Recent publications from members of the Bateson Centre

Kinsella CM, Ruiz-Ruano FJ, Dion-Cote AM, Charles AJ, Grossmann TI, Cabrero J, Dappei D, Hemmings N, Simons MJP, Camacho JPM, Forstmeier W, Suh A (2019). Programmed DNA elimination of germline development genes in songbirds. Nat Commun. 10(1):5468.

Hajdamowicz NH, Hull RC, Foster SJ, Condliffe AM (2019). The Impact of Hypoxia on the Host-Pathogen Interaction between Neutrophils and Staphylococcus aureus. Int J Mol Sci 20(22).

Li N, Oakes JA, Storbeck K, Cunliffe VT, Krone N (2019). The P450 side chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish. J Endocrinol. doi: 10.1530/JOE-19-0384 [Epub ahead of print.

Johnston JM, Angyal A, Bauer RC, Hamby S, Suvarna SK, Baidzajevas K, Hegedus Z, Dear TN, Turner M, Cardiogenics Consortium, Wilson HL, Goodall AH, Rader DJ, Shoulders CC, Francis SE, Kiss-Toth E (2019). Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Sci Adv. 5(10):eaax9183.

Scott JG, Maini PK, Anderson ARA, Fletcher AG (2019). Inferring Tumour Proliferative Organsiation from Phoylogenetic Tree Measures in a Computational Model. Syst Biol. doi: 10.1093/sys 070 [Epub ahead of print].

Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A, Job L, Hughes RM, Boschian C, Bayatti N, Heath PR, Bandmann O, Mortiboys H, Ferraiuolo L, Shaw PJ (2019). C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis. Brain doi: 10.1093/brain/awz302 [Epub ahead of print].

Batalha IL, Bernut A, Schiebler M, Ouberai MM, Passemar C, Klapholz C, Kinna S, Michel S, Sader K, Castro-Hartmann P, Renshaw SA, Welland ME, Andres Floto R (2019). Polymeric nanobiotics as a novel treatment for mycobacterial infections. J Control Resease doi: 10.1016/ j.jconrel.2019.10.009 [Epub ahead of print].

Rahman A, Henry KM, Herman KD, Thompson AAR, Isles HM, Tulotta C, Sammut D, Rougeot JJ, Khoshaein N, Reese AE, Higgins K, Tabor C, Sabroe I, Zuercher WJ, Savage CO, Meijer AH, Whyte MK, Dockrell DH, Renshaw SA, Prince LR (2019). Inhibition of ErbB kinase signaling promotes resolution of neutrophilic inflammation.

Zun PS, Narracott AJ, Evans PC, van Rooij BJM, Hoekstra AG (2019). A particle-based model for endothelial cell migration under flow conditions. Biomech Model Mechanobiol. doi: 10.1007/ s10237-019-01239-w. [Epub ahead of print]

Lewis A, Elks PM (2019). Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo. Front. Immunol. doi.org/10.3389/fimmu. 2019.02321.

Soman SK, Bazala M, Keatinge M, Bandmann O, Kuznicki J (2019). Restriction of mitochondrial calcium overload by mcu inactivation renders neuroprotective effect in Zebrafish models of Parkinson’s disease. Biol Open. doi: 10.1242/bio.044347 [Epub ahead of print].

Pickering J, Chinnaiya K, Towers M (2019). An autoregulatory cell cycle timer integrates growth and specification in chick wing digit development. Elife 23;8.

Francis S, Thomas S, Luben R, Sousos N, Mead A, Snowden JA, Zeidler MP (2019). Low-dose methotrexate: potential clinical impact on haematological and constitutional symptoms in myeloproliferative neoplasms. Br J Haematol. doi: 10.111/bjh.16193.

Rutherford HA, Hamilton N (2019). Animal Models of Leukodystrophy: A new perspective for the development of therapies. FEBS J doi:10.1111/ febs.15060.

