Prof. Iain Coldham
Professor of Synthetic Organic Chemistry
Tel: +44-(0)114-22-29428
Fax: +44-(0)114-22-29346
email:
Biographical Sketch
Professor Coldham obtained a BA in Chemistry from the University of Cambridge in 1986, followed by a PhD in 1989. After a postdoctoral research fellowship at the University of Texas at Austin (1989-1991), he was a member of staff at the University of Exeter as a Lecturer/Senior Lecturer from 1991 to 2003. In 2003 he became a Reader at the University of Sheffield, where he was promoted to Professor of Synthetic Organic Chemistry in 2008.
Research Keywords
Organic synthesis, new methodology in organic chemistry, asymmetric organolithium chemistry, heterocyclic chemistry
Teaching Keywords
Organic Chemistry
Selected Publications:
- Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones.
Saruengkhanphasit R, Collier D & Coldham I, The Journal of Organic Chemistry, 82(12), 6489-6496, (2017). - Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition.
Furnival R, Saruengkhanphasit R, Holberry H, Shewring J, Guerrand H, Adams H & Coldham I (2016).em>Org. Biomol. Chem.. - Highly enantioselective metallation-substitution alpha to a chiral nitrile.
Sadhukhan A, Hobbs MC, Meijer AJHM & Coldham I, Chemical Science, 8, 1436-1441, (2016). - Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench.
Talk RA, Duperray A, Li X & Coldham I, Org. Biomol. Chem., 14(21), 4908-4917, (2016). - Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay.
Gotham VJB, Hobbs MC, Burgin R, Turton D, Smythe C & Coldham I, Org. Biomol. Chem., 14(5), 1559-1563, (2016). - Preparation of 1-Substituted Tetrahydro-β-carbolines by Lithiation-Substitution.
Cochrane EJ, Hassall LA & Coldham I, The Journal of Organic Chemistry, 80(11), 5964-5969, (2015). - Synthesis and kinetic resolution of N-Boc-2-arylpiperidines.
Cochrane EJ, Leonori D, Hassall LA & Coldham I, Chemical Communications, 50(69), 9910-9913, (2014). - Synthesis of 1,1-disubstituted tetrahydroisoquinolines by lithiation and substitution, with in situ IR spectroscopy and configurational stability studies..
Li X & Coldham I, J Am Chem Soc, 136(15), 5551-5554, (2014). - Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine.
Li X, Leonori D, Sheikh NS & Coldham I, Chemistry - A European Journal, 19(24), 7724-7730, (2013). - An experimental and in situ IR spectroscopic study of the lithiation-substitution of N-Boc-2-phenylpyrrolidine and -piperidine: controlling the formation of quaternary stereocenters..
Sheikh NS, Leonori D, Barker G, Firth JD, Campos KR, Meijer AJHM, O'Brien P & Coldham I, J Am Chem Soc, 134(11), 5300-5308, (2012).
