Dr Vincent Cunliffe: Publications
Li N, Oakes JA, Storbeck K, Cunliffe VT & Krone N (2019)
The P450 side chain cleavage enzyme Cyp11a2 facilitates steroidogenesis in zebrafish. Journal of Endocrinology.
Oakes JA, Li N, Wistow BRC, Griffin A, Barnard L, Storbeck K-H, Cunliffe VT & Krone NP (2019)
Ferredoxin 1b deficiency leads to testis disorganization, impaired spermatogenesis and feminization in zebrafish.. Endocrinology. View this article in WRRO
Wu X, Scott H, Carlsson SV, Sjoberg DD, Cerundolo L, Lilja H, Prevo R, Rieunier G, Macaulay V, Higgins GS , Verrill CL et al (2019)
Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy. The Prostate, 79(10), 1079-1089. View this article in WRRO
Chhabria K, Plant K, Bandmann O, Wilkinson R, Martin C, Kugler E, Armitage P, Santoscoy P, Cunliffe V, Huisken J , Mcgown A et al (2018)
The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism. View this article in WRRO
Wong SQ, Jones A, Dodd S, Grimes D, Barclay JW, Marson AG, Cunliffe VT, Burgoyne RD, Sills GJ & Morgan A (2018)
A Caenorhabditis elegans assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action. Journal of Neuroscience Methods, 309, 132-142. View this article in WRRO
Bergmann K, Meza Santoscoy P, Lygdas K, Nikolaeva Y, MacDonald R, Cunliffe V & Nikolaev AV (2018)
Imaging Neuronal Activity in the Optic Tectum of Late Stage Larval Zebrafish. Journal of Developmental Biology, 6(1). View this article in WRRO
Lehane D, Cunliffe V, Mitchell C & Burton C (2018)
Epigenetics and primary care. British Journal of General Practice, 68(666), 8-9. View this article in WRRO
Eachus H, Zaucker A, Oakes JA, Griffin A, Weger M, Güran T, Taylor A, Harris A, Greenfield A, Quanson JL , Storbeck K-H et al (2017)
Genetic disruption of 21-hydroxylase in zebrafish causes interrenal hyperplasia. Endocrinology, 158(12), 4165-4173. View this article in WRRO
Cunliffe VT & Eachus (2017)
Biological Embedding of Psychosocial Stress Over the Life Course. Translational Epigenetics, 4, 251-270. View this article in WRRO
Pickering J, Cunliffe VT, Van Eeden F & Borycki A-G (2017)
Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix Biology, 62, 58-74. View this article in WRRO
Eachus H, Bright C, Cunliffe VT, Placzek M, Wood JD & Watt PJ (2017)
Disrupted-in-Schizophrenia-1 is essential for normal hypothalamic-pituitary-interrenal (HPI) axis function. Human Molecular Genetics, 26(11), 1992-2005. View this article in WRRO
Vineis P, Chatziioannou A, Cunliffe VT, Flanagan JM, Hanson M, Kirsch-Volders M & Kyrtopoulos S (2017)
Epigenetic memory in response to environmental stressors.. FASEB J. View this article in WRRO
Cunliffe VT (2016)
The epigenetic impacts of social stress: how does social adversity become biologically embedded?. Epigenomics, 8(12), 1653-1669. View this article in WRRO
Cunliffe VT (2016)
Histone modifications in zebrafish development. Methods in Cell Biology, 135, 361-385. View this article in WRRO
Cunliffe VT (2016)
Building a zebrafish toolkit for investigating the pathobiology of epilepsy and identifying new treatments for epileptic seizures. Journal of Neuroscience Methods, 260, 91-95.
Boyd PJ, Cunliffe VT, Roy S & Wood JD (2015)
Sonic hedgehog functions upstream of disrupted-in-schizophrenia 1 (disc1): implications for mental illness. Biology Open, 4(10), 1336-1343. View this article in WRRO
Cunliffe VT (2015)
Experience-sensitive epigenetic mechanisms, developmental plasticity, and the biological embedding of chronic disease risk. Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 7(2), 53-71.
Jackson HE, Ono Y, Wang X, Elworthy S, Cunliffe VT & Ingham PW (2015)
The role of Sox6 in zebrafish muscle fiber type specification. Skeletal Muscle, 5(1), 2-2. View this article in WRRO
Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M , Hajji N et al (2015)
Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nature Communications, 6. View this article in WRRO
Cunliffe VT, Baines RA, Giachello CNG, Lin W-H, Morgan A, Reuber M, Russell C, Walker MC & Williams RSB (2015)
Epilepsy research methods update: Understanding the causes of epileptic seizures and identifying new treatments using non-mammalian model organisms. Seizure, 24, 44-51.