Souihol C, Gauci I, Feng S, Tardajos Ayllon B, Mahmoud M, Canham L, Fragiadaki M, Serbanovic-Canic J, Ridger V, Evans PC (2019). Homeobox B9 integrates bone morphogenic protein 4 with inflammation at atheroprone sites. Cardiovasc Res. Doi: 10.1093/cvr/cvz235 [Epub ahead of print].

Ibler AEM, Elghazaly M, Naylor KL, Bulgakova NA, El-Khamisy S, Humphreys D (2019). Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection. Nat Commun. 10(1):4040.

Chhabria K, Vouros A, Gray C, MacDonald RB, Jiang Z, Wilkinson RN, Plant K, Vasilaki E, Howarth C, Chico TJA (2019). Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish. Dis Model Mech. doi: 10.1242/dmm.039867. [Epub ahead of print]

Tosi S, Campbell K (2019). 3D tracking of migrating cells from live microscopy time-lapses. Methods Mol Biol. 2040:385-395.

Fernandes JG, Franco NH, Grierson AJ, Hultgren J, Furley AJW, Olsson IAS (2019). Methodological standards, quality of reporting and regulatory compliance in animal research on amyotrophic lateral sclerosis: a systematic review. BMJ Open Science 3:e000016.

Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC, Dockrell DH, Marriott HM, Sabroe I, Condliffe AM, Prince LR (2019). Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease. Front Immunol. 10:1721.

Tomecka MJ, Ethiraj LP, Sanchez LM, Roehl HH, Carney TJ (2019). Clinical pathologies of bone fracture modelled in zebrafish. Dis Model Mech. 12(9).

Souihol C, Serbanovic-Canic J, Fragiadaki M, Chico TJ, Ridger V, Roddie H, Evans PC (2019). Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes. Nature Reviews Cardiology

Isles HM, Herman KD, Robertson AL, Loynes CA, Prince LR, Elks PM, Renshaw SA (2019). The CXCL12/CXCR4 signaling axis retains neutrophils at inflammatory sites in zebrafish. Front. Immunol. doi: 10.3389/fimmu.2019.017 84.

Li Y, James SJ, Wyllie DH, Wynne C, Czibula A, Bukhari A, Pye K, Bte Mustafah SM, Fajka-Boja R, Szabo E, Angyal A, Hegedus Z, Kovacs L, Hill AVS, Jefferies CA, Wilson HL, Yongliang Z, Kiss-Toth E (2019). TMEM203 is a binding partner and regulator of STING-mediated inflammatory signaling in macrophages. Proc Natl Acad Sci U S A doi: 10.1073/pnas. 190109 0116. [Epub ahead of print].

Abugable AA, Morris JLM, Palminha NM, Zaksauskaite R, Ray S, El-Khamisy SF (2019). DNA repair and neurological disease: From molecular understanding to the development of diagnostics and model organisms. DNA Repair (Amst). 102669.

Oakes JA, Li N, Wistow BRC, Griffin A, Barnard L, Storbeck KH, Cunliffe VT, Krone NP (2019). Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish. Endocrinology. doi: 10.1210/2n.2019-00068 [Epub ahead of print].

Gremese E, Alivernini S, Tolusso B, Zeidler MP, Ferraccioli G (2019). JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy. J Leukoc Biol. doi: 10.1002/JLB.5RU0519-145R [Epub ahead of print].

Amin H, Lin AC (2019). Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila. Current opinion in Insect Science 36:9-17.

Fisher KH, Strutt D, Fletcher AG (2019). Experimental and Theoretical Evidence for Bidirectional Signaling via Core Planar Polarity Protein Complexes in Drosophila. iScience 17:49-66.

Osman DI, El-Sheikh SM, Sheta SM, Ali OI, Salem AM, Shousha WG, El-Khamisy SF, Shawky SM (2019). Nucleic acids biosensors based on metal-organic framework (MOF): Paving the way to clinical laboratory diagnosis. Biosens Bioelectron 141:111451.