Journal articles
- Alkayar Z & Coldham I (2018) Cascade cyclization and intramolecular nitrone dipolar cycloaddition and formal synthesis of 19-hydroxyibogamine. Organic & Biomolecular Chemistry. View this article in WRRO
- Aeyad T, Jones C & Coldham I (2018) Preparation of substituted tetrahydro-1-benzazepines by lithiation-trapping. European Journal of Organic Chemistry. View this article in WRRO
- Carter N, Li X, Reavey L, Meijer A & Coldham I (2017) Synthesis and kinetic resolution of substituted tetrahydroquinolines by lithiation then electrophilic quench. Chemical Science, 9. View this article in WRRO
- Aeyad T, Williams J, Meijer A & Coldham I (2017) Lithiation–Substitution of N-Boc-2-phenylazepane. Synlett. View this article in WRRO
- Saruengkhanphasit R, Collier D & Coldham I (2017) Synthesis of Spirocyclic Amines by Using Dipolar Cycloadditions of Nitrones. The Journal of Organic Chemistry, 82(12), 6489-6496. View this article in WRRO
- Coldham I, Meijer AJHM, Sadhukhan A & Hobbs M (2017) Highly Enantioselective Metalation-Substitution alpha to a Chiral Nitrile. SYNLETT, A80-A82. View this article in WRRO
- Alshawish MR, Barker G, Measom ND & Coldham I (2016) Metallation–substitution of an α-oxygenated chiral nitrile. Comptes Rendus Chimie. View this article in WRRO
- Furnival R, Saruengkhanphasit R, Holberry H, Shewring J, Guerrand H, Adams H & Coldham I (2016) Cascade oxime formation, cyclization to a nitrone, and intermolecular dipolar cycloaddition. Org. Biomol. Chem.. View this article in WRRO
- Sadhukhan A, Hobbs MC, Meijer AJHM & Coldham I (2016) Highly enantioselective metallation–substitution alpha to a chiral nitrile. Chemical Science, 8, 1436-1441. View this article in WRRO
- Talk RA, Duperray A, Li X & Coldham I (2016) Synthesis of substituted tetrahydroisoquinolines by lithiation then electrophilic quench. Org. Biomol. Chem., 14(21), 4908-4917. View this article in WRRO
- Alkayar Z, Adams H & Coldham I (2016) Regiochemical and Stereochemical Studies of the Intramolecular Dipolar Cycloaddition of Nitrones Derived from Quaternary Aldehydes. Synlett, 27(03), 447-449. View this article in WRRO
- Gotham VJB, Hobbs MC, Burgin R, Turton D, Smythe C & Coldham I (2016) Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay. Org. Biomol. Chem., 14(5), 1559-1563. View this article in WRRO
- Cochrane EJ, Hassall LA & Coldham I (2015) Preparation of 1-Substituted Tetrahydro-β-carbolines by Lithiation–Substitution. The Journal of Organic Chemistry, 80(11), 5964-5969. View this article in WRRO
- Pathak RB, Dobson BC, Ghosh N, Ageel KA, Alshawish MR, Saruengkhanphasit R & Coldham I (2015) Synthesis of the tricyclic core of manzamine A. Organic & Biomolecular Chemistry, 13(11), 3331-3340. View this article in WRRO
- Cochrane EJ, Leonori D, Hassall LA & Coldham I (2014) Synthesis and kinetic resolution of N-Boc-2-arylpiperidines. Chemical Communications, 50(69), 9910-9913. View this article in WRRO
- Li X & Coldham I (2014) Synthesis of 1,1-disubstituted tetrahydroisoquinolines by lithiation and substitution, with in situ IR spectroscopy and configurational stability studies.. J Am Chem Soc, 136(15), 5551-5554. View this article in WRRO
- Mortimer D, Whiting M, Harrity JPA, Jones S & Coldham I (2014) Synthesis of an azabicyclic framework towards (±)-actinophyllic acid. Tetrahedron Letters, 55(6), 1255-1257. View this article in WRRO
- Nath D, Skilbeck MC, Coldham I & Fleming FF (2014) Arylthio-metal exchange of α-arylthioalkanenitriles.. Org Lett, 16(1), 62-65.
- Barker G, Alshawish MR, Skilbeck MC & Coldham I (2013) Remarkable configurational stability of magnesiated nitriles.. Angew Chem Int Ed Engl, 52(30), 7700-7703.
- Li X, Leonori D, Sheikh NS & Coldham I (2013) Synthesis of 1-substituted tetrahydroisoquinolines by lithiation and electrophilic quenching guided by in situ IR and NMR spectroscopy and application to the synthesis of salsolidine, carnegine and laudanosine. Chemistry - A European Journal, 19(24), 7724-7730.
- García-Calvo O, Coya E, Lage S, Coldham I, Sotomayor N & Lete E (2013) Intramolecular carbolithiation reactions in the construction of medium-sized rings. Synthesis of pyrroloisoquinolines, benzazepines, and benzazocines. European Journal of Organic Chemistry(8), 1460-1470.
