Grant summary

How do the atypical cadherins Fat and Dachsous integrate growth and patterning during development?

BBSRC responsive mode grant £591,938

Prof David Strutt (BMS), Dr Alexander Fletcher (SoMaS), Dr Paul Richmond (CS), with Dr Katherine Fisher (BMS) as Researcher Co-investigator.

How do organs in our bodies grow to form the correct size and shape? How is this controlled so that they don’t overgrow? This research sparks an exciting new collaboration at the interface of biology and applied mathematics. Using the wing of the fruit fly as a model system, we will combine experiments with mathematical modelling to find out how cells communicate with one another to build a sense of direction, how this sense of direction orients growth and how cell-level information provides feedback to the system to halt growth.