Dr Patrick Baker

School of Biosciences

Senior Lecturer

Patrick Baker
Profile picture of Patrick Baker
+44 114 222 2725

Full contact details

Dr Patrick Baker
School of Biosciences
Firth Court
Western Bank
S10 2TN

Career history

  • 2010 - Senior Lecturer, School of Biosciences, The University of Sheffield
  • 2015 - 2019 Director Of Studies and Deputy Head of Department, Dept of Molecular Biology and Biotechnology, The University of Sheffield
  • 2010: Visiting Lecturer, Dept Bioquimica, Faculdad Sciencias, The University of Alicante, Spain
  • 2008 -2010: Lecturer, Dept. of Molecular Biology and Biotechnology, The University of Sheffield
  • 1993 -2010: Senior Experimental Officer (X-ray facility manager) in the Krebs Institute, University of Sheffield
  • 1987-1993: Postdoctoral Research Associate, Dept. of Biochemistry, The University of Sheffield
  • 1984-1987: PhD. Student, Dept. of Biochemistry, The University of Sheffield
  • 1982-1984: Research Assistant, Dept. of Clinical Haematology, University College, London
Research interests

In my group we use X-ray crystallography to determine the atomic structure of biological macromolecules and thus to elucidate their structure/function relationships. We work closely with the other structural biology groups in Sheffield and have strong collaborations with numerous research groups across the world. Our research can be divided into three broad areas:

  • developing new antimicrobial targets
  • substrate specificity and chiral synthesis in enzymes
  • the molecular basis of extreme stability in proteins from extremophiles

Show: Featured publications All publications

Journal articles

All publications

Journal articles


Conference proceedings papers

  • Asano Y, Kato Y, Levy C, Baker P & Rice D (2004) Structure and Function of Amino Acid Ammonia-lyases. Biocatalysis and Biotransformation, Vol. 22(2) (pp 133-140) RIS download Bibtex download
  • Bailey S, Abdelghany HM, Sedelnikova SE, Blackburn GM, Baker PJ, Rafferty JB & McLennan AG (2002) Crystal structure and mutational analysis of the diadenosine tetraphosphate (Ap4A) 'Nudix' hydrolase from Caenorhabditis elegans. DRUG DEVELOPMENT RESEARCH, Vol. 56(4) (pp 567-567) RIS download Bibtex download
  • Buckley PA, Jackson JB, Rice DW, Sedelnikova SE, Burke J, Shneider T, Roth M & Baker PJ (2000) The Crystallization and structure analysis of the dI Component of Transhydrogenase, a Proton-Translocating Membrane Protein. Acta Crystallographica Section A Foundations of Crystallography, Vol. 56(s1) (pp s270-s270) RIS download Bibtex download
  • Wang XG, Britton LK, Baker PJ, Rice DW & Engel PC (1996) Improving the engineered activity of mutants of clostridial glutamate dehydrogenase towards monocarboxylic substrates: Substitution of Ala163 with glycine. BIOCHEMICAL SOCIETY TRANSACTIONS, Vol. 24(1) (pp S126-S126) RIS download Bibtex download
Research group

Structural Biology

Teaching activities

Level 4 modules

  • MBB403 Extended Research Project
  • MBB402 Advanced Literature Review 

Level 3 modules

  • MBB340 The Microbiology of Extreme Environments
  • MBB361 Literature Review
  • MBB380 Project

Level 2 modules

  • MBB261 Biochemistry 2 (Module coordinator)
  • MBB265 Practical Molecular Bioscience 2
  • MBB266 Biostructures, Energetics and Synthesis

Level 1 modules

  • MBB161 Biochemistry
  • MBB165 Practical Molecular Bioscience 1