- Ince HH, Dedeoglu B, Gul S, Aviyente V & Coldham I (2012) Selectivity in the aggregates of the chiral organolithium N-Boc-2-lithiopiperidine with a chiral ligand: A DFT study. Molecular Physics, 110(6), 353-359.
- Sheikh NS, Leonori D, Barker G, Firth JD, Campos KR, Meijer AJHM, O'Brien P & Coldham I (2012) An experimental and in situ IR spectroscopic study of the lithiation-substitution of N-Boc-2-phenylpyrrolidine and -piperidine: controlling the formation of quaternary stereocenters.. J Am Chem Soc, 134(11), 5300-5308.
- Thompson MJ, Louth JC, Little SM, Jackson MP, Boursereau Y, Chen B & Coldham I (2012) Synthesis and evaluation of 1-amino-6-halo-β-carbolines as antimalarial and antiprion agents.. ChemMedChem, 7(4), 578-586.
- Coldham I, Burrell AJM, Guerrand HDS, Watson L, Martin NG & Oram N (2012) Synthesis of fused tricyclic amines unsubstituted at the ring-junction positions by a cascade condensation, cyclization, cycloaddition then decarbonylation strategy. Beilstein Journal of Organic Chemistry, 8, 107-111. View this article in WRRO
- Coldham I, Robinson SP & Baxter CA (2012) Asymmetric synthesis of 2-arylpyrrolidines by cationic cyclization. Synlett, 23(16), 2405-2407.
- Guerrand HDS, Adams H & Coldham I (2011) Cascade cyclization, dipolar cycloaddition of azomethine imines for the synthesis of pyrazolidines.. Org Biomol Chem, 9(22), 7921-7928.
- Thompson MJ, Louth JC, Little SM, Chen B & Coldham I (2011) 2,4-diarylthiazole antiprion compounds as a novel structural class of antimalarial leads.. Bioorg Med Chem Lett, 21(12), 3644-3647.
- Coldham I, Watson L, Adams H & Martin NG (2011) Synthesis of the core ring system of the yuzurimine-type Daphniphyllum alkaloids by cascade condensation, cyclization, cycloaddition chemistry.. J Org Chem, 76(7), 2360-2366.
- Coldham I, Burrell AJM, Guerrand HDS & Oram N (2011) Cascade cyclization, dipolar cycloaddition to bridged tricyclic amines related to the Daphniphyllum alkaloids.. Org Lett, 13(6), 1267-1269.
- Franklin AI, Bensa D, Adams H & Coldham I (2011) Transannular dipolar cycloaddition as an approach towards the synthesis of the core ring system of the sarain alkaloids.. Org Biomol Chem, 9(6), 1901-1907.
- Coldham I, Burrell AJM, Watson L, Oram N & Martinc NG (2011) Synthesis of fused tricyclic heterocycles by condensation, cyclization, dipolar cycloaddition cascade of α-benzenesulfonyl and α-phenylthio substituted aldehydes. Heterocycles, 84(1), 597-613.
- García-Calvo O, Sotomayor N, Lete E & Coldham I (2011) Organolithium or Heck-type cyclization of N-ortho-iodobenzyl-2- alkenylpyrrolidines to give indolizidines. Arkivoc, 2011(5), 57-66.
- Shakhidoyatov KM, Coldham I & Ibragimov TF (2011) LITHIATION OF DEOXYPEGANINE AND CHIRAL SYNTHESIS OF DEOXYPEGANINE DERIVATIVES. CHEM NAT COMPD+, 46(6), 929-931.
- Burrell AJM, Watson L, Martin NG, Oram N & Coldham I (2010) Synthesis of the core ring system of the stemona alkaloids by cascade condensation, cyclization, intramolecular cycloaddition.. Org Biomol Chem, 8(20), 4530-4532.
- Burrell AJM & Coldham I (2010) Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions. CURR ORG SYNTH, 7(4), 312-331.
