Stem Cells and Regenerative Medicine
Stem cells are cells that can divide indefinitely while retaining not only their own characteristics, but also the ability to differentiate into other cell types. In Biomedical Science, we focus on different types of stem cells, adult stem cells of the nervous system and muscles, which play key roles in replacing functional cells lost through ageing or injury, pluripotent stem cells, which can be isolated from the very early embryo or induced by ‘reprogramming’ of adult cells. These cells are capable of differentiating to form all of the many cell types found in the adult body, opening up the prospect of using them to produce specific cells for regenerative medicine, to replace degenerating or diseased tissue.
In Biomedical Science we are working to understand the mechanisms that control the proliferation and differentiation of human pluripotent stem cells so that they can be used safely, for example, to treat diseases affecting the eyes, the ears and the nervous system.
Mechanisms of fate determination in human pluripotent stem cells (hPSC); genetic stability and the relation of hPSC to cancer; neural crest differentiation from hPSC.
Genetic stability of hPSC; fate determination in hPSC.
Satellite cell biology and skeletal muscle regeneration.
To understand and define the source of uncertainty in quantitative biology it is a key aspect for improving sensitivity and accuracy in the analysis of high throughput genomic data.
Differentiation of auditory cells from hPSC; regenerative applications for the treatment of deafness.
Neural patterning and hypothalamic differentiation.
Zebrafish musculoskeletal development.
Stem cell potency in development and disease.