Dr Vincent Cunliffe

All publications

Journal articles

• Eachus H, Oberski L, Paveley J, Bacila I, Ashton J-P, Esposito U, Seifuddin F, Pirooznia M, Elhaik E, Placzek M , Krone N et al (2023) Glucocorticoid Receptor regulates protein chaperone, circadian clock and affective disorder genes in the zebrafish brain.. Dis Model Mech.
• Bacila I, Cunliffe VT & Krone NP (2021) Interrenal development and function in zebrafish. Molecular and Cellular Endocrinology, 535, 111372-111372.
• Jones A, Barker‐Haliski M, Ilie AS, Herd MB, Baxendale S, Holdsworth CJ, Ashton J, Placzek M, Jayasekera BAP, Cowie CJA , Lambert JJ et al (2020) A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ‐aminobutyric acidergic anticonvulsant. Epilepsia.
• Oakes JA, Barnard L, Storbeck K-H, Cunliffe VT & Krone NP (2020) 11β-hydroxylase loss disrupts steroidogenesis and reproductive function in zebrafish. Journal of Endocrinology.
• Li N, Oakes JA, Storbeck K-H, Cunliffe VT & Krone N (2020) The P450 side chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish. Journal of Endocrinology, 244(2), 309-321. View this article in WRRO
• Oakes JA, Li N, Wistow BRC, Griffin A, Barnard L, Storbeck K-H, Cunliffe VT & Krone NP (2019) Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish.. Endocrinology. View this article in WRRO
• Wu X, Scott H, Carlsson SV, Sjoberg DD, Cerundolo L, Lilja H, Prevo R, Rieunier G, Macaulay V, Higgins GS , Verrill CL et al (2019) Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy. The Prostate, 79(10), 1079-1089. View this article in WRRO
• Chhabria K, Plant K, Bandmann O, Wilkinson R, Martin C, Kugler E, Armitage P, Santoscoy P, Cunliffe V, Huisken J , Mcgown A et al (2018) The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
• Wong SQ, Jones A, Dodd S, Grimes D, Barclay JW, Marson AG, Cunliffe VT, Burgoyne RD, Sills GJ & Morgan A (2018) A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. Journal of Neuroscience Methods, 309, 132-142. View this article in WRRO
• Bergmann K, Meza Santoscoy P, Lygdas K, Nikolaeva Y, MacDonald R, Cunliffe V & Nikolaev AV (2018) Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish. Journal of Developmental Biology, 6(1). View this article in WRRO
• Lehane D, Cunliffe V, Mitchell C & Burton C (2018) Epigenetics and primary care. British Journal of General Practice, 68(666), 8-9. View this article in WRRO
• Eachus H, Zaucker A, Oakes JA, Griffin A, Weger M, Güran T, Taylor A, Harris A, Greenfield A, Quanson JL , Storbeck K-H et al (2017) Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158(12), 4165-4173. View this article in WRRO
• Cunliffe VT & Eachus (2017) Biological Embedding of Psychosocial Stress Over the Life Course. Translational Epigenetics, 4, 251-270. View this article in WRRO
• Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017) Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix Biology, 62, 58-74. View this article in WRRO
• Eachus H, Bright C, Cunliffe VT, Placzek M, Wood JD & Watt PJ (2017) Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Human Molecular Genetics, 26(11), 1992-2005. View this article in WRRO
• Vineis P, Chatziioannou A, Cunliffe VT, Flanagan JM, Hanson M, Kirsch-Volders M & Kyrtopoulos S (2017) Epigenetic memory in response to environmental stressors.. FASEB J. View this article in WRRO
• Cunliffe VT (2016) The epigenetic impacts of social stress: how does social adversity become biologically embedded?. Epigenomics, 8(12), 1653-1669. View this article in WRRO
• Cunliffe VT (2016) Histone modifications in zebrafish development. Methods in Cell Biology, 135, 361-385. View this article in WRRO
• Cunliffe VT (2016) Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures. Journal of Neuroscience Methods, 260, 91-95.
• Boyd PJ, Cunliffe VT, Roy S & Wood JD (2015) Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open, 4(10), 1336-1343. View this article in WRRO
• Cunliffe VT (2015) Experience-sensitive epigenetic mechanisms, developmental plasticity, and the biological embedding of chronic disease risk. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7(2), 53-71.
• Jackson HE, Ono Y, Wang X, Elworthy S, Cunliffe VT & Ingham PW (2015) The role of Sox6 in zebrafish muscle fiber type specification. Skeletal Muscle, 5(1), 2-2. View this article in WRRO
• Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M , Hajji N et al (2015) Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature Communications, 6. View this article in WRRO
• Cunliffe VT, Baines RA, Giachello CNG, Lin W-H, Morgan A, Reuber M, Russell C, Walker MC & Williams RSB (2015) Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms. Seizure, 24, 44-51.
• Baxendale S, Holdsworth CJ, Meza Santoscoy PL, Harrison MRM, Fox J, Parkin CA, Ingham PW & Cunliffe VT (2012) Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.. Dis Model Mech, 5(6), 773-784. View this article in WRRO
• Harrison MRM, Georgiou AS, Spaink HP & Cunliffe VT (2011) The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos.. BMC Genomics, 12, 24. View this article in WRRO
• Lightman EG, Harrison MRM & Cunliffe VT (2011) Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis.. Int J Dev Biol, 55(6), 597-602.
• Butler R, Wood JD, Landers JA & Cunliffe VT (2010) Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.. Dis Model Mech, 3(11-12), 743-751.
• Walker RA, Cunliffe VT, Whittle JD, Steele DA & Short RD (2009) Submillimeter-scale surface gradients of immobilized protein ligands.. Langmuir, 25(8), 4243-4246.
• Wood JD, Bonath F, Kumar S, Ross CA & Cunliffe VT (2009) Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.. Hum Mol Genet, 18(3), 391-404.