- Robinson SP, Sheikh NS, Baxter CA & Coldham I (2010) Dynamic thermodynamic resolution of lithiated N-Boc-N '-alkylpiperazines. TETRAHEDRON LETT, 51(28), 3642-3644.
- Coldham I & Leonori D (2010) Regioselective and stereoselective copper(I)-promoted allylation and conjugate addition of N-Boc-2-lithiopyrrolidine and N-Boc-2-lithiopiperidine.. J Org Chem, 75(12), 4069-4077.
- Stead D, Carbone G, O'Brien P, Campos KR, Coldham I & Sanderson A (2010) Asymmetric deprotonation of N-boc piperidine: react IR monitoring and mechanistic aspects.. J Am Chem Soc, 132(21), 7260-7261.
- Coldham I, Adams H, Ashweek NJ, Barker TA, Reeder AT & Skilbeck MC (2010) Synthesis of 2-hydroxy-3-indolinones and 3-hydroxy-2-indolinones by anionic cyclization, in situ oxidation and rearrangement. TETRAHEDRON LETT, 51(18), 2457-2460. View this article in WRRO
- Coldham I, Raimbault S, Whittaker DTE, Chovatia PT, Leonori D, Patel JJ & Sheikh NS (2010) Asymmetric substitutions of 2-lithiated N-boc-piperidine and N-Boc-azepine by dynamic resolution.. Chemistry, 16(13), 4082-4090.
- Coldham I & Sheikh NS (2010) Dynamic resolutions of chiral organolithiums. Topics in Stereochemistry, 26, 253-293.
- Leonori D & Coldham I (2009) Direct Preparation of 7-Allyl- and 7-Arylindolines. ADV SYNTH CATAL, 351(16), 2619-2623.
- Coldham I, Leonori D, Beng TK & Gawley RE (2009) The barrier to enantiomerization and dynamic resolution of N-Boc-2-lithiopiperidine and the effect of TMEDA.. Chem Commun (Camb)(35), 5239-5241.
- Beng TK, Yousaf TI, Coldham I & Gawley RE (2009) Enantiomerization dynamics and a catalytic dynamic resolution of N-trimethylallyl-2-lithiopyrrolidine.. J Am Chem Soc, 131(20), 6908-6909.
- Coldham I, Jana S, Watson L & Martin NG (2009) Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (+/-)-crispine A.. Org Biomol Chem, 7(8), 1674-1679.
- Burrell AJM, Coldham I & Oram N (2009) Synthesis of fused tricyclic amines from enolizable acyclic aldehydes by cyclization then dipolar cycloaddition cascade: synthesis of myrioxazine A.. Org Lett, 11(7), 1515-1518.
- Burrell AJM, Coldham I, Watson L, Oram N, Pilgram CD & Martin NG (2009) Stereoselective formation of fused tricyclic amines from acyclic aldehydes by a cascade process involving condensation, cyclization, and dipolar cycloaddition.. J Org Chem, 74(6), 2290-2300.
- Coldham I, Raimbault S, Chovatia PT, Patel JJ, Leonori D, Sheikh NS & Whittaker DTE (2008) Dynamic resolution of N-Boc-2-lithiopiperidine.. Chem Commun (Camb)(35), 4174-4176.
- Coldham I, Jana S, Watson L & Pilgram CD (2008) Cascade cyclization intermolecular dipolar cycloaddition by multi-component couplings - synthesis of indolizidines and pyrrolizidines. TETRAHEDRON LETT, 49(37), 5408-5410.
- Coldham I & Leonori D (2008) Synthesis of 2-arylpiperidines by palladium couplings of aryl bromides with organozinc species derived from deprotonation of N-boc-piperidine.. Org Lett, 10(17), 3923-3925.
- Bensa D, Coldham I, Feinäugle P, Pathak RB & Butlin RJ (2008) Synthesis of carboxylic amides by ring-opening of oxazolidinones with Grignard reagents.. Org Biomol Chem, 6(8), 1410-1415.
