Dr Vincent Cunliffe: Publications
The P450 side chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish. Journal of Endocrinology. View this article in WRRO
Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish.. Endocrinology. View this article in WRRO
Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy. The Prostate, 79(10), 1079-1089. View this article in WRRO
The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. Journal of Neuroscience Methods, 309, 132-142. View this article in WRRO
Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish. Journal of Developmental Biology, 6(1). View this article in WRRO
Epigenetics and primary care. British Journal of General Practice, 68(666), 8-9. View this article in WRRO
Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158(12), 4165-4173. View this article in WRRO
Biological Embedding of Psychosocial Stress Over the Life Course. Translational Epigenetics, 4, 251-270. View this article in WRRO
Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix Biology, 62, 58-74. View this article in WRRO
Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Human Molecular Genetics, 26(11), 1992-2005. View this article in WRRO
Epigenetic memory in response to environmental stressors.. FASEB J. View this article in WRRO
The epigenetic impacts of social stress: how does social adversity become biologically embedded?. Epigenomics, 8(12), 1653-1669. View this article in WRRO
Histone modifications in zebrafish development. Methods in Cell Biology, 135, 361-385. View this article in WRRO
Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures. Journal of Neuroscience Methods, 260, 91-95.
Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open, 4(10), 1336-1343. View this article in WRRO
Experience-sensitive epigenetic mechanisms, developmental plasticity, and the biological embedding of chronic disease risk. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7(2), 53-71.
The role of Sox6 in zebrafish muscle fiber type specification. Skeletal Muscle, 5(1), 2-2. View this article in WRRO
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature Communications, 6. View this article in WRRO
Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms. Seizure, 24, 44-51.
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.. Dis Model Mech, 5(6), 773-784. View this article in WRRO
The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos.. BMC Genomics, 12, 24.
Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis.. Int J Dev Biol, 55(6), 597-602.
Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.. Dis Model Mech, 3(11-12), 743-751.
Submillimeter-scale surface gradients of immobilized protein ligands.. Langmuir, 25(8), 4243-4246.
Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.. Hum Mol Genet, 18(3), 391-404.
A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens.. Cell Microbiol, 10(11), 2312-2325.
Eloquent silence: developmental functions of Class I histone deacetylases.. Curr Opin Genet Dev, 18(5), 404-410.
The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells.. Prostate, 68(3), 255-263.
EZH2 promotes proliferation and invasiveness of prostate cancer cells.. Prostate, 67(5), 547-556.
The polycomb group protein EZH2 is required for transcriptional repression of p21 and MMP7 in prostate cancer cells. EUR UROL SUPPL, 6(2), 131-131.
The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.. Hum Mol Genet, 15(18), 2763-2771.
Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS.. Mech Dev, 123(1), 24-30.
Foxn1 is required for tissue assembly and desmosomal cadherin expression in the hair shaft.. Dev Dyn, 232(4), 1062-1068.
Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling.. Development, 131(12), 2983-2995.
Zebrafish: A Practical Approach. Edited by C. NÜSSLEIN-VOLHARD and R. DAHM. Oxford University Press. 2002. 322 pages. ISBN 0 19 963808 X. Price £40.00 (paperback). ISBN 0 19 963809 8. Price £80.00 (hardback).. Genetical Research, 82(1), 79-79.
Memory by modification: the influence of chromatin structure on gene expression during vertebrate development.. Gene, 305(2), 141-150.
Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed.. Gene, 291(1-2), 95-104.
Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene.. Mamm Genome, 13(5), 245-252.
Functional studies of the Xenopus Polycomb-group proteins Xeed and XEz.. DEV BIOL, 235(1), 262-263.
Epigenetic inheritance of coat colour. Trends in Genetics, 16(3), 116-116.
Switching on the notochord.. Genes Dev, 13(13), 1643-1646.
Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins. Gene Therapy, 5(7), 946-954.
Erratum: The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins (Genes and Development (1997) 11 (3265-3276)). Genes and Development, 12(8), 1240.
Regulation of the frog brachyury promoter by activin and FGF. FASEB Journal, 11(9).
The Xenopus Brachyury promoter is activated by FGF and low concentrations ofactivinandsuppressed by high concentrationsof activin and by paired-type homeodomain proteins. Genes & Development, 11(23), 3265-3276.
Patterning of the mesoderm in Xenopus: Dose-dependent and synergistic effects of Brachyury and Pintallavis. Development, 121(5), 1351-1359.
Innovative approaches to gene therapy. Current Opinion in Biotechnology, 6(6), 709-713.
Xenopus Brachyury. Seminars in Developmental Biology, 6(6), 405-410.
Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.. The EMBO Journal, 13(2), 349-359.
Intercellular signalling in mesoderm formation during amphibian development. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 340(1293), 287-296.
Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue. Nature, 358(6385), 427-430.
A mouse zinc finger gene which is transiently expressed during spermatogenesis.. The EMBO Journal, 9(1), 197-205.
Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-regulated during spermatogenesis. Genomics, 8(2), 331-339.
The molecular genetics of human chromosome 6.. Journal of Medical Genetics, 24(11), 649-658.
Investigating the roles of steroids in gonadal development and maintenance using an androgen and cortisol deficient zebrafish model. Endocrine Abstracts.
Towards an understanding of the function of the mineralocorticoid receptor in zebrafish: the stress response, behaviour and osmoregulation. Endocrine Abstracts.
Conference proceedings papers
The P450 side-chain cleavage isozyme cyp11a2 facilitates interrenal and gonadal steroid hormone biosynthesis in developing and adult zebrafish. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 66-67)
Investigating the roles of androgens in male reproductive development, maintenance and function by characterisation of androgen and cortisol deficient 11 beta-hydroxylase mutant zebrafish lines. HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 50-50)
Glucocorticoid Deficiency Causes Differentially Dysregulated Oxidative Stress Depending on the Steroidogenic Defects. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 71-72)
The Roles of Steroids in Gonadal Development and Maintenance - Insights from a Zebrafish Model of Androgen and Cortisol Deficiency. HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 53-53)
Neurodevelopmental functions of the epigenetic machinery in the zebrafish embryo: Histone Deacetylase 1 regulates transformation of neural progenitors into neurons and glia. DEVELOPMENTAL BIOLOGY, Vol. 331(2) (pp 408-408)