• Prajsnar TK, Cunliffe VT, Foster SJ & Renshaw SA (2008) A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens.. Cell Microbiol, 10(11), 2312-2325.
• Cunliffe VT (2008) Eloquent silence: developmental functions of Class I histone deacetylases.. Curr Opin Genet Dev, 18(5), 404-410.
• Bryant RJ, Winder SJ, Cross SS, Hamdy FC & Cunliffe VT (2008) The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells.. Prostate, 68(3), 255-263.
• Bryant RJ, Cross NA, Eaton CL, Hamdy FC & Cunliffe VT (2007) EZH2 promotes proliferation and invasiveness of prostate cancer cells.. Prostate, 67(5), 547-556.
• Bryant RJ, Cross NA, Eaton CL, Hamdy FC & Cunliffe VT (2007) The polycomb group protein EZH2 is required for transcriptional repression of p21 and MMP7 in prostate cancer cells. EUR UROL SUPPL, 6(2), 131-131.
• Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ & Cunliffe VT (2006) The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.. Hum Mol Genet, 15(18), 2763-2771.
• Cunliffe VT & Casaccia-Bonnefil P (2006) Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS.. Mech Dev, 123(1), 24-30.
• Johns SA, Soullier S, Rashbass P & Cunliffe VT (2005) Foxn1 is required for tissue assembly and desmosomal cadherin expression in the hair shaft.. Dev Dyn, 232(4), 1062-1068.
• Cunliffe VT (2004) Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling.. Development, 131(12), 2983-2995.
• CUNLIFFE VT (2003) Zebrafish: A Practical Approach. Edited by C. NÜSSLEIN-VOLHARD and R. DAHM. Oxford University Press. 2002. 322 pages. ISBN 0 19 963808 X. Price £40.00 (paperback). ISBN 0 19 963809 8. Price £80.00 (hardback).. Genetical Research, 82(1), 79-79.
• Cunliffe VT (2003) Memory by modification: the influence of chromatin structure on gene expression during vertebrate development.. Gene, 305(2), 141-150.
• Showell C & Cunliffe VT (2002) Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed.. Gene, 291(1-2), 95-104.
• Cunliffe VT, Furley AJW & Keenan D (2002) Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene.. Mamm Genome, 13(5), 245-252.
• Showell C, Rafferty JB & Cunliffe VT (2001) Functional studies of the Xenopus Polycomb-group proteins Xeed and XEz.. DEV BIOL, 235(1), 262-263.
• Cunliffe V (2000) Epigenetic inheritance of coat colour. Trends in Genetics, 16(3), 116-116.
• Cunliffe V (1999) Why snakes don't have legs. Trends in Genetics, 15(8), 306-306.
• Cunliffe VT & Ingham PW (1999) Switching on the notochord.. Genes Dev, 13(13), 1643-1646.
• Fraisier C, Abraham DA, van Oijen M, Cunliffe V, Irvine A, Craig R & Dzierzak EA (1998) Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins. Gene Therapy, 5(7), 946-954.
• Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1998) Erratum: The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins (Genes and Development (1997) 11 (3265-3276)). Genes and Development, 12(8), 1240.
• Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1998) The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins (vol 11, pg 3265, 1997). GENES & DEVELOPMENT, 12(8), 1240-1240.
• Latinkic BV, Umbhauer M, Neal KA, Smith JC & Cunliffe V (1997) Regulation of the frog brachyury promoter by activin and FGF. FASEB Journal, 11(9).
• Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1997) The Xenopus Brachyury promoter is activated by FGF and low concentrations ofactivinandsuppressed by high concentrationsof activin and by paired-type homeodomain proteins. Genes & Development, 11(23), 3265-3276.
• Cunliffe V, Thatcher D & Craig R (1995) Innovative approaches to gene therapy. Current Opinion in Biotechnology, 6(6), 709-713.
• O'Reilly MAJ, Smith JC & Cunliffe V (1995) Patterning of the mesoderm in Xenopus: Dose-dependent and synergistic effects of Brachyury and Pintallavis. Development, 121(5), 1351-1359.
• Smith JC, Cunliffe V, O'Reilly M-AJ, Schulte-Merker S & Umbhauer M (1995) Xenopus Brachyury. Seminars in Developmental Biology, 6(6), 405-410.
• Cunliffe V & Smith JC (1994) Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.. The EMBO Journal, 13(2), 349-359.
• (1993) Intercellular signalling in mesoderm formation during amphibian development. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 340(1293), 287-296.
• Cunliffe V & Smith JC (1992) Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue. Nature, 358(6385), 427-430.
• Cunliffe V, Koopman P, McLaren A & Trowsdale J (1990) A mouse zinc finger gene which is transiently expressed during spermatogenesis.. The EMBO Journal, 9(1), 197-205.
• Cunliffe V, Williams S & Trowsdale J (1990) Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-regulated during spermatogenesis. Genomics, 8(2), 331-339.
• Cunliffe V & Trowsdale J (1987) The molecular genetics of human chromosome 6.. Journal of Medical Genetics, 24(11), 649-658.
• Pinho JS, Cunliffe V, Kareklas K, Petri G & Oliveira RF () Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation. Communications Biology, 6(1).
• Jubber I, Morhardt DR, Griffin J, Cumberbatch M, Glover M, Zheng Y, Rehman I, Loynes C, Hussain SA, Renshaw SA , Leach SD et al () Analysis of the distal urinary tract in larval and adult zebrafish reveals homology to the human system. Disease Models & Mechanisms.
• H E, C B, VT C, M P, JD W & PJ W () Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Yearbook of Paediatric Endocrinology.
• Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM () Bidirectional crosstalk between hypoxia-inducible factor and glucocorticoid signalling in zebrafish larvae. PLOS Genetics, 16(5). View this article in WRRO