- Yousaf TI, Williams RL, Coldham I & Gawley RE (2008) The barrier to enantiomerization of N-Boc-2-lithiopyrrolidine: the effect of chiral and achiral diamines.. Chem Commun (Camb)(1), 97-98.
- Coldham I, Patel JJ, Raimbault S, Whittaker DTE, Adams H, Fang GY & Aggarwal VK (2008) Asymmetric lithiation-substitution of amines involving rearrangement of borates.. Org Lett, 10(1), 141-143.
- Coldham I, Patel JJ, Raimbault S & Whittaker DTE (2007) Dynamic kinetic and kinetic resolution of N-Boc-2-lithiopiperidine.. Chem Commun (Camb)(43), 4534-4536.
- Coldham I, O'Brien P, Patel JJ, Raimbault S, Sanderson AJ, Stead D & Whittaker DTE (2007) Asymmetric deprotonation of N-boc-piperidines. TETRAHEDRON-ASYMMETR, 18(17), 2113-2119.
- Coldham I, Dobson BC, Fletcher SR & Franklin AI (2007) Intramolecular dipolar cycloaddition reactions to give substituted indoles - A formal synthesis of deethylibophyllidine. EUR J ORG CHEM(16), 2676-2686.
- Coldham I, Dobson BC, Franklin AI & Fletcher SR (2007) Synthesis of tetracyclic indole-containing ring systems by intramolecular cycloadditions of azomethine ylides. TETRAHEDRON LETT, 48(5), 873-875.
- Coldham I, Burrell AJM, White LE, Adams H & Oram N (2007) Highly efficient synthesis of tricyclic amines by a cyclization/cycloaddition cascade: total syntheses of aspidospermine, aspidospermidine, and quebrachamine.. Angew Chem Int Ed Engl, 46(32), 6159-6162.
- Christoph G, Stratmann C, Coldham I & Hoppe D (2006) Asymmetric synthesis of 3-hydroxy-pyrrolidines via tin-lithium exchange and cyclization.. Org Lett, 8(20), 4469-4471.
- Coldham I, Dufour S, Haxell TFN, Patel JJ & Sanchez-Jimenez G (2006) Dynamic thermodynamic and dynamic kinetic resolution of 2-lithiopyrrolidines.. J Am Chem Soc, 128(33), 10943-10951.
- Coldham I, Pih SM & Rabot R (2005) Dipolar cycloaddition and ring-closing metathesis in the synthesis of the tetracyclic ABCE ring system of manzamine A. SYNLETT(11), 1743-1745.
- Coldham I & Hufton R (2005) Intramolecular dipolar cycloaddition reactions of azomethine ylides.. Chem Rev, 105(7), 2765-2810.
- Coldham I, Patel JJ & Sanchez-Jimenez G (2005) Dynamic kinetic resolution of N-Boc-2-lithiopyrrolidine.. Chem Commun (Camb)(24), 3083-3085.
- Gawley RE, Klein R, Ashweek NJ & Coldham I (2005) Structural studies of {Li-6} 2-lithiopyrrolidines using NMR spectroscopy. TETRAHEDRON, 61(13), 3271-3280.
- Coldham I, Dufour S, Haxell TFN & Vennall GP (2005) Dynamic resolution of N-alkyl-2-lithiopyrrolidines with the chiral ligand (-)-sparteine. TETRAHEDRON, 61(13), 3205-3220.
- Ashweek NJ, Brandt P, Coldham I, Dufour S, Gawley RE, Haeffner F, Klein R & Sanchez-Jimenez G (2005) Barrier to enantiomerization of unstabilized, chelated, and dipole-stabilized 2-lithiopyrrolidines. J AM CHEM SOC, 127(1), 449-457.
- Boursereau Y & Coldham I (2004) Synthesis and biological studies of 1-amino beta-carbolines.. Bioorg Med Chem Lett, 14(23), 5841-5844.