Bielopolski N, Amin H, Apostolopoulou AA, Rozenfeld E, Lerner H, Huetteroth W, Lin AC, Parnas M (2019). Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila. Elife e48264.

Kugler EC, van Lessen M, Daetwyler S, Chhabria K, Savage AM, Silva V, Plant K, MacDonald RB, Huisken J, Wilkinson RN, Schulte-Merker S, Armitage P, Chico TJA (2019). Cerebrovascular endothelial cells from transient Notch-dependent cystic structures in zebrafish. EMBO Reps. e47047.

Diamantopoulou E, Baxendale S, de la Vega de Leon A, Asad A, Holdsworth CJ, Abbas L, Gillet VJ, Wiggin GR, Whitfield TT (2019). Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant. Elife e44889.

Nowotschin S, Hadjantonakis A-K, Campbell K (2019). The endoderm: a divergent cell lineage with many commanalities. Development 146:dev150920.

Campbell K, Rossi F, Adams J, Pitsidianaki I, Barriga FM, Garcia-Gerique L, Batlle E, Casanova J, Casali A (2019). Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. Nature Comms. 10: 2311.

Roddie HG, Armitage EL, Coates JA, Johnston SA, Evans IR (2019). Simu-dependent clearance of dying cells regulates macrophage function and inflammation resolution. PLoS Biol. 17(5):e2006741.

Xanthis I, Souihol C, Serbanovic-Canic J, Roddie H, Kalli AC, Fragiadaki M, Wong R, Shah DR, Askari JA, Canham L, Akhtar N, Feng S, ridger V, Waltho J, Pinteaux E, Humphries MJ, Byran MT, Evans PC (2019). β1 integrin is a sensor of blood flow direction. J Cell Sci. doi: 10.1242/jcs.229542.

Fu T, Pearson C, Towers M, Placzek M (2019). Development of the Basal Hypothalamus through Anisotropic Growth. J Neuroendocrinol. e12727.

Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honore E, Patel A (2019). TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nat Commun 10(1):2024.

Hartwell RD, England SJ, Monk NAM, van Hateren NJ, Baxendale S, Marzo M, Lewis KE, Whitfield TT (2019). Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genet. 15(4):e1008051.

Elworthy S, Savage AM, Wilkinson RN, Malicki JJ, Chico TJA (2019). The role of endothelial cilia in post-embryonic vascular development. Dev Dyn. doi: 10.1002/dvdy.40 [Epub ahead of print].

Watson L, Keatinge M, Gegg M, Bai Q, Sandulescu C, Vardi A, Futeman AH, Schapira AHV, Burton EA, Bandmann O (2019). Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher’s disease. Neurobiol Dis. doi: 10.1016/j .nbd.2019.04.008 [Epub ahead of print].

Buchan KD, Prajsnar TK, Ogryzko NV, de Jong NWM, van Gent M, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA (2019). A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase. PLoS One 14(4):e0215592.

King JS, Kay RR (2019). The origins and evolution of micropinocytosis. Philos Trans R Soc Lond B: Biol Sci 374(1765):20180158.

Swanson JA, King JS (2019). The breadth of micropinocytosis research. Philos Trans R Soc Lond B: Biol Sci 374(1765):20180146.

Charlton-Perkins M, Almeida AD, MacDonald RB, Harris WA (2019). Genetic control of cellular morphogenesis in Müller glia. Glia doi: 10.1002/glia.23615. [Epub ahead of print]

Abbas L, Rivolta MN (2019). The use of animal models to study cell transplantation in neuropathic hearing loss. Hear Res. 377:72-87.