Chapters

• Jones A, Marson AG, Cunliffe VT, Sills GJ & Morgan A (2021) C. elegans as a Potential Model for Acute Seizure-Like Activity, Neuromethods (pp. 233-248). Springer US
• Adwan-Shekhidem H, Atzmon G, Benayoun BA, Bowman JD, Braun KVE, Cacabelos R, Caiafa P, Cao X, Choudhury M, Chowdhury R , Ciccarone F et al (2018) List of Contributors, Epigenetics of Aging and Longevity (pp. xix-xxii). Elsevier

Conference proceedings papers

• Bacila I, Li N, Eachus H, Storbeck K-H, Cunliffe VT & Krone NP (2022) Towards understanding the metabolic phenotype of glucocorticoid deficiency in 21-hydroxylase deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 95(SUPPL 2) (pp 79-79)
• Li N, Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) The P450 side-chain cleavage isozyme cyp11a2 facilitates interrenal and gonadal steroid hormone biosynthesis in developing and adult zebrafish. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 66-67)
• Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) Investigating the roles of androgens in male reproductive development, maintenance and function by characterisation of androgen and cortisol deficient 11 beta-hydroxylase mutant zebrafish lines. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 50-50)
• Li N, Weger M, Griffin A, Eachus H, Cunliffe VT & Krone N (2018) Glucocorticoid Deficiency Causes Differentially Dysregulated Oxidative Stress Depending on the Steroidogenic Defects. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 71-72)
• Oakes JA, Liz N, Wistow B, Storbeck K-H, Cunliffe VT & Krone N (2018) The Roles of Steroids in Gonadal Development and Maintenance - Insights from a Zebrafish Model of Androgen and Cortisol Deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 53-53)
• Harrison MR, Georgiou AS, Lightman EG, Buckle AJ, Spaink HP & Cunliffe VT (2009) Neurodevelopmental functions of the epigenetic machinery in the zebrafish embryo: Histone Deacetylase 1 regulates transformation of neural progenitors into neurons and glia. DEVELOPMENTAL BIOLOGY, Vol. 331(2) (pp 408-408)

Preprints

• Jubber I, Morhardt DR, Griffin J, Cumberbatch M, Glover M, Zheng Y, Rehman I, Loynes C, Hussain SA, Renshaw SA , Leach SD et al (2023) Analysis of the Distal Urinary Tract in Larval and Adult Zebrafish Reveals Unrecognized Homology to the Human System, Cold Spring Harbor Laboratory.
• Pinho J, Cunliffe V, Petri G & Oliveira RF () Social and asocial learning in zebrafish are encoded by a shared brain network that is differentially modulated by local activation, Cold Spring Harbor Laboratory.
• Marchi D, Santhakumar K, Markham E, Li N, Storbeck K-H, Krone N, Cunliffe VT & van Eeden FJM () Bidirectional crosstalk between Hypoxia-Inducible Factor and glucocorticoid signalling in zebrafish larvae, Cold Spring Harbor Laboratory.