- Coldham I, Price KN & Rathmell RE (2003) Intramolecular carbolithiation reactions for the preparation of 3-alkenylpyrrolidines.. Org Biomol Chem, 1(12), 2111-2119.
- Ashweek NJ, Coldham I, Haxell TF & Howard S (2003) Preparation of diamines by lithiation-substitution of imidazolidines and pyrimidines.. Org Biomol Chem, 1(9), 1532-1544.
- Coldham I, Dufour S, Haxell TFN, Howard S & Vennall GP (2002) Enantioselective synthesis of substituted pyrrolidines by dynamic resolution.. Angew Chem Int Ed Engl, 41(20), 3887-3889.
- Coldham I, Crapnell KM, Fernàndez J-C, Moseley JD & Rabot R (2002) Synthesis of the ABC ring system of manzamine A.. J Org Chem, 67(17), 6181-6187.
- Ashweek NJ, Coldham I, Snowden DJ & Vennall GP (2002) Intramolecular carbolithiation reactions of chiral alpha-amino-organolithium species.. Chemistry, 8(1), 195-207.
- Coldham I, Copley RC, Haxell TF & Howard S (2001) Synthesis of chiral 1,2-diamines by asymmetric lithiation-substitution.. Org Lett, 3(23), 3799-3801.
- Coldham I, Hufton R, Price KN, Rathmell RE, Snowden DJ & Vennall GP (2001) Stereoselective synthesis of pyrrolidines and pyrrolizidines by intramolecular carbolithiation. SYNTHESIS-STUTTGART(10), 1523-1531.
- Coldham I, Crapnell KM, Moseley JD & Rabot R (2001) Intramolecular azomethine ylide cycloaddition reactions to give octahydroindoles. J CHEM SOC PERK T 1(15), 1758-1763.
- Coldham I, Fernandez JC, Price KN & Snowden DJ (2000) Intramolecular carbolithiation reactions for the preparation of azabicyclo[2.2.1] heptanes. J ORG CHEM, 65(12), 3788-3795.
- Ashweek NJ, Coldham I & Vennall GP (2000) A convenient route to N-alkyl-2-tributylstannyl-pyrrolidines involving reductive amination. TETRAHEDRON LETT, 41(13), 2235-2237.
- Arbore APA, Cane-Honeysett DJ, Coldham I & Middleton ML (2000) A rapid approach to amino-acid derivatives by [2,3]-Stevens rearrangement. SYNLETT(2), 236-238.
- Coldham I & Vennall GP (2000) Chiral organolithium species: determination of the rate of cyclization and extent of racemization. CHEM COMMUN(17), 1569-1570.
- Coldham I, Coles SJ, Crapnell KM, Fernandez JC, Haxell TFN, Hursthouse MB, Moseley JD & Treacy AB (1999) A new stereoselective approach to the manzamine alkaloids. CHEM COMMUN(17), 1757-1758.
- Buston JEH, Coldham I & Mulholland KR (1999) Meisenheimer rearrangements of N-allyl 2-azabornane derivatives. J CHEM SOC PERK T 1(16), 2327-2334.
- Coldham I, Fernandez JC & Snowden DJ (1999) Synthesis of 7-azabicyclo[2.2.1]heptanes by anionic cyclization. TETRAHEDRON LETT, 40(9), 1819-1822.
- Coldham I, Judkins RA & Witty DR (1998) Proton abstraction and electrophilic quench at C-2 of imidazolidines. TETRAHEDRON, 54(47), 14255-14264.
- Coldham I, Houdayer PMA, Judkins RA & Witty DR (1998) N,N '-bisacylimidazolidines from 1,2-diamines. SYNTHESIS-STUTTGART(10), 1463-1466.
- Coldham I, Middleton ML & Taylor PL (1998) Investigations into the [2,3]-aza-Wittig rearrangement of N-alkyl N-allyl alpha-amino esters. J CHEM SOC PERK T 1(17), 2817-2821.