Serbanovic-Canic J, Souihol C, Evans PC (2019). Shear stress makes its mark on the endothelial genome. Cardiovas Res. doi: 10.1093/cvr/cvz088. [Epub ahead of print]

Evans RJ, Pline K, Loynes CA, Needs S, Aldrovandi M, Tiefenbach J, Bielska E, Rubino RE, Nicol CJ, May RC, Krause HM, O’Donnell VB, Renshaw SA, Johnston SA (2019). 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathogens doi.org/10 .1371/journal.ppat.1007597

Bannard C, Leriche M, Bandmann O, Brown CH, Ferracane E, Sanchez-Ferro A, Obeso J, Redgrave P, Stafford T (2019). Reduced habit-driven errors in Parkinson’s Disease. Sci Rep 9(1):3423.

Mahmoud M, Souihol C, Serbanovic-Canic J, Evans P (2019). GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis. Cardiovasc Drugs Ther. doi: 10.1007/s10557-019-06863-3 [Epub ahread of print].

Sharma D, Otto G, Warren E, Beesley P, King JS, William RSB (2019). Gamma secretase orthologs are required for lysosomal activity and autophagic degradation in Dictyostelium discoideum, independent of PSEN (presenilin) proteolytic function. Autophagy. doi: 10.1080/15548627. [Epub ahead of print].

Hodgkinson JW, Belosevic M, Elks PM, Barreda DR (2019). Teleost contributions to the understanding of mycobacterial diseases. Dev & Comparative Immunology doi: 10.1016/j.dci. 2019.02.011. [Epub ahead of print].

King JS (2019). Cellular microbiology interview – Dr Jason King. Cll Microbiol. e13007.

Bernut A, Dupont C, Ogryzko NV, Neyret A, Hermann J-L, Floto RA, Renshaw SA, Kremer L (2019). CFTR protects against Mycobacterium abscessus infection by fine-tuning host oxidative defences. Cell Reports. 26(7):1828-1840.

Savage AM, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald RB, Kim HR, Wilson HL, van Eeden FJM, Armesilla AL, Chico TJA, Wilkinson RN (2019). tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nature Comms. 10: 732.

Buckley CM, Heath VL, Gueho A, Bosmani C, Knobloch P, Sikakana P, Personnic N, Dove SK, Michell RH, Meier R, Hilbi H, Soldati T, Insall RH, King JS (2019). PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection. PLoS Pathog. 15(2):e1007551.

Fleifel D, Rahmoon, MA, AlOkda A, Nasr M, Elserafy M, El-Khamisy SF (2019). Recent advances in stem cells therapy: A focus on cancer, Parkinson’s and Alzheimer’s. J Genet Eng Biotechnol. 16(2):427-432.

Davidson AJ, Millard TH, Evans IR, Wood W (2019). Ena orchestrates remodelling within the actin cytoskeleton to drive robust Drosophila macrophage chemotaxis. J Cell Sci. doi: 10.1242/jcs.224618. [Epub ahead of print].

Parker A, Vaux L, Patterson AM, Modasia A, Muraro D, Fletcher AG, Byrne HM, Maini PK, Watson AJM, Pin C (2019). Elevated apoptosis impairs epithelial cell turnover and shortens villi in TNF-driven intestinal inflammation. Cell Death & Disease 10: 108.

Martins RR, Ellis PS, MacDonald RB, Richardson RJ and Henriques CM (2019). Resident Immunity in Tissue Repair and Maintenance: The Zebrafish Model Coming of Age. Front. Cell Dev. Biol. 7:12. doi: 10.3389/fcell.2019.00012.

Fehri H, Gooya A, Lu Y, Meijering E, Johnston SA, Frangi AF (2019). Bayesian Polytrees with Learned Deep Features for Multi-Class Cell Segmentation. IEEE Trans Image Process doi: 10.1109/TIP.2019.28955455.

Duvenage L, Walker LA, Bojarczuk A, Johnston SA, MacCallum DM, Munro CA, Gourlay CW (2019). Inhibition of Classical and Alternative Modes of Respiration in Candida albicans Leads to Cell Wall Remodeling and Increased Macrophage Recognition. MBio. 10(1).

