Dr Ewald Hettema

Department of Molecular Biology and Biotechnology

Reader in Molecular Cell Biology

e.hettema@sheffield.ac.uk
+44 114 222 2732

Full contact details

Dr Ewald Hettema
Department of Molecular Biology and Biotechnology
Firth Court
Western Bank
Sheffield
S10 2TN
Profile

Career history

  • 2014 - present: Reader in Molecular Cell Biology, Dept. Molecular Biology and Biotechnology, University of Sheffield
  • 2008 - 2014: Wellcome Trust Senior Research Fellow in Basic Biomedical Science at University of Sheffield
  • 2004 - 2008: Wellcome Trust Career Development Fellow at University of Sheffield
  • 2000 - 2004: Postdoctoral Reserach Associate, MRC LMB, Cambridge
  • 1998 - 2000: Postdoctoral Reserach Associate, University of Amsterdam
  • 1998: PhD, University of Amsterdam
Research interests

My group aims to improve understanding of the molecular mechanisms underlying peroxisome dynamics at the cellular level.

Cells contain a large number of distinct membrane bound organelles. These compartments rely on complex machineries to acquire and maintain their unique composition and function.

We are studying one of these organelles, the peroxisome. Lack of functional peroxisomes results in a deficiency of a large number of enzymatic reactions and a disorder called Zellweger (ZS-) or cerebro-hepato-renal syndrome.

Proteins required for peroxisome formation are called peroxins and these have been found mutated in ZS patients.

Publications

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Journal articles

All publications

Journal articles

Conference proceedings papers

  • Al-hejjaj M, Watts D & Hettema EH (2016) Attempt to develop a CRISPR system for use in Dictyostelium discoideum.. MOLECULAR BIOLOGY OF THE CELL, Vol. 27 RIS download Bibtex download
Teaching activities

Level 3 modules

MBB342 Genetics of Cell Growth and Division

Level 1 modules

MBB164 Molecular Biology