- Buston JEH, Coldham I & Mulholland KR (1998) Studies into the asymmetric Meisenheimer rearrangement. TETRAHEDRON-ASYMMETR, 9(11), 1995-2009.
- Coldham I (1998) Main group organometallics in synthesis. J CHEM SOC PERK T 1(7), 1343-1364.
- Coldham I, LangAnderson MMS, Rathmell RE & Snowden DJ (1997) Synthesis of pyrrolidines by anionic cyclization onto allylic ethers, alkynes and carboxylic groups. TETRAHEDRON LETT, 38(43), 7621-7624.
- Coldham I, Hufton R & Rathmell RE (1997) Stereoselective anionic cyclizations to pyrrolidines. TETRAHEDRON LETT, 38(43), 7617-7620.
- Coldham I, Middleton ML & Taylor PL (1997) N-alkylation and [2,3]-sigmatropic rearrangement of N-allyl alpha-amino esters. J CHEM SOC PERK T 1(20), 2951-2952.
- Coldham I, Holman S & LangAnderson MS (1997) Preparation of beta-amino alcohols by carbon-carbon bond formation using substituted lithiomethylpyrrolidines. J CHEM SOC PERK T 1(10), 1481-1485.
- Coldham I (1997) Main group organometallics in synthesis. CONTEMP ORG SYNTH, 4(2), 136-163.
- Buston JEH, Coldham I & Mulholland KR (1997) Chirality transfer from nitrogen to carbon in the [2,3]-Meisenheimer rearrangement. SYNLETT(3), 322-&.
- Coldham I, Houdayer PMA, Judkins RA & Witty DR (1996) One-pot synthesis of N,N'-bisacylimidazolidines; Potential new acyl anion equivalents. SYNLETT(11), 1109-&.
- Coldham I & Hufton R (1996) Synthesis of 3-alkylpyrrolidines by anionic cyclization. TETRAHEDRON, 52(38), 12541-12552.
- Coldham I, Hufton R & Snowden DJ (1996) Anionic cyclizations of alpha-aminoorganolithiums. Determination of the stereoselectivity at the carbanion center and the synthesis of (+)-pseudoheliotridane. J AM CHEM SOC, 118(22), 5322-5323.
- COLDHAM I, COLLIS AJ, MOULD RJ & RATHMELL RE (1995) SYNTHESIS OF 4-PHENYLPIPERIDINES BY TANDEM WITTIG OLEFINATION-AZA-WITTIG REARRANGEMENT OF 2-BENZOYLAZIRIDINES. J CHEM SOC PERK T 1(21), 2739-2745.
- MAGNUS P, LACOUR J, COLDHAM I, MUGRAGE B & BAUTA WB (1995) NEW TRIALKYLSILYL ENOL ETHER CHEMISTRY - ALPHA-N-TOSYLAMINATION OF TRIISOPROPYLSILYL ENOL ETHERS. TETRAHEDRON, 51(41), 11087-11110.
- COLDHAM I, COLLIS AJ, MOULD RJ & ROBINSON DE (1995) PYRROLIDINES BY 1,3-DIPOLAR CYCLOADDITION OF CONJUGATED AZOMETHINE YLIDES. SYNTHESIS-STUTTGART(9), 1147-&.
- COLDHAM I, COLLIS AJ, MOULD RJ & RATHMELL RE (1995) RING EXPANSION OF AZIRIDINES TO PIPERIDINES USING THE AZA-WITTIG REARRANGEMENT. TETRAHEDRON LETT, 36(20), 3557-3560.
- COLDHAM I & HUFTON R (1995) A NEW ROUTE TO CYCLIC AMINES BY ANIONIC CYCLIZATION. TETRAHEDRON LETT, 36(12), 2157-2160.
- COLDHAM I & WARREN S (1993) SYNTHESIS OF CYCLIC AMINES AND ALLYLIC SULFIDES BY PHENYLTHIO MIGRATION OF BETA-HYDROXY SULFIDES. J CHEM SOC PERK T 1(14), 1637-1656.