Neal A, Nornes S, Payne S, Wallace MD, Fritzsche M, Louphrasitthiphol P, Wilkinson RN, Chouliaras KM, Liu K, Plant K, Sholapurkar R, Ratnayaka I, Herzog W, Bond G, Chico T, Bou-Gharios G, De Val S (2019). Venous identity requires BMP signalling through ALK3. Nat Commun 10(1):453.

McCracken AW, Adams G, Hartshorne L, Simons MJP (2019). The hidden costs of dietary restriction: implications for its evolutionary and mechanistic origins. bioRxiv. Doi.org/10.1101 /533711.

Simms RJ, Doshi T, Metherall P, Ryan D, Wright P, Gruel N, van Gastel MDA, Gansevoort RT, Tindale W, Ong ACM (2019). A rapid high-performance semi-automatd tool to measure total kidney volume from MRI in autosomal dominant polycystic kidney disease. Eur Radiol. Doi: 10.1007/s00330-018-5918-9 [Epub ahead of print].

Kugler E, Plant K, Chico TJ, Armitage PA (2019). Enhancement and Segmentation Workflow for the Developing Zebrafish Vasculature. J. Imaging 5(1), 14.

de Groot SC, Sliedregt K, van Benthem PPG, Rivolta MN, Huisman MA (2019). Building an Artificial Stem Cell Niche: Prerequisites for Future 3D-Formation of Inner Ear Structures – Towards 3D Inner Ear Biotechnology. Anat Rec (Hoboken). Doi: 10.1002/ar.24067 [Epub ahead of print].

Cayuela ML, Claes KBM, Ferreira MG, Henriques CM, van Eeden F, Varga M, Vierstraete J, Mione MC (2019). The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases. Front Cell Dev Biol 6:178.

Buchan KD, Foster SJ, Renshaw SA (2019). Staphylococcus aureus: setting its sights on the human innate immune system. Microbiology doi: 10.1099/mic.0.000759 [Epub ahead of print].

Vogt KL, Summers C, Condliffe AM (2019). The clinical consequences of neutrophil priming. Curr Opin Hematol. 26(1):22-27.

Tuñón J, Badimón L, Bochaton-Piallat ML, Cariou B, Daemen MJ, Egido J, Evans PC, Hoefer IE, Ketelhuth DF, Lutgens E, Matter CM, Monaco C, Steffens S, Stroes E, Vindis C, Weber C, Bäck M (2019). Identifying the anti-inflammatory response to lipid lowering therapy. A Position Paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology. Cardiovasc Res. 115(1):10-19.

Lopez-Jimenez AT, Munoz EC, Leuba F, Gerstenmaier L, Hagedorn M, King JS and Soldati T (2018). ESCRT and autophagy cooperate to repair ESX-1-dependent damage to the Mycobacterium-containing vacuole. PLoS Pathogens 14(12):e1007501.

Hamilton N, Sabroe I, Renshaw SA (2018). A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models. F1000Res. eCollection 2018. Revised December 2018.

Gimpel C, Avni EF, Breysem L, Burgmaier K, Caroli A, Cetiner M, Haffner D, Hartung EA, Franke D, König J, Liebau MC, Mekahli D, Ong ACM, Pape L, Titieni A, Torra R, Winyard PJD, Schaefer F (2018). Imaging of Kidney Cysts and Cystic Kidney Diseases in Children: An International Working Group Consensus Statement. Radiology 181243.

Ogryzko NV, Lewis A, Wilson HL, Meijer AH, Renshaw SA, Elks PM (2018). Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. J Immunol. 202(2):494-502.

Nenko I, Heyward AD, Simons MJP, Lummaa V (2018). Early-life environment and differences in costs of reproduction in a preindustrial human population. PLoS One 13(12): e0207236.