The zebrafish, Danio rerio, frequently sold commercially under the name Zebra Danio, has become an important vertebrate model organism in scientific research. The zebrafish owes much of this success to its hardiness, cold resistance, easiness to breed and variable omnivorous diet. This popular fish, is well established as a powerful tool in the research of cellular and molecular mechanisms that underlie development and disease. Genetic engineering is widely used, with much success, to recapitulate and track pathological processes.
The Fish Facility at The University of Sheffield is located in the North wing of Firth Court alongside research groups in the Bateson Centre, Department of Biomedical Science, Department of Animal and Plant Sciences and Departments within the Faculty of Medicine, Dentistry and Health. This lies at the heart of the Life Sciences complex at Firth Court on Western Bank (15 minutes walk from Sheffield city centre).
The fish research community in Sheffield comprises over 140 researchers across more than 25 research groups and is supported by a team of 8 technical staff.
The facility provides support for research with adequate provision of microscopes (both light and fluorescent), injection rigs, a needle puller, incubators (including light cycle incubators), behavioural analysis and all aquarium associated equipment. Some tanks are equipped with light boxes so that day and night photoperiods can be changed, and some tanks are designed as coordinates for a multiwell plate. Full list of facilities includes:
- Behavioural Analysis Booths Suite
- Microinjection Rooms
- Microscope Rooms
- Programmable light boxes and light cycle incubators
- Quarantine Facilities
- Live food rearing provisions
- Cryogenic storage for IVF service
There are two quarantine facilities to support fish imports and a cold room to store all our feeds.