- COLDHAM I (1993) AZA-WITTIG REARRANGEMENTS AND CYCLIZATIONS BY TRANSMETALATION OF N-BENZYLAMINOMETHYLSTANNANES. J CHEM SOC PERK T 1(12), 1275-1276.
- COLDHAM I & WARREN S (1992) STEREOSPECIFIC PHENYLTHIO MIGRATIONS IN THE SYNTHESIS OF SPIROCYCLIC LACTONES AND ETHERS FROM N-METHYL-4-PIPERIDONE AND QUINUCLIDIN-3-ONE. J CHEM SOC PERK T 1(18), 2303-2307.
- AGGARWAL VK, COLDHAM I, MCINTYRE S & WARREN S (1991) TRANSFORMATION OF CYCLIC ALPHA-PHENYLTHIO ALDEHYDES BY STEREOSELECTIVE ALDOL REACTIONS AND PHENYLTHIO MIGRATION INTO SPIROCYCLIC LACTONES AND ETHERS, AND E-ALLYLIC ALCOHOLS WITH 1,4-RELATED CHIRAL CENTERS. J CHEM SOC PERK T 1(2), 451-460.
- MAGNUS P & COLDHAM I (1991) NEW TRIALKYLSILYL ENOL ETHER CHEMISTRY - SYNTHESIS OF THE BENZOMORPHANONE CORE STRUCTURE USING A STEREOELECTRONIC CONFORMATIONAL LOCK. J AM CHEM SOC, 113(2), 672-673.
- COLDHAM I & WARREN S (1989) STEREOCONTROLLED AMIDOCYCLIZATIONS WITH PHENYLTHIO MIGRATION. TETRAHEDRON LETT, 30(43), 5937-5940.
- AGGARWAL VK, COLDHAM I, MCINTYRE S, SANSBURY FH, VILLA MJ & WARREN S (1988) STEREOCHEMICAL CONTROL IN THE SYNTHESIS OF TETRAHYDROFURANS BY CYCLIZATION OF DIOLS WITH PHENYLTHIO MIGRATION. TETRAHEDRON LETT, 29(38), 4885-4888.
- COLDHAM I, COLLINGTON EW, HALLETT P & WARREN S (1988) STEREOCHEMICALLY CONTROLLED SYNTHESIS OF SPIROCYCLIC LACTONES AND ETHERS FROM N-METHYL-4-PIPERIDONE AND 3-QUINUCLIDINONE BY PHENYLTHIO MIGRATION. TETRAHEDRON LETT, 29(41), 5321-5324.
Chapters
- (2010) Dynamic Resolutions of Chiral Organolithiums, Stereochemical Aspects of Organolithium Compounds (pp. 253-293).
Conference proceedings papers
- Coldham I, Burrell AJM & Oram N (2008) ORGN 422-Highly efficient synthesis of tricyclic amines by a cyclization/cycloaddition cascade: Total syntheses of aspidospermidine, aspidospermine and quebrachamine. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 235
- Pih SM & Coldham I (2005) Towards the total synthesis of manzamine a using 1,3 dipolar cycloaddition of azomethine ylides.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 229 (pp U370-U370)
- Coldham I & Dufour S (2003) Dynamic resolution of alpha-amino-organolithium species.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 226 (pp U169-U169)
- Klein R, Gawley RE, Ashweek NJ, Brandt P, Coldham I, Dufour S & Haeffner F (2003) Enantiomerization of unstabilized and dipole-stabilized 2-lithiopyrrolidines: (Absolute) barrier to inversion. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Vol. 226 (pp U149-U149)
- Coldham I, Fernandez JC, Rabot R & Crapnell KM (2001) Synthesis of the core ring system of manzamine A using azomethine ylide cycloaddition chemistry.. ABSTR PAP AM CHEM S, Vol. 221 (pp U100-U100)