Dr Jarema Malicki
Reader in Developmental Genetics
Room: D18 Firth Court
Eukaryotic cilia are fascinating highly polarized cell surface features that frequently detect and/or process extracellular signals, including small molecules, light, and polypeptides. We aim to understand how signal transduction mechanisms are assembled in cilia and how they function is processes as diverse as embryonic patterning, vision, and metabolism.
The laboratory has also some interest in other aspects of cell polarity, such as membrane subcompartmentalization and organelle positioning in cell’s cytoplasm.
Ciliogenesis and Cell Polarity
We use several types of microscopy to visualize cilia: conventional confocal microscopy, selective plane illumination microscopy (SPIM), and stochastic optical reconstruction microscopy (STORM).
To identify binding partners of ciliary proteins, we use tandem affinity purification (TAP) followed by mass spectrometry and yeast two-hybrid screens. We also use mass spectrometry to identify post-translational modifications, such as acetylation, on ciliary proteins.
Undergraduate and postgraduate taught modules
Postgraduate PhD Opportunities
We advertise PhD opportunities (Funded or Self-Funded) on FindAPhD.com
For further information and details of other projects on offer, please see the department PhD Opportunities page:
- Hazime K & Malicki JJ (2017) Apico-basal Polarity Determinants Encoded by crumbs Genes Affect Ciliary Shaft Protein Composition, IFT Movement Dynamics, and Cilia Length. Genetics, 207(3), 1041-1051. View this article in WRRO
- Malicki JJ & Johnson CA (2017) The Cilium: Cellular Antenna and Central Processing Unit. Trends in Cell Biology, 27(2), 126-140. View this article in WRRO
- Pooranachandran N & Malicki JJ (2016) Unexpected Roles for Ciliary Kinesins and Intraflagellar Transport Proteins. Genetics, 203(2), 771-785.
- Jin D, Ni TT, Sun J, Wan H, Amack JD, Yu G, Fleming J, Chiang C, Li W, Papierniak A, Cheepala S, Conseil G, Cole SPC, Zhou B, Drummond IA, Schuetz JD, Malicki J & Zhong TP (2014) Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport. Nature Cell Biology, 16(9), 841-851. View this article in WRRO
- Malicki J (2012) Who drives the ciliary highway?. Bioarchitecture, 2(4), 111-117. View this article in WRRO
- Zhao C, Omori Y, Brodowska K, Kovach P & Malicki J (2012) Kinesin-2 family in vertebrate ciliogenesis.. Proc Natl Acad Sci U S A, 109(7), 2388-2393.
- Zhao C & Malicki J (2011) Nephrocystins and MKS proteins interact with IFT particle and facilitate transport of selected ciliary cargos.. EMBO J, 30(13), 2532-2544.