Baxendale S, Holdsworth CJ, Meza Santoscoy PL, Harrison MRM, Fox J, Parkin CA, Ingham PW & Cunliffe VT (2012)
Identification of compounds with anti-convulsant properties in a zebrafish model of epileptic seizures.. Dis Model Mech, 5(6), 773-784. View this article in WRRO
Harrison MRM, Georgiou AS, Spaink HP & Cunliffe VT (2011)
The epigenetic regulator Histone Deacetylase 1 promotes transcription of a core neurogenic programme in zebrafish embryos.. BMC Genomics, 12, 24.
Lightman EG, Harrison MRM & Cunliffe VT (2011)
Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis.. Int J Dev Biol, 55(6), 597-602.
Butler R, Wood JD, Landers JA & Cunliffe VT (2010)
Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia.. Dis Model Mech, 3(11-12), 743-751.
Walker RA, Cunliffe VT, Whittle JD, Steele DA & Short RD (2009)
Submillimeter-scale surface gradients of immobilized protein ligands.. Langmuir, 25(8), 4243-4246.
Wood JD, Bonath F, Kumar S, Ross CA & Cunliffe VT (2009)
Disrupted-in-schizophrenia 1 and neuregulin 1 are required for the specification of oligodendrocytes and neurones in the zebrafish brain.. Hum Mol Genet, 18(3), 391-404.
Prajsnar TK, Cunliffe VT, Foster SJ & Renshaw SA (2008)
A novel vertebrate model of Staphylococcus aureus infection reveals phagocyte-dependent resistance of zebrafish to non-host specialized pathogens.. Cell Microbiol, 10(11), 2312-2325.
Cunliffe VT (2008)
Eloquent silence: developmental functions of Class I histone deacetylases.. Curr Opin Genet Dev, 18(5), 404-410.
Bryant RJ, Winder SJ, Cross SS, Hamdy FC & Cunliffe VT (2008)
The Polycomb Group protein EZH2 regulates actin polymerization in human prostate cancer cells.. Prostate, 68(3), 255-263.
Bryant RJ, Cross NA, Eaton CL, Hamdy FC & Cunliffe VT (2007)
EZH2 promotes proliferation and invasiveness of prostate cancer cells.. Prostate, 67(5), 547-556.
Bryant RJ, Cross NA, Eaton CL, Hamdy FC & Cunliffe VT (2007) The polycomb group protein EZH2 is required for transcriptional repression of p21 and MMP7 in prostate cancer cells.
EUR UROL SUPPL, 6(2), 131-131.
Wood JD, Landers JA, Bingley M, McDermott CJ, Thomas-McArthur V, Gleadall LJ, Shaw PJ & Cunliffe VT (2006)
The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo.. Hum Mol Genet, 15(18), 2763-2771.
Cunliffe VT & Casaccia-Bonnefil P (2006)
Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS.. Mech Dev, 123(1), 24-30.
Johns SA, Soullier S, Rashbass P & Cunliffe VT (2005)
Foxn1 is required for tissue assembly and desmosomal cadherin expression in the hair shaft.. Dev Dyn, 232(4), 1062-1068.
Cunliffe VT (2004)
Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling.. Development, 131(12), 2983-2995.
CUNLIFFE VINCENTT (2003)
Zebrafish: A Practical Approach. Edited by C. NÜSSLEIN-VOLHARD and R. DAHM. Oxford University Press. 2002. 322 pages. ISBN 0 19 963808 X. Price £40.00 (paperback). ISBN 0 19 963809 8. Price £80.00 (hardback).. Genetical Research, 82(1), 79-79.
Cunliffe VT (2003)
Memory by modification: the influence of chromatin structure on gene expression during vertebrate development.. Gene, 305(2), 141-150.
Showell C & Cunliffe VT (2002)
Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed.. Gene, 291(1-2), 95-104.
Cunliffe VT, Furley AJW & Keenan D (2002)
Complete rescue of the nude mutant phenotype by a wild-type Foxn1 transgene.. Mamm Genome, 13(5), 245-252.
Showell C, Rafferty JB & Cunliffe VT (2001) Functional studies of the Xenopus Polycomb-group proteins Xeed and XEz..
DEV BIOL, 235(1), 262-263.
Cunliffe V (2000)
Epigenetic inheritance of coat colour. Trends in Genetics, 16(3), 116-116.
Cunliffe VT & Ingham PW (1999)
Switching on the notochord.. Genes Dev, 13(13), 1643-1646.
Fraisier C, Abraham DA, van Oijen M, Cunliffe V, Irvine A, Craig R & Dzierzak EA (1998)
Inhibition of Tat-mediated transactivation and HIV replication with Tat mutant and repressor domain fusion proteins. Gene Therapy, 5(7), 946-954.
Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1998) Erratum: The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins (Genes and Development (1997) 11 (3265-3276)).
Genes and Development, 12(8), 1240.
Latinkic BV, Umbhauer M, Neal KA, Smith JC & Cunliffe V (1997) Regulation of the frog brachyury promoter by activin and FGF.
FASEB Journal, 11(9).
Latinkic BV, Umbhauer M, Neal KA, Lerchner W, Smith JC & Cunliffe V (1997)
The Xenopus Brachyury promoter is activated by FGF and low concentrations ofactivinandsuppressed by high concentrationsof activin and by paired-type homeodomain proteins. Genes & Development, 11(23), 3265-3276.
O'Reilly MAJ, Smith JC & Cunliffe V (1995) Patterning of the mesoderm in Xenopus: Dose-dependent and synergistic effects of Brachyury and Pintallavis.
Development, 121(5), 1351-1359.
Cunliffe V, Thatcher D & Craig R (1995)
Innovative approaches to gene therapy. Current Opinion in Biotechnology, 6(6), 709-713.
Smith JC, Cunliffe V, O'Reilly M-AJ, Schulte-Merker S & Umbhauer M (1995)
Xenopus Brachyury. Seminars in Developmental Biology, 6(6), 405-410.
Cunliffe V & Smith JC (1994)
Specification of mesodermal pattern in Xenopus laevis by interactions between Brachyury, noggin and Xwnt-8.. The EMBO Journal, 13(2), 349-359.
Intercellular signalling in mesoderm formation during amphibian development. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 340(1293), 287-296.
Cunliffe V & Smith JC (1992)
Ectopic mesoderm formation in Xenopus embryos caused by widespread expression of a Brachyury homologue. Nature, 358(6385), 427-430.
Cunliffe V, Koopman P, McLaren A & Trowsdale J (1990)
A mouse zinc finger gene which is transiently expressed during spermatogenesis.. The EMBO Journal, 9(1), 197-205.
Cunliffe V, Williams S & Trowsdale J (1990)
Genomic analysis of a mouse zinc finger gene, Zfp-35, that is up-regulated during spermatogenesis. Genomics, 8(2), 331-339.
Cunliffe V & Trowsdale J (1987)
The molecular genetics of human chromosome 6.. Journal of Medical Genetics, 24(11), 649-658.
Oakes J, Li N, Wistow B, Storbeck K-H, Cunliffe V & Krone N ()
Investigating the roles of steroids in gonadal development and maintenance using an androgen and cortisol deficient zebrafish model. Endocrine Abstracts.
Paveley J, Cunliffe V & Krone N () Towards an understanding of the function of the mineralocorticoid receptor in zebrafish: the stress response, behaviour and osmoregulation. Endocrine Abstracts.
Adwan-Shekhidem H, Atzmon G, Benayoun BA, Bowman JD, Braun KVE, Cacabelos R, Caiafa P, Cao X, Choudhury M, Chowdhury R , Ciccarone F et al (2018) List of Contributors, Epigenetics of Aging and Longevity (pp. xix-xxii). Elsevier
Conference proceedings papers
Li N, Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) The P450 side-chain cleavage isozyme cyp11a2 facilitates interrenal and gonadal steroid hormone biosynthesis in developing and adult zebrafish.
HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 66-67)
Oakes JA, Storbeck K-H, Cunliffe VT & Krone NP (2019) Investigating the roles of androgens in male reproductive development, maintenance and function by characterisation of androgen and cortisol deficient 11 beta-hydroxylase mutant zebrafish lines.
HORMONE RESEARCH IN PAEDIATRICS, Vol. 91 (pp 50-50)
Li N, Weger M, Griffin A, Eachus H, Cunliffe VT & Krone N (2018) Glucocorticoid Deficiency Causes Differentially Dysregulated Oxidative Stress Depending on the Steroidogenic Defects.
HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 71-72)
Oakes JA, Liz N, Wistow B, Storbeck K-H, Cunliffe VT & Krone N (2018) The Roles of Steroids in Gonadal Development and Maintenance - Insights from a Zebrafish Model of Androgen and Cortisol Deficiency.
HORMONE RESEARCH IN PAEDIATRICS, Vol. 90 (pp 53-53)
Harrison MR, Georgiou AS, Lightman EG, Buckle AJ, Spaink HP & Cunliffe VT (2009) Neurodevelopmental functions of the epigenetic machinery in the zebrafish embryo: Histone Deacetylase 1 regulates transformation of neural progenitors into neurons and glia. DEVELOPMENTAL BIOLOGY, Vol. 331(2) (pp 408-408)