Dr Martin Zeidler: Publications
How does methotrexate work?. Biochemical Society Transactions, 48(2), 559-567.
JAK inhibition by methotrexate (and csDMARDs) may explain clinical efficacy as monotherapy and combination therapy. Journal of Leukocyte Biology, 106(5), 1063-1068. View this article in WRRO
Low‐dose methotrexate: potential clinical impact on haematological and constitutional symptoms in myeloproliferative neoplasms. British Journal of Haematology, 187(3).
ZOLEDRONATE EXTENDS LIFESPAN AND HEALTHSPAN IN VIVO. Innovation in Aging, 2(suppl_1), 545-545.
A genome-wide RNAi screen identifies MASK as a positive regulator of cytokine receptor stability.. Journal of Cell Science, 131(13). View this article in WRRO
Ankyrin repeat and Single KH domain 1 (ANKHD1) drives renal cancer cell proliferation via binding to and altering a subset of miRNAs.. The Journal of Biological Chemistry, 293, 9570-9579. View this article in WRRO
Low-dose methotrexate in myeloproliferative neoplasm models.. Haematologica, 102, e336-e339. View this article in WRRO
Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran. Molecular Biology of the Cell, 27(3), 421-598. View this article in WRRO
The role of JAK/STAT signalling in the pathogenesis, prognosis and treatment of solid tumours. British Journal of Cancer, 113(3), 365-371. View this article in WRRO
Methotrexate Is a JAK/STAT Pathway Inhibitor. PLOS ONE, 10(7). View this article in WRRO
Effect of methotrexate on JAK/STAT pathway activation in myeloproliferative neoplasms. The Lancet, 385, S98-S98.
G 73B is a downstream effector of JAK/STAT signalling and a regulator of Rho1 in Drosophila haematopoiesis. Development, 141(3), e308-e308.
Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.. Mol Biol Cell, 24(18), 3000-3009. View this article in WRRO
Control of tissue morphology by Fasciclin III-mediated intercellular adhesion.. Development, 140(18), 3858-3868.
Localised JAK/STAT pathway activation is required for Drosophila wing hinge development.. PLoS One, 8(5), e65076. View this article in WRRO
The Drosophila JAK-STAT pathway. JAK-STAT, 2(3).
Gα73Β is a downstream effector of JAK/STAT signaling and a regulator of Rho1 in Drosophila hematopoiesis. J Cell Sci.
Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway.. BMC Genomics, 13, 506. View this article in WRRO
Matters of the heart. JAK-STAT, 1(3), 208-210. View this article in WRRO
Simplified Insertion of Transgenes Onto Balancer Chromosomes via Recombinase-Mediated Cassette Exchange.. G3 (Bethesda), 2(5), 551-553. View this article in WRRO
Modulation of human JAK-STAT pathway signaling by functionally conserved regulators. JAK-STAT, 1(1), 34-43. View this article in WRRO
Drosophila SOCS Proteins.. J Signal Transduct, 2011, 894510. View this article in WRRO
Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. Cellular Signalling, 23(5), 920-927.
Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. Development, 137(21), e2107-e2107.
Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.. J Cell Sci, 123(Pt 20), 3457-3466.
Transcriptional targets of Drosophila JAK/STAT pathway signalling as effectors of haematopoietic tumour formation.. EMBO Rep, 11(3), 201-207.
Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences.. EMBO Rep, 9(11), 1114-1120. View this article in WRRO
Unphosphorylated STATs go nuclear.. Curr Opin Genet Dev, 18(5), 455-460.
MsSOCS expression indicates a potential role for JAK/STAT signalling in the early stages of Manduca sexta spermatogenesis.. Insect Mol Biol, 17(5), 475-483.
Identification of JAK/STAT pathway regulators--insights from RNAi screens.. Semin Cell Dev Biol, 19(4), 360-369.
JAK/STAT signalling in Drosophila: insights into conserved regulatory and cellular functions.. Development, 133(14), 2605-2616.
Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E.. Cell Signal, 18(6), 819-829.
JAK/STAT signalling in Drosophila controls cell motility during germ cell migration.. Dev Dyn, 235(4), 958-966.
Identification of Drosophila genes modulating Janus kinase/signal transducer and activator of transcription signal transduction.. Genetics, 172(3), 1683-1697.
Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes.. Curr Biol, 16(1), 80-88.
Characterisation of Upd2, a Drosophila JAK/STAT pathway ligand.. Dev Biol, 288(2), 420-433.
Identification of JAK/STAT signalling components by genome-wide RNA interference.. Nature, 436(7052), 871-875.
Opposing roles for Drosophila JAK/STAT signalling during cellular proliferation.. Oncogene, 24(15), 2503-2511.
Temperature-sensitive control of protein activity by conditionally splicing inteins.. Nat Biotechnol, 22(7), 871-876.
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway.. Genetics, 165(3), 1149-1166.
Cloning and expression of Drosophila SOCS36E and its potential regulation by the JAK/STAT pathway.. Mech Dev, 117(1-2), 343-346.
Multiple roles for four-jointed in planar polarity and limb patterning.. Dev Biol, 228(2), 181-196.
Sex determination: co-opted signals determine gender.. Curr Biol, 10(18), R682-R684.
The roles of the Drosophila JAK/STAT pathway.. Oncogene, 19(21), 2598-2606.
The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification.. Curr Biol, 9(23), 1363-1372.
Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling.. Genes Dev, 13(10), 1342-1353.
six-banded, a novel Drosophila gene, is expressed in 6 segmental stripes during embryonic development and in the eye imaginal disc.. Biol Chem, 378(10), 1119-1124.
Drosophila TFIIA-S is up-regulated and required during Ras-mediated photoreceptor determination.. Genes Dev, 10(1), 50-59.
Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation.. Genes Dev, 8(19), 2313-2323.
Comparative anatomy of serotonin-like immunoreactive neurons in isopods: putative homologues in several species.. J Comp Neurol, 347(4), 553-569.
Zoledronate extends healthspan and survival via the mevalonate pathway in a FOXO-dependent manner.
Identification of functionally-distinct macrophage subpopulations regulated by efferocytosis in Drosophila.
Conference proceedings papers