS and Soldati T (2018). ESCRT and autophagy cooperate to repair ESX-1-dependent damage to the Mycobacterium-containing vacuole. PLoS Pathogens 14(12):e1007501.

Hamilton N, Sabroe I, Renshaw SA (2018). A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Res. eCollection 2018. Revised December 2018.

Gimpel C, Avni EF, Breysem L, Burgmaier K, Caroli A, Cetiner M, Haffner D, Hartung EA, Franke D, König J, Liebau MC, Mekahli D, Ong ACM, Pape L, Titieni A, Torra R, Winyard PJD, Schaefer F (2018). Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Group Consensus Statement. Radiology 181243.

Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA, Elks PM (2018). Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. J Immunol. 202(2):494-502.

Nenko I, Heyward AD, Simons MJP, Lummaa V (2018). Early-life environment and differences in costs of reproduction in a preindustrial human population. PLoS One 13(12): e0207236.

Fragiadaki M, Evans PC (2018) The Bernard and Joan Marshall Early Career Investigators and Distinguished Investigator Award 2018. Cardiovasc Drugs Ther. doi: 10.1007/s10557-018-6842-6. [Epub ahead of print].

Stacey G, Andrews P, Asante C, … Rivolta MN, … Williams D (2018). Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop. Regen Med. Doi: 10.2217/mme-2018-0120. [Epub ahead of print].

Finegan TM, Na D, Cammarota C, Skeeters AV, Nadasi TJ, Dawney NS, Fletcher AG, Oakes PW, Bergstralh DT (2018). Tissue tension and not interphase cell shape determines cell division orientation in the Drosophila follicular epithelium. EMBO J pii: e100072. doi: 10.15252/embj.2018100072. [Epub ahead of print].

Shaw MP, Higginbottom A, McGown A, Castelli LM, James E, Hautbergue GM, Shaw PJ, Ramesh TM (2018). Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features. Acta Neuropathologica Comms 6:125.

Cooper RL, Thiery AP, Fletcher AG, Delbarre DJ, Rasch LJ, Fraser GJ (2018). An ancient Turing-like patterning mechanism regulates skin denticle development in sharks. Sci Adv 4(11):eaau5484.

Chhabria K, Plant K, Bandmann O, Wilkinson RN, Martin C, Kugler E, Armitage PA, Santoscoy PL, Cunliffe VT, Huisken J, McGown A, Ramesh T, Chico TJ, Howarth C (2018). The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. J Cereb Blood Flow Metab. 271678X18810615. [Epub ahead of print].

Weatherley ND, Stewart NJ, Chan HF, Austin M, Smith LJ, Collier G, Rao M, Marshall H, Norquay G, Renshaw SA, Bianchi SM, Wild JM (2018). Hyperpolarised xenon magnetic resonance spectroscopy for the longitudinal assessment of changes in gas diffusion in IPF. Thorax. pii: thoraxjnl-2018-211851 [Epub ahead of print]

Shawky SM, Awad AM, Abugable AA, El-Khamisy SF (2018). Gold nanoparticles – an optical biosensor for RNA quantification for cancer and neurologic disorders diagnosis. Int J Nanomedicine 13:8137-8151.

Akhtar N (2018). Hijacking a Morphogenesis Proteinase for Cancer Cell Invasion. Dev Cell. 47(2):135-137.

Stainton H, Towers M (2018). Polarizing Region Tissue Grafting in the Chick Embryo Limb Bud. Methods Mol Biol. 1863:143-153.

Burrows DJ, McGown A, Jain SA, De Felice M, Ramesh TM, Sharrack B, Majid A (2018). Animal models of multiple sclerosis: From rodents to zebrafish. Mult Scler [Epub ahead of print].

D Sharma, G Otto, E Warren, P Beesley, JS King and RSB Williams (2018). Gamma secretase orthologues are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of Presenillin proteolytic function. Autophagy. In press

JS King and RR Kay (2018). The origins and evolution of macropinocytosis. Phil. Trans. R Soc. B. In press.

Moore C, Richens JL, Hough Y, Ucanok D, Malla S, Sang F, Chen Y, Elworthy S, Wilkinson RN, Gering M (2018). Gfiaa and Gfi1b set the pace for primitive erythroblast differentiation from hemangioblasts in the zebrafish embryo. Blood Adv. 2(20):2589-2606.

Romero MMG, McCathie G, Jankun P, Roehl HH (2018). Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells. Nat Commun. 9(1):4010.

Weger M, Weger BD, Gorling B, Poschet G, Yildiz M, Hell R, Luy B, Akcay T, Guran T, Dickmeis T, Muller F, Krone N (2018). Glucocorticoid deficiency causes transcriptional an dpost-transcriptional reprogramming of glutamine metabolism. EBioMedicine 36:376-389.

Bornstein SR, Steenblock C, Chrousos GP, Schally AV, Beuschlein F, Kline G, Krone NP, Licinio J, Wong ML, Ullmann E, Ruiz-Babot G, Boehm BO, Behrens A, Brennand A, Santambrogio A, Berger I, Werdermann M, Sancho R, Linkermann A, Lenders JW, Eisenhofer G, Andoniadou CL (2018). Stress-inducible-stem cells: a new view on endocrine, metabolic and mental disease? Mol Psychiatry. Sep 21;. [Epub ahead of print]

Xing R, Moerman AM, Ridwan RY, Gaalen KV, Meester EJ, van der Steen AFW, Evans PC, Gijsen FJH, Van der Heiden K (2018). The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice. Sci Rep. 8(1):14014.

Moradzadeh M, Ghorbani A, Erfanian S, Mohaddes ST, Rahimi H, Karimiani EG, Mashkani B, Chiang SC, El-Khamisy SF, Tabarrai A, Sadeghnia HR (2018). Study of the mechanisms of crocetin-induced differentiation and apoptosis in human acute promyelocytic leukemia cells. J Cell Biochem doi: 10.1002/jcb.27489 [Epub ahead of print].

Loynes CA, Lee JA, Robertson AL, Steel MJ, Ellett F, Feng Y, Levy BD, Whyte MKB, Renshaw SA (2018). PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Sci Adv. 2018 4(9):eaar8320

Quan Wong S, Jones A, Dodd S, Grimes D, Barclay JW, Marson AG, Cunliffe VT, Burgoyne RD, Sills GJ, Morgan A (2018). A Caenorhabditis elegans assay of seizure-like activity optimized for identifying antiepileptic drugs and their mechanisms of action. J Neurosci Methods doi: 10.1016/j.neumeth. 2018.09.004 [Epub ahead of print].