Neuroscience in Biomedical Science extends from development of the nervous system and neuronal cell biology, through to sensory neurophysiology and computational modelling.
We have internationally recognised strengths in sensory neuroscience of visual, auditory and olfactory systems. We also have a growing interest in understanding the sensing and alleviation of chronic pain and in developing effective model systems for gaining insight into complex behavioural disorders such as stress and anxiety.
Cell Signalling and Proteome Dynamics.
Development of the Zebrafish Central Nervous System.
Biomolecular assembly, neuronal blockers, medicines for chronic pain, anti-cancer biological drugs.
Role of L1CAM-like adhesion molecules in neural development.
Neurogastroenterology: the neural control of gut function.
Protein SUMOylation and deSUMOylation in health and disease.
Development of mammalian inner ear.
Signalling characteristics of cochlear hair cells.
Neural processing, particularly in the visual system of Drosophila. Efficient codes and circuitry, form-function relationships, attention, learning and memory.
Sensory coding, synaptic plasticity, and learning and memory in the Drosophila olfactory system.
Cell polarity and ciliogenesis.
Development of mammalian cochlear hair cells.
Endocytosis - Molecular mechanisms of cargo sorting along the endocytic pathway with particular emphasis on the regulation of the clathrin coated vesicle cycle by rab5 and reversible phosphorylation. Interplay between endocytic trafficking and signaling pathways.
In vivo imaging of neuronal activity in zebrafish and visual information processing in the central nervous system.
Differentiation of auditory cells from hPSC; regenerative applications for the treatment of deafness.
Role of ion channels in epithelial health and disease.
Neural patterning and hypothalamic differentiation.
Ion channels, receptors and regulation of exocytosis.
Development of the fish inner ear.