Group members

Our key research PIs encompass several departments from the Faculties of Science to the Schools of Medicine, Dentistry and Health.

Group themes

Principal investigators and research interests

Professor Kathryn Ayscough (BMS)
Cytoskeleton and endocytosis – Regulation of the actin cytoskeleton during endocytosis and membrane trafficking in both healthy and stressed cells. Role in diseases including neurodegeneration and cancer.
Dr Mark Bass (BMS)
Fibroblast migration during wound healing: signalling from extracellular matrix receptors to Rho-family GTPase
Dr Ashley Cadby (Physics and Astronomy)
Photonic systems, photovoltaic systems, advanced microscopy.
Dr Barbara Ciani (Chemistry)
Role of coiled-coiled proteins in membrane traffic.
Dr Mark Collins (BMS)
Biological mass spectrometry
Professor Bazbek Davletov (BMS)
Protein stapling as a mechanism of drug targeting.
Professor David Dockrell (Infection and Immunity)
How macrophages contribute to innate immunity with particular emphasis on the phagocytic process.
Dr Kurt De Vos (SiTran)
Mitochondrial dynamics in motorneurone disease.
Dr Kai Erdmann (BMS)
Membrane trafficking and signalling in polarised cells. Role of multi-PDZ domain proteins in cancer formation, metastasis and tumor invasion.
Dr Andy Furley (BMS)
Role of L1CAM-like adhesion molecules in neural development.
Dr Andy Grierson (SiTran)
Regulation of axonal transport in health and disease using zebrafish and mouse as model organisms.
Dr Chun Guo (BMS)
Protein SUMOylation and deSUMOylation in health and disease.
Dr Rhoda Hawkins (Physics and Astronomy)
Biological Physics, soft matter physics, active matter.
Dr Ewald Hettema (MBB)
Membrane trafficking and fission. Growth and division of peroxisomes and interactions with the endoplasmic reticulum. Regulation by the dynamin-related proteins Vps1 and Dnm1.
Professor Jamie Hobbs (Physics and Astronomy)
Non-destructive observations of processes in polymers in real time under a wide variety of environmental conditions. Development and application of scanning probe microscopy (SPM) techniques for the study of polymers. Studies on polymer crystallisation.
Dr Daniel Humphreys (BMS)
Manipulation of mammalian host cell biology by bacterial toxins and virulence effectors.
Dr Stuart Johnson (BMS)
Post-synaptic physiology – Vesicle release and information transfer in the auditory system.
Dr Jason King (BMS)
The regulation and integration of autophagy
Dr Jarema Malicki (BMS)
Cell polarity and ciliogenesis.
Professor Walter Marcotti (BMS)
Pre-synaptic physiology – Calcium sensitivity of ribbon synapses in auditory hair cells. Physiology of vesicle docking and release.
Professor Nick Monk (SoMaS)
Mathematical and computational modelling in biological systems.
Dr Anton Nikolaev (BMS)
In vivo imaging of neuronal activity in zebrafish and visual information processing in the central nervous system.
Dr Lisa Parker (Infection and Immunity)
Modulation of cell membrane function as novel target (with Prof Sabroe). Study of roles of autophagy in control of viral infection, and potential to manipulate autophagy to reduce airway inflammation in response to rhinoviral infection.
Dr Andrew Peden (BMS)
Regulation of secretion and how trafficking impacts on disease.
Dr Elena Rainero (BMS)
Understanding the role of extracellular matrix internalisation in cell migration and invasion.
Professor Ian Sabroe (Infection and Immunity)
Modulation of cell membrane function as novel therapeutic target. Targeting of lipid rafts and TLR signalling from membrane microdomains to reduce airways inflammation. Study of consequences of membrane manipulation on phagocyte function, endosomal function and trafficking.
Dr Elizabeth Seward (BMS)
Exocytosis – Identification of the signalling pathways and molecules controlling secretion from neurones and mast cells, with special interest in voltage-gated, ligand-gated (P2X and nAChR), receptor-operated (TRPC) and store-operated (Orai) calcium channels, IgE and G protein coupled receptors (P2Y, Histamine), and SNARE regulatory proteins (synaptotagmins, Doc2 and Munc13).
Professor Elizabeth Smythe (BMS)
Endocytosis - Molecular mechanisms of cargo sorting along the endocytic pathway with particular emphasis on the regulation of the clathrin coated vesicle cycle by rab5 and reversible phosphorylation. Interplay between endocytic trafficking and signaling pathways.
Professor David Strutt (BMS)
Planar cell polarity – Coordination and maintenance of cell polarity during development, with a primary interest in the roles of the Frizzled sevenpass transmembrane receptor.
Professor Pete Sudbery (MBB)
Cellular morphogenesis in the human pathogen Candida albicans.
Professor Steve Winder (BMS)
Membrane proteins and the cytoskeleton - The biology of the cell adhesion and signalling adaptor protein dystroglycan and its role in diseases such as muscular dystrophy and cancer. Regulation of the actin cytoskeleton, cell adhesion mediated signalling and cell motility
Dr Martin Zeidler (BMS)
JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies. High throughput RNAi screening technologies and developmental genetic assays in Drosophila to determine the mechanisms of action of pathway regulators and their interactions in vivo.