Dr Mohammed Nassar: Publications full
An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. PAIN. View this article in WRRO
Mice lacking Kcns1 in peripheral neurons show increased basal and neuropathic pain sensitivity. PAIN, 159(8), 1641-1651. View this article in WRRO
NaV1.7 and pain: contribution of peripheral nerves.. Pain. View this article in WRRO
Veratridine produces distinct calcium response profiles in mouse Dorsal Root Ganglia neurons. Scientific Reports, 7. View this article in WRRO
Reduced excitability and impaired nociception in peripheral unmyelinated fibers from Nav1.9-null mice. PAIN, 158(1), 58-67.
Use dependence of peripheral nociceptive conduction in the absence of TTXr sodium channel subtypes. Journal of Physiology, 594(19), 5529-5541.
Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins, 8(3), 78-78. View this article in WRRO
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis. Acta Neuropathologica Communications, 3(1). View this article in WRRO
Mouse DRG Cell Line with Properties of Nociceptors. PLOS ONE, 10(6). View this article in WRRO
Na+current properties in islet α- and β-cells reflect cell-specificScn3aandScn9aexpression. The Journal of Physiology, 592(21), 4677-4696.
Multiple roles for NaV1.9 in the activation of visceral afferents by noxious inflammatory, mechanical, and human disease-derived stimuli.. Pain, 155(10), 1962-1975.
Pain without nociceptors? Nav1.7-independent pain mechanisms.. Cell Rep, 6(2), 301-312. View this article in WRRO
Sodium channels and mammalian sensory mechanotransduction. Molecular Pain, 8. View this article in WRRO
Mo1862 The Effect of Human Supernatants From IBS Patients on Neuronal Excitability and Sodium Channel Trafficking. Gastroenterology, 142(5).
Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. Nature Communications, 3. View this article in WRRO
Role of na. v1.9 in activity-dependent axon growth in motoneurons Human Molecular Genetics, 21(16), 3655-3667.
Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. PAIN, 152(6), 1238-1248.
Small RNAs control sodium channel expression, nociceptor excitability, and pain thresholds.. J Neurosci, 30(32), 10860-10871.
RET Signaling Is Required for Survival and Normal Function of Nonpeptidergic Nociceptors. JOURNAL OF NEUROSCIENCE, 30(11), 3983-3994.
GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain. JOURNAL OF NEUROSCIENCE, 30(6), 2138-2149.
Nociceptor-expressed ephrin-B2 regulates inflammatory and neuropathic pain. Molecular Pain, 6. View this article in WRRO
Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. LEARNING & MEMORY, 16(10), 635-644.
SENSORY AXON-DERIVED NEUREGULIN-1 IS REQUIRED FOR AXOGLIAL SIGNALLING AND NORMAL SENSORY FUNCTION BUT NOT FOR LONG TERM AXON MAINTENANCE. JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, 14, 51-51.
Sensory Axon-Derived Neuregulin-1 Is Required for Axoglial Signaling and Normal Sensory Function But Not for Long-Term Axon Maintenance. JOURNAL OF NEUROSCIENCE, 29(24), 7667-7678.
The cell and molecular basis of mechanical, cold, and inflammatory pain.. Science, 321(5889), 702-705.
GTP up-regulated persistent Na(+) current and enhanced nociceptor excitability require Na(V)1.9. JOURNAL OF PHYSIOLOGY-LONDON, 586(4), 1077-1087.
Nerve Injury Induces Robust Allodynia and Ectopic Discharges in Nav1.3 Null Mutant Mice. Molecular Pain, 2. View this article in WRRO
Deletion of Annexin 2 Light Chain p11 in Nociceptors Causes Deficits in Somatosensory Coding and Pain Behavior. Journal of Neuroscience, 26(41), 10499-10507.
Tamoxifen-inducible NaV1.8-CreERT2 recombinase activity in nociceptive neurons of dorsal root ganglia. genesis, 44(8), 364-371.
Nociceptor-derived brain-derived neurotrophic factor regulates acute and inflammatory but not neuropathic pain. Molecular and Cellular Neuroscience, 31(3), 539-548.
Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor. Neuron, 47(6), 787-793.
Neuropathic Pain Develops Normally in Mice Lacking both Nav1.7 and Nav1.8. Molecular Pain, 1. View this article in WRRO
Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice. Pain, 113(1), 27-36.
Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proceedings of the National Academy of Sciences, 101(34), 12706-12711.
Absence of Whisker-Related Pattern Formation in Mice with NMDA Receptors Lacking Coincidence Detection Properties and Calcium Signaling. The Journal of Neuroscience, 23(6), 2323-2332.
Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour.. The Journal of Physiology, 500(1), 123-138.
Single-channel currents from recombinant NM DANRla /NR2D receptors expressed in Xenopus oocytes. Proceedings of the Royal Society of London. Series B: Biological Sciences, 263(1373), 1079-1086.
Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proceedings of the Royal Society of London. Series B: Biological Sciences, 262(1364), 205-213.
A P2X purinoceptor cDNA conferring a novel pharmacological profile. FEBS Letters, 375(1-2), 129-133.
Sodium Channels in Primary Sensory Neurons: Relationship to Pain States, 159-172.
Painful and painless mutations of SCN9A and SCN11A voltage-gated sodium channels. Pflügers Archiv - European Journal of Physiology, 865-880.