BMS301 - Membrane Receptors (10 credits)

Module Co-ordinator: Dr. EP Seward

Aims

To provide an understanding of membrane receptors for extracellular signalling molecules, including their molecular structure and transduction mechanisms, their roles in physiology, and how these may be exploited as targets for therapeutic drugs.

Content

The module will examine the main families of integral membrane proteins that act as surface receptors to sense the extracellular environment and signal this information to produce changes in cell function. Specific emphasis is placed on receptors which are therapeutic targets for the treatment of common human diseases, including cancer, and chronic inflammatory, cardiovascular and neurological disorders.

The lectures will review current knowledge and thinking about the molecular structure and function of receptors in mammalian cells.  Lecturers will describe how research involving vertebrate and invertebrate model organisms together with state-of-the-art biochemical and molecular techniques have been used to increase our understanding of receptor signalling and how this knowledge may be exploited to develop novel therapeutics.

Objectives

At the end of the module students should be able to:

  • Outline the molecular structure and modus operandi of G protein coupled receptors and enzyme-coupled surface receptors
  • Understand the importance of scaffold and adaptor proteins in organizing and regulating receptor function
  • Describe and understand current experimental methods used to study receptors and be able to use this knowledge to critically analyze published research
  • Describe how drugs interact with and may be used to manipulate surface receptor function
  • Discuss several human diseases that result from abnormal function of surface receptors
  • Utilise and integrate information from different sources.

Teaching Methods

The module is divided into four blocks, each focussed on a particular family of receptors. A reading list consisting of ‘review’ style and research papers is provided to accompany each block of lectures. Teaching in each block consists of a series of formal lectures summarising current knowledge and highlighting key research that has lead to our current  knowledge  about a particular receptor family.  Each block of lectures finishes with a lecturer-lead group discussion and critical analysis of  an original research article taken from the reading list. Questions which form the basis of the discussion are pre-circulated together with the research paper at the start of each block of lectures. These sessions are designed to give students practice and insight into the analysis and interpretation of data generated by the experimental methods described in lectures.

Assessment

This module will be assessed by a 120 minute written examination (100%). The examination will consist of two sections, one section involves analysis of data from one of the research papers on the reading list; the other section requires students to write a short essay demonstrating their knowledge and understanding of topics